Immunology

Circadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment

1. Amelia M. Knudsen-Clark
2. Daniel Mwangi
3. Juliana Cazarin
4. Kristina Morris
5. Cameron Baker
6. Lauren M. Hablitz
7. Matthew N. McCall
8. Minsoo Kim
9. Brian J. Altman

Reviewed by Review Commons

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

1. Long-Feng Lu
2. Can Zhang
3. Zhuo-Cong Li
4. Bao-Jie Cui
5. Yang-Yang Wang
6. Ke-Jia Han
7. Xiao Xu
8. Chu-Jing Zhou
9. Xiao-Yu Zhou
10. Yue Wu
11. Na Xu
12. Xiao-Li Yang
13. Dan-Dan Chen
14. Xi-Yin Li
15. Li Zhou
16. Shun Li

• Curated by eLife

  eLife assessment

  This study makes a valuable contribution to understanding antiviral responses in fish by revealing a role for the cell cycle protein kinase CDK2 in type I interferon signaling. The evidence supporting the authors' claims is solid, including both in vivo and in vitro investigative approaches. However, the mechanisms underlying CDK2 activity are not completely established. This work will be of interest to cell biologists, immunologists, and virologists.

Reviewed by eLife

Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

1. Bethany Moyse
2. Joanna Moss
3. Laura Bevan
4. Aaron Scott
5. Valérie Wittamer
6. Rebecca J Richardson

• Curated by eLife

  eLife assessment

  The manuscript presented by Moyse and colleagues provides valuable insight into the origin, morphology, dynamics, and behavior of several populations of mononuclear phagocytes in the zebrafish heart. The study presents solid evidence through the use of transgenic lines and live imaging, although some limitations related to lineage tracing and molecular profiles should be considered. This work exemplifies the use of zebrafish as a model to study the role of leukocytes in cardiac development and regeneration and potentially draw broader interest to biologists working in immunology fields.

Reviewed by eLife

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

1. Matias A Medina
2. Francisco Fuentes-Villalobos
3. Claudio Quevedo
4. Felipe Aguilera
5. Raul Riquelme
6. Maria Luisa Rioseco
7. Sebastian Barria
8. Yazmin Pinos
9. Mario Calvo
10. Ian Burbulis
11. Camila Kossack
12. Raymond A Alvarez
13. COVID 19 South Chile Group
14. Jose Luis Garrido
15. Maria Ines Barria

• Curated by eLife

  eLife assessment

  This valuable paper compares blood gene signature responses between small cohorts of individuals with mild and severe COVID-19. The authors provide solid evidence for distinct transcriptional profiles during early COVID-19 infections that may be predictive of severity, within the limitations of studying human patients displaying heterogeneity in infection timelines and limited cohort size.

Reviewed by eLife

Broadly inhibitory antibodies against severe malaria virulence proteins

1. Raphael A. Reyes
2. Sai Sundar Rajan Raghavan
3. Nicholas K. Hurlburt
4. Viola Introini
5. Ikhlaq Hussain Kana
6. Rasmus W. Jensen
7. Elizabeth Martinez-Scholze
8. Maria Gestal-Mato
9. Cristina Bancells Bau
10. Monica Lisa Fernández-Quintero
11. Johannes R. Loeffler
12. James Alexander Ferguson
13. Wen-Hsin Lee
14. Greg Michael Martin
15. Thor G. Theander
16. Isaac Ssewanyana
17. Margaret E. Feeney
18. Bryan Greenhouse
19. Sebastiaan Bol
20. Andrew B. Ward
21. Maria Bernabeu
22. Marie Pancera
23. Louise Turner
24. Evelien M. Bunnik
25. Thomas Lavstsen

Reviewed by Rapid Reviews Infectious Diseases

PIM kinase control of CD8 T cell protein synthesis and cell trafficking

1. Julia M Marchingo
2. Laura Spinelli
3. Shalini Pathak
4. Doreen A Cantrell

• Curated by eLife

  eLife assessment

  This is an important study, as PIM1/2 control of protein synthesis in differentiated cells has implications beyond T cells. The evidence is convincing in that it makes extensive use of the mouse knockout model and validation in mouse T cells with inhibitors. A rescue experiment in mouse KO T cells would be even stronger than the inhibitor studies to validate the KO phenotype and the evidence would be truly impressive if the results from the rescue experiment support the working model. Extending the observations to human T cells would also be a step towards translation and would further increase the potential impact of the work.

Reviewed by eLife

REL2 overexpression in the Anopheles gambiae midgut causes major transcriptional changes but fails to induce an immune response

1. Astrid Hoermann
2. Paolo Capriotti
3. Giuseppe Del Corsano
4. Maria Grazia Inghilterra
5. Tibebu Habtewold
6. Julia A. Cai
7. Gauri Sachiko Saini
8. Huong Nguyen
9. Nikolai Windbichler
10. George K. Christophides

Reviewed by PREreview

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

1. Teng-Feng Li
2. Paul Rothhaar
3. Arthur Lang
4. Oliver Grünvogel
5. Ombretta Colasanti
6. Santa Mariela Olivera Ugarte
7. Jannik Traut
8. Antonio Piras
9. Nelson Acosta-Rivero
10. Vladimir Gonçalves Magalhães
11. Emely Springer
12. Andreas Betz
13. Hao-En Huang
14. Jeongbin Park
15. Ruiyue Qiu
16. Gnimah Eva Gnouamozi
17. Ann-Kathrin Mehnert
18. Viet Loan Dao Thi
19. Stephan Urban
20. Martina Muckenthaler
21. Matthias Schlesner
22. Dirk Wohlleber
23. Marco Binder
24. Ralf Bartenschlager
25. Andreas Pichlmair
26. Volker Lohmann

Reviewed by Review Commons

Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

1. S.V. Krasik
2. E.A. Bryushkova
3. G.V. Sharonov
4. D.S. Myalik
5. E.V. Shurganova
6. D.V. Komarov
7. I.A. Shagina
8. P.S. Shpudeiko
9. M.A. Turchaninova
10. M.T. Vakhitova
11. I.V. Samoylenko
12. D.T. Marinov
13. LV Demidov
14. V.E. Zagainov
15. D.M. Chudakov
16. E.O. Serebrovskaya

• Curated by eLife

  eLife assessment

  This study provides useful insights into inter- and intra-site B cell receptor repertoire heterogeneity, noting that B cell clones from the tumour interact more with their draining lymph node than with the blood and that there is less mutation/expansion/activation of B cell clones in tumours. Unfortunately, the main claims are incomplete and only partially supported. The work could be of interest to an audience including medical biologists/immunologists and computational biologists across cancer specialities.

Reviewed by eLife

Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice

1. Chia-Lo Ho
2. Li-Tzu Yeh
3. Yu-Wen Liu
4. Jia-Ling Dong
5. Huey-Kang Sytwu

• Curated by eLife

  eLife assessment

  This valuable study explores T cell receptor activation during autoreactive T cell development and how the strength of T cell receptor engagement in naïve cells can predispose T cells to develop into effector/memory T cells. Solid evidence confirms published data that naïve T cells with higher CD5 expression were poised for activation and more pathogenic in the mouse model of autoimmune diabetes. However, the evidence regarding the regulation of differentiation of these cells during development is still incomplete.

Reviewed by eLife