1. The integration mechanism of the four positional cues—anterior, posterior, dorsal, and ventral—in axolotl limb regeneration

    This article has 5 authors:
    1. Sakiya Yamamoto
    2. Saya Furukawa
    3. Ayaka Ohashi
    4. Mayuko Hamada
    5. Akira Satoh
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work by Yamamoto and colleagues advances our understanding of how positional information is coordinated between axes during limb outgrowth and patterning. They provide solid evidence that the dorsal-ventral axis feeds into anterior-posterior signaling, and identify the responsible molecules by combining transplantations with molecular manipulations. This work will be of broad interest to regeneration, tissue engineering, and evolutionary biologists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Linage priming and cell type proportioning depends on the interplay between stochastic and deterministic factors

    This article has 7 authors:
    1. William M Salvidge
    2. Chris Brimson
    3. Nicole Gruenheit
    4. Li-Yao Huang
    5. Catherine J Pears
    6. Jason B Wolf
    7. Christopher RL Thompson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates how stochastic and deterministic factors are integrated during cellular decision-making, particularly in situations where cells differentiate into distinct fates despite being exposed to the same environmental conditions. The authors present convincing evidence that gene expression variability contributes to the robustness of cell fate decisions in D. discoideum, which sheds light into the role of stochasticity during cell differentiation.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  3. SVEP1 enables efficient binding of Angiopoietin-2 to the TIE1 receptor, allowing receptor phosphorylation and downstream signaling

    This article has 9 authors:
    1. Katharina Uphoff
    2. Melina Hußmann
    3. Dörte Schulte-Ostermann
    4. Yvonne Huisman
    5. Matthias Mörgelin
    6. Fabian Metzen
    7. J Fernando Bazan
    8. Manuel Koch
    9. Stefan Schulte-Merker
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript focuses on developing a structural model of how the multidomain ECM protein SVEP1 enables Angiopoietin (ANG) binding to the orphan receptor TIE1, resulting in downstream receptor phosphorylation and signaling. This is a potentially important study, however, it currently lacks key controls and is therefore incomplete. The data will be of interest to scientists working in vascular biology and RTK signaling.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. An increase in reactive oxygen species underlies neonatal cerebellum repair

    This article has 8 authors:
    1. Anna Pakula
    2. Salsabiel El Nagar
    3. N Sumru Bayin
    4. Jens Bager Christensen
    5. Daniel N Stephen
    6. Adam James Reid
    7. Richard Koche
    8. Alexandra L Joyner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work substantially advances our understanding of reactive oxygen species (ROS) as a regenerative signal during postnatal cerebellum repair by activating adaptive progenitor reprogramming. The evidence supporting the conclusions is compelling, with rigorous genomic assays and in vivo analyses. This work will be of broad interest to biologists working on stem cells, neurodevelopment and regenerative medicine.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16

    This article has 18 authors:
    1. Ying Ru
    2. Meng Ma
    3. Xianxiao Zhou
    4. Divya Kriti
    5. Ninette Cohen
    6. Sunita D’Souza
    7. Christoph Schaniel
    8. Susan M Motch Perrine
    9. Sharon Kuo
    10. Oksana Pichurin
    11. Dalila Pinto
    12. Genevieve Housman
    13. Greg Holmes
    14. Eric Schadt
    15. Harm van Bakel
    16. Bin Zhang
    17. Ethylin Wang Jabs
    18. Meng Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors investigated KLF Transcription Factor 16 (KLF16) as an inhibitor of osteogenic differentiation, which plays a critical role in bone development, metabolism and repair. The results of the study are valuable as they could help to facilitate future research on the regulation of osteogenesis in vitro and in vivo. However, the evidence overall is incomplete, as validation by knockout mouse models would help to strengthen the conclusions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease

    This article has 3 authors:
    1. Merry Faye E Graff
    2. Emma EM Heeg
    3. Sarah J Childs
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings that advance our understanding of mural cell dynamics and vascular pathology in a zebrafish model of cerebral small vessel disease. The authors provide compelling evidence that partial loss of foxf2 function leads to progressive, cell-intrinsic defects in pericytes and associated endothelial abnormalities across the lifespan, leveraging powerful in vivo imaging and genetic tools. The strength of evidence could be further improved by additional mechanistic insight and quantitative or lineage-tracing analyses to clarify how pericyte number and identity are affected in the mutant model.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus

    This article has 9 authors:
    1. Guozhu Ning
    2. Yu Lin
    3. Haixia Ma
    4. Jiaqi Zhang
    5. Liping Yang
    6. Zhengyu Liu
    7. Lei Li
    8. Xinyu He
    9. Qiang Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work supports the role of breast carcinoma amplified sequence 2 (Bcas2) in positively regulating primitive wave hematopoiesis through amplification of beta-catenin-dependent (canonical) Wnt signaling. The study is convincing: it uses appropriate and validated methodology in line with the current state-of-the-art, and there is a first-rate analysis of a strong phenotype with highly supportive mechanistic data. The findings shed light on the controversial question of whether, when, and how canonical Wnt signaling may be involved in hematopoietic development. The work will be of interest to hematologists and developmental biologists.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  8. A myofilament lattice model of Drosophila flight muscle sarcomeres based on multiscale morphometric analysis during development

    This article has 12 authors:
    1. Péter Görög
    2. Tibor Novák
    3. Tamás F. Polgár
    4. Péter Bíró
    5. Adél Gutheil
    6. Csaba Kozma
    7. Tamás Gajdos
    8. Krisztina Tóth
    9. Alexandra Tóth
    10. Miklós Erdélyi
    11. József Mihály
    12. Szilárd Szikora

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. The PIDDosome controls cardiomyocyte polyploidization during postnatal heart development

    This article has 19 authors:
    1. M Leone
    2. N Kinz
    3. F Eichin
    4. D Obwegs
    5. VC Sladky
    6. VZ Braun
    7. D Rizzotto
    8. L Englmaier
    9. C Manzl
    10. K Moos
    11. Julia Mergner
    12. P Giansanti
    13. MN Garcia
    14. MM Marques
    15. ED Jacotot
    16. C Savko
    17. M Boerries
    18. MA Sussman
    19. A Villunger

    Reviewed by Review Commons

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  10. A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

    This article has 10 authors:
    1. Jens Bager Christensen
    2. Alex P.A. Donovan
    3. Marzieh Moradi
    4. Giada Vanacore
    5. Mohab Helmy
    6. Adam J. Reid
    7. Jimmy Tsz Hang Lee
    8. Omer Ali Bayraktar
    9. Andrea H. Brand
    10. N. Sumru Bayin

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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