1. RAG suppresses group 2 innate lymphoid cells

    This article has 13 authors:
    1. Aaron M Ver Heul
    2. Madison Mack
    3. Lydia Zamidar
    4. Masato Tamari
    5. Ting-Lin Yang
    6. Anna M Trier
    7. Do-Hyun Kim
    8. Hannah Janzen-Meza
    9. Steven J Van Dyken
    10. Chyi-Song Hsieh
    11. Jenny M Karo
    12. Joseph C Sun
    13. Brian S Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides new insights into the expression profile of ILCs that demonstrate a history of RAG expression. It examines in part the potential intrinsic regulation of RAG expression and seeks to understand how the epigenetic state of ILCs is established, although a full understanding of intrinsic factors is only partially supported. The work provides a convincing and important molecular dataset, and strengthens our understanding of intrinsic regulation, and would be of interest more broadly to cell biologists seeking to understand immune cell development.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity

    This article has 4 authors:
    1. Karen Giménez-Orenga
    2. Eva Martín-Martínez
    3. Lubov Nathanson
    4. Elisa Oltra
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study substantially expands observations of HERV expression in the clinical settings. The evidence provided by the authors that HERV activity is an underlying etiological factor in ME/CFS and fibromyalgia is compelling and suggests further investigation into mechanisms. This work will be of broad interest to clinicians and researchers alike.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  3. A modular platform to display multiple hemagglutinin subtypes on a single immunogen

    This article has 7 authors:
    1. Dana Thornlow Lamson
    2. Faez Amokrane Nait Mohamed
    3. Mya Vu
    4. Daniel P Maurer
    5. Larance Ronsard
    6. Daniel Lingwood
    7. Aaron G Schmidt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable manuscript describes the immunogenicity of a bead-on-a-string immunogen that allows the inclusion of multiple HA subtypes. The evidence to support the claims is convincing, and more importantly, this approach could be adapted to other vaccine platforms.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  4. Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms

    This article has 6 authors:
    1. Jie Zhang
    2. Hui Tang
    3. Haoming Wu
    4. Xuewen Pang
    5. Rong Jin
    6. Yu Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a useful reassessment of the potential role of dendritic cell-derived IL-27 p28 cytokine in the functional maturation of CD4+CD8- thymocytes, and CD4+ recent thymic emigrants. The evidence supporting the claims of the authors is solid and serves to reaffirm what has been previously described, with the overall advance in understanding the mechanism(s) responsible for the intrathymic functional programming of CD4+ T cells being limited.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Contributions of T helper 9 cells in endometriosis-associated inflammation and lesion growth

    This article has 8 authors:
    1. Alison McCallion
    2. Katherine B. Zutautas
    3. Danielle J. Sisnett
    4. Priyanka Yolmo
    5. Harshavardhan Lingegowda
    6. Asha K. Ravishanker
    7. Dan Vo Hoang
    8. Chandrakant Tayade

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

    This article has 9 authors:
    1. Lulu Qin
    2. Chongbin Hu
    3. Qiong Zhao
    4. Yong Wang
    5. Dongdong Fan
    6. Aifu Lin
    7. Lixin Xiang
    8. Ye Chen
    9. Jianzhong Shao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study focuses on the role of a T-cell-specific receptor, ctla-4, in a new zebrafish model of IBD-like phenotype. Although implicated in IBD diseases, the function of ctla-4 has been hard to study in mice as the KO is lethal. Ctla-4 mutant zebrafish exhibited significant intestinal inflammation and dysbiosis, mirroring the pathology of inflammatory bowel disease (IBD) in mammals, providing a new valuable model to the field of IBD research. This is an key study with convincing evidence, comprehensive transcriptomic analysis, histological examinations, and functional assays all supporting the findings.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations

    This article has 9 authors:
    1. Sebastien De La Forest Divonne
    2. Juliette Pouzadoux
    3. Oceane Romatif
    4. Caroline Montagnani
    5. Guillaume Mitta
    6. Delphine Destoumieux-Garzón
    7. Benjamin Gourbal
    8. Guillaume M Charriere
    9. Emmanuel Vignal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript by de La Forest Divonne et al. offers an important and detailed exploration of the immune cells in the oyster Crassostrea gigas, by correlating distinct hemocyte morphotypes with specific single-cell transcriptional profiles. The evidence supporting the conclusion is convincing, deriving from the comprehensive dataset that not only captures unicellular diversity but also associates these cells with distinct immune roles, making it an invaluable resource for the broader research community.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  8. T-follicular helper cell profiles differ by malaria antigen and for children compared to adults

    This article has 8 authors:
    1. Catherine Suzanne Forconi
    2. Christina Nixon
    3. Hannah W Wu
    4. Boaz Odwar
    5. Sunthorn Pond-Tor
    6. John M Ong'echa
    7. Jonathan D Kurtis
    8. Ann M Moormann
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This descriptive study used multiparameter spectral flow cytometry and clustering analysis of a subset of CD4 T cells, termed circulating T follicular helper (cTfh), responding to Plasmodium falciparum antigens, PfSEA -1A and PfGARP. The results from this comprehensive study provide valuable information regarding differences in cTfh response profiles between children and adults living in malaria-endemic Kenya and thus offer a potential usefulness towards improving choices of antigen candidates for malaria vaccines. However, the analysis and interpretation of antigen-specific CD4 cTfh responses remain incomplete.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Temporal dynamics of viral fitness and the adaptive immune response in HCV infection

    This article has 7 authors:
    1. Melanie Rose Walker
    2. Preston Leung
    3. Elizabeth Keoshkerian
    4. Mehdi R Pirozyan
    5. Andrew Lloyd
    6. Fabio Luciani
    7. Rowena A Bull
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors examined the evolution of hepatitis C virus (HCV) in a cohort of 14 subjects with recent HCV infections. They showed that viral fitness declines as the virus mutates to escape the immune response and can rebound later in infection as HCV accumulates additional mutations. The study contributes to an important aspect of viral evolution. The combination of approaches contributes to a convincing study.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

    This article has 18 authors:
    1. Zhiyan Wang
    2. Nore Ojogun
    3. Yiling Liu
    4. Lu Gan
    5. Zeling Xiao
    6. Jintao Feng
    7. Wei Jiang
    8. Yeying Chen
    9. Benkun Zou
    10. ChengYun Yu
    11. Changshun Li
    12. Asha Ashuo
    13. Xiaobo Li
    14. Mingsheng Fu
    15. Jian Wu
    16. Yiwei Chu
    17. Robert S Munford
    18. Mingfang Lu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study highlights the key role of the gut-liver axis mediated by LPS in causing hepatic steatosis. The authors provide solid evidence, in vivo, in vitro, and in silico, for the role of acyloxyacyl hydrolase in mediating this effect using KO mice subjected to MASD-inducing diets. The findings are significant for the liver research community and others interested in the gut-liver axis.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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