Developmental Biology

Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration

1. Laura Celotto
2. Fabian Rost
3. Anja Machate
4. Juliane Bläsche
5. Andreas Dahl
6. Anke Weber
7. Stefan Hans
8. Michael Brand

• Curated by eLife

  eLife assessment

  Müller glial cells of the zebrafish retina can differentiate into all neural cell classes following injury, providing full regenerative capabilities of the zebrafish retina. This valuable study presents a description of transcriptional changes of Müller glia cells in the adult and regenerating retina using single-cell RNA sequencing. The overall evidence supporting the main claims of the authors is solid.

Reviewed by eLife

Sperm induction of somatic cell-cell fusion as a novel functional test

1. Nicolas G Brukman
2. Clari Valansi
3. Benjamin Podbilewicz

Reviewed by Review Commons

Molecular basis for positional memory and its reprogrammability in limb regeneration

1. L Otsuki
2. SA Plattner
3. Y Taniguchi-Sugiura
4. EM Tanaka

Reviewed by Arcadia Science

Abnormal behavior is reversible in a chromatin mutant

1. Juan D. Rodriguez
2. Monica N. Reeves
3. Hsiao-Lin V. Wang
4. Jaely Z. Chavez
5. Rhea Rastogi
6. Sindy R. Chavez
7. Elicia A Preston
8. Madhav S. Chadha
9. Liyang Sun
10. Emily J. Hill
11. Victor G. Corces
12. Karen L. Schmeichel
13. John I. Murray
14. David J. Katz

Reviewed by Arcadia Science

Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

1. Chhavi Sood
2. Md Ausrafuggaman Nahid
3. Kendall R Branham
4. Matt Pahl
5. Susan E Doyle
6. Sarah E Siegrist

• Curated by eLife

  eLife assessment

  This useful study reports on how Notch activity regulates the termination of neurogenesis in central brain during larval-pupal stages in Drosophila. The evidence supporting the claims is solid. The work will be of interest to developmental neurobiologists.

Reviewed by eLife

LincRNAs enable germ cells differentiation by promoting PUF proteins condensation

1. Roni Falk
2. Noa Gilad
3. Hanna Achache
4. Yisrael Rappaport
5. Reut Shabtai
6. Hasan Ishtayeh
7. Laura Wolovelsky
8. Yonatan B. Tzur

Reviewed by preLights

Multiple cis -regulatory elements control prox1a expression in distinct lymphatic vascular beds

1. Virginia Panara
2. Hujun Yu
3. Di Peng
4. Karin Staxäng
5. Monika Hodik
6. Beata Filipek-Gorniok
7. Jan Kazenwadel
8. Renae Skoczylas
9. Elizabeth Mason
10. Amin Allalou
11. Natasha L. Harvey
12. Tatjana Haitina
13. Benjamin M. Hogan
14. Katarzyna Koltowska

Reviewed by Review Commons

Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle

1. Eric J. G. Pollitt
2. Juliana Sánchez-Posada
3. Corinna M. Snashall
4. Christopher J. Derrick
5. Emily S. Noël

Reviewed by Review Commons

Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells

1. Marta Grzonka
2. Hisham Bazzi

Reviewed by Review Commons

Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

1. Simon Schneider
2. Andjela Kovacevic
3. Michelle Mayer
4. Ann-Kristin Dicke
5. Lena Arévalo
6. Sophie A Koser
7. Jan N Hansen
8. Samuel Young
9. Christoph Brenker
10. Sabine Kliesch
11. Dagmar Wachten
12. Gregor Kirfel
13. Timo Strünker
14. Frank Tüttelmann
15. Hubert Schorle

• Curated by eLife

  eLife assessment

  This study provides valuable insights into the role of two under-researched sperm-specific proteins (Cylicin 1 and Cylicin 2). The authors provide convincing evidence that they have an essential role in sperm head structure during spermatogenesis, and that their loss leads to subfertility or infertility, with a dose-dependent phenotype. Importantly, the authors identify infertile males with mutations in both Cylicin1 and Cylicin2. Thus, the findings from the mouse models might be applicable to understanding human male infertility with similar structural defects.

Reviewed by eLife