Immunology

  1. SARS-CoV-2 B.1.1.7 (alpha) and B.1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains

    1. Peter Radvak
    2. Hyung-Joon Kwon
    3. Martina Kosikova
    4. Uriel Ortega-Rodriguez
    5. Ruoxuan Xiang
    6. Je-Nie Phue
    7. Rong-Fong Shen
    8. James Rozzelle
    9. Neeraj Kapoor
    10. Taylor Rabara
    11. Jeff Fairman
    12. Hang Xie

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Mapping Potential Antigenic Drift Sites (PADS) on SARS-CoV-2 Spike in Continuous Epitope-Paratope Space

    1. Nathaniel L. Miller
    2. Thomas Clark
    3. Rahul Raman
    4. Ram Sasisekharan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. An interactive single cell web portal identifies gene and cell networks in COVID-19 host responses

    1. Kang Jin
    2. Eric E. Bardes
    3. Alexis Mitelpunkt
    4. Jake Y. Wang
    5. Surbhi Bhatnagar
    6. Soma Sengupta
    7. Daniel Pomeranz Krummel
    8. Marc E. Rothenberg
    9. Bruce J. Aronow

    Reviewed by ScreenIT

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  4. Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

    1. Isobel C Mouat
    2. Zachary J Morse
    3. Iryna Shanina
    4. Kelly L Brown
    5. Marc S Horwitz

    • Curated by eLife

      Evaluation Summary:

      This study could help shed light on mechanistic connections between latent infection by EBV with an age-dependent autoimmune condition, such as rheumatoid arthritis. The authors use two models: a murine model of rheumatoid arthritis (CIA), and a murine analog of human EBV: 𝜸HV68. The use of these two models allows the investigation of how latent viral infection exacerbates the autoimmune condition via the action of a special class of B cells: Age-associated B cells.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  5. Immunological Profiling of COVID-19 Patients with Pulmonary Sequelae

    1. Jianghua Wu
    2. Lu Tang
    3. Yanling Ma
    4. Yu Li
    5. Dongmei Zhang
    6. Qian Li
    7. Heng Mei
    8. Yu Hu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Pathogenic neutrophilia drives acute respiratory distress syndrome in severe COVID-19 patients

    1. Devon J. Eddins
    2. Junkai Yang
    3. Astrid Kosters
    4. Vincent D. Giacalone
    5. Ximo Pechuan
    6. Joshua D. Chandler
    7. Jinyoung Eum
    8. Benjamin R. Babcock
    9. Brian S. Dobosh
    10. Mindy R. Hernández
    11. Fathma Abdulkhader
    12. Genoah L. Collins
    13. Richard P. Ramonell
    14. Christine Moussion
    15. Darya Y. Orlova
    16. Ignacio Sanz
    17. F. Eun-Hyung Lee
    18. Rabindra M. Tirouvanziam
    19. Eliver E.B. Ghosn

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Efficacy of ancestral receptor-binding domain, S1 and trimeric spike protein vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1

    1. Yong Yang
    2. Jinkai Zang
    3. Shiqi Xu
    4. Xueyang Zhang
    5. Sule Yuan
    6. Dimitri Lavillette
    7. Chao Zhang
    8. Zhong Huang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner

    1. David J. Hamelin
    2. Dominique Fournelle
    3. Jean-Christophe Grenier
    4. Jana Schockaert
    5. Kevin A. Kovalchik
    6. Peter Kubiniok
    7. Fatima Mostefai
    8. Jérôme D. Duquette
    9. Frederic Saab
    10. Isabelle Sirois
    11. Martin A. Smith
    12. Sofie Pattijn
    13. Hugo Soudeyns
    14. Hélène Decaluwe
    15. Julie Hussin
    16. Etienne Caron

    Reviewed by ScreenIT

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  9. Immune dynamics in a time of covid

    1. Troy Shinbrot

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. CD4 + T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

    1. Iulia Popescu
    2. Mark E. Snyder
    3. Carlo J. Iasella
    4. Stefanie J. Hannan
    5. Ritchie Koshy
    6. Robin Burke
    7. Antu Das
    8. Mark J. Brown
    9. Emily J. Lyons
    10. Sophia C. Lieber
    11. Xiaoping Chen
    12. John C. Sembrat
    13. Xiaojing An
    14. Kelsey Linstrum
    15. Georgios Kitsios
    16. Ioannis Konstantinidis
    17. Melissa Saul
    18. Daniel J. Kass
    19. Jonathan K. Alder
    20. Bill B. Chen
    21. Elizabeth A. Lendermon
    22. Silpa Kilaru
    23. Bruce Johnson
    24. Matthew R. Morrell
    25. Joseph M. Pilewski
    26. Joseph E. Kiss
    27. Alan H. Wells
    28. Alison Morris
    29. Bryan J. McVerry
    30. Deborah K. McMahon
    31. Darrell J. Triulzi
    32. Kong Chen
    33. Pablo G. Sanchez
    34. John F. McDyer

    Reviewed by ScreenIT

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