Microbiology

Thermoregulation network governing virulence of a critical human fungal pathogen

1. Vikas Yadav
2. Joseph Heitman

Reviewed by Review Commons

A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

1. Surbhi Verma
2. Shweta Thakur
3. Mrinmoy Das
4. Raman D Sharma
5. Vikas Yadav
6. Priya Sharma
7. Mardiana Marzuki
8. Shihui Foo
9. Giulia M Piperno
10. Mehak Z Khan
11. Babu Mathew
12. Meenu Bajpai
13. Jaswinder Singh Maras
14. Shanshan Howland
15. Sovan Sarkar
16. Federica Benvenuti
17. Amit Singh
18. Vinay Nandicoori
19. Amit Singhal
20. Dhiraj Kumar

• Curated by eLife

  eLife Assessment

  Verma and colleagues interrogate the mechanisms of phagosome maturation arrest during Mycobacterium tuberculosis infection. While cellular events that culminate in this arrest have been largely elucidated, involvement of other organelles, such as mitochondria, has not been highlighted mechanistically. In this valuable study, elements of mitochondrial quality control, such as mitophagy and mitochondrial-derived vesicles involvement, are shown to be paramount in the host-pathogen tussle. The evidence supporting the main conclusions is solid, based on multiple complementary approaches and appropriate controls, although some central mechanistic aspects of the proposed pathway remain only partially resolved.

Reviewed by eLife