Immunology

NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection

1. Júlia Torné
2. Claudia Chica
3. Tiphaine Camarasa
4. Bernd Jagla
5. Matilde Enes Dias
6. Aymeric Zellner
7. Sébastien Mella
8. Valentina Libri
9. Mélanie Anne Hamon

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Alterations in Circulating T-Cell Subsets with Gut-Homing/Residency Phenotypes Predict HIV-1 Status and Subclinical Atherosclerosis

1. Etiene Moreira Gabriel
2. Jonathan Dias
3. Abdelali Filali-Mouhim
4. Ramon Edwin Caballero
5. Tomas Raul Wiche Salinas
6. Manon Nayrac
7. Carl Chartrand-Lefebvre
8. Jean-Pierre Routy
9. Madeleine Durand
10. Mohamed El-Far
11. Cécile Tremblay
12. Petronela Ancuta

Reviewed by Rapid Reviews Infectious Diseases

Predestined neutrophil heterogeneity in homeostasis varies in transcriptional and phenotypic response to Candida

1. Allison K. Scherer
2. Alex Hopke
3. Shuying Xu
4. Adam Viens
5. Natalie J. Alexander
6. Kyle D. Timmer
7. Dakota Archambault
8. Daniel Floyd
9. Natalie J. Atallah
10. Catherine Rhee
11. Murat Cetinbas
12. David T. Scadden
13. Daniel Irimia
14. David B. Sykes
15. Ruslan I. Sadreyev
16. Michael K. Mansour

• Curated by eLife

  eLife Assessment

  In their study, Scherer and colleagues aim to use analyses of single-cell clones of murine granulocyte monocyte progenitors that are conditionally immortalized, and analyses of neutrophils derived from those clones to characterize an experimental system for studying neutrophil heterogeneity. The multi-omic and functional analyses reported are valuable but the strength of the evidence presented in support of them is incomplete because the study lacks a rigorous demonstration that the neutrophil-like cells that they derive are fully mature neutrophils.

Reviewed by eLife

Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier

1. Alina Batzilla
2. Pia Dernick
3. Jon Bezney
4. Andreas R. Gschwind
5. Fumio Nakaki
6. Mireia Altadill
7. Hannah Fleckenstein
8. Livia Piatti
9. Silvia Sanz Sender
10. Manuel Fiegl
11. Olawunmi Rashidat Oyerinde
12. Borja Lopez Gutierrez
13. Miguel Lopez-Botet
14. James Sharpe
15. Lars Steinmetz
16. Gemma Moncunill
17. Maria Bernabeu

Reviewed by Rapid Reviews Infectious Diseases

Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles

1. Guiqing Liu
2. Yao Tian
3. Mark Austin Hanson
4. Prince Kumar Sah
5. Jun Li
6. Bruno Lemaitre

Reviewed by Review Commons

PDL-1+ Neutrophils mediate susceptibility during endotoxemia in Metabolically Dysfunctional-Associated Fatty Liver Disease

1. Cleyson da Cruz Oliveira Barros
2. Alexandre Kanashiro
3. Gabriel Victor Lucena da Silva
4. Paulo Sérgio de Almeida Augusto
5. Guilherme Cesar Martelossi Cebinelli
6. Luiz Osório Leiria
7. Thiago Mattar Cunha
8. José Carlos Alves Filho
9. Fernando Queiroz Cunha

• Curated by eLife

  eLife Assessment

  This valuable study highlights the key role of NK cells and PD-L1+ neutrophils in worsening sepsis responses in the context of MASH (metabolic dysfunction-associated steatohepatitis). It focused on the role of neutrophils in mediating this effect, which is based on a choline-deficient high-fat diet model of various knockouts or selective ablation of immune cell types. While the data presented are of great interest, there are concerns around the reliability of the strength of the evidence provided, which is currently considered incomplete. The study may be of interest to researchers in immunopathological disease mechanisms once confirmatory studies have been completed.

  [Editors' note: the authors no longer have access to the original flow cytometry data and plan to compile new datasets in the future.]

Reviewed by eLife

Natural Killer Cell Receptor Signaling and Activation Depend on Cell Cycle Stages

1. Darren Wethington
2. Indrani Nayak
3. Helle Jensen
4. William C. Stewart
5. Oscar A. Aguilar
6. Shih-Yu Chen
7. Garry P. Nolan
8. Gregory K. Behbehani
9. Lewis L. Lanier
10. Jayajit Das

Reviewed by Review Commons