Immunology

Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection

1. Luisa Cervantes-Barragan
2. Abigail Vanderheiden
3. Charlotte J. Royer
4. Meredith E. Davis-Gardner
5. Philipp Ralfs
6. Tatiana Chirkova
7. Larry J. Anderson
8. Arash Grakoui
9. Mehul S. Suthar

Reviewed by ScreenIT

Optimised non-coding regions of mRNA SARS-CoV-2 vaccine CV2CoV improves homogeneous and heterogenous neutralising antibody responses

1. Nicole Roth
2. Jacob Schön
3. Donata Hoffmann
4. Moritz Thran
5. Andreas Thess
6. Stefan O. Mueller
7. Benjamin Petsch
8. Susanne Rauch

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Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

1. Shiyu Sun
2. Yueqi Cai
3. Tian-Zhang Song
4. Yang Pu
5. Lin Cheng
6. Hairong Xu
7. Jing Sun
8. Chaoyang Meng
9. Yifan Lin
10. Haibin Huang
11. Fang Zhao
12. Silin Zhang
13. Yu Gao
14. Jian-Bao Han
15. Xiao-Li Feng
16. Dan-Dan Yu
17. Yalan Zhu
18. Pu Gao
19. Haidong Tang
20. Jincun Zhao
21. Zheng Zhang
22. Jiaming Yang
23. Zhenxiang Hu
24. Yang-Xin Fu
25. Yong-Tang Zheng
26. Hua Peng

Reviewed by ScreenIT

Design, immunogenicity and efficacy of a Pan-SARS-CoV-2 synthetic DNA vaccine

1. Charles C. Reed
2. Katherine Schultheis
3. Viviane M. Andrade
4. Richa Kalia
5. Jared Tur
6. Blake Schouest
7. Dustin Elwood
8. Jewell N. Walters
9. Igor Maricic
10. Arthur Doan
11. Miguel Vazquez
12. Zeena Eblimit
13. Patrick Pezzoli
14. Dinah Amante
15. Maciel Porto
16. Brandon Narvaez
17. Megan Lok
18. Brittany Spence
19. Heath Bradette
20. Heather Horn
21. Maria Yang
22. Joseph Fader
23. Roi Ferrer
24. David B. Weiner
25. Swagata Kar
26. J. Joseph Kim
27. Laurent M. Humeau
28. Stephanie J. Ramos
29. Trevor R.F. Smith
30. Kate E. Broderick

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mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

1. Jason Neidleman
2. Xiaoyu Luo
3. Matthew McGregor
4. Guorui Xie
5. Victoria Murray
6. Warner C Greene
7. Sulggi A Lee
8. Nadia R Roan

• Curated by eLife

  Evaluation Summary:

  This work will be of broad interest to those studying adaptive immunity to SARS-CoV-2, particularly with a focus on T cell immunology. The study confirms that mRNA vaccine-elicited T cell responses maintain recognition of peptides derived from VOC, and provides phenotypic characterisation of spike-specific T cells from both convalescent and infection-naive subjects.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

1. Paulina Kaplonek
2. Chuangqi Wang
3. Yannic Bartsch
4. Stephanie Fischinger
5. Matthew J. Gorman
6. Kathryn Bowman
7. Jaewon Kang
8. Diana Dayal
9. Patrick Martin
10. Radoslaw Nowak
11. Ching-Lin Hsieh
12. Jared Feldman
13. Boris Julg
14. Eric J. Nilles
15. Elon R. Musk
16. Anil S. Menon
17. Eric S. Fischer
18. Jason S. McLellan
19. Aaron Schmidt
20. Marcia B. Goldberg
21. Michael Filbin
22. Nir Hacohen
23. Douglas A Lauffenburger
24. Galit Alter

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Neutralization Potential of Covishield Vaccinated Individuals Sera Against B.1.617.1

1. Pragya D Yadav
2. Gajanan N Sapkal
3. Priya Abraham
4. Gururaj Deshpande
5. Dimpal A Nyayanit
6. Deepak Y Patil
7. Nivedita Gupta
8. Rima R Sahay
9. Anita M Shete
10. Sanjay Kumar
11. Samiran Panda
12. Balram Bhargava

Reviewed by ScreenIT

Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B

1. Jun Liu
2. Patrick Budylowski
3. Reuben Samson
4. Bryan D. Griffin
5. Giorgi Babuadze
6. Bhavisha Rathod
7. Karen Colwill
8. Jumai A. Abioye
9. Jordan A. Schwartz
10. Ryan Law
11. Lily Yip
12. Sang Kyun Ahn
13. Serena Chau
14. Maedeh Naghibosadat
15. Yuko Arita
16. Queenie Hu
17. Feng Yun Yue
18. Arinjay Banerjee
19. W. Rod Hardy
20. Karen Mossman
21. Samira Mubareka
22. Robert A. Kozak
23. Michael S. Pollanen
24. Natalia Martin Orozco
25. Anne-Claude Gingras
26. Eric G. Marcusson
27. Mario A. Ostrowski

Reviewed by ScreenIT

SARS-CoV-2 receptor ACE2 identifies immuno-hot tumors in breast cancer

1. Jie Mei
2. Yun Cai
3. Rui Xu
4. Xinqian Yu
5. Lingyan Chen
6. Tao Ma
7. Tianshu Gao
8. Fei Gao
9. Yichao Zhu
10. Yan Zhang

Reviewed by ScreenIT

Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19

1. Sokratis A. Apostolidis
2. Amrita Sarkar
3. Heather M. Giannini
4. Rishi R. Goel
5. Divij Mathew
6. Aae Suzuki
7. Amy E. Baxter
8. Allison R. Greenplate
9. Cécile Alanio
10. Mohamed Abdel-Hakeem
11. Derek A. Oldridge
12. Josephine R. Giles
13. Jennifer E. Wu
14. Zeyu Chen
15. Yinghui Jane Huang
16. Jonathan Belman
17. Ajinkya Pattekar
18. Sasikanth Manne
19. Oliva Kuthuru
20. Jeanette Dougherty
21. Brittany Weiderhold
22. Ariel R. Weisman
23. Caroline A. G. Ittner
24. Sigrid Gouma
25. Debora Dunbar
26. Ian Frank
27. Alexander C. Huang
28. Laura A. Vella
29. The UPenn COVID Processing Unit
30. John P. Reilly
31. Scott E. Hensley
32. Lubica Rauova
33. Liang Zhao
34. Nuala J. Meyer
35. Mortimer Poncz
36. Charles S. Abrams
37. E. John Wherry

Reviewed by ScreenIT