Immunology

Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens

1. Vijayashree Mysore
2. Xavier Cullere
3. Matthew L. Settles
4. Xinge Ji
5. Michael W. Kattan
6. Michaël Desjardins
7. Blythe Durbin-Johnson
8. Tal Gilboa
9. Lindsey R. Baden
10. David R. Walt
11. Andrew H. Lichtman
12. Lara Jehi
13. Tanya N. Mayadas

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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

1. Zijun Wang
2. Frauke Muecksch
3. Dennis Schaefer-Babajew
4. Shlomo Finkin
5. Charlotte Viant
6. Christian Gaebler
7. Hans- Heinrich Hoffmann
8. Christopher O. Barnes
9. Melissa Cipolla
10. Victor Ramos
11. Thiago Y. Oliveira
12. Alice Cho
13. Fabian Schmidt
14. Justin Da Silva
15. Eva Bednarski
16. Lauren Aguado
17. Jim Yee
18. Mridushi Daga
19. Martina Turroja
20. Katrina G. Millard
21. Mila Jankovic
22. Anna Gazumyan
23. Zhen Zhao
24. Charles M. Rice
25. Paul D. Bieniasz
26. Marina Caskey
27. Theodora Hatziioannou
28. Michel C. Nussenzweig

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The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men

1. Gizem Kilic
2. Ozlem Bulut
3. Martin Jaeger
4. Rob ter Horst
5. Valerie A. C. M. Koeken
6. Simone J. C. F. M. Moorlag
7. Vera P. Mourits
8. Charlotte de Bree
9. Jorge Domínguez-Andrés
10. Leo A. B. Joosten
11. Mihai G. Netea

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Preliminary Immunogenicity of a Pan-COVID-19 T Cell Vaccine in HLA-A*02:01 Mice

1. Brandon Carter
2. Jinjin Chen
3. Clarety Kaseke
4. Alexander Dimitrakakis
5. Gaurav D. Gaiha
6. Qiaobing Xu
7. David K. Gifford

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Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

1. Chethan Ashokkumar
2. Vinayak Rohan
3. Alexander H Kroemer
4. Sohail Rao
5. George Mazariegos
6. Brandon W Higgs
7. Satish Nadig
8. Jose Almeda
9. Harmeet Dhani
10. Khalid Khan
11. Nada Yazigi
12. Udeme Ekong
13. Stuart Kaufman
14. Monica M Betancourt-Garcia
15. Kavitha Mukund
16. Pradeep Sethi
17. Shikhar Mehrotra
18. Kyle Soltys
19. Manasi S Singh
20. Geoffrey Bond
21. Ajai Khanna
22. Mylarappa Ningappa
23. Brianna Spishock
24. Elizabeth Sindhi
25. Neha Atale
26. Maggie Saunders
27. Prabhakar Baliga
28. Thomas Fishbein
29. Shankar Subramaniam
30. Rakesh Sindhi

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Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

1. Luca Mazzarella
2. Fabio Santoro
3. Roberto Ravasio
4. Paul E. Massa
5. Simona Rodighiero
6. Elena Gavilán
7. Mauro Romanenghi
8. Bruno Achutti Duso
9. Emanuele Bonetti
10. Rani Pallavi
11. Deborah Trastulli
12. Isabella Pallavicini
13. Claudia Gentile
14. Tommaso Leonardi
15. Sebastiano Pasqualato
16. Gabriele Buttinelli
17. Angela Di Martino
18. Giorgio Fedele
19. Ilaria Schiavoni
20. Paola Stefanelli
21. Giuseppe Meroni
22. Christian Steinkuhler
23. Gianluca Fossati
24. Saverio Minucci
25. Pier Giuseppe Pelicci

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Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

1. Sayumi Fujimori
2. Izumi Ohigashi
3. Hayato Abe
4. Yosuke Matsushita
5. Toyomasa Katagiri
6. Makoto M Taketo
7. Yousuke Takahama
8. Shinji Takada

• Curated by eLife

  Evaluation Summary:

  This paper is of interest to scientists within the field of thymus development and function. Analysis of the data is overall rigorous and conclusions are justified. The work presented builds upon previous studies that have shown that alterations of Wnt/beta-catenin signaling in thymic epithelial cells impact the normal development and or maintenance of thymic epithelial microenvironment critical for the proper development and selection of functional self-tolerant T cell repertoire. The surprise that a thymus epithelial cell specific loss of function of beta-catenin only showed a rather minor phenotype is interesting, but it would be good to also address whether TEC recovery after a challenge, or in aging, is also affected in a minor manner or perhaps more dramatically than the steady-state situation. The author's claims are well supported by the data presented and will be of great interest to scientists and clinicians interested in understanding the signaling pathways important in thymic maintenance, as well as the development of strategies to counteract thymic involution in the aging population and cancer patients.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Stereotypic Neutralizing V _H Clonotypes Against SARS-CoV-2 RBD in COVID-19 Patients and the Healthy Population

1. Sang Il Kim
2. Jinsung Noh
3. Sujeong Kim
4. Younggeun Choi
5. Duck Kyun Yoo
6. Yonghee Lee
7. Hyunho Lee
8. Jongtak Jung
9. Chang Kyung Kang
10. Kyoung-Ho Song
11. Pyoeng Gyun Choe
12. Hong Bin Kim
13. Eu Suk Kim
14. Nam-Joong Kim
15. Moon-Woo Seong
16. Wan Beom Park
17. Myoung-don Oh
18. Sunghoon Kwon
19. Junho Chung

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Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice

1. Wenjun Wang
2. Baoying Huang
3. Yanping Zhu
4. Wenjie Tan
5. Mingzhao Zhu

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Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages

1. Bernard S. Stikker
2. Grégoire Stik
3. Antoinette F. van Ouwerkerk
4. Lianne Trap
5. Salvatore Spicuglia
6. Rudi W. Hendriks
7. Ralph Stadhouders

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