Developmental Biology

An actomyosin-mediated mechanical mechanism for brain neural tube elevation

1. Juana De La O
2. Chidera Okeke
3. Gabriel L. Galea
4. Adam C. Martin

Reviewed by Review Commons

Nrf2 promotes thyroid development and hormone synthesis

1. Gillotay Pierre
2. Romitti Mirian
3. Dassy Benjamin
4. Haerlingen Benoit
5. Parakkal Shankar Meghna
6. Faria Fonseca Barbara
7. Ziros G. Panos
8. Pal Singh Sumeet
9. Sykiotis P. Gerasimos
10. Costagliola Sabine

Reviewed by Review Commons

Tug-of-war between cortical and cytoplasmic forces shaping planar 4-cell stage embryos

1. Silvia Caballero-Mancebo
2. Daniel Gonzalez Suarez
3. Janet Chenevert
4. Sameh Ben-Aicha
5. Lydia Besnardeau
6. Alex McDougall
7. Rémi Dumollard

Reviewed by preLights

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development

1. Zoe R. Sudderick
2. Tiernan Briggs
3. Shirooza Mubarak
4. Melinda Van Kerckvoorde
5. Ana R. Hernandez-Rodriguez
6. Sudeepta K. Panda
7. Jon Riddell;
8. Cameron Batho-Samblas
9. Lorna Taylor
10. Lynn McTeir
11. Dominique Meunier
12. Amy Findlay
13. Flossie Roberts
14. Anna Raper
15. Asako Sakaue-Sawano
16. Atsushi Miyawaki
17. Joe Rainger
18. Jeffrey J. Schoenebeck
19. Cornelis J. Weijer
20. Mike J. McGrew
21. Denis J. Headon
22. Megan G. Davey
23. Richard L. Mort
24. James D. Glover

Reviewed by Review Commons

Trehalose metabolism regulates transcriptional control of muscle development in lepidopteran insects

1. Sharada Mohite
2. Tanaji Devkate
3. Prashant Kalaskar
4. Prashant Singh
5. Abhishek Subramanian
6. Rakesh Shamsunder Joshi

• Curated by eLife

  eLife Assessment

  This useful study examines whether the sugar trehalose, coordinates energy supply with the gene programs that build muscle in the cotton bollworm (Helicoverpa armigera). The evidence for this currently is incomplete. The central claim - that trehalose specifically regulates an E2F/Dp-driven myogenic program - is not supported by the specificity of the data: perturbations and sequencing are systemic, alternative explanations such as general energy or amino-acid scarcity remain plausible, and mechanistic anchors are also limited. The work will interest researchers in insect metabolism and development; focused, tissue-resolved measurements together with stronger mechanistic controls would substantially strengthen the conclusions.

Reviewed by eLife

PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

1. Julia Raulino Lima
2. Nicha Ungvijanpunya
3. Qing Chen
4. Hoang Quoc Hai Pham
5. Tal Rosen
6. Greg Park
7. Mohammadreza Vatankhah
8. Steven Yen
9. Yang Chai
10. Amy E Merrill
11. Zhaoyang Liu
12. Jian-Fu Chen
13. Yanzhong Yang
14. Weiqun Peng
15. Jian Xu

• Curated by eLife

  eLife Assessment

  This important work establishes a connection between PRMT1 and SFPQ by identifying common phenotypes downstream of their inactivation. In the resubmission, authors now include NMD as a contributor to aberrant gene expression underpinning craniofacial development. The complementary experiments help strengthen some solid conclusions. This paper describes an interesting mechanism for the regulation of RNA levels, which is of interest to the readers of eLife.

Reviewed by eLife

Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis

1. Romie Angelo G Azur
2. Daniel Feliciano
3. Isabel Espinosa-Medina
4. Raghabendra Adhikari
5. Joaquin Lilao-Garzón
6. Ella Jansen
7. Ching-Po Yang
8. Tzumin Lee

• Curated by eLife

  eLife Assessment

  This important study presents new insights into the post-transcriptional mechanisms that govern cortical development. Through state-of-the-art methodology to track neuronal birth order, the data provide compelling evidence that Imp1 (Igf2bp1/Zbp1) orchestrates radial glia fate transitions and cortical neurogenesis. The findings establish a new framework for understanding how post-transcriptional mechanisms integrate with transcriptional and epigenetic regulatory layers to control cortical temporal patterning.

Reviewed by eLife

Heterochronic scaling of neurogenesis for species-specific dosing of cortical excitatory subtypes

1. Yuki Y. Yamauchi
2. Xuanhao D. Sheu
3. Rafat Tarfder
4. Takuma Kumamoto
5. Jun Hatakeyama
6. Haruka Sato
7. Pauline Rouillard
8. Merve Bilgic
9. Shuto Deguchi
10. Tomonori Nakamura
11. Yusuke Kishi
12. Kazuo Emoto
13. Ikuo K. Suzuki

Reviewed by Review Commons

Jam2 Signaling Functions Downstream of Hand2 To Initiate The Formation Of Organ-Specific Vascular Progenitors In Zebrafish

1. Martyna Griciunaite
2. Julius Martinkus
3. Sanjeeva Metikala
4. Ricardo DeMoya
5. Suman Gurung
6. Diandra Rufin Florat
7. Saulius Sumanas

• Curated by eLife

  eLife Assessment

  This important study addresses the question of how organ-specific blood vessels form during different stages of development, and how specific genes may regulate these processes. New genetic tools were developed to label distinct endothelial cell populations and track them over time in different mutant backgrounds. The results are solid; however, additional data quantification, lineage tracing, and cell autonomy experiments would further strengthen the conclusions.

Reviewed by eLife