Immunology

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

1. Noella Lopes
2. Nicolas Boucherit
3. Jérémy C Santamaria
4. Nathan Provin
5. Jonathan Charaix
6. Pierre Ferrier
7. Matthieu Giraud
8. Magali Irla

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to readers in the field of immunology and especially in the induction of immune tolerance in the thymus. The work uses several mouse models to substantially broaden the current understanding of MHCII/TCR -mediated cell-cell crosstalk in the thymus and suggests a novel mechanism that contributes to the generation of functional and self-tolerant T-cells.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

1. Magdalena L Russell
2. Aisha Souquette
3. David M Levine
4. Stefan A Schattgen
5. E Kaitlynn Allen
6. Guillermina Kuan
7. Noah Simon
8. Angel Balmaseda
9. Aubree Gordon
10. Paul G Thomas
11. Frederick A Matsen
12. Philip Bradley

• Curated by eLife

  Evaluation Summary:

  This study demonstrates that differences in areas outside the regions that encode the TCR genes can affect the properties of TCRs that get made. This paper will be of interest to a broad swathe of immunologists who study such variable lymphocyte receptors. It combines several large datasets in an extremely statistically rigorous analysis, producing results consistent with but substantially expanding upon the prior knowledge of the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

SARS-CoV-2 spike conformation determines plasma neutralizing activity

1. John E. Bowen
2. Alexandra C. Walls
3. Anshu Joshi
4. Kaitlin R. Sprouse
5. Cameron Stewart
6. M. Alejandra Tortorici
7. Nicholas M. Franko
8. Jennifer K. Logue
9. Ignacio G. Mazzitelli
10. Sasha W Tiles
11. Kumail Ahmed
12. Asefa Shariq
13. Gyorgy Snell
14. Najeeha Talat Iqbal
15. Jorge Geffner
16. Alessandra Bandera
17. Andrea Gori
18. Renata Grifantini
19. Helen Y. Chu
20. Wesley C. Van Voorhis
21. Davide Corti
22. David Veesler

Reviewed by ScreenIT

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

1. Ana C. Puhl
2. Giovanni F. Gomes
3. Samara Damasceno
4. Ethan J. Fritch
5. James A. Levi
6. Nicole J. Johnson
7. Frank Scholle
8. Lakshmanane Premkumar
9. Brett L. Hurst
10. Felipe LeeMontiel
11. Flavio P. Veras
12. Sabrina S. Batah
13. Alexandre T. Fabro
14. Nathaniel J. Moorman
15. Boyd L. Yount
16. Rebekah Dickmander
17. Ralph Baric
18. Kenneth H. Pearce
19. Fernando Q. Cunha
20. José C. Alves-Filho
21. Thiago M. Cunha
22. Sean Ekins

Reviewed by ScreenIT

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

1. Manon Nayrac
2. Mathieu Dubé
3. Gérémy Sannier
4. Alexandre Nicolas
5. Lorie Marchitto
6. Olivier Tastet
7. Alexandra Tauzin
8. Nathalie Brassard
9. Raphaël Lima-Barbosa
10. Guillaume Beaudoin-Bussières
11. Dani Vézina
12. Shang Yu Gong
13. Mehdi Benlarbi
14. Romain Gasser
15. Annemarie Laumaea
16. Jérémie Prévost
17. Catherine Bourassa
18. Gabrielle Gendron-Lepage
19. Halima Medjahed
20. Guillaume Goyette
21. Gloria-Gabrielle Ortega-Delgado
22. Mélanie Laporte
23. Julia Niessl
24. Laurie Gokool
25. Chantal Morrisseau
26. Pascale Arlotto
27. Jonathan Richard
28. Justin Bélair
29. Alexandre Prat
30. Cécile Tremblay
31. Valérie Martel-Laferrière
32. Andrés Finzi
33. Daniel E. Kaufmann

Reviewed by ScreenIT

Reduced sera neutralization to Omicron SARS-CoV-2 by both inactivated and protein subunit vaccines and the convalescents

1. Xin Zhao
2. Dedong Li
3. Wenjing Ruan
4. Rong Zhang
5. Anqi Zheng
6. Shitong Qiao
7. Xinlei Zheng
8. Yingze Zhao
9. Zhihai Chen
10. Lianpan Dai
11. Pengcheng Han
12. George F. Gao

Reviewed by ScreenIT

Possible Cross-Reactivity of Feline and White-Tailed Deer Antibodies against the SARS-CoV-2 Receptor Binding Domain

1. Trevor J. Hancock
2. Peyton Hickman
3. Niloo Kazerooni
4. Melissa Kennedy
5. Stephen A. Kania
6. Michelle Dennis
7. Nicole Szafranski
8. Richard Gerhold
9. Chunlei Su
10. Tom Masi
11. Stephen Smith
12. Tim E. Sparer

Reviewed by ScreenIT

Modeling and predicting the overlap of B- and T-cell receptor repertoires in healthy and SARS-CoV-2 infected individuals

1. Maria Ruiz Ortega
2. Natanael Spisak
3. Thierry Mora
4. Aleksandra M. Walczak

• Curated by eLife

  Evaluation Summary:

  This work is potentially very important to dissect the immune repertoire of T/B cells, which is one of the most critical/difficult parts for the adaptive immune system to achieve antigen specificity. These conclusions and proposed methods will require additional experimental support and further validation in different disease conditions.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Disrupted Peyer’s Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus

1. Silvia C. Trevelin
2. Suzanne Pickering
3. Katrina Todd
4. Cynthia Bishop
5. Michael Pitcher
6. Jose Garrido Mesa
7. Lucia Montorsi
8. Filomena Spada
9. Nedyalko Petrov
10. Anna Green
11. Manu Shankar-Hari
12. Stuart J.D. Neil
13. Jo Spencer

Reviewed by ScreenIT

Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

1. Daniel J. Sheward
2. Changil Kim
3. Roy A. Ehling
4. Alec Pankow
5. Xaquin Castro Dopico
6. Darren Martin
7. Sai Reddy
8. Joakim Dillner
9. Gunilla B. Karlsson Hedestam
10. Jan Albert
11. Ben Murrell

Reviewed by ScreenIT