Developmental Biology

  2. Inverted Assembly of the Lens Within Ocular Organoids Reveals Alternate Paths to Ocular Morphogenesis

    1. Elin Stahl
    2. Miguel Angel Delgado-Toscano
    3. Ishwariya Saravanan
    4. Anastasija Paneva
    5. Joachim Wittbrodt
    6. Lucie Zilova

    • Curated by eLife

      eLife Assessment

      This important study demonstrates that ocular organoids can generate both retina and lens through a non-canonical, "inside-out" morphogenetic route. The work is supported by convincing data, with well-designed experiments combining imaging, molecular analysis, and transcriptomics to establish that lens formation in organoids follows conserved molecular programs despite an alternative morphogenesis. These findings expand our understanding of self-organization and developmental plasticity, and will be of broad interest to researchers working on eye development, organoids, and tissue engineering.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity

  9. Dual contributions of Xrp1 to genome integrity through the DNA damage response and cell competition

    1. Chaitali Khan
    2. Nasser M Rusan
    3. Nicholas E Baker

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

    1. Ye Lynne Kim
    2. Young-Woo Jo
    3. Takwon Yoo
    4. Kyusang Yoo
    5. Ji-Hoon Kim
    6. Myungsun Park
    7. In-Wook Song
    8. Hyun Kim
    9. Yea-Eun Kim
    10. Sang-Hyeon Hann
    11. Jong-Eun Park
    12. Daehyun Baek
    13. Young-Yun Kong

    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into aged muscle stem cell biology by revealing phenotypic and functional heterogeneity within the geriatric MuSC pool and proposing a VCam-low/negative subpopulation that may account for the reported decline in MuSC numbers with age. These findings have implications for understanding aging-related changes in stem cell maintenance and for improving strategies to isolate or rejuvenate aged MuSCs. However, the evidence supporting the main claims is incomplete, key analyses such as absolute MuSC quantification, fate assessment of VCam-low/negative cells, inclusion of standard aged cohorts, and validation of proposed surface markers are still needed to confirm that overall MuSC abundance is maintained and that a distinct subpopulation has been identified.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity
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