Immunology

Amphibian mast cells serve as barriers to chytrid fungus infections

1. Kelsey A Hauser
2. Christina N Garvey
3. Ryley S Crow
4. Muhammad RH Hossainey
5. Dustin T Howard
6. Netra Ranganathan
7. Lindsey K Gentry
8. Amulya Yaparla
9. Namarta Kalia
10. Mira Zelle
11. Elizabeth J Jones
12. Anju N Duttargi
13. Louise A Rollins-Smith
14. Carly R Muletz-Wolz
15. Leon Grayfer

• Curated by eLife

  eLife assessment

  This important study reveals the role of skin-resident mast cells in amphibians in mediating antimicrobial responses. The data are compelling and highlight species-specific biology that can cross-inform human mast cell biology in a species that does not rely on IgE as a primary mechanism for antimicrobial skin responses.

Reviewed by eLife

Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles

1. Xu Zheng
2. Shi Yu
3. Yanqiu Zhou
4. Kuai Yu
5. Yuhui Gao
6. Mengdan Chen
7. Dong Duan
8. Yunyi Li
9. Xiaoxian Cui
10. Jiabin Mou
11. Yuying Yang
12. Xun Wang
13. Min Chen
14. Yaming Jiu
15. Jincun Zhao
16. Guangxun Meng

• Curated by eLife

  eLife assessment

  This study provides valuable insights into how IL-1 cytokines may protect cells against SARS-COV-2 infection. By inducing a non-canonical RhoA/ROCK signaling pathway, IL-1beta appears to inhibit the ability of SARS-COV-2 infected cells to fuse with uninfected cells and produce syncytia. The evidence underlying the identification of the key signaling components required for this inhibitory phenotype in vitro is solid and could be further improved by addressing key weaknesses. However, data supporting this specific mechanism of inhibition in IL-1-mediated control of SARS-COV-2 infection in vivo remains incomplete.

Reviewed by eLife

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

1. Kely C Matteucci
2. Patricia A Assis
3. Isabella C Hirako
4. Nathalia PS Leite
5. Franciele Pioto
6. Ogooluwa Ojelabi
7. Juliana E Toller-Kawahisa
8. Diego L Costa
9. João S Da Silva
10. José C Alves-Filho
11. Ricardo T Gazzinelli

• Curated by eLife

  eLife assessment

  This important study examines the role of TNF in modulating energy metabolism during parasite infection. The authors perform an elegant set of studies, however the evidence supporting the major claims of the manuscript is incomplete. This work integrates an interesting set of observations that will be of interest to the Plasmodium and pathogenesis communities with an expanded set of experiments.

Reviewed by eLife

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice

1. Juan Manuel Leyva-Castillo
2. Maria Strakosha
3. Sophia E.M. Smith
4. Daniela Vega-Mendoza
5. Megan Elkins
6. Janet Chou
7. Peter Vogel
8. Nathalie Boulanger

Reviewed by Arcadia Science

NK Cell Exhaustion in Wilson’s Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

1. Yong Jin
2. Jiayu Xing
3. Chenyu Dai
4. Lei Jin
5. Wanying Zhang
6. Qianqian Tao
7. Mei Hou
8. Ziyi Li
9. Wen Yang
10. Qiyu Feng
11. Hongyang Wang
12. Qingsheng Yu

• Curated by eLife

  eLife assessment

  The findings are useful for understanding the disease's pathology and immune dysregulation, but the evidence is still incomplete regarding whether these immune changes are directly caused by copper metabolism alterations or are secondary to liver dysfunction.

Reviewed by eLife

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

1. Hella Luksch
2. Felix Schulze
3. David Geißler-Lösch
4. David Sprott
5. Lennart Höfs
6. Eva M. Szegö
7. Wulf Tonnus
8. Stefan Winkler
9. Claudia Günther
10. Andreas Linkermann
11. Rayk Behrendt
12. Lino L. Teichmann
13. Björn H. Falkenburger
14. Angela Rösen-Wolff

Reviewed by Review Commons

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

1. Daniela Bottero
2. Erika Rudi
3. Pablo Martin Aispuro
4. Eugenia Zurita
5. Emilia Gaillard
6. Maria M. Gonzalez Lopez Ledesma
7. Juan Malito
8. Matthew Stuible
9. Nicolas Ambrosis
10. Yves Durocher
11. Andrea V. Gamarnik
12. Andrés Wigdorovitz
13. Daniela Hozbor

Reviewed by Rapid Reviews Infectious Diseases

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

1. Zhengyang Lei
2. Shiyao Zhai
3. Xi Yuan
4. Runming Wang
5. Yunpeng Wang
6. Vijay Pandey
7. Can Yang Zhang
8. Jiansong Ji
9. Dongmei Yu
10. Zhenglin Chen
11. Sumin Bian
12. Peiwu Qin

Reviewed by Rapid Reviews Infectious Diseases

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variants

1. Qian Wang
2. Yicheng Guo
3. Anthony Bowen
4. Ian A. Mellis
5. Riccardo Valdez
6. Carmen Gherasim
7. Aubree Gordon
8. Lihong Liu
9. David D. Ho

Reviewed by Rapid Reviews Infectious Diseases

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2

1. Ruth I. Connor
2. Mrunal Sakharkar
3. C. Garrett Rappazzo
4. Chengzi I. Kaku
5. Nicholas C. Curtis
6. Seungmin Shin
7. Wendy F. Wieland-Alter
8. Joshua A. Weiner
9. Margaret E. Ackerman
10. Laura M. Walker
11. Jiwon Lee
12. Peter F. Wright

Reviewed by Rapid Reviews Infectious Diseases