Developmental Biology

Foxe1 orchestrates thyroid and lung cell lineage divergence in mouse stem cell-derived organoids

1. Barbara F. Fonseca
2. Cindy Barbée
3. Mirian Romitti
4. Sema Elif Eski
5. Pierre Gillotay
6. Daniel Monteyne
7. David Perez Morga
8. Samuel Refetoff
9. Sumeet Pal Singh
10. Sabine Costagliola

Reviewed by Review Commons

ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain

1. Matthew T Schmitz
2. Jingwen W Ding
3. Sara Nolbrant
4. Reed McMullen
5. Chang N Kim
6. Bryan J Pavlovic
7. Tomasz J Nowakowski
8. Trygve E Bakken
9. Chun Jimmie Ye
10. Alex A Pollen

• Curated by eLife

  eLife Assessment

  This valuable study is an approach to integrating and comparing single-cell genomics data across species. The evidence supporting the conclusions of this work is solid, and ANTIPODE presents an updated methodological approach to determining how gene expression at the cell-type level has evolved. Thus, ANTIPODE should provide broad utility to studies of comparative neurogenomics and be of use to neuroscientists and evolutionary biologists.

Reviewed by eLife

A minimal tooth enhancer regulates dlx2b expression during zebrafish tooth formation: insights into cis-regulatory logic in organogenesis

1. William R Jackman
2. Yujin Moon
3. Carol K Cox
4. Drew R Anderson
5. Audrey A DeFusco
6. Vy M Nguyen
7. Sarah Y Liu
8. Elisabeth H Carter
9. Hana E Littleford
10. Elizabeth K Richards
11. Andrea L Jowdry
12. Yann Gibert

• Curated by eLife

  eLife Assessment

  This study provides valuable findings in the study of enhancer biology by identifying and dissecting a minimal enhancer regulating dlx2b expression during zebrafish tooth development, supported by promoter dissection, reporter assays, and genome-editing approaches. The work offers a resource and extends previous findings but has limited broader impact, with several conclusions about general cis-regulatory principles and functional consequences remaining only partially supported. Accordingly, the strength of evidence is at present incomplete, as additional functional validation would be needed to fully substantiate some of the claims.

Reviewed by eLife

Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

1. Tao Cheng
2. Xiang Liu
3. Yang Dong
4. Yi-Meng Tian
5. Yan-Yi Xing
6. Chen-Yi Chen
7. Cong Liu
8. Yun-Fei Li
9. Ying Huang
10. Ding-Hao Zhuo
11. Xiao Xu
12. Jing-Yun Luan
13. Xin-Xin Fu
14. Zi-Xin Jin
15. Jing Mo
16. Xiang Xu
17. Hong-Qing Liang
18. Peng-Fei Xu

• Curated by eLife

  eLife Assessment

  This study provides a useful analysis of the changes in chromatin organization and gene expression that occur during the differentiation of two cell types (anterior endoderm and prechordal plate) from a common progenitor in zebrafish, together with investigations into the molecular factors involved. Although the findings are consistent with previous work, the evidence presented appears to be incomplete and would benefit from more rigorous quantification of live imaging and Cre-Lox experiments, a stronger rationale and controls for experiments manipulating chromatin remodeling factors, and a strong justification for the explant model especially given differences between explant and whole embryo data. This work may be of interest to zebrafish developmental biologists investigating the mechanisms underlying specification.

Reviewed by eLife, Review Commons

An actomyosin-mediated mechanical mechanism for brain neural tube elevation

1. Juana De La O
2. Chidera Okeke
3. Gabriel L. Galea
4. Adam C. Martin

Reviewed by Review Commons

Nrf2 promotes thyroid development and hormone synthesis

1. Gillotay Pierre
2. Romitti Mirian
3. Dassy Benjamin
4. Haerlingen Benoit
5. Parakkal Shankar Meghna
6. Faria Fonseca Barbara
7. Ziros G. Panos
8. Pal Singh Sumeet
9. Sykiotis P. Gerasimos
10. Costagliola Sabine

Reviewed by Review Commons

Tug-of-war between cortical and cytoplasmic forces shaping planar 4-cell stage embryos

1. Silvia Caballero-Mancebo
2. Daniel Gonzalez Suarez
3. Janet Chenevert
4. Sameh Ben-Aicha
5. Lydia Besnardeau
6. Alex McDougall
7. Rémi Dumollard

Reviewed by preLights

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development

1. Zoe R. Sudderick
2. Tiernan Briggs
3. Shirooza Mubarak
4. Melinda Van Kerckvoorde
5. Ana R. Hernandez-Rodriguez
6. Sudeepta K. Panda
7. Jon Riddell;
8. Cameron Batho-Samblas
9. Lorna Taylor
10. Lynn McTeir
11. Dominique Meunier
12. Amy Findlay
13. Flossie Roberts
14. Anna Raper
15. Asako Sakaue-Sawano
16. Atsushi Miyawaki
17. Joe Rainger
18. Jeffrey J. Schoenebeck
19. Cornelis J. Weijer
20. Mike J. McGrew
21. Denis J. Headon
22. Megan G. Davey
23. Richard L. Mort
24. James D. Glover

Reviewed by Review Commons

Trehalose metabolism regulates transcriptional control of muscle development in lepidopteran insects

1. Sharada Mohite
2. Tanaji Devkate
3. Prashant Kalaskar
4. Prashant Singh
5. Abhishek Subramanian
6. Rakesh Shamsunder Joshi

• Curated by eLife

  eLife Assessment

  This useful study examines whether the sugar trehalose, coordinates energy supply with the gene programs that build muscle in the cotton bollworm (Helicoverpa armigera). The evidence for this currently is incomplete. The central claim - that trehalose specifically regulates an E2F/Dp-driven myogenic program - is not supported by the specificity of the data: perturbations and sequencing are systemic, alternative explanations such as general energy or amino-acid scarcity remain plausible, and mechanistic anchors are also limited. The work will interest researchers in insect metabolism and development; focused, tissue-resolved measurements together with stronger mechanistic controls would substantially strengthen the conclusions.

Reviewed by eLife

PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

1. Julia Raulino Lima
2. Nicha Ungvijanpunya
3. Qing Chen
4. Hoang Quoc Hai Pham
5. Tal Rosen
6. Greg Park
7. Mohammadreza Vatankhah
8. Steven Yen
9. Yang Chai
10. Amy E Merrill
11. Zhaoyang Liu
12. Jian-Fu Chen
13. Yanzhong Yang
14. Weiqun Peng
15. Jian Xu

• Curated by eLife

  eLife Assessment

  This important work establishes a connection between PRMT1 and SFPQ by identifying common phenotypes downstream of their inactivation. In the resubmission, authors now include NMD as a contributor to aberrant gene expression underpinning craniofacial development. The complementary experiments help strengthen some solid conclusions. This paper describes an interesting mechanism for the regulation of RNA levels, which is of interest to the readers of eLife.

Reviewed by eLife