Genetics

Ciliary ARL13B is essential for body weight regulation in adult mice

1. Tiffany T. Terry
2. Eduardo D. Gigante
3. Coralie M. Alexandre
4. Kathryn M. Brewer
5. Xinyu Yue
6. Nicolas F. Berbari
7. Christian Vaisse
8. Tamara Caspary

Reviewed by PREreview

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

1. Denis Dacheux
2. Guillaume Martinez
3. Christine E Broster Reix
4. Julie Beurois
5. Patrick Lores
6. Magamba Tounkara
7. Jean-William Dupuy
8. Derrick Roy Robinson
9. Corinne Loeuillet
10. Emeline Lambert
11. Zeina Wehbe
12. Jessica Escoffier
13. Amir Amiri-Yekta
14. Abbas Daneshipour
15. Seyedeh-Hanieh Hosseini
16. Raoudha Zouari
17. Selima Fourati Ben Mustapha
18. Lazhar Halouani
19. Xiaohui Jiang
20. Ying Shen
21. Chunyu Liu
22. Nicolas Thierry-Mieg
23. Amandine Septier
24. Marie Bidart
25. Véronique Satre
26. Caroline Cazin
27. Zine Eddine Kherraf
28. Christophe Arnoult
29. Pierre F Ray
30. Aminata Toure
31. Mélanie Bonhivers
32. Charles Coutton

• Curated by eLife

  eLife assessment

  This important study reports the physiological role of ZMYND21 in the regulation of sperm flagellar development and male fertility. The data supporting the conclusion are solid, although the inclusion of more patients and ultrastructural studies would have further strengthened the study. This work will be of interest to clinicians and researchers who work on either sperm biology or ciliopathy due to cilial defects.

Reviewed by eLife

Epithelial Ca ²⁺ waves triggered by enteric neurons heal the gut

1. Afroditi Petsakou
2. Yifang Liu
3. Ying Liu
4. Aram Comjean
5. Yanhui Hu
6. Norbert Perrimon

Reviewed by Arcadia Science

Evolutionary insights from profiling LINE-1 activity at allelic resolution in a single human genome

1. Lei Yang
2. Genevieve A Metzger
3. Ricky Padilla Del Valle
4. Diego Delgadillo Rubalcaba
5. Richard N McLaughlin

Reviewed by Review Commons

Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

1. Yiqiao Zheng
2. Chi Sun
3. Xiaodong Zhang
4. Philip A Ruzycki
5. Shiming Chen

• Curated by eLife

  eLife assessment

  This manuscript is of interest to readers in the field of neural development and neurodegeneration. The study is important as it examines two disease-causing mutations within the homeodomain transcription factor Cone-Rod Homeobox (CRX) that causes retinopathy in humans. The data are solid and the work contributes to our understanding of the underlying pathogenetic mechanisms.

Reviewed by eLife

A scalable and tunable platform for functional interrogation of peptide hormones in fish

1. Eitan Moses
2. Roman Franek
3. Itamar Harel

• Curated by eLife

  eLife assessment

  Moises and Harel generate an important set of novel molecular tools in African turquoise killifish, an innovative model to study aging biology. The new solid tools described in this paper can boost this buddying model system for broad biotechnological applications. The authors showcase the efficacy of their tools in the context of peptide hormones involved in growth and gonad development. The killifish community will greatly benefit from these novel tools and the relevance of the developed methods will likely go beyond the killifish community.

Reviewed by eLife

High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS)

1. Zachary C Stevenson
2. Megan J Moerdyk-Schauwecker
3. Stephen A Banse
4. Dhaval S Patel
5. Hang Lu
6. Patrick C Phillips

• Curated by eLife

  eLife assessment

  This manuscript provides a description of an approach for efficiently integrating diverse libraries into the C. elegans genome and tools that enable researchers to use the method. It is a valuable contribution for researchers carrying out experiments that would benefit from easy generation of such libraries, and the data for the effectiveness of the method is solid. The advantages of this approach in terms of ease and effectiveness relative to others with similar aims will emerge as they are put to more general use in addressing biological problems.

Reviewed by eLife, Arcadia Science

Cas9-induced nonhomologous recombination in C. elegans

1. Stefan Zdraljevic
2. Laura Walter-McNeill
3. Heriberto Marquez
4. Leonid Kruglyak

Reviewed by Arcadia Science

Disparate patterns of genetic divergence in three widespread corals across a pan-Pacific environmental gradient highlights species-specific adaptation trajectories

1. Benjamin C C Hume
2. Christian R Voolstra
3. Eric Armstrong
4. Guinther Mitushasi
5. Barbara Porro
6. Nicolas Oury
7. Sylvain Agostini
8. Emilie Boissin
9. Julie Poulain
10. Quentin Carradec
11. David A. Paz-García
12. Didier Zoccola
13. Hélène Magalon
14. Clémentine Moulin
15. Guillaume Bourdin
16. Guillaume Iwankow
17. Sarah Romac
18. Bernard Banaigs
19. Emmanuel Boss
20. Chris Bowler
21. Colomban de Vargas
22. Eric Douville
23. Michel Flores
24. Paola Furla
25. Pierre E Galand
26. Eric Gilson
27. Fabien Lombard
28. Stéphane Pesant
29. Stéphanie Reynaud
30. Matthew B. Sullivan
31. Shinichi Sunagawa
32. Olivier Thomas
33. Romain Troublé
34. Rebecca Vega Thurber
35. Patrick Wincker
36. Serge Planes
37. Denis Allemand
38. Didier Forcioli

Reviewed by Arcadia Science

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

1. Ignacy Czajewski
2. Bijayalaxmi Swain
3. Jiawei Xu
4. Laurin McDowall
5. Andrew T Ferenbach
6. Daan MF van Aalten

Reviewed by Review Commons