Immunology

TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni

1. Juan M. Inclan-Rico
2. Adriana Stephenson
3. Camila M. Napuri
4. Heather L. Rossi
5. Li-Yin Hung
6. Christopher F. Pastore
7. Wenqin Luo
8. De’Broski R. Herbert

Reviewed by Arcadia Science

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

1. Erin F. McCaffrey
2. Alea C. Delmastro
3. Isobel Fitzhugh
4. Jolene S. Ranek
5. Sarah Douglas
6. Joshua M. Peters
7. Christine Camacho Fullaway
8. Marc Bosse
9. Candace C. Liu
10. Craig Gillen
11. Noah F. Greenwald
12. Sarah Anzick
13. Craig Martens
14. Seth Winfree
15. Yunhao Bai
16. Cameron Sowers
17. Mako Goldston
18. Alex Kong
19. Potchara Boonrat
20. Carolyn L. Bigbee
21. Roopa Venugopalan
22. Pauline Maiello
23. Edwin Klein
24. Mark A. Rodgers
25. Charles A. Scanga
26. Philana Ling Lin
27. Denise Kirschner
28. Sarah Fortune
29. Bryan D. Bryson
30. J. Russell Butler
31. Joshua T. Mattila
32. JoAnne L. Flynn
33. Michael Angelo

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Longitudinal analysis of drift in the circulating human antibody repertoire over four years

1. Collin Joyce
2. Benjamin Nemoz
3. Raiza Bastidas
4. Bryan Briney
5. Dennis R. Burton

Reviewed by PREreview

Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction

1. Hicham Sid
2. Theresa von Heyl
3. Sabrina Schleibinger
4. Romina Klinger
5. Leah Heymelot Nabel
6. Hanna Vikkula
7. Rodrigo Guabiraba
8. Vanaique Guillory
9. Ryan Scicluna
10. Mohanned Naif Alhussien
11. Brigitte Böhm
12. Benjamin Schade
13. Daniel Elleder
14. Samantha Sives
15. Lonneke Vervelde
16. Sascha Trapp
17. Benjamin Schusser

Reviewed by PREreview

Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

1. Jan Stuchly
2. David Novak
3. Nadezda Brdickova
4. Petra Hadlova
5. Vojen Sadilek
6. Ahmad Iksi
7. Daniela Kuzilkova
8. Michael Svaton
9. George Alehandro Saad
10. Pablo Engel
11. Herve Luche
12. Ana E Sousa
13. Afonso RM Almeida
14. Tomas Kalina

• Curated by eLife

  eLife Assessment

  The authors present an algorithm and workflow for the inference of developmental trajectories from single-cell data, including a mathematical approach to increase computational efficiency. In this latest version, the authors addressed the benchmarking of the novel method, but the absence of quantitative comparisons to state-of-the-art methods still make this study incomplete. Based on the shown validation approaches, one can neither ultimately judge if the shown method will be an advance over previous work nor whether the approach will be of general useful applicability.

Reviewed by eLife

PIM kinase control of CD8 T cell protein synthesis and cell trafficking

1. Julia M Marchingo
2. Laura Spinelli
3. Shalini Pathak
4. Doreen A Cantrell

• Curated by eLife

  eLife Assessment

  These important findings detail the role of Pim1 and Pim2 in controlling the behaviour and activity of 'killer' T cells; a vital cell within of our immune system. The authors capitalized on high resolution quantitative analysis of the proteomes and transcriptomes of Pim1/Pim2-deficient CD8 T cells to provide compelling evidence for how the PIM1/2 kinases control TCR-driven activation and IL-2/IL-15-driven proliferation and differentiation into effector T cells. It's also noteworthy that Pim1/Pim2 impact is better revealed through quantitative proteomics than transcriptomics.

Reviewed by eLife

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

1. Israel Ríos
2. Cristina Herrero
3. Mónica Torres-Torresano
4. Baltasar López-Navarro
5. María Teresa Schiaffino
6. Francisco Díaz Crespo
7. Alicia Nieto-Valle
8. Rafael Samaniego
9. Yolanda Sierra-Palomares
10. Eduardo Oliver
11. Fernando Revuelta-Salgado
12. Ricardo García-Luján
13. Paloma Sánchez-Mateos
14. Rafael Delgado
15. Amaya Puig-Kröger
16. Angel L Corbí

• Curated by eLife

  eLife Assessment

  This important study provides compelling data from in vitro models and patient-derived samples to demonstrate how modulation of GSK3 activity can reprogram macrophages, revealing potential therapeutic applications in inflammatory diseases such as severe COVID-19. The study stands out for its clear and systematic presentation, convincing experimental approach, and the relevance of its findings to the field of immunology.

Reviewed by eLife

Comprehensive analysis of nasal IgA antibodies induced by intranasal administration of the SARS-CoV-2 spike protein

1. Kentarou Waki
2. Hideki Tani
3. Eigo Kawahara
4. Yumiko Saga
5. Takahisa Shimada
6. Emiko Yamazaki
7. Seiichi Koike
8. Yoshitomo Morinaga
9. Masaharu Isobe
10. Nobuyuki Kurosawa

• Curated by eLife

  eLife Assessment

  This work provides important insights into mucosal antibody responses against SARS-CoV-2 following intranasal immunization by characterizing a large number of monoclonal antibodies at both mucosal and non-mucosal sites. The evidence supporting the claims is solid. The demonstrated in vitro antiviral activity of antibodies characterized provides a rationale for developing mucosal vaccines, especially if confirmed in vivo and benchmarked against antibodies generated following intramuscular vaccination.

Reviewed by eLife

Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

1. Pramila Rijal
2. Leiyan Wei
3. Guido C Paesen
4. David I Stuart
5. Mark Haworth
6. Kuan-Ying A Huang
7. Thomas A Bowden
8. Alain RM Townsend

• Curated by eLife

  eLife Assessment

  The authors developed a methodology to graph antigenic surface loops on influenza virus neuraminidases. The hybrid proteins retained the structure of the neuraminidase scaffold and the antigenicity of the grafted loops. This fundamental work should help in developing novel neuraminidase constructs for use in influenza virus vaccines. The paper presents compelling evidence supporting the conclusions arrived at by the authors.

Reviewed by eLife