Developmental Biology

Ectopic head regeneration after nervous system ablation in a sea anemone

1. Fatemeh Mazloumi Gavgani
2. Johanna E.M. Kraus
3. Joshua November
4. Layla Al-Shaer
5. Anna Cosima Seybold
6. Benjamin Lerstad
7. Harald Hausen
8. Michael J. Layden
9. Fabian Rentzsch

Reviewed by preLights

Temporally resolved single cell transcriptomics in a human model of amniogenesis

1. Nikola Sekulovski
2. Amber E Carleton
3. Anusha A Rengarajan
4. Chien-Wei Lin
5. Lauren L Juga
6. Allison E Whorton
7. Jenna Kropp Schmidt
8. Thaddeus Golos
9. Kenichiro Taniguchi

Reviewed by Review Commons

Hyaluronic Acid and Emergent Tissue Mechanics Orchestrate Digit Tip Regeneration

1. Byron W.H. Mui
2. Joseph Y. Wong
3. Toni Bray
4. Lauren Connolly
5. Jia Hua Wang
6. Alexander Winkel
7. Pamela G. Robey
8. Kristian Franze
9. Kevin J. Chalut
10. Mekayla A. Storer

Reviewed by preLights

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

1. Mehmet Mahsum Kaplan
2. Erika Hudacova
3. Miroslav Matejcek
4. Haneen Tuaima
5. Jan Křivánek
6. Ondrej Machon

• Curated by eLife

  eLife Assessment

  This study provides valuable insight into the role of Meis2 in whisker hair follicle formation and confirms prior work that nerves are dispensable for this process. The solid imaging techniques support the authors' conclusions, however the data provides limited evidence to support the mechanism of Meis2 in whisker formation.

Reviewed by eLife

A Dual Role for the PP2A Phosphatase in Hippo Signalling Regulation

1. Aashika Sekar
2. Alberto Rizzo
3. Elodie Sins
4. Alexander D. Fulford
5. Paulo S. Ribeiro

Reviewed by Review Commons

Mac/Lac-tosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling

1. Kebei Tang
2. Xuewen Li
3. Jiulong Hu
4. Jingyuan Shi
5. Yumei Li
6. Yansu Chen
7. Chang Yin
8. Fengchao Wang
9. Rongwen Xi

• Curated by eLife

  eLife Assessment

  This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal cells. Mutations in GlcT compromise Notch signaling in the Drosophila intestinal stem cell lineage resulting in the formation of enteroendocrine tumors, and preliminary data suggests that a homolog of glucosylceramide synthase also influences Notch signaling in the mammalian intestine. While the outstanding strengths of the initial genetic and downstream pathway analyses are noted, there are weaknesses in the data regarding the potential role of this pathway in Delta trafficking. Nevertheless, this study opens the way for future mechanistic studies addressing how specific lipids modulate Notch signalling activity.

Reviewed by eLife

Dendritic atoh1a+ cells serve as transient intermediates during zebrafish Merkel cell development and regeneration

1. Evan W. Craig
2. Erik C. Black
3. Camille E.A. Goo
4. Avery Angell Swearer
5. Nathaniel G. Yee
6. Jeffrey P. Rasmussen

Reviewed by Review Commons

Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

1. Yi Wu
2. Weilin Guo
3. Haoyue Kuang
4. Xiaohai Wu
5. Yuexin Wang
6. Shizheng Zhao
7. Zilong Wen
8. Tao Yu

• Curated by eLife

  eLife Assessment

  This study presents valuable findings on the control of survival and maintenance of a specific set of brain resident immune cells. The authors generate a new animal model to enable sophisticated analysis of cell function in vivo. The sophisticated knock-in/knock-out alleles are compelling, although the work would ultimately be strengthened with further mechanistic analyses.

Reviewed by eLife

Neuroprotective role of Hippo signaling by microtubule stability control in Caenorhabditis elegans

1. Hanee Lee
2. Junsu Kang
3. Sang-Hee Lee
4. Dowoon Lee
5. Christine H Chung
6. Junho Lee

• Curated by eLife

  eLife Assessment

  In their valuable study, Lee et al. explore a role for the Hippo signaling pathway, specifically wts-1/LATS and the downstream regulator yap, in age-dependent neurodegeneration and microtubule dynamics using C. elegans mechanosensory neurons as a model. The authors demonstrate that disruption of wts-1/LATS leads to age-associated morphological and functional neuronal abnormalities, linked to enhanced microtubule stabilization, and show a genetic connection between yap and microtubule stability. Overall, the study employs robust genetic and molecular approaches to reveal a convincing link between the Hippo pathway, microtubule dynamics, and neurodegeneration.

Reviewed by eLife

A conserved chronobiological complex times C. elegans development

1. Rebecca K. Spangler
2. Kathrin Braun
3. Guinevere E. Ashley
4. Marit van der Does
5. Daniel Wruck
6. Andrea Ramos Coronado
7. James Matthew Ragle
8. Vytautas Iesmantavicius
9. Lucas J. Morales Moya
10. Keya Jonnalagadda
11. Carrie L. Partch
12. Helge Großhans
13. Jordan D. Ward

Reviewed by Review Commons