Developmental Biology

Dissecting PADI6 function defines oocyte cytoplasmic lattices as regulatory hubs for fundamental cellular processes

1. Jack P. C. Williams
2. Tania Auchynnikava
3. Afshan McCarthy
4. M. Teresa Bertran
5. Obah A. Ojarikre
6. Anne E. Weston
7. Daniel Leonce
8. Jessica Olsen
9. Kathy K. Niakan
10. Mark Skehel
11. James M. A. Turner
12. Louise J. Walport

Reviewed by Review Commons

Gcn5 – mTORC1 – TFEB signalling axis mediated control of autophagy regulates Drosophila blood cell homeostasis

1. Arjun Aji Reeja
2. Mincy Kunjumon
3. Suraj Math
4. Laxmi Kata
5. Rohan Jayant Khadilkar

• Curated by eLife

  eLife Assessment

  This valuable study identifies Gcn5 as a regulator of blood cell development in the Drosophila lymph gland, with links to autophagy and nutrient-sensing mTORC1 signalling. The evidence is solid that altering Gcn5, autophagy genes and mTORC1 activity perturbs blood cell homeostasis, and the revised manuscript adds helpful genetic and quantitative analyses. However, the evidence for a clean linear Gcn5-mTORC1-TFEB/autophagy pathway is insufficient, because several cell-type-specific phenotypes remain difficult to reconcile and the pathway logic relies on different genetic tools, cell populations and pharmacological perturbations.

Reviewed by eLife

Spatial activation of Kinesin-1 by Ensconsin shapes microtubule networks via ncMTOCs recruitment

1. Anne-Marie Berisha
2. Aude Pascal
3. Marine Guelle
4. Clément Bousquet
5. Denis Chrétien
6. Laetitia Bataillé
7. Régis Giet

Reviewed by Review Commons

Hox – Meis -relayed gene regulatory transition underlies cardiopharyngeal neural crest diversification

1. Akiyasu Iwase
2. Yasunobu Uchijima
3. Daiki Seya
4. Mayuko Kida
5. Hiroki Higashiyama
6. Kazuhiro Matsui
7. Akashi Taguchi
8. Yukihiro Harada
9. Yunce Wang
10. Shogo Yamamoto
11. Shiro Fukuda
12. Seitaro Nomura
13. Takahide Kohro
14. Chisa Shukunami
15. Haruhiko Akiyama
16. Masahide Seki
17. Akinori Kanai
18. Yutaka Suzuki
19. Teruhisa Kawamura
20. Osamu Nakagawa
21. Hiroto Katoh
22. Shumpei Ishikawa
23. Youichiro Wada
24. Hiroyuki Aburatani
25. Yukiko Kurihara
26. Sachiko Miyagawa-Tomita
27. Hiroki Kurihara

Reviewed by Review Commons

Genotype-phenotype correlations and de novo induction of cancer stem cells in Wilms tumor initiation

1. N.S. Pop
2. D. Koot
3. C.M. Brouwers
4. M.M. Linssen
5. J.W.C. Claassens
6. C.W.J. Cartlidge
7. D.D. Özdemir
8. K.S. Dolt
9. P. Hohenstein

Reviewed by Review Commons

The neurotrophin DNT-2 regulates cell survival and connectivity via the Toll-2 receptor during visual system development of Drosophila

1. Naser Alshamsi
2. Francisca Rojo-Cortés
3. Bangfu Zhu
4. Samaher Fahy
5. Guiyi Li
6. Anna Lassota
7. Marta Moreira
8. Alicia Hidalgo

Reviewed by Review Commons

The co-repressor Groucho limits progression through the early transcription elongation checkpoint in vivo

1. María Lorena Martínez Quiles
2. Barbara H Jennings

Reviewed by Review Commons