Genetics

Variation in predicted COVID-19 risk among lemurs and lorises

1. Amanda D. Melin
2. Joseph D. Orkin
3. Mareike C. Janiak
4. Alejandro Valenzuela
5. Lukas Kuderna
6. Frank Marrone
7. Hasinala Ramangason
8. Julie E. Horvath
9. Christian Roos
10. Andrew C. Kitchener
11. Chiea Chuen Khor
12. Weng Khong Lim
13. Jessica G. H. Lee
14. Patrick Tan
15. Govindhaswamy Umapathy
16. Muthuswamy Raveendran
17. R. Alan Harris
18. Ivo Gut
19. Marta Gut
20. Esther Lizano
21. Tilo Nadler
22. Dietmar Zinner
23. Steig E. Johnson
24. Erich D. Jarvis
25. Olivier Fedrigo
26. Dongdong Wu
27. Guojie Zhang
28. Kyle Kai-How Farh
29. Jeffrey Rogers
30. Tomas Marques-Bonet
31. Arcadi Navarro
32. David Juan
33. Paramjit S. Arora
34. James P. Higham

Reviewed by ScreenIT

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

1. Scott B. Biering
2. Sylvia A. Sarnik
3. Eleanor Wang
4. James R. Zengel
5. Sarah R. Leist
6. Alexandra Schäfer
7. Varun Sathyan
8. Padraig Hawkins
9. Kenichi Okuda
10. Cyrus Tau
11. Aditya R. Jangid
12. Connor V. Duffy
13. Jin Wei
14. Rodney C. Gilmore
15. Mia Madel Alfajaro
16. Madison S. Strine
17. Xammy Huu Wrynla
18. Erik Van Dis
19. Carmelle Catamura
20. Livia H. Yamashiro
21. Julia A. Belk
22. Adam Begeman
23. Jessica C. Stark
24. D. Judy Shon
25. Douglas M. Fox
26. Shahrzad Ezzatpour
27. Emily Huang
28. Nico Olegario
29. Arjun Rustagi
30. Allison S. Volmer
31. Alessandra Livraghi-Butrico
32. Eddie Wehri
33. Richard R. Behringer
34. Dong-Joo Cheon
35. Julia Schaletzky
36. Hector C. Aguilar
37. Andreas S. Puschnik
38. Brian Button
39. Benjamin A. Pinsky
40. Catherine A. Blish
41. Ralph S. Baric
42. Wanda K. O’Neal
43. Carolyn R. Bertozzi
44. Craig B. Wilen
45. Richard C. Boucher
46. Jan E. Carette
47. Sarah A. Stanley
48. Eva Harris
49. Silvana Konermann
50. Patrick D. Hsu

Reviewed by ScreenIT

Highly Distinguished Amino Acid Sequences of 2019-nCoV (Wuhan Coronavirus)

1. Jacob Beal
2. Thomas Mitchell
3. Daniel Wyschogrod
4. Jeff Manthey
5. Adam Clore

Reviewed by ScreenIT

Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein

1. Pete Heinzelman
2. Philip A. Romero

Reviewed by ScreenIT

SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational bursts

1. Rafail Nikolaos Tasakis
2. Georgios Samaras
3. Anna Jamison
4. Michelle Lee
5. Alexandra Paulus
6. Gabrielle Whitehouse
7. Laurent Verkoczy
8. F. Nina Papavasiliou
9. Marilyn Diaz

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan

1. Kyoko Yamashita
2. Ayano Oi
3. Hina Kosakamoto
4. Toshitaka Yamauchi
5. Hibiki Kadoguchi
6. Takayuki Kuraishi
7. Masayuki Miura
8. Fumiaki Obata

Reviewed by Review Commons

Distinct spermiogenic phenotypes underlie sperm elimination in the Segregation Distorter meiotic drive system

1. Marion Herbette
2. Xiaolu Wei
3. Ching-Ho Chang
4. Amanda M. Larracuente
5. Benjamin Loppin
6. Raphaëlle Dubruille

Reviewed by Review Commons

Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

1. Eyal Ben-David
2. James Boocock
3. Longhua Guo
4. Stefan Zdraljevic
5. Joshua S. Bloom
6. Leonid Kruglyak

• Curated by eLife

  Evaluation Summary:

  The authors use a pooled single cell sequencing approach to simultaneously genotype and phenotype C. elegans. This allows them to begin to query the genetic architecture of cell specific eQTLs in a multi-cellular organism.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Somatic drift and rapid loss of heterozygosity suggest small effective population size of stem cells and high somatic mutation rate in asexual planaria

1. Hosseinali Asgharian
2. Joseph Dunham
3. Paul Marjoram
4. Sergey V. Nuzhdin

Reviewed by Review Commons

Stress resets ancestral heritable small RNA responses

1. Leah Houri-Zeevi
2. Guy Teichman
3. Hila Gingold
4. Oded Rechavi

• Curated by eLife

  Evaluation Summary:

  In humans, extreme stresses, such as famine, can trigger multi-generational physiological responses through altered metabolism. In C. elegans, environmental stresses, such as heat shock, can similarly promote changes in gene expression and physiology. Here, the authors convincingly show that environmental stress can alter small RNA populations in such a manner that can alter gene expression over multiple generations. The work is beginning to tease out some of the mechanisms by which non-genetic information can regulate descendants biology.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife, preLights