1. Neuroprotective role of Hippo signaling by microtubule stability control in C. elegans

    This article has 6 authors:
    1. Hanee Lee
    2. Junsu Kang
    3. Sang-Hee Lee
    4. Dowoon Lee
    5. Christine H. Chung
    6. Junho Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In their valuable study, Lee et al. explore a role for the Hippo signaling pathway, specifically wts-1/LATS and the downstream regulator yap, in age-dependent neurodegeneration and microtubule dynamics using C. elegans mechanosensory neurons as a model. The authors demonstrate that disruption of wts-1/LATS leads to age-associated morphological and functional neuronal abnormalities, linked to enhanced microtubule stabilization, and show a genetic connection between yap and microtubule stability. Overall, the study employs robust genetic and molecular approaches to reveal a convincing link between the Hippo pathway, microtubule dynamics, and neurodegeneration.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. A conserved chronobiological complex times C. elegans development

    This article has 13 authors:
    1. Rebecca K. Spangler
    2. Kathrin Braun
    3. Guinevere E. Ashley
    4. Marit van der Does
    5. Daniel Wruck
    6. Andrea Ramos Coronado
    7. James Matthew Ragle
    8. Vytautas Iesmantavicius
    9. Lucas J. Morales Moya
    10. Keya Jonnalagadda
    11. Carrie L. Partch
    12. Helge Großhans
    13. Jordan D. Ward

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Contribution of the epididymis beyond fertilization: relevance of CRISP1 and CRISP3 for sperm DNA integrity and early embryo development

    This article has 6 authors:
    1. Valeria Sulzyk
    2. Ludmila Curci
    3. Lucas N González
    4. Abril Rebagliati Cid
    5. Mariana Weigel Muñoz
    6. Patricia S Cuasnicu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports that epididymal proteins are required for embryogenesis after fertilization. The data presented are generally supportive of the conclusion and considered solid. This work will be of interest to reproductive biologists and andrologists.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. A comparative analysis of planarian regeneration specificity reveals tissue polarity contributions of the axial cWnt signalling gradient

    This article has 8 authors:
    1. James P Cleland
    2. Hanh T.-K Vu
    3. Johanna EM Dickmann
    4. Andrei Rozanski
    5. Steffen Werner
    6. Andrea Schuhmann
    7. Anna Shevchenko
    8. Jochen C Rink
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates the different mechanisms that provide instructions for a missing body part to regenerate its appropriate identity. The authors use two species of planarians to identify a key role for bodywide canonical Wnt gradients in controlling the outcome of regeneration. The study provides convincing evidence for variable regeneration efficiency among planarian species that will be of interest to developmental biologists interested in regeneration. However, some of the results are over-interpreted and the additional experiments could provide better support for the authors' claims.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Dual roles of EGO-1 and RRF-1 in regulating germline exo-RNAi efficiency in Caenorhabditis elegans

    This article has 3 authors:
    1. Katsufumi Dejima
    2. Keita Yoshida
    3. Shohei Mitani

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. 3D Reconstruction of Neuronal Allometry and Neuromuscular Projections in Asexual Planarians Using Expansion Tiling Light Sheet Microscopy

    This article has 7 authors:
    1. Jing Lu
    2. Hao Xu
    3. Dongyue Wang
    4. Yanlu Chen
    5. Takeshi Inoue
    6. Liang Gao
    7. Kai Lei
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Lu and colleagues developed an important imaging protocol that combines expansion microscopy, light-sheet microscopy, and image segmentation for use with the planarian Schmidtea mediterranea, a powerful model system for regeneration. This represents a substantial improvement on current standards and enables more rapid data acquisition. The utility of this solid protocol is demonstrated by quantifying several aspects of this flatworm's neural anatomy and musculature during homeostasis and regeneration. This work will be of interest to researchers looking to implement more systematic approaches towards imaging and quantifying intact specimens.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Modularity of the segmentation clock and morphogenesis

    This article has 3 authors:
    1. James E Hammond
    2. Ruth E Baker
    3. Berta Verd
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable manuscript uses mathematical modeling to address the synchrony of the vertebrate segmentation clock with the developmental processes. The authors use convincing arguments to support the idea that this would allow the evolution of flexible body plans and a variable number of segments. This manuscript could be of interest to developmental biologists and systems biologists.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  8. Extracellular adenosine deamination primes tip organizer development in Dictyostelium

    This article has 2 authors:
    1. Pavani Hathi
    2. Ramamurthy Baskar
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study identifies a protein called adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation in the slime mold Dictyostelium discoideum. The authors convincingly show that ADGF catalyses the formation of ammonia from adenosine, allowing ammonia to initiate tip formation, and then elucidate pathways upstream and downstream from ADGF. The authors discuss the intriguing possibility that mammalian ADGF may also similarly regulate development.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Distinct proliferative and neuronal programmes of chromatin binding and gene activation by ASCL1 are cell cycle stage-specific

    This article has 4 authors:
    1. William F. Beckman
    2. Lydia M. Parkinson
    3. Lewis Chaytor
    4. Anna Philpott

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. One probe fits all: a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes

    This article has 5 authors:
    1. Kirill Ustyantsev
    2. Mattia Stranges
    3. Filippo Giovanni Volpe
    4. Stijn Mouton
    5. Eugene Berezikov

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
Page 1 of 84 Next