Developmental Biology

  1. A spatiotemporal transcriptomic atlas of the mouse placenta reveals glycogen cell-mediated metabolic support essential for fetal viability

    1. Yuting Fu
    2. Xiaoqi Zeng
    3. Yifang Liu
    4. Shikai Jia
    5. Yujia Jiang
    6. Jia Ping Tan
    7. Yue Yuan
    8. Tianchang Xia
    9. Yun Mei
    10. Shan Wen
    11. Xiaojing Liu
    12. Yue You
    13. Weike Pei
    14. Chengshuo Yang
    15. Sida Shao
    16. Junhua Shen
    17. Liangshan Mu
    18. Xiaoxue Ma
    19. Matthew Paul McCormack
    20. Saifeng Cheng
    21. Luyi Tian
    22. Longqi Liu
    23. Xiaoyu Wei
    24. Xiaodong Liu

    • Curated by eLife

      eLife Assessment

      This valuable study reports a spatiotemporal atlas of mouse placental development and explores the role of glycogen trophoblast cells in fetal viability. Solid data are presented to support the main conclusion. This work will be of great interest to developmental DNA reproductive biologists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Label-free assessment of pre-implantation embryo quality by the Fluorescence Lifetime Imaging Microscopy (FLIM)-phasor approach

    1. Ning Ma
    2. Nabora Reyes de Mochel
    3. Paula Duyen Pham
    4. Tae Yeon Yoo
    5. Ken W. Y. Cho
    6. Michelle A. Digman

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity

  6. Inverted Assembly of the Lens Within Ocular Organoids Reveals Alternate Paths to Ocular Morphogenesis

    1. Elin Stahl
    2. Miguel Angel Delgado-Toscano
    3. Ishwariya Saravanan
    4. Anastasija Paneva
    5. Joachim Wittbrodt
    6. Lucie Zilova

    • Curated by eLife

      eLife Assessment

      This important study demonstrates that ocular organoids can generate both retina and lens through a non-canonical, "inside-out" morphogenetic route. The work is supported by convincing data, with well-designed experiments combining imaging, molecular analysis, and transcriptomics to establish that lens formation in organoids follows conserved molecular programs despite an alternative morphogenesis. These findings expand our understanding of self-organization and developmental plasticity, and will be of broad interest to researchers working on eye development, organoids, and tissue engineering.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    14 evaluationsAppears in 2 listsLatest version Latest activity
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