Genomics

Crossing host boundaries: the evolutionary drivers and correlates of viral host jumps

1. Cedric C.S. Tan
2. Lucy van Dorp
3. Francois Balloux

Reviewed by Rapid Reviews Infectious Diseases

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

1. Alexandre Pellan Cheng
2. Itai Rusinek
3. Aaron Sossin
4. Adam J. Widman
5. Eti Meiri
6. Gat Krieger
7. Ori Hirschberg
8. Doron Shem Tov
9. Shlomit Gilad
10. Ariel Jaimovich
11. Omer Barad
12. Sammantha Avaylon
13. Srinivas Rajagopalan
14. Catherine Potenski
15. Tamara Prieto
16. Dennis J. Yuan
17. Rob Furatero
18. Alexi Runnels
19. Benjamin M. Costa
20. Jonathan E. Shoag
21. Majd Al Assaad
22. Michael Sigouros
23. Jyothi Manohar
24. Abigail King
25. David Wilkes
26. John Otilano
27. Murtaza S. Malbari
28. Olivier Elemento
29. Juan Miguel Mosquera
30. Nasser K. Altorki
31. Ashish Saxena
32. Margaret K. Callahan
33. Nicolas Robine
34. Soren Germer
35. Gilad D. Evrony
36. Bishoy M. Faltas
37. Dan-Avi Landau

Reviewed by PREreview

MicroFinder: conserved gene-set mapping and assembly ordering for manual curation of bird dot microchromosomes

1. Thomas C Mathers
2. Michael Paulini
3. Cibele G Sotero-Caio
4. Jonathan M D Wood

Reviewed by GigaScience

Optics-free reconstruction of shapes, images and volumes with DNA barcode proximity graphs

1. Hanna Liao
2. Sanjay Kottapalli
3. Yuqi Huang
4. Matthew Chaw
5. Jase Gehring
6. Olivia Waltner
7. Melissa Phung-Rojas
8. Riza M Daza
9. Frederick A Matsen
10. Cole Trapnell
11. Jay Shendure
12. Sanjay Srivatsan

• Curated by eLife

  eLife Assessment

  This important technical study introduces SCOPE, an optics-free spatial reconstruction method based on bidirectional sender and receiver oligonucleotides on barcoded hydrogel beads. By sequencing proximity-encoded chimeric molecules, the authors computationally reconstruct 2D and 3D spatial information at an impressive scale. The technical demonstrations in synthetic bead systems are convincing and establish proof-of-principle that large spatial domains can be reconstructed without microscopy. The methodological advance is clear and the scale is impressive. Direct validation in biological samples would help clarify what additional limitations on applicability may exist. This work will be of interest to those working on spatial mapping.

Reviewed by eLife

Sex Chromosome Turnover and Structural Interspecific Genome Divergence Shapes Meiotic Outcomes in Hybridizing Cobitis

1. S. A. Schlebusch
2. V. Trifonov
3. Z. Halenková
4. M. Klianitskaya
5. D. Dedukh
6. A. Ruiz Herrera
7. L. Álvarez González
8. G. Pujol Infantes
9. E. Hřibová
10. L. Andjel
11. O. Bartoš
12. P. Pajer
13. T. Tichopád
14. D. Kulik
15. J. Kotusz
16. M. Kaštánková Doležálková
17. A. Bohne
18. A. Marta
19. P. Horna
20. R. Reifová
21. Y. Guiguen
22. J. Pačes
23. K. Janko

Reviewed by GigaScience

The CLAMP GA-binding transcription factor regulates heat stress-induced transcriptional repression

1. Joseph Aguilera
2. Jingyue Duan
3. Kaitlyn Cortez
4. Rachel S Lee
5. Angelica Aragon
6. Mukulika Ray
7. Erica Larschan

• Curated by eLife

  eLife Assessment

  This important study presents evidence that the Chromatin-linked adaptor for MSL complex proteins (CLAMP) GA-binding transcription factor (TF) regulates ~75% of HS-induced repression in Drosophila and suggests that CLAMP is the first known transcription factor to induce heat-stress-mediated repression of gene expression. While mechanistic details remain to be sorted out, this manuscript provides convincing evidence that novel pathways involving the CLAMP transcription factor repress gene expression during heat shock stress.

Reviewed by eLife