Genetics

Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

1. Adhithi R Raghavan
2. Kieron May
3. Vijayalakshmi V Subramanian
4. Hannah G Blitzblau
5. Neem J Patel
6. Jonathan Houseley
7. Andreas Hochwagen

• Curated by eLife

  eLife Assessment

  This valuable paper describes the regulation of the association of meiotic chromosome axis proteins on chromosome ends with sub-telomeric elements in budding yeast. The genome-wide analyses of binding of chromosome components as well as chromatin regulators, complemented with the mapping of meiotic DNA double-strand breaks on chromosome ends, provided solid evidence to support the authors' conclusion. The results in the paper are of interest to researchers studying meiotic recombination and the structure of genomes and chromosomes.

Reviewed by eLife

Trans- acting mutations reveal non-nuclear modulators of both intrinsic and extrinsic gene expression noise in a eukaryote

1. Nena Martin
2. Julie Kleine-Schultjann
3. Elena Paris
4. Quentin Boussau
5. Agnès Dumont
6. Hélène Duplus-Bottin
7. Margaux Prieux
8. Adelme Bazin
9. Laurent Modolo
10. Gaël Yvert
11. Patricia J. Wittkopp
12. Fabien Duveau

Reviewed by Review Commons

Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

1. Kuei Ching Hsiung
2. Hannah Chapman
3. Xiaoya Wei
4. Xiaoyu Sun
5. Isadora Rawlinson
6. David Gems

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the condition dependence of autophagy-mediated lifespan regulation in C. elegans. The evidence is solid, as the data broadly support the main claims, although variability between biological replicates and limited mechanistic exploration leave some conclusions less firmly established. The work will be of interest to researchers studying autophagy, ageing, and intracellular trafficking.

Reviewed by eLife