Immunology

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

1. Sabelo Hadebe
2. Anca Flavia Savulescu
3. Jermaine Khumalo
4. Katelyn Jones
5. Sandisiwe Mangali
6. Nontobeko Mthembu
7. Fungai Musaigwa
8. Welcome Maepa
9. Hlumani Ndlovu
10. Amkele Ngomti
11. Martyna Scibiorek
12. Javan Okendo
13. Frank Brombacher

• Curated by eLife

  eLife Assessment

  This important study demonstrates a reduction in airway hyperresponsiveness (one of the mechanisms of allergic asthma) in the absence of IgM in a house dust mite-induced mouse model of allergic asthma. While this result suggests a new mechanistic role for IgM, the proposed new function is not as yet robustly supported by the current experiments and thus the evidence remains incomplete. A connection between the findings and human disease is not established so far, but the study will be interest to clinical immunologists.

Reviewed by eLife

The Impact of Malaria-Induced Neutrophil Subset Shift and a Link to Burkitt Lymphoma

1. Sharon Akinyi
2. Ronald K. Tonui
3. Titus K. Maina
4. Eddy Agwati
5. Cliff I. Oduor
6. Festus M. Njuguna
7. Kibet K. Keitany
8. Daniel Chepsiror
9. Cyrus Ayieko
10. Ann Moormann
11. Ann W. Kinyua
12. Catherine S. Forconi

Reviewed by PREreview

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

1. Pien Margien van Paassen
2. Alexander O Pasternak
3. Dita C Bolluyt
4. Karel A van Dort
5. Ad C van Nuenen
6. Irma Maurer
7. Brigitte Boeser-Nunnink
8. Ninée VEJ Buchholtz
9. Tokameh Mahmoudi
10. Cynthia Lungu
11. Reinout van Crevel
12. Casper Rokx
13. Jori Symons
14. Monique Nijhuis
15. Annelou LIP van der Veen
16. Liffert Vogt
17. Michelle J Klouwens
18. Jan M Prins
19. Neeltje A Kootstra
20. Godelieve J de Bree

• Curated by eLife

  eLife Assessment

  The findings of this study are valuable as it demonstrates that when treatment is initiated during acute infection, HIV specific CD8 T cell responses are maintained long term and continued proliferative capacity of these cells may play a role in reducing HIV DNA levels. The evidence supporting the conclusions are solid with rigorous and advanced methodology used with the major limitations being that the findings are association level and do not meet strict criteria for causality. The work is of interest to the HIV cure field and suggests that enhancing early HIV specific CD8 T cell responses should be considered in the design of interventional cure strategies.

Reviewed by eLife

A major histocompatibility complex (MHC) class II molecule that binds the same viral pathogen peptide with both nonamer and decamer core sequences for presentation to T cells

1. Anastasia Goryanin
2. Atlanta G. Cook
3. Shahriar Behboudi
4. Jim Kaufman
5. Samer Halabi

Reviewed by preLights

B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size

1. Sung Hoon Cho
2. Marissa A Jones
3. Kaylor Meyer
4. David M Anderson
5. Sergiy Chetyrkin
6. M Wade Calcutt
7. Richard M Caprioli
8. Clay F Semenkovich
9. Mark R Boothby

• Curated by eLife

  eLife Assessment

  This study provides useful insights into the ways in which germinal center B cell metabolism, particularly lipid metabolism, affects cellular responses. The authors use sophisticated mouse models to convincingly demonstrate that ether lipids are relevant for B cell homeostasis and efficient humoral responses. The authors then conducted in vivo as well as in vitro experiments, thereby strengthening their conclusions.

Reviewed by eLife

Explosive cytotoxicity of ‘ruptoblasts’ bridges hormonal surveillance and immune defense

1. Chew Chai
2. Eliya Sultan
3. Souradeep R. Sarkar
4. Lihan Zhong
5. Dania Nanes Sarfati
6. Orly Gershoni-Yahalom
7. Christine Jacobs-Wagner
8. Hawa Racine Thiam
9. Benyamin Rosental
10. Bo Wang

Reviewed by preLights

RadD from Fusobacterium nucleatum engages NKp46 to promote antitumor cytotoxicity

1. Ahmed Rishiq
2. Johanna Galski
3. Reem Bsoul
4. Mingdong Liu
5. Rema Darawshe
6. Renate Lux
7. Gilad Bachrach
8. Ofer Mandelboim

• Curated by eLife

  eLife Assessment

  This useful study describes a mechanism of microbial modulation of anti-tumor immunity, which is of considerable interest in the field. However, the experimental supports for the key mechanistic claim, the interaction between RadD and NKp46, are not robust. Multiple experimental inconsistencies, especially in vivo, weaken the conclusions, making the strength of evidence incomplete. Additional controls, direct binding assays, and clarification of in vivo mechanistic relevance would strengthen the work.

Reviewed by eLife

Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike Protein

1. T Tsoleridis
2. I Singh
3. D Onion
4. JG Chappell
5. A Kelly
6. J Nightingale
7. AM Valdes
8. BJ Ollivere
9. KB Hoehn
10. RA Urbanowicz
11. JK Ball

Reviewed by PREreview

Layers of immunity: Deconstructing the Drosophila effector response

1. Faustine Ryckebusch
2. Yao Tian
3. Mylene Rapin
4. Fanny Schüpfer
5. Mark Austin Hanson
6. Bruno Lemaitre

• Curated by eLife

  eLife Assessment

  This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are compelling and the tools provided can be used as they are, or built upon, in various contexts.

Reviewed by eLife

IRF2 degradation tunes the innate immune response

1. Cristhian Cadena
2. Rohit Reja
3. Emma Bolech
4. Joshua D. Webster
5. Vasumathi Kameswaran
6. Marco de Simone
7. Cynthia Chen
8. Jian Jiang
9. Kathy Hotzel
10. Kamela Alegre
11. Zhenyu Tan
12. Raymond Newland
13. Ryan Kelly
14. Spyros Darmanis
15. Bence Daniel
16. Ishan Deshpande
17. Kim Newton
18. Nobuhiko Kayagaki
19. Vishva M. Dixit

Reviewed by Arcadia Science