Microbiology

Simple Sequence Repeats Mediate Phase Variation of the Mucoid Phenotype in Hypervirulent Klebsiella pneumoniae

1. Oliwia Stawarska
2. Aarabhi Ravikrishnan Nair
3. Ania W. Y. Man
4. Luke R. Green
5. Ozcan Gazioglu
6. Francesco Flandi
7. Margaret M. C. Lam
8. Kathryn E. Holt
9. Hasan Yesilkaya
10. Marco R. Oggioni
11. Jose A. Bengoechea
12. Charlotte Odendall
13. Alex J. McCarthy
14. Joseph J. Wanford

Reviewed by PREreview

Mycobacterium tuberculosis partitions the Krebs cycle under iron starvation

1. Agnese Serafini
2. Acely Garza-Garcia
3. Davide Sorze
4. Luiz Pedro Sorio de Carvalho
5. Riccardo Manganelli

• Curated by eLife

  eLife Assessment

  This well-designed, valuable study uses isotope tracing to analyse how iron limitation alters TCA cycle metabolism in Mycobacterium tuberculosis, revealing potential antibiotic targets for non-replicating bacteria in the host. The evidence is solid, providing insights into metabolic remodelling under iron-limited conditions.

Reviewed by eLife

Membrane Binding Controls the ATPase Cycle and Localization of MinD in Bacillus subtilis

1. Helge Feddersen
2. Charlotte Dyckmans
3. Marc Bramkamp

• Curated by eLife

  eLife Assessment

  This important study provides convincing data suggesting that subcellular localization of the spatial regulator of cell division, MinD, is an intrinsic feature of the protein's ability to associate with the membrane as both a dimer and a monomer. These findings distinguish the behavior of MinD in B. subtilis from its counterpart in E. coli and suggest that there is not a need to invoke additional localization factors. The reviewers felt that the revisions, particularly the additional experiments and changes to the text to make the experimental design and conclusions clearer, improve the quality of the manuscript.

Reviewed by eLife

A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

1. Sebastian Schaefer
2. Raghav Vij
3. Jakob L. Sprague
4. Sophie Austermeier
5. Hue Dinh
6. Peter R. Judzewitsch
7. Sven Müller-Loennies
8. Taynara Lopes Silva
9. Eric Seemann
10. Britta Qualmann
11. Christian Hertweck
12. Kirstin Scherlach
13. Thomas Gutsmann
14. Amy K. Cain
15. Nathaniel Corrigan
16. Mark S. Gresnigt
17. Cyrille Boyer
18. Megan D. Lenardon
19. Sascha Brunke

Reviewed by Rapid Reviews Infectious Diseases

A fast-acting inhibitor of blood-stage P. falciparum with mechanism distinct from artemisinin and chloroquine

1. Stephanie Kabeche
2. Thomas Meister
3. Ellen Yeh

Reviewed by Rapid Reviews Infectious Diseases

Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection

1. Laura Belmont
2. Maya Contreras
3. Catiana H. Cartwright-Acar
4. Caleb D. Marceau
5. Aditi Agrawal
6. Lisa M. Levoir
7. Jay Lubow
8. Leslie Goo

Reviewed by Rapid Reviews Infectious Diseases

Release of P-TEFb from the Super Elongation Complex promotes HIV-1 latency reversal

1. William J. Cisneros
2. Shimaa H. A. Soliman
3. Miriam Walter
4. Lacy M. Simons
5. Daphne Cornish
6. Simone De Fabritiis
7. Ariel W. Halle
8. Eun-Young Kim
9. Steven M. Wolinsky
10. Ramon Lorenzo-Redondo
11. Ali Shilatifard
12. Judd F. Hultquist

Reviewed by Rapid Reviews Infectious Diseases

MX2 restricts HIV-1 and herpes simplex virus type 1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes

1. George D. Moschonas
2. Louis Delhaye
3. Robin Cooreman
4. Franziska Hüsers
5. Anayat Bhat
6. Delphine De Sutter
7. Eef Parthoens
8. Anne-Sophie Desmet
9. Aleksandra Maciejczuk
10. Hanna Grzesik
11. Saskia Lippens
12. Zeger Debyser
13. Beate Sodeik
14. Sven Eyckerman
15. Xavier Saelens

Reviewed by Rapid Reviews Infectious Diseases

Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence

1. John A Buglino
2. Yaprak Ozakman
3. Chad E Hatch
4. Anna Benjamin
5. Derek S Tan
6. Michael S Glickman

• Curated by eLife

  eLife Assessment

  In this important study, the authors advance our understanding of copper uptake by chalkophores and their targeted metalloproteins in Mycobacterium tuberculosis. These convincing data demonstrate that chalkophore-acquired copper is solely incorporated into the Mtb bcc:aa3 copper-iron respiratory oxidase under low copper conditions, and that chalkophore-mediated protection of the respiratory chain is critical to Mtb virulence. These findings may be leveraged for drug discovery and will be of broad interest to those studying bacterial pathogenesis.

Reviewed by eLife, Rapid Reviews Infectious Diseases

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

1. Marisa E. McGrath
2. Yong Xue
3. Louis Taylor
4. Carly Dillen
5. Jeremy Ardanuy
6. Norberto Gonzalez-Juarbe
7. Lauren Baracco
8. Raymond Kim
9. Rebecca Hart
10. Nacyra Assad-Garcia
11. Sanjay Vashee
12. Matthew B. Frieman

Reviewed by Rapid Reviews Infectious Diseases, PREreview