HIV/AIDS

  1. Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    1. Colin LaMont
    2. Jakub Otwinowski
    3. Kanika Vanshylla
    4. Henning Gruell
    5. Florian Klein
    6. Armita Nourmohammad

    • Curated by eLife

      Evaluation Summary:

      This study provides computational predictions on optimal combinations of broadly neutralizing antibodies for treating HIV-1, based on the finding that population diversity alone permits the prediction of the timing of viral escape from broadly neutralizing antibodies. The idea behind the approach used is good, although the analyses and computational data/results highlight important limitations of the modeling approach. Nonetheless, the study should be of broad interest to those studying viral responses to therapeutic interventions as well as to both evolutionary and computational biologists.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. CLINICAL MANIFESTATIONS AND DIAGNOSIS OF CO-INFECTION OF COVID-19, TUBERCULOSIS AND OPPORTUNISTIC PULMONARY INFECTIONS IN LATE-STAGE HIV PATIENTS

    1. A.V. Mishina
    2. V.Yu. Mishin
    3. I. V. Shashenkov

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Analysis of Severe Illness After Postvaccination COVID-19 Breakthrough Among Adults With and Without HIV in the US

    1. Raynell Lang
    2. Elizabeth Humes
    3. Sally B. Coburn
    4. Michael A. Horberg
    5. Lily F. Fathi
    6. Eric Watson
    7. Celeena R. Jefferson
    8. Lesley S. Park
    9. Kirsha S. Gordon
    10. Kathleen M. Akgün
    11. Amy C. Justice
    12. Sonia Napravnik
    13. Jessie K. Edwards
    14. Lindsay E. Browne
    15. Deana M. Agil
    16. Michael J. Silverberg
    17. Jacek Skarbinski
    18. Wendy A. Leyden
    19. Cameron Stewart
    20. Brenna C. Hogan
    21. Kelly A. Gebo
    22. Vincent C. Marconi
    23. Carolyn F. Williams
    24. Keri N. Althoff
    25. Corona-Infectious-Virus Epidemiology Team (CIVETs) of the NA-ACORD of IeDEA

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Immunogenicity and reactogenicity of SARS-CoV-2 vaccines in people living with HIV in the Netherlands: A nationwide prospective cohort study

    1. Kathryn S. Hensley
    2. Marlou J. Jongkees
    3. Daryl Geers
    4. Corine H. GeurtsvanKessel
    5. Yvonne M. Mueller
    6. Virgil A. S. H. Dalm
    7. Grigorios Papageorgiou
    8. Hanka Steggink
    9. Alicja Gorska
    10. Susanne Bogers
    11. Jan G. den Hollander
    12. Wouter F. W. Bierman
    13. Luc B. S. Gelinck
    14. Emile F. Schippers
    15. Heidi S. M. Ammerlaan
    16. Marc van der Valk
    17. Marit G. A. van Vonderen
    18. Corine E. Delsing
    19. Elisabeth H. Gisolf
    20. Anke H. W. Bruns
    21. Fanny N. Lauw
    22. Marvin A. H. Berrevoets
    23. Kim C. E. Sigaloff
    24. Robert Soetekouw
    25. Judith Branger
    26. Quirijn de Mast
    27. Adriana J. J. Lammers
    28. Selwyn H. Lowe
    29. Rory D. de Vries
    30. Peter D. Katsikis
    31. Bart J. A. Rijnders
    32. Kees Brinkman
    33. Anna H. E. Roukens
    34. Casper Rokx

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection

    1. Michael J. Peluso
    2. Matthew A. Spinelli
    3. Tyler-Marie Deveau
    4. Carrie A. Forman
    5. Sadie E. Munter
    6. Sujata Mathur
    7. Alex F. Tang
    8. Scott Lu
    9. Sarah A. Goldberg
    10. Mireya I. Arreguin
    11. Rebecca Hoh
    12. Viva Tai
    13. Jessica Y. Chen
    14. Enrique O. Martinez
    15. Brandon C. Yee
    16. Ahmed Chenna
    17. John W. Winslow
    18. Christos J. Petropoulos
    19. Alessandro Sette
    20. Daniella Weiskopf
    21. Nitasha Kumar
    22. Kara L. Lynch
    23. Peter W. Hunt
    24. Matthew S. Durstenfeld
    25. Priscilla Y. Hsue
    26. J. Daniel Kelly
    27. Jeffrey N. Martin
    28. David V. Glidden
    29. Monica Gandhi
    30. Steven G. Deeks
    31. Rachel L. Rutishauser
    32. Timothy J. Henrich

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial – BCPP/Ya Tsie trial

    1. Lerato E Magosi
    2. Yinfeng Zhang
    3. Tanya Golubchik
    4. Victor DeGruttola
    5. Eric Tchetgen Tchetgen
    6. Vladimir Novitsky
    7. Janet Moore
    8. Pam Bachanas
    9. Tebogo Segolodi
    10. Refeletswe Lebelonyane
    11. Molly Pretorius Holme
    12. Sikhulile Moyo
    13. Joseph Makhema
    14. Shahin Lockman
    15. Christophe Fraser
    16. Myron Max Essex
    17. Marc Lipsitch
    18. On behalf of The Botswana Combination Prevention Project and PANGEA consortium

    • Curated by eLife

      Evaluation Summary:

      One hypothesis to explain recent worse-than-expected outcomes of universal test-and-treat HIV prevention trials is population mobility. The authors show phylogenetically that mobility could play a role in transmission events in a large trial in Botswana. This study is of public health interest, has a large sample size for a phylogenetic study in this setting, and overall precise analysis. A few methodological clarifications are still needed to ensure that the data supports the study's claims.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. People with HIV have a higher risk of COVID‐19 diagnosis but similar outcomes to the general population

    1. Michael E. Tang
    2. Thaidra Gaufin
    3. Ryan Anson
    4. Wenhong Zhu
    5. William C. Mathews
    6. Edward R. Cachay

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Systematic review and meta-analysis of COVID-19 vaccines safety, tolerability, and efficacy among HIV-infected patients

    1. Jacques L Tamuzi
    2. Ley M Muyaya
    3. Amal Mitra
    4. Peter S Nyasulu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Time Between Viral Loads for People With HIV During the COVID-19 Pandemic

    1. Walid G. El-Nahal
    2. Nicola M. Shen
    3. Jeanne C. Keruly
    4. Joyce L. Jones
    5. Anthony T. Fojo
    6. Yukari C. Manabe
    7. Richard D. Moore
    8. Kelly A. Gebo
    9. Geetanjali Chander
    10. Catherine R. Lesko

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Safety and Immunogenicity of SARS-CoV-2 S-2P Protein Vaccine MVC-COV1901 in People Living with HIV

    1. Shu-Hsing Cheng
    2. Chia En Lien
    3. Szu-Min Hsieh
    4. Chien-Yu Cheng
    5. Wang-Da Liu
    6. Ching-Lung Lo
    7. Wen-Chien Ko
    8. Yen-Hsu Chen
    9. Ching-Tai Huang
    10. Hsiao-Ting Chang
    11. Shinn-Jang Hwang
    12. Ning-Chi Wang
    13. Ming-Che Liu
    14. Yu-Lin Lee
    15. I-Chen Tai
    16. Josue Antonio Garcia Estrada
    17. Tzou-Yien Lin
    18. Wen-Sen Lee

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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