Developmental Biology

Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells

1. Marta Grzonka
2. Hisham Bazzi

Reviewed by Review Commons

Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human

1. Simon Schneider
2. Andjela Kovacevic
3. Michelle Mayer
4. Ann-Kristin Dicke
5. Lena Arévalo
6. Sophie A Koser
7. Jan N Hansen
8. Samuel Young
9. Christoph Brenker
10. Sabine Kliesch
11. Dagmar Wachten
12. Gregor Kirfel
13. Timo Strünker
14. Frank Tüttelmann
15. Hubert Schorle

• Curated by eLife

  eLife assessment

  This study provides valuable insights into the role of two under-researched sperm-specific proteins (Cylicin 1 and Cylicin 2). The authors provide convincing evidence that they have an essential role in sperm head structure during spermatogenesis, and that their loss leads to subfertility or infertility, with a dose-dependent phenotype. Importantly, the authors identify infertile males with mutations in both Cylicin1 and Cylicin2. Thus, the findings from the mouse models might be applicable to understanding human male infertility with similar structural defects.

Reviewed by eLife

Capitella teleta gets left out: Possible evolutionary shift causes loss of left tissues rather than increased neural tissue from dominant-negative BMPR1

1. Nicole B. Webster
2. Néva P. Meyer

Reviewed by Arcadia Science

scMultiome analysis identifies embryonic hindbrain progenitors with mixed rhombomere identities

1. Yong-Il Kim
2. Rebecca O'Rourke
3. Charles G Sagerström

• Curated by eLife

  eLife assessment

  This study transcriptomically profiles the developing zebrafish hindbrain from gastrulation through stages of rhombomere formation. The strength is that the transcriptomic data will be a valuable resource to the field. The paper would profit from a deeper analysis of functional aspects of hindbrain development during its segmentation into rhombomeres.

Reviewed by eLife

The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

1. Nydia Tejeda-Munoz
2. Yagmur Azbazdar
3. Julia Monka
4. Grace Binder
5. Alex Dayrit
6. Raul Ayala
7. Neil O'Brien
8. Edward M De Robertis

• Curated by eLife

  eLife assessment

  The strength of this important study is that it provides compelling evidence in several biological models, including Xenopus embryos, that Wnt3a increases macropinocytosis and that PMA increases this cellular response. This novel link between Wnt, focal adhesions, lysosomes, and macropinocytosis will be very interesting for cell and tumor biologists. In future work, it will be good to identify the underlying mechanism, i.e., the molecular node whereby this interaction occurs.

Reviewed by eLife

Gene regulatory patterning codes in early cell fate specification of the C. elegans embryo

1. Alison G Cole
2. Tamar Hashimshony
3. Zhuo Du
4. Itai Yanai

• Curated by eLife

  eLife assessment

  This valuable work fills a gap in the mapping of gene expression patterns in the early embryo of C. elegans. The presented data are solid and provides a resource for future analysis.

Reviewed by eLife

Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

1. Merve Bilgic
2. Quan Wu
3. Taeko Suetsugu
4. Atsunori Shitamukai
5. Yuji Tsunekawa
6. Tomomi Shimogori
7. Mitsutaka Kadota
8. Osamu Nishimura
9. Shigehiro Kuraku
10. Hiroshi Kiyonari
11. Fumio Matsuzaki

• Curated by eLife

  eLife assessment

  This is an important study that improves gene models for the ferret genome and identifies neural progenitors that are comparable to those found in developing human brains. The data are convincing and clearly presented. Of particular interest to the field, the work identifies enriched expression of FOXJ1 in late truncated radial glia, strongly indicating that towards the end of neurogenesis, these cells likely give rise to ependymal cells. The work is of interest to anyone studying the development of the nervous system, especially colleagues studying the evolution of development.

Reviewed by eLife, Review Commons

Drosophila axis extension is robust to an orthogonal pull by invaginating mesoderm

1. Claire M Lye
2. Guy B. Blanchard
3. Jenny Evans
4. Alexander Nestor-Bergmann
5. Bénédicte Sanson

Reviewed by Review Commons

Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis

1. Wesley A Phelps
2. Matthew D Hurton
3. Taylor N Ayers
4. Anne E Carlson
5. Joel C Rosenbaum
6. Miler T Lee

• Curated by eLife

  eLife assessment

  This paper reports fundamental findings that substantially advance our understanding of a major research question - how hybridization events influence gene regulatory programs and how evolutionary pressures have shaped these programs in response to such events. The methods, data, and analyses are solid and broadly support the claims with only minor weaknesses. This convincing work uses appropriate and validated methodology in line with the current state-of-the-art.

Reviewed by eLife

Epsilon tubulin is an essential determinant of microtubule-based structures in male germ cells

1. G Gemma Stathatos
2. D Jo Merriner
3. Anne E O’Connor
4. Jennifer Zenker
5. Jessica EM Dunleavy
6. Moira K O’Bryan

Reviewed by Review Commons