Immunology

Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

1. Alina Xiaoyu Yang
2. Lisa Ramos-Rodriguez
3. Parand Sorkhdini
4. Dongqin Yang
5. Carmelissa Norbrun
6. Sonoor Majid
7. Sanghyun Lee
8. Yong Zhang
9. Michael Holtzman
10. David F Boyd
11. Yang Zhou

• Curated by eLife

  eLife Assessment

  This valuable manuscript presents a potentially novel mechanism by which the phospholipid scramblase, PLSCR1, defends against influenza A virus infection. The strength of the paper rests on solid findings involving knockout and lung specific over-expressing Plscr1 mice, airway tissue expression and mechanistic studies to show Plscr1 enhances type III interferon-mediated viral clearance.

Reviewed by eLife

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

1. Kamini Jakhar
2. Sudipta Sonar
3. Gagandeep Singh
4. Tejeswara Rao Asuru
5. Garima Joshi
6. Nisha Beniwal
7. Tania Sarkar
8. Mahima Tiwari
9. Jaskaran Kaur
10. Deepak Kumar Rathore
11. Banwari Lal
12. Sandeep Kumar
13. Puneet Srivastav
14. Satendra Kumar
15. Vikas Phagna
16. Sushma Mithina
17. Lokesh Kumar
18. Vishal Gupta
19. Pallavi Kshetrapal
20. Savita Singh
21. Nitya Wadhwa
22. Ramachandran Thiruvengadam
23. Sreevatsan Raghavan
24. Mudita Gosain
25. Tripti Shrivastava
26. Sankar Bhattacharyya
27. Shailendra Asthana
28. Prasenjit Guchhait
29. Shailendra Mani

Reviewed by Rapid Reviews Infectious Diseases

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

1. Zhengyang Lei
2. Shiyao Zhai
3. Xi Yuan
4. Runming Wang
5. Yunpeng Wang
6. Vijay Pandey
7. Can Yang Zhang
8. Jiansong Ji
9. Dongmei Yu
10. Zhenglin Chen
11. Sumin Bian
12. Peiwu Qin

Reviewed by Rapid Reviews Infectious Diseases

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variants

1. Qian Wang
2. Yicheng Guo
3. Anthony Bowen
4. Ian A. Mellis
5. Riccardo Valdez
6. Carmen Gherasim
7. Aubree Gordon
8. Lihong Liu
9. David D. Ho

Reviewed by Rapid Reviews Infectious Diseases

Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

1. Ruth Connor
2. Mrunal Sakharkar
3. Garrett Rappazzo
4. Chengzi Kaku
5. Nicholas Curtis
6. Seungmin Shin
7. Wendy Wieland-Alter
8. Jordan Wentworth
9. Daniel Mielcarz
10. Joshua Weiner
11. Margaret Ackerman
12. Laura Walker
13. Jiwon Lee
14. Peter Wright

Reviewed by Rapid Reviews Infectious Diseases

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

1. Rami Musharrafieh
2. Yana Safonova
3. Ge Song
4. Ryan S. Roark
5. Fang-Hua Lee
6. Shiyu Zhang
7. Jonathan Hurtado
8. Peter Yong
9. Shuyi Wang
10. Ronnie M. Russell
11. Wenge Ding
12. Yingying Li
13. Juliette Rando
14. Alexander I. Murphy
15. Emily Lindemuth
16. Chengyan Zhao
17. Andrew Jesse Connell
18. Wen-Hsin Lee
19. Nitesh Mishra
20. Gabriel Avillion
21. Wanting He
22. Sean Callaghan
23. Katharina Dueker
24. Anh L. Vo
25. Xuduo Li
26. Tazio Capozzola
27. Collin Joyce
28. Fangzhu Zhao
29. Fabio Anzanello
30. Weimin Liu
31. Frederic Bibollet-Ruche
32. Alejandra Ramos
33. Hui Li
34. Mark G. Lewis
35. Gabriel Ozorowski
36. Elise Landais
37. Brian T. Foley
38. Kshitij Wagh
39. Devin Sok
40. Bryan Briney
41. Andrew B. Ward
42. Beatrice H. Hahn
43. Dennis R. Burton
44. George M. Shaw
45. Raiees Andrabi

Reviewed by Rapid Reviews Infectious Diseases

Mast cells promote pathology and susceptibility in tuberculosis

1. Ananya Gupta
2. Vibha Taneja
3. Javier Rangel-Moreno
4. Nilofer Naqvi
5. Abhimanyu
6. Yun Tao
7. Mushtaq Ahmed
8. Kuldeep Singh Chauhan
9. Daniela Trejo-Ponce de Leon
10. Gustavo Ramírez-Martínez
11. Luis Jiménez-Alvarez
12. Cesar Luna-Rivero
13. Joaquin Zuniga
14. Deepak Kaushal
15. Shabaana A Khader

• Curated by eLife

  eLife Assessment

  In this useful study, the authors utilize published scRNA-seq data to highlight the potential importance of mast cells (MCs) in TB granulomas, presenting a solid comparative assessment of chymase- and tryptase-expressing MCs in the lungs of Mycobacterium tuberculosis-infected individuals and non-human primates. While the authors appropriately discussed the inconsistencies across models, adoptive transfer experiments in MC-deficient mice would substantially strengthen the causal link between MCs and TB outcomes, providing more direct functional validation of the proposed role of MCs in TB pathogenesis.

Reviewed by eLife, Arcadia Science

Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

1. Priya Sharma
2. Raman Deep Sharma
3. Binayak Sarkar
4. Varnika Panwar
5. Mrinmoy Das
6. Lakshya Veer Singh
7. Neharika Jain
8. Shivam Chaturvedi
9. Lalita Mehra
10. Aditya Rathee
11. Shilpa Sharma
12. Shihui Foo
13. Andrea Lee
14. Pavan Kumar N
15. Prasenjit Das
16. Vijay Viswanathan
17. Hardy Kornfeld
18. Shanshan W Howland
19. Subash Babu
20. Vinay Kumar Nandicoori
21. Amit Singhal
22. Dhiraj Kumar

• Curated by eLife

  eLife Assessment

  This valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors provide solid data reporting that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. The specific contribution of neutrophil-derived IL-17 to disease pathogenesis remains to be definitively established through direct demonstration of IL-17 production by neutrophils and targeted depletion studies.

Reviewed by eLife

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

1. Sabelo Hadebe
2. Anca Flavia Savulescu
3. Jermaine Khumalo
4. Katelyn Jones
5. Sandisiwe Mangali
6. Nontobeko Mthembu
7. Fungai Musaigwa
8. Welcome Maepa
9. Hlumani Ndlovu
10. Amkele Ngomti
11. Martyna Scibiorek
12. Javan Okendo
13. Frank Brombacher

• Curated by eLife

  eLife Assessment

  This important study demonstrates a reduction in airway hyperresponsiveness (one of the mechanisms of allergic asthma) in the absence of IgM in a house dust mite-induced mouse model of allergic asthma. While this result suggests a new mechanistic role for IgM, the proposed new function is not as yet robustly supported by the current experiments and thus the evidence remains incomplete. A connection between the findings and human disease is not established so far, but the study will be interest to clinical immunologists.

Reviewed by eLife

The Impact of Malaria-Induced Neutrophil Subset Shift and a Link to Burkitt Lymphoma

1. Sharon Akinyi
2. Ronald K. Tonui
3. Titus K. Maina
4. Eddy Agwati
5. Cliff I. Oduor
6. Festus M. Njuguna
7. Kibet K. Keitany
8. Daniel Chepsiror
9. Cyrus Ayieko
10. Ann Moormann
11. Ann W. Kinyua
12. Catherine S. Forconi

Reviewed by PREreview