Immunology

  1. Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

    1. Chethan Ashokkumar
    2. Vinayak Rohan
    3. Alexander H Kroemer
    4. Sohail Rao
    5. George Mazariegos
    6. Brandon W Higgs
    7. Satish Nadig
    8. Jose Almeda
    9. Harmeet Dhani
    10. Khalid Khan
    11. Nada Yazigi
    12. Udeme Ekong
    13. Stuart Kaufman
    14. Monica M Betancourt-Garcia
    15. Kavitha Mukund
    16. Pradeep Sethi
    17. Shikhar Mehrotra
    18. Kyle Soltys
    19. Manasi S Singh
    20. Geoffrey Bond
    21. Ajai Khanna
    22. Mylarappa Ningappa
    23. Brianna Spishock
    24. Elizabeth Sindhi
    25. Neha Atale
    26. Maggie Saunders
    27. Prabhakar Baliga
    28. Thomas Fishbein
    29. Shankar Subramaniam
    30. Rakesh Sindhi

    Reviewed by ScreenIT

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  2. Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

    1. Luca Mazzarella
    2. Fabio Santoro
    3. Roberto Ravasio
    4. Paul E. Massa
    5. Simona Rodighiero
    6. Elena Gavilán
    7. Mauro Romanenghi
    8. Bruno Achutti Duso
    9. Emanuele Bonetti
    10. Rani Pallavi
    11. Deborah Trastulli
    12. Isabella Pallavicini
    13. Claudia Gentile
    14. Tommaso Leonardi
    15. Sebastiano Pasqualato
    16. Gabriele Buttinelli
    17. Angela Di Martino
    18. Giorgio Fedele
    19. Ilaria Schiavoni
    20. Paola Stefanelli
    21. Giuseppe Meroni
    22. Christian Steinkuhler
    23. Gianluca Fossati
    24. Saverio Minucci
    25. Pier Giuseppe Pelicci

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

    1. Sayumi Fujimori
    2. Izumi Ohigashi
    3. Hayato Abe
    4. Yosuke Matsushita
    5. Toyomasa Katagiri
    6. Makoto M Taketo
    7. Yousuke Takahama
    8. Shinji Takada

    • Curated by eLife

      Evaluation Summary:

      This paper is of interest to scientists within the field of thymus development and function. Analysis of the data is overall rigorous and conclusions are justified. The work presented builds upon previous studies that have shown that alterations of Wnt/beta-catenin signaling in thymic epithelial cells impact the normal development and or maintenance of thymic epithelial microenvironment critical for the proper development and selection of functional self-tolerant T cell repertoire. The surprise that a thymus epithelial cell specific loss of function of beta-catenin only showed a rather minor phenotype is interesting, but it would be good to also address whether TEC recovery after a challenge, or in aging, is also affected in a minor manner or perhaps more dramatically than the steady-state situation. The author's claims are well supported by the data presented and will be of great interest to scientists and clinicians interested in understanding the signaling pathways important in thymic maintenance, as well as the development of strategies to counteract thymic involution in the aging population and cancer patients.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. Stereotypic Neutralizing V H Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

    1. Sang Il Kim
    2. Jinsung Noh
    3. Sujeong Kim
    4. Younggeun Choi
    5. Duck Kyun Yoo
    6. Yonghee Lee
    7. Hyunho Lee
    8. Jongtak Jung
    9. Chang Kyung Kang
    10. Kyoung-Ho Song
    11. Pyoeng Gyun Choe
    12. Hong Bin Kim
    13. Eu Suk Kim
    14. Nam-Joong Kim
    15. Moon-Woo Seong
    16. Wan Beom Park
    17. Myoung-don Oh
    18. Sunghoon Kwon
    19. Junho Chung

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Ferritin nanoparticle based SARS-CoV-2 RBD vaccine induces persistent antibody response and long-term memory in mice

    1. Wenjun Wang
    2. Baoying Huang
    3. Yanping Zhu
    4. Wenjie Tan
    5. Mingzhao Zhu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Severe COVID-19 associated variants linked to chemokine receptor gene control in monocytes and macrophages

    1. Bernard Stikker
    2. Grégoire Stik
    3. Rudi W. Hendriks
    4. Ralph Stadhouders

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

    1. Romain Rouet
    2. Ohan Mazigi
    3. Gregory J. Walker
    4. David B. Langley
    5. Meghna Sobti
    6. Peter Schofield
    7. Helen Lenthall
    8. Jennifer Jackson
    9. Stephanie Ubiparipovic
    10. Jake Y. Henry
    11. Arunasingam Abayasingam
    12. Deborah Burnett
    13. Anthony Kelleher
    14. Robert Brink
    15. Rowena A. Bull
    16. Stuart Turville
    17. Alastair G. Stewart
    18. Christopher C. Goodnow
    19. William D. Rawlinson
    20. Daniel Christ

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients

    1. Sunil Kumar Saini
    2. Ditte Stampe Hersby
    3. Tripti Tamhane
    4. Helle Rus Povlsen
    5. Susana Patricia Amaya Hernandez
    6. Morten Nielsen
    7. Anne Ortved Gang
    8. Sine Reker Hadrup

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

    1. Teresa R. Wagner
    2. Philipp D. Kaiser
    3. Marius Gramlich
    4. Elena Ostertag
    5. Natalia Ruetalo
    6. Daniel Junker
    7. Julia Haering
    8. Bjoern Traenkle
    9. Matthias Becker
    10. Alex Dulovic
    11. Helen Schweizer
    12. Stefan Nueske
    13. Armin Scholz
    14. Anne Zeck
    15. Katja Schenke-Layland
    16. Annika Nelde
    17. Monika Strengert
    18. Juliane S. Walz
    19. Georg Zocher
    20. Thilo Stehle
    21. Michael Schindler
    22. Nicole Schneiderhan-Marra
    23. Ulrich Rothbauer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity

    1. Hamid Bolouri
    2. Cate Speake
    3. David Skibinski
    4. S. Alice Long
    5. Anne M. Hocking
    6. Daniel J. Campbell
    7. Jessica A. Hamerman
    8. Uma Malhotra
    9. Jane H. Buckner
    10. the BRI COVID-19 Research Team

    Reviewed by ScreenIT

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