Developmental Biology

Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition

1. Chaitali Khan
2. Nasser M Rusan
3. Nicholas E Baker

Reviewed by Review Commons

Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

1. Ye Lynne Kim
2. Young-Woo Jo
3. Takwon Yoo
4. Kyusang Yoo
5. Ji-Hoon Kim
6. Myungsun Park
7. In-Wook Song
8. Hyun Kim
9. Yea-Eun Kim
10. Sang-Hyeon Hann
11. Jong-Eun Park
12. Daehyun Baek
13. Young-Yun Kong

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into aged muscle stem cell biology by revealing phenotypic and functional heterogeneity within the geriatric MuSC pool and proposing a VCam-low/negative subpopulation that may account for the reported decline in MuSC numbers with age. These findings have implications for understanding aging-related changes in stem cell maintenance and for improving strategies to isolate or rejuvenate aged MuSCs. However, the evidence supporting the main claims is incomplete, key analyses such as absolute MuSC quantification, fate assessment of VCam-low/negative cells, inclusion of standard aged cohorts, and validation of proposed surface markers are still needed to confirm that overall MuSC abundance is maintained and that a distinct subpopulation has been identified.

Reviewed by eLife

The protein-tyrosine phosphatase Shp2 is essential for lymphatic endothelial cell differentiation in zebrafish

1. Daniëlle T.J. Woutersen
2. Andreas van Impel
3. Stefan Schulte-Merker
4. Jeroen den Hertog

Reviewed by Review Commons

Transcriptional repression of central spindle factors controls endomitosis in the C. elegans intestine

1. Ramon Barrull-Mascaró
2. Sonia Veltkamp
3. Samia Boutaibi
4. Lotte M. van Rijnberk
5. Rebecca Lippmann
6. Matilde Galli

Reviewed by Review Commons

Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

1. Ayanthi Bhattacharya
2. Hemalatha Rao
3. Sonia Q Sen

• Curated by eLife

  eLife assessment

  The study provides an important advance towards understanding how spatial and temporal transcriptional programs are integrated to regulate lineage-specific chromatin and enhancer activation. The functional evidence is currently incomplete, but the current data provide a solid correlative and conceptual foundation. Functional experiments directly linking Gsb occupancy to chromatin state and regulation of some lineage-specific targets would further strengthen the causal interpretation of the model. Clarifying the scope of conclusions and explicitly acknowledging the technical limitations of current chromatin assays would provide a more balanced interpretation of the manuscript.

Reviewed by eLife

Wnt/β-catenin is required for proprioception by coordinating the multi-compartment development of muscle spindles

1. Qingyuan Guo
2. Ava Gatterer
3. Avital Rosner
4. Sharon Krief
5. Fabian S. Passini
6. Ron Rotkopf
7. Noa Wigoda
8. Michael Tsoory
9. Bavat Bornstein
10. Elazar Zelzer

Reviewed by Review Commons