Microbiology

Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

1. Cheryll M Sia
2. Rebecca L Ambrose
3. Mary Valcanis
4. Patiyan Andersson
5. Susan A Ballard
6. Benjamin P Howden
7. Deborah A Williamson
8. Jaclyn S Pearson
9. Danielle J Ingle

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into the evolutionary histories and cellular infection responses of two Salmonella Dublin genotypes. While the evidence is compelling, a more phylogenetically diverse bacterial collection would enhance the findings. This research is relevant to scientists studying Salmonella and gastroenteritis-related pathogens.

Reviewed by eLife

Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

1. Shahriar Mowla
2. Linda Farahani
3. Tharu Tharakan
4. Rhianna Davies
5. Gonçalo DS Correia
6. Yun S Lee
7. Samit Kundu
8. Shirin Khanjani
9. Emad Sindi
10. Raj Rai
11. Lesley Regan
12. Dalia Khalifa
13. Ralf Henkel
14. Suks Minhas
15. Waljit S Dhillo
16. Jara Ben Nagi
17. Phillip R Bennett
18. David A MacIntyre
19. Channa N Jayasena

• Curated by eLife

  eLife Assessment

  This valuable study reports a potential connection between the seminal microbiome and sperm quality/male fertility. The data are generally convincing. This study will be of interest to clinicians and biomedical researchers who work on microbiome and male fertility.

Reviewed by eLife

Structural basis for collagen recognition by the Streptococcus pyogenes M3 protein and its involvement in biofilm

1. Marta Wojnowska
2. Takeaki Wajima
3. Tamas Yelland
4. Hannes Ludewig
5. Robert M Hagan
6. Grant Watt
7. Samir W Hamaia
8. Dominique Bihan
9. Jean-Daniel Malcor
10. Arkadiusz Bonna
11. Helena Bergsten
12. Mattias Svensson
13. Oddvar Oppegaard
14. Steinar Skrede
15. Per Arnell
16. Ole Hyldegaard
17. Richard W Farndale
18. Anna Norrby-Teglund
19. Ulrich Schwarz-Linek

• Curated by eLife

  eLife Assessment

  In this paper, the authors report important structural and functional findings on the interaction of how the group A streptococci (GAS) M3 protein (expressed on GAS strains emm3, which are associated with invasive disease) binds to human collagens. They demonstrate an unusual T-shaped structure within the N-terminal hypervariable region of M3 protein that can bind two copies of collagen triple helix in parallel. These solid data advance understanding of how GAS M3 interacts with human collagen, information relevant to understanding and developing treatments for GAS infection. A major limitation of the work is the lack of mutational work to test if the T-shaped structure is necessary for binding collagen.

Reviewed by eLife

Whole Genome Sequencing Reveals Enterobacter hormaechei as a Key Bloodstream Pathogen in Six Tertiary Care Hospitals in Southwestern Nigeria

1. Faith I. Oni
2. Ayorinde O. Afolayan
3. Anderson O. Oaikhena
4. Erkison Ewomazino Odih
5. Odion O. Ikhimiukor
6. Veronica O. Ogunleye
7. Aaron O. Aboderin
8. Olatunde F. Olabisi
9. Adewale A. Amupitan
10. Abayomi Fadeyi
11. Rasaki A. Raheem
12. Bashirat A. Olanipekun
13. Charles J. Elikwu
14. Oluwadamilola A. Sadare
15. Phillip O. Oshun
16. Oyinlola O. Oduyebo
17. Folashade Ojo
18. Abolaji T. Adeyemo
19. Ifeanyi E Mba
20. Abiodun Egwuenu
21. Tochi Okwor
22. Anthony Underwood
23. Silvia Argimón
24. Chikwe Ihekweazu
25. David M. Aanensen
26. Iruka N. Okeke

Reviewed by Rapid Reviews Infectious Diseases

Discovery of antibiotics in the archaeome using deep learning

1. Marcelo D. T. Torres
2. Fangping Wan
3. Cesar de la Fuente-Nunez

Reviewed by Arcadia Science

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor

1. Jeremy D. Volkening
2. Stephen J. Spatz
3. Maricarmen García
4. Teresa A. Ross
5. Daniel A. Maekawa
6. Kenneth S. Rosenthal
7. Ana C. Zamora
8. April Skipper
9. Julia Blakey
10. Roshan Paudel

Reviewed by Arcadia Science

Morphology-dependent entry kinetics and spread of influenza A virus

1. Sarah Peterl
2. Carmen M. Lahr
3. Carl N. Schneider
4. Janis Meyer
5. Xenia Podlipensky
6. Vera Lechner
7. Maria Villiou
8. Larissa Eis
9. Steffen Klein
10. Charlotta Funaya
11. Elisabetta Ada Cavalcanti-Adam
12. Frederik Graw
13. Christine Selhuber-Unkel
14. Karl Rohr
15. Petr Chlanda

Reviewed by Review Commons, PREreview

Effects of parental care on skin microbial community composition in poison frogs

1. Marie-Therese Fischer
2. Katherine S Xue
3. Elizabeth K Costello
4. Mai Dvorak
5. Gaëlle Raboisson
6. Anna Robaczewska
7. Stephanie N Caty
8. David A Relman
9. Lauren A O’Connell

• Curated by eLife

  eLife Assessment

  This study provides an important first look at the influence of vertical transmission in the establishment of the amphibian microbiome, with a specific focus on the potential role of parental care. Through a combination of cross-fostering experimental work, comparative analysis across species that show variable levels of care, and developmental time series, the authors provide convincing evidence that vertical transmission through care is possible, but incomplete evidence that it plays a significant role in shaping frog skin microbiomes in nature or across time. This work will be of interest to researchers studying the evolution of parental care and microbiomes in vertebrates.

Reviewed by eLife

Neutralizing human monoclonal antibodies that target the PcrV component of the Type III Secretion System of Pseudomonas aeruginosa act through distinct mechanisms

1. Jean-Mathieu Desveaux
2. Eric Faudry
3. Carlos Contreras-Martel
4. François Cretin
5. Leonardo Sebastian Dergan-Dylon
6. Axelle Amen
7. Isabelle Bally
8. Victor Tardivy-Casemajor
9. Fabien Chenavier
10. Delphine Fouquenet
11. Yvan Caspar
12. Ina Attrée
13. Andréa Dessen
14. Pascal Poignard

• Curated by eLife

  eLife Assessment

  This useful study identifies new monoclonal antibodies produced by cystic fibrosis patients against the Pseudomonas aeruginosa type three secretion system. The evidence supporting the authors' claim is solid. However, in the current version of the manuscript, it is unclear what the benefits of the newly isolated antibodies are with respect to antibodies previously identified using a similar approach. The study will be of interest to those working on developing mAbs against Pseudomonas aeruginosa and also against other pathogens that harbor the T3SS.

Reviewed by eLife

Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

1. Jennifer M. Baker
2. Thomas L. Flott
3. Laura A. McLellan
4. Ingrid G. Bustos
5. Jose L. Guerrero
6. Lina M. Mendez
7. Annastasia M. Petouhoff
8. Piyush Ranjan
9. Joseph D. Metcalf
10. Roderick A. McDonald
11. Nicole R. Falkowski
12. Ying He
13. Mónica P. Cala
14. Gary B. Huffnagle
15. Michael W. Sjoding
16. Luis F. Reyes
17. Kathleen A. Stringer
18. Robert P. Dickson

Reviewed by PREreview