Microbiology

  7. Thermoregulation network governing virulence of a critical human fungal pathogen

    1. Vikas Yadav
    2. Joseph Heitman

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

    1. Surbhi Verma
    2. Shweta Thakur
    3. Mrinmoy Das
    4. Raman D Sharma
    5. Vikas Yadav
    6. Priya Sharma
    7. Mardiana Marzuki
    8. Shihui Foo
    9. Giulia M Piperno
    10. Mehak Z Khan
    11. Babu Mathew
    12. Meenu Bajpai
    13. Jaswinder Singh Maras
    14. Shanshan Howland
    15. Sovan Sarkar
    16. Federica Benvenuti
    17. Amit Singh
    18. Vinay Nandicoori
    19. Amit Singhal
    20. Dhiraj Kumar

    • Curated by eLife

      eLife Assessment

      Verma and colleagues interrogate the mechanisms of phagosome maturation arrest during Mycobacterium tuberculosis infection. While cellular events that culminate in this arrest have been largely elucidated, involvement of other organelles, such as mitochondria, has not been highlighted mechanistically. In this valuable study, elements of mitochondrial quality control, such as mitophagy and mitochondrial-derived vesicles involvement, are shown to be paramount in the host-pathogen tussle. The evidence supporting the main conclusions is solid, based on multiple complementary approaches and appropriate controls, although some central mechanistic aspects of the proposed pathway remain only partially resolved.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  10. The vaccine candidate Liver Stage Antigen 3 is exported during Plasmodium falciparum infection and required for liver-stage development

    1. Robyn McConville
    2. Ryan WJ Steel
    3. Matthew T O’Neill
    4. Alan F Cowman
    5. Norman Kneteman
    6. Justin A Boddey

    • Curated by eLife

      eLife Assessment

      This useful study provides new insights into the liver-stage antigen LSA3, its export to erythrocytes, and its role in liver-stage development. While the functional importance of LSA3 is well demonstrated, the data underlying the conclusions regarding antibody specificity, liver-stage localization, and phenotype remain incomplete. A key strength of the study is the use of mosquito and humanized mouse models to access life-cycle stages that are rarely studied in most laboratories.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity
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