1. BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection

    This article has 11 authors:
    1. Guillermo Najarro
    2. Kevin Brackett
    3. Hunter Woosley
    4. Catya Faeldonea
    5. Osvaldo Kevin Moreno
    6. Adriana Ramirez Negron
    7. Christina Love
    8. Ryan Ward
    9. Charles Langelier
    10. Brooke M. Gardner
    11. Carolina Arias

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

    This article has 4 authors:
    1. Abigail Knecht
    2. Denise Sirias
    3. Daniel R. Utter
    4. Karine A. Gibbs
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable insights into the specificity and promiscuity of toxic effector and immunity protein pairs. While the work is improved over a previous version, there are still some questions regarding the methodology used to draw certain conclusions, rendering the study somewhat incomplete. Nevertheless, this work will likely be of interest to microbiologists and biochemists working with toxin-antitoxin systems and effector-immunity proteins.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  3. Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

    This article has 11 authors:
    1. Astrid K.M. Stubbusch
    2. Johannes M. Keegstra
    3. Julia Schwartzman
    4. Sammy Pontrelli
    5. Estelle E. Clerc
    6. Samuel Charlton
    7. Roman Stocker
    8. Cara Magnabosco
    9. Olga T. Schubert
    10. Martin Ackermann
    11. Glen G. D’Souza
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript is a valuable contribution to our understanding of foraging behaviors in marine bacteria. The authors present a conceptual model for how a marine bacterial species consumes an abundant polysaccharide. Using experiments in microfluidic devices and through measurements of motility and gene expression, the authors offer convincing evidence that the degradation products of polysaccharide digestion can stimulate motility.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum

    This article has 6 authors:
    1. Penny C Sparkes
    2. Mufuliat Toyin Famodimu
    3. Eduardo Alves
    4. Eric Springer
    5. Jude Przyborski
    6. Michael J Delves

    Reviewed by PREreview

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  5. Late killing of Plasmodium berghei in the liver by an anti-circumsporozoite protein monoclonal antibody

    This article has 8 authors:
    1. Manuela C. Aguirre-Botero
    2. Olga Pacios
    3. Susanna Celli
    4. Eduardo Aliprandini
    5. Anisha Gladston
    6. Jean-Michel Thiberge
    7. Pauline Formaglio
    8. Rogerio Amino

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

    This article has 8 authors:
    1. Mengdie Fang
    2. Ruiting Zhang
    3. Chenyu Wang
    4. Zhizhi Liu
    5. Mingyue Fei
    6. Biao Tang
    7. Hua Yang
    8. Dongchang Sun

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle

    This article has 5 authors:
    1. Alice L Herneisen
    2. Michelle L Peters
    3. Tyler A Smith
    4. Emily Shortt
    5. Sebastian Lourido
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study identifies protein kinases in the parasitic protozoan, Toxoplasma gondii that are required for parasite invasion of host cells and differentiation to drug-resistant chronic stages. The use of advanced proteomic and functional approaches provides compelling evidence for the proposed signalling pathway, although additional analyses are needed to fully validate some findings. The work will be of broad interest to cell biologists and parasitologists with an interest in cell signalling and environmental sensing.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

    This article has 16 authors:
    1. Srinivasan Vijay
    2. Nguyen Le Hoai Bao
    3. Dao Nguyen Vinh
    4. Le Thanh Hoang Nhat
    5. Do Dang Anh Thu
    6. Nguyen Le Quang
    7. Le Pham Tien Trieu
    8. Hoang Ngoc Nhung
    9. Vu Thi Ngoc Ha
    10. Phan Vuong Khac Thai
    11. Dang Thi Minh Ha
    12. Nguyen Huu Lan
    13. Maxine Caws
    14. Guy E Thwaites
    15. Babak Javid
    16. Nguyen Thuy Thuong Thuong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study demonstrates that there is significant variation in the susceptibility of isoniazid-resistant Mycobacterium tuberculosis clinical isolates to killing by rifampicin, in some cases at the same tolerance levels as bona fide resistant strains. The evidence provided is solid, with no clear genetic marker for increased tolerance, suggesting that there may be multiple routes to achieving this phenotype. The work will be of interest to infectious disease researchers.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

    This article has 5 authors:
    1. Dipasree Hajra
    2. Raju S Rajmani
    3. Ayushi Devendrasingh Chaudhary
    4. Shashi Kumar Gupta
    5. Dipshikha Chakravortty
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on the role of the sirtuins SIRT1 and SIRT3 during Salmonella Typhimurium infection. Although the work increases our understanding of the mechanisms used by this pathogen to interact with its host and may have implications for other intracellular pathogens, the reviewers found that the evidence to support the claims is incomplete. In particular, the discrepancy between results obtained using cultured cell lines and the animal model of infection, as well as potential indirect effects through the microbiome stand out.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

    This article has 8 authors:
    1. Xin Ma
    2. Li Meng
    3. Yuanyuan Zhang
    4. Tingting Xu
    5. Xinchen Zhou
    6. Mengqi Qian
    7. Zhiren Yang
    8. Xinyan Han
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The work by Han and collaborators describes valuable findings on the role of Akkermansia muciniphila during ETEC infection. If confirmed, these findings will add to a growing list of beneficial properties of this organism. However, as it stands, the strength of the evidence used to justify the conclusions in the manuscript is incomplete.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity