Genetics

  1. Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation

    1. Michael T Kimble
    2. Matthew J Johnson
    3. Mattie R Nester
    4. Lorraine S Symington

    • Curated by eLife

      eLife assessment:

      This fundamental study provides compelling evidence that long-range resection is important for recombination between distal, but not proximal, homologous sequences. It is thus proposed that a major role of long resection of a double-strand break mediated by Sgs1 and Exo1 is to activate the DNA damage checkpoint to allow the chromosomal mobility needed for the DNA ends to find a distant homologous sequence with which repair via homologous recombination, adding a new biological meaning to the role of long DNA resection in homologous recombination.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    1. Lucydalila Cedillo
    2. Fasih M Ahsan
    3. Sainan Li
    4. Nicole L Stuhr
    5. Yifei Zhou
    6. Yuyao Zhang
    7. Adebanjo Adedoja
    8. Luke M Murphy
    9. Armen Yerevanian
    10. Sinclair Emans
    11. Khoi Dao
    12. Zhaozhi Li
    13. Nicholas D Peterson
    14. Jeramie Watrous
    15. Mohit Jain
    16. Sudeshna Das
    17. Read Pukkila-Worley
    18. Sean P Curran
    19. Alexander A Soukas

    • Curated by eLife

      eLife assessment

      Using C. elegans as a model organism, the study hones in on the role of ether lipid biosynthesis as an effector of metformin--a process previously implicated in extending lifespan in response to diet--, TOR signalling, and mitochondrial interventions. The data in this paper are compelling, and a better understanding of biguanide impact on metabolism is highly important in the field.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Genes associated with liver damage signalling pathways may impact the severity of COVID-19 symptoms in Spanish and Italian populations

    1. Leire Moya
    2. Samaneh Farashi
    3. Prashanth N Suravajhala
    4. Panchadsaram Janaththani
    5. Jyotsna Batra

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity

    1. Alex Graudenzi
    2. Davide Maspero
    3. Fabrizio Angaroni
    4. Rocco Piazza
    5. Daniele Ramazzotti

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. A genetic element in the SARS-CoV-2 genome is shared with multiple insect species

    1. Torstein Tengs
    2. Charles F. Delwiche
    3. Christine Monceyron Jonassen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

    1. Daxi Wang
    2. Yanqun Wang
    3. Wanying Sun
    4. Lu Zhang
    5. Jingkai Ji
    6. Zhaoyong Zhang
    7. Xinyi Cheng
    8. Yimin Li
    9. Fei Xiao
    10. Airu Zhu
    11. Bei Zhong
    12. Shicong Ruan
    13. Jiandong Li
    14. Peidi Ren
    15. Zhihua Ou
    16. Minfeng Xiao
    17. Min Li
    18. Ziqing Deng
    19. Huanzi Zhong
    20. Fuqiang Li
    21. Wen-jing Wang
    22. Yongwei Zhang
    23. Weijun Chen
    24. Shida Zhu
    25. Xun Xu
    26. Xin Jin
    27. Jingxian Zhao
    28. Nanshan Zhong
    29. Wenwei Zhang
    30. Jincun Zhao
    31. Junhua Li
    32. Yonghao Xu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Integration of viral transcriptome sequencing with structure and sequence motifs predicts novel regulatory elements in SARS-CoV-2

    1. Brian J. Cox

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Female reproductive tract has low concentration of SARS-CoV2 receptors

    1. Jyoti Goad
    2. Joshua Rudolph
    3. Aleksandar Rajkovic

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Phylogenetic pattern of SARS-CoV-2 from COVID-19 patients from Bosnia and Herzegovina: lessons learned to optimize future molecular and epidemiological approaches

    1. Teufik Goletic
    2. Rijad Konjhodzic
    3. Nihad Fejzic
    4. Sejla Goletic
    5. Toni Eterovic
    6. Adis Softic
    7. Aida Kustura
    8. Lana Salihefendic
    9. Maja Ostojic
    10. Maja Travar
    11. Visnja Mrdjen
    12. Nijaz Tihic
    13. Sead Jazic
    14. Sanjin Musa
    15. Damir Marjanovic
    16. Mirsada Hukic

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

    1. Jin Wei
    2. Mia Madel Alfajaro
    3. Ruth E. Hanna
    4. Peter C. DeWeirdt
    5. Madison S. Strine
    6. William J. Lu-Culligan
    7. Shang-Min Zhang
    8. Vincent R. Graziano
    9. Cameron O. Schmitz
    10. Jennifer S. Chen
    11. Madeleine C. Mankowski
    12. Renata B. Filler
    13. Victor Gasque
    14. Fernando de Miguel
    15. Huacui Chen
    16. Kasopefoluwa Oguntuyo
    17. Laura Abriola
    18. Yulia V. Surovtseva
    19. Robert C. Orchard
    20. Benhur Lee
    21. Brett Lindenbach
    22. Katerina Politi
    23. David van Dijk
    24. Matthew D. Simon
    25. Qin Yan
    26. John G. Doench
    27. Craig B. Wilen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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