Immunology

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2

1. Ruth I. Connor
2. Mrunal Sakharkar
3. C. Garrett Rappazzo
4. Chengzi I. Kaku
5. Nicholas C. Curtis
6. Seungmin Shin
7. Wendy F. Wieland-Alter
8. Joshua A. Weiner
9. Margaret E. Ackerman
10. Laura M. Walker
11. Jiwon Lee
12. Peter F. Wright

Reviewed by Rapid Reviews Infectious Diseases

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

1. Ole Bæk
2. Tik Muk
3. Ziyuan Wu
4. Yongxin Ye
5. Bekzod Khakimov
6. Alessandra Maria Casano
7. Bagirath Gangadharan
8. Ivan Bilic
9. Anders Brunse
10. Per Torp Sangild
11. Duc Ninh Nguyen

• Curated by eLife

  eLife assessment

  This interesting and important study follows up on the authors' observations that lower glucose parental nutrition leads to lower rates of sepsis from Staphylococcus epidermis in a preterm pig model. Sepsis in early life, particularly in premature infants, has significant morbidity and mortality and the authors present convincing evidence that glycemic state affects hepatic metabolism-dependent immune function and improved clearance of coagulase-negative staphylococcal infection. The authors provide a robust multi-omic dataset for the use of the scientific community. However, there are also several concerns that will limit the impact of the work, including that the model does not reflect early onset sepsis that is observed in premature infants, and the question of whether low glucose parental nutrition (PN) is protective versus high glucose PN is harmful as the levels of glucose in the high PN were incredibly high.

Reviewed by eLife

Activity-dependent FosB gene expression negatively regulates mast cell functions

1. Natalia Duque-Wilckens
2. Nidia Maradiaga
3. Yeh Szu-Ying
4. Dimitry Joseph
5. Vidhula Srinavasan
6. Kyan Thelen
7. Fabiola Sotomayor
8. Kait Durga
9. Eric Nestler
10. Adam J Moeser
11. A.J. Robison

Reviewed by Arcadia Science

Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

1. Jitian He
2. Le Gao
3. Peiying Wang
4. Wing Keung Chan
5. Yiran Zheng
6. Yumo Zhang
7. Jiaman Sun
8. Xue Li
9. Jiming Wang
10. Xiao-Hong Li
11. Huaiyong Chen
12. Zhouxin Yang
13. Youwei Wang

• Curated by eLife

  eLife assessment

  The authors investigated the requirement and function of Blimp1/Prdm1 in murine natural killer (NK) cells and the ILC1 lineage of innate lymphoid cells, using a conditional knockout model. The single-cell mRNA-seq data provided here represent a valuable resource for the community, but the lack of mechanistic investigations leaves the study partially incomplete. The work will be of interest to the fields of innate lymphoid cell biology and tissue immunology.

Reviewed by eLife

T follicular helper cell profiles differ by malaria antigen and for children compared to adults

1. Catherine S. Forconi
2. Christina Nixon
3. Hannah W. Wu
4. Boaz Odwar
5. Sunthorn Pond-Tor
6. John M. Ong’echa
7. Jonathan Kurtis
8. Ann M. Moormann

• Curated by eLife

  eLife assessment

  Using multiparameter spectral flow cytometry and unbiased clustering analysis, this study provides useful insights into the heterogeneity of antigens-specific circulating T follicular helper cells from children and adults living in malaria-endemic areas of Kenya. Although the study is well-designed, the analysis and interpretation of the potential functional roles for PfSEA-1A- and PfGARP-specific subsets of circulating T follicular helper cells are incomplete.

Reviewed by eLife

Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

1. Shih-Wen Huang
2. Yein-Gei Lai
3. Hao-Ting Liao
4. Chin-Ling Chang
5. Ruo-Yu Ma
6. Yung-Hsiang Chen
7. Yae-Huei Liou
8. Zhen-Qi Wu
9. Yu-Chen Wu
10. Ko-Jiunn Liu
11. Yen-Tsung Huang
12. Jen-Lung Yang
13. Ming-Shen Dai
14. Nan-Shih Liao

• Curated by eLife

  eLife assessment

  This valuable study provides solid in vivo data that transfer of IL-15/IL-12-conditioned syngeneic NK cells after primary tumor resection promotes long-term survival of mice with low metastatic burden from breast cancer. Also, the authors conducted an investigator-initiated clinical trial that demonstrated that similar NK cell infusions in cancer patients after resections were safe and showed signs of efficacy. Therefore, this study is of interest and value to oncologists in the field of breast cancer research.

Reviewed by eLife

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

1. Weigao Zhang
2. Hu Liu
3. Danyang Zhang
4. Yuguo Yi
5. Liang Tao
6. Shuxian Huang
7. Xunan Zhao
8. Qianchao Shao
9. Peiqi Li
10. Jianfa Zhang
11. Yan Pan
12. Wei Lu
13. Haibing Zhang
14. Yuxin Chen
15. Dan Weng

• Curated by eLife

  eLife assessment

  The study presents valuable findings on the role of RIPK1 in maintaining liver homeostasis under metabolic stress. Strengths include the intriguing findings that RIPK1 deficiency sensitizes the liver to acute liver injury and apoptosis, but because the conclusions require additional experimental support, the evidence is incomplete.

Reviewed by eLife

Control of Inflammatory Response by Tissue Microenvironment

1. Zhongyang Wu
2. Scott D. Pope
3. Nasiha S. Ahmed
4. Diana L. Leung
5. Stephanie Hajjar
6. Qiuyu Yue
7. Diya M. Anand
8. Elizabeth B. Kopp
9. Daniel Okin
10. Weiyi Ma
11. Jonathan C. Kagan
12. Diana C. Hargreaves
13. Ruslan Medzhitov
14. Xu Zhou

Reviewed by preLights

Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

1. Mariano Maio
2. Joaquina Barros
3. Marine Joly
4. Zoi Vahlas
5. José Luis Marín Franco
6. Melanie Genoula
7. Sarah C Monard
8. María Belén Vecchione
9. Federico Fuentes
10. Virginia Gonzalez Polo
11. María Florencia Quiroga
12. Mónica Vermeulen
13. Thien-Phong Vu Manh
14. Rafael J Argüello
15. Sandra Inwentarz
16. Rosa Musella
17. Lorena Ciallella
18. Pablo González Montaner
19. Domingo Palmero
20. Geanncarlo Lugo Villarino
21. María del Carmen Sasiain
22. Olivier Neyrolles
23. Christel Vérollet
24. Luciana Balboa

• Curated by eLife

  eLife assessment

  This useful study tests the hypothesis that monocytes purified from tuberculosis patients differentiate into dendritic cells with different migratory capacities. The authors conclude that these monocytes are metabolically pre-conditioned to differentiate, with reduced expression of Hif1a and a glycolytically exhaustive phenotype, resulting in low migratory and immunologic potential. Overall, the evidence provided is convincing, advancing the field substantively and providing novel insights.

Reviewed by eLife

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

1. Jyotsna
2. Binayak Sarkar
3. Mohit Yadav
4. Alvina Deka
5. Manasvini Markandey
6. Priyadarshini Sanyal
7. Perumal Nagarajan
8. Nilesh Gaikward
9. Vineet Ahuja
10. Debasisa Mohanty
11. Soumen Basak
12. Rajesh S Gokhale

• Curated by eLife

  eLife assessment

  The current version of the study presents important findings on how the RelA/Stat3-dependent gene program in the liver influences intestinal homeostasis. The evidence supporting the conclusions is solid, with new data added compared to an earlier version of the study. The work will be of interest to scientists in gastrointestinal research fields.

Reviewed by eLife