Developmental Biology

Identification of optimal fluorophores for use in the Drosophila embryo

1. Bernardo Chapa-y-Lazo
2. Thamarailingam Athilingam
3. Prabhat Tiwari
4. Prachi Pathak
5. Shaobo Zhang
6. Sophie Theis
7. Timothy E Saunders

Reviewed by Review Commons

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

1. Julien Pigeon
2. Tamina Dietl
3. Myriame Abou Mrad
4. Ludovico Rizzuti
5. Miguel V. Silva
6. Natasha Danda
7. Corentine Marie
8. Clarisse Brunet Avalos
9. Hayat Mokrani
10. Laila El Khattabi
11. Alexandre D. Baffet
12. Diogo S. Castro
13. Carlos Parras
14. Boyan Bonev
15. Bassem A. Hassan

Reviewed by preLights

SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians

1. Mallory L. Cathell
2. Mohamad A. Auwal
3. Sarai Alvarez Zepeda
4. Kelly G. Ross
5. Ricardo M. Zayas

Reviewed by Review Commons

E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila

1. Katrin Strobel
2. Jennifer Falconi
3. Cédric Leyrat
4. Rémi Logeay
5. Sarah J Bray
6. Alexandre Djiane

• Curated by eLife

  eLife Assessment

  The authors identify the Bearded-type small protein E(spl)m4 as a physical and genetic interactor of TRAF4 in the Drosophila wing disc. These valuable findings with potential biomedical relevance are, however, supported by incomplete evidence based largely on overexpression studies that lack quantification, limited molecular support for their model, and issues with Bearded family protein specificity. The work could be of interest to researchers in the fields of cell signaling and developmental biology.

Reviewed by eLife

Mac/Lac-tosylceramide regulates intestinal homeostasis and secretory cell fate commitment by facilitating Notch signaling

1. Kebei Tang
2. Xuewen Li
3. Jiulong Hu
4. Jingyuan Shi
5. Yumei Li
6. Yansu Chen
7. Chang Yin
8. Fengchao Wang
9. Rongwen Xi

• Curated by eLife

  eLife Assessment

  This important study provides convincing evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal cells. Mutations in GlcT compromise Notch signaling in the Drosophila intestinal stem cell lineage, resulting in the formation of enteroendocrine tumors. Further data suggest that a homolog of glucosylceramide synthase also influences Notch signaling in the mammalian intestine. While the outstanding strengths of the initial genetic and downstream pathway analyses are noted, there are minor weaknesses in the data regarding the potential role of this pathway in Delta trafficking. Nevertheless, this study opens the way for future mechanistic studies addressing how specific lipids modulate Notch signalling activity.

Reviewed by eLife

Genome-wide association study shows developmental robustness control by intestinal maltase via internal environment in Drosophila

1. Soshiro Kashio
2. Izumi Enoki
3. Yuto Yoshinari
4. Takashi Nishimura
5. Masayuki Miura

Reviewed by Review Commons

Spatial activation of Kinesin-1 by Ensconsin shapes microtubule networks via ncMTOCs recruitment

1. Anne-Marie Berisha
2. Aude Pascal
3. Marine Guelle
4. Clément Bousquet
5. Denis Chrétien
6. Laetitia Bataillé
7. Régis Giet

Reviewed by Review Commons

VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity

1. Paul Palmquist-Gomes
2. Gaëlle Letort
3. Ayushi U. Hegde
4. José María Pérez-Pomares
5. Sigolène M. Meilhac

Reviewed by preLights

Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

1. Ioakeim Ampartzidis
2. Elliott M Thompson
3. Yashica Gupta
4. Andrea Krstevski
5. Nicola Elvassore
6. Eirini Maniou
7. Paolo de Coppi
8. Gabriel L Galea

Reviewed by Review Commons

The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice

1. Atsuko Kageyama
2. Narumi Ogonuki
3. Takuya Wakai
4. Takafumi Namiki
5. Yui Kawata
6. Manabu Ozawa
7. Yasuhiro Yamada
8. Toshiyuki Fukada
9. Atsuo Ogura
10. Rafael A Fissore
11. Naomi Kashiwazaki
12. Junya Ito

• Curated by eLife

  eLife Assessment

  This study presents significant and novel insights into the roles of zinc in mammalian meiosis/fertilization events. These findings are useful to our understanding of these processes. The evidence presented is solid, with experiments being well-designed, carefully described, and interpreted with appropriate rigor. The authors acknowledge the lack of mechanistic insight which represents the main limitation of the study.

Reviewed by eLife