Gastroenterology

  1. Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

    1. Ruijie Zeng
    2. Yuying Ma
    3. Lijun Zhang
    4. Dongling Luo
    5. Rui Jiang
    6. Huihuan Wu
    7. Zewei Zhuo
    8. Qi Yang
    9. Jingwei Li
    10. Felix W Leung
    11. Chongyang Duan
    12. Weihong Sha
    13. Hao Chen

    • Curated by eLife

      eLife assessment

      This useful study aimed to quantify associations between regular use of proton-pump inhibitors (PPI) with the occurrence of respiratory infections, such as influenza, pneumonia, COVID-19, and others over a period of several years. PPI use was associated with increased risks of influenza, pneumonia, but not of COVID-19, although severity and mortality of COVID-19 infections were higher in PPI users. There are inevitable weaknesses of the study design used, such as the fact that PPI use was only measured at one time-point whereas infections were assessed over a long time period, but these are appropriately highlighted in the discussion. Weaknesses are highlighted in the discussion and the study presents convincing evidence for the conclusions overall.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  2. Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    1. Hengqi Betty Zheng
    2. Benjamin A. Doran
    3. Kyle Kimler
    4. Alison Yu
    5. Victor Tkachev
    6. Veronika Niederlova
    7. Kayla Cribbin
    8. Ryan Fleming
    9. Brandi Bratrude
    10. Kayla Betz
    11. Lorenzo Cagnin
    12. Connor McGuckin
    13. Paula Keskula
    14. Alexandre Albanese
    15. Maria Sacta
    16. Joshua de Sousa Casal
    17. Ruben van Esch
    18. Andrew C. Kwong
    19. Conner Kummerlowe
    20. Faith Taliaferro
    21. Nathalie Fiaschi
    22. Baijun Kou
    23. Sandra Coetzee
    24. Sumreen Jalal
    25. Yoko Yabe
    26. Michael Dobosz
    27. Matthew F. Wipperman
    28. Sara Hamon
    29. George D. Kalliolias
    30. Andrea Hooper
    31. Wei Keat Lim
    32. Sokol Haxhinasto
    33. Yi Wei
    34. Madeline Ford
    35. Lusine Ambartsumyan
    36. David L. Suskind
    37. Dale Lee
    38. Gail Deutsch
    39. Xuemei Deng
    40. Lauren V. Collen
    41. Vanessa Mitsialis
    42. Scott B. Snapper
    43. Ghassan Wahbeh
    44. Alex K. Shalek
    45. Jose Ordovas-Montanes
    46. Leslie S. Kean

    • Curated by eLife

      eLife assessment

      This important study substantially advances our understanding of pediatric Crohn's disease, mapping the cellular make-up of this disease and how patients respond to treatment. The evidence supporting the conclusions is compelling, with thorough bioinformatic analyses, underpinned by rigorous methodology and data integration. The work will be of broad interest to pediatric clinicians, immunologists and bioinformaticians.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. The Fecal Microbiome in Quiescent Crohn’s Disease with Persistent Gastrointestinal Symptoms Show Enrichment of Oral Microbes But Depletion of Butyrate and Indole Producers

    1. Jonathan Golob
    2. Krishna Rao
    3. Jeffrey Berinstein
    4. William Chey
    5. Chung Owyang
    6. Nobuhiko Kamada
    7. Peter Higgins
    8. Vincent Young
    9. Shrinivas Bishu
    10. Allen Lee

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Digestive Manifestations in Patients Hospitalized With Coronavirus Disease 2019

    1. B. Joseph Elmunzer
    2. Rebecca L. Spitzer
    3. Lydia D. Foster
    4. Ambreen A. Merchant
    5. Eric F. Howard
    6. Vaishali A. Patel
    7. Mary K. West
    8. Emad Qayed
    9. Rosemary Nustas
    10. Ali Zakaria
    11. Marc S. Piper
    12. Jason R. Taylor
    13. Lujain Jaza
    14. Nauzer Forbes
    15. Millie Chau
    16. Luis F. Lara
    17. Georgios I. Papachristou
    18. Michael L. Volk
    19. Liam G. Hilson
    20. Selena Zhou
    21. Vladimir M. Kushnir
    22. Alexandria M. Lenyo
    23. Caroline G. McLeod
    24. Sunil Amin
    25. Gabriela N. Kuftinec
    26. Dhiraj Yadav
    27. Charlie Fox
    28. Jennifer M. Kolb
    29. Swati Pawa
    30. Rishi Pawa
    31. Andrew Canakis
    32. Christopher Huang
    33. Laith H. Jamil
    34. Andrew M. Aneese
    35. Benita K. Glamour
    36. Zachary L. Smith
    37. Katherine A. Hanley
    38. Jordan Wood
    39. Harsh K. Patel
    40. Janak N. Shah
    41. Emil Agarunov
    42. Amrita Sethi
    43. Evan L. Fogel
    44. Gail McNulty
    45. Abdul Haseeb
    46. Judy A. Trieu
    47. Rebekah E. Dixon
    48. Jeong Yun Yang
    49. Robin B. Mendelsohn
    50. Delia Calo
    51. Olga C. Aroniadis
    52. Joseph F. LaComb
    53. James M. Scheiman
    54. Bryan G. Sauer
    55. Duyen T. Dang
    56. Cyrus R. Piraka
    57. Eric D. Shah
    58. Heiko Pohl
    59. William M. Tierney
    60. Stephanie Mitchell
    61. Ashwinee Condon
    62. Adrienne Lenhart
    63. Kulwinder S. Dua
    64. Vikram S. Kanagala
    65. Ayesha Kamal
    66. Vikesh K. Singh
    67. Maria Ines Pinto-Sanchez
    68. Joy M. Hutchinson
    69. Richard S. Kwon
    70. Sheryl J. Korsnes
    71. Harminder Singh
    72. Zahra Solati
    73. Field F. Willingham
    74. Patrick S. Yachimski
    75. Darwin L. Conwell
    76. Evan Mosier
    77. Mohamed Azab
    78. Anish Patel
    79. James Buxbaum
    80. Sachin Wani
    81. Amitabh Chak
    82. Amy E. Hosmer
    83. Rajesh N. Keswani
    84. Christopher J. DiMaio
    85. Michael S. Bronze
    86. Raman Muthusamy
    87. Marcia I. Canto
    88. V. Mihajlo Gjeorgjievski
    89. Zaid Imam
    90. Fadi Odish
    91. Ahmed I. Edhi
    92. Molly Orosey
    93. Abhinav Tiwari
    94. Soumil Patwardhan
    95. Nicholas G. Brown
    96. Anish A. Patel
    97. Collins O. Ordiah
    98. Ian P. Sloan
    99. Lilian Cruz
    100. Casey L. Koza
    101. Uchechi Okafor
    102. Thomas Hollander
    103. Nancy Furey
    104. Olga Reykhart
    105. Natalia H. Zbib
    106. John A. Damianos
    107. James Esteban
    108. Nick Hajidiacos
    109. Melissa Saul
    110. Melanie Mays
    111. Gulsum Anderson
    112. Kelley Wood
    113. Laura Mathews
    114. Galina Diakova
    115. Molly Caisse
    116. Lauren Wakefield
    117. Haley Nitchie
    118. Akbar K. Waljee
    119. Weijing Tang
    120. Yueyang Zhang
    121. Ji Zhu
    122. Amar R. Deshpande
    123. Don C. Rockey
    124. Teldon B. Alford
    125. Valerie Durkalski

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. High Liver Fat Associates with Higher Risk of Developing Symptomatic COVID-19 Infection - Initial UK Biobank Observations

    1. A Roca-Fernández
    2. A Dennis
    3. R Nicolls
    4. J McGonigle
    5. M Kelly
    6. R Banerjee

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Liver Function in Novel Coronavirus Disease (COVID-19): A Systematic Review and Meta-Analysis

    1. Mohammad Zahedi
    2. Mohammad Yousefi
    3. Mahdi Abounoori
    4. Mohammad Malekan
    5. Fatemeh Tajik
    6. Keyvan Heydari
    7. Parham Mortazavi
    8. Monireh Ghazaeian
    9. Fateme Sheydaee
    10. Amirreza Nasirzadeh
    11. Reza Alizadeh-Navaei

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Dynamic liver function indexes monitoring and clinical characteristics in three types of COVID-19 patients

    1. Cheng Chen
    2. Jie Jiang
    3. Xiaoxiao Xu
    4. Yiyang Hu
    5. Yi Hu
    6. Yu Zhao

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges

    1. Iolanda Valentina Popa
    2. Mircea Diculescu
    3. Cătălina Mihai
    4. Cristina Cijevschi-Prelipcean
    5. Alexandru Burlacu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease

    1. Alka A. Potdar
    2. Shishir Dube
    3. Takeo Naito
    4. Katherine Li
    5. Gregory Botwin
    6. Talin Haritunians
    7. Dalin Li
    8. David Casero
    9. Shaohong Yang
    10. Janine Bilsborough
    11. Jacqueline G. Perrigoue
    12. Lee A. Denson
    13. Mark Daly
    14. Stephan R. Targan
    15. Phillip Fleshner
    16. Jonathan Braun
    17. Subra Kugathasan
    18. Thaddeus S. Stappenbeck
    19. Dermot P.B. McGovern

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Are German endoscopy units prepared for the COVID-19 pandemic? A nationwide survey

    1. Jakob Garbe
    2. Stephan Eisenmann
    3. Clara S. Heidemann
    4. Marko Damm
    5. Sebastian Krug
    6. Steffen Walter
    7. Frank Lammert
    8. Kaid Darwiche
    9. Patrick Michl
    10. Jonas Rosendahl

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity