Microbiology

Antiviral roles of interferon regulatory factor (IRF)-1, 3 and 7 against human coronavirus infection

1. Danyang Xu
2. Joseph K. Sampson Duncan
3. Maria Licursi
4. Jin Gohda
5. Yasushi Kawaguchi
6. Kensuke Hirasawa

Reviewed by ScreenIT

Optimized production and fluorescent labelling of SARS-CoV-2 Virus-Like-Particles to study virus assembly and entry

1. Manon Gourdelier
2. Jitendriya Swain
3. Coline Arone
4. Anita Mouttou
5. David Bracquemond
6. Peggy Merida
7. Saveez Saffarian
8. Sébastien Lyonnais
9. Cyril Favard
10. Delphine Muriaux

Reviewed by ScreenIT

Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes

1. Ola Diebold
2. Victoria Gonzalez
3. Luca Venditti
4. Colin Sharp
5. Rosemary A. Blake
6. Joanne Stevens
7. Sarah Caddy
8. Paul Digard
9. Alexander Borodavka
10. Eleanor Gaunt

Reviewed by ScreenIT

SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein

1. Hope Waisner
2. Brandon Grieshaber
3. Rabina Saud
4. Wyatt Henke
5. Edward B. Stephens
6. Maria Kalamvoki

Reviewed by ScreenIT

Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model

1. Lisa Bauer
2. Melanie Rissmann
3. Feline F. W. Benavides
4. Lonneke Leijten
5. Lineke Begeman
6. Edwin Veldhuis Kroeze
7. Peter van Run
8. Marion P. G. Koopmans
9. Barry Rockx
10. Debby van Riel

Reviewed by ScreenIT

The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

1. Pramod K Jangir
2. Lois Ogunlana
3. Petra Szili
4. Marton Czikkely
5. Liam P Shaw
6. Emily J Stevens
7. Yang Yu
8. Qiue Yang
9. Yang Wang
10. Csaba Pál
11. Timothy R Walsh
12. Craig R MacLean

• Curated by eLife

  eLife assessment

  Antimicrobial peptides (AMP) are a class of antibiotics that are inspired by natural components of innate immunity, which raises the specter of bacteria becoming resistant to both. The author this important study test this idea and find compelling evidence that a plasmid that encodes resistance to the AMP colistin also increases resistance to AMPS produced by humans, pigs, and chickens, enables the bacteria to grow better in low levels of AMP, and increases bacterial virulence in an insect model of infection. The study will be of interest to both evolutionary biologists and microbiologists focused on antimicrobial therapy and suggests that the evolution of resistance to these compounds can have collateral effects on immune evasion as well.

Reviewed by eLife, PREreview

Cellulosic copper nanoparticles and a hydrogen peroxide-based disinfectant protect Vero E6 cells against infection by viral pseudotyped particles expressing SARS-CoV-2, SARS-CoV or MERS-CoV Spike protein

1. Ariane Brault
2. Raphael Néré
3. Jérôme Prados
4. Simon Boudreault
5. Martin Bisaillon
6. Patrick Marchand
7. Patrick Couture
8. Simon Labbé

Reviewed by ScreenIT

An Archaea-specific c-type cytochrome maturation machinery is crucial for methanogenesis in Methanosarcina acetivorans

1. Dinesh Gupta
2. Katie E Shalvarjian
3. Dipti D Nayak

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to scientists interested in archaea and the field of bioenergetics. Using a series of elegant experiments the authors show that that archaea have a streamlined and functional cytochrome c biogenesis machinery.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

1. Dallas L Mould
2. Mirjana Stevanovic
3. Alix Ashare
4. Daniel Schultz
5. Deborah A Hogan

• Curated by eLife

  Evaluation Summary:

  This study aimed to identify the genetic foundation favoring selection of lasR mutants in laboratory and clinical isolates from persons with CF. They selected these mutants using a predictable and quantitative framework of evolution experiments and then identified their genetic underpinnings by a a suppressor screen. The role of cbrAB as a key intermediate is important and ties together several reports of nutrient-dependent advantages of lasR like phenylalanine.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan

1. Tetsuya Komatsu
2. Kenji Ohya
3. Atsushi Ota
4. Yukiko Nishiuchi
5. Hirokazu Yano
6. Kayoko Matsuo
7. Justice Opare Odoi
8. Shota Suganuma
9. Kotaro Sawai
10. Akemi Hasebe
11. Tetsuo Asai
12. Tokuma Yanai
13. Hideto Fukushi
14. Takayuki Wada
15. Shiomi Yoshida
16. Toshihiro Ito
17. Kentaro Arikawa
18. Mikihiko Kawai
19. Manabu Ato
20. Anthony D Baughn
21. Tomotada Iwamoto
22. Fumito Maruyama

Reviewed by GigaByte