Developmental Biology

Gcn5 – mTORC1 – TFEB signalling axis mediated control of autophagy regulates Drosophila blood cell homeostasis

1. Arjun Aji Reeja
2. Mincy Kunjumon
3. Suraj Math
4. Laxmi Kata
5. Rohan Jayant Khadilkar

• Curated by eLife

  eLife Assessment

  This valuable study identifies Gcn5 as a regulator of blood cell development in the Drosophila lymph gland, with links to autophagy and nutrient-sensing mTORC1 signalling. While the mechanistic ordering between Gcn5, mTORC1 and TFEB/autophagy remains less fully resolved, the evidence is solid that perturbing Gcn5, autophagy genes and mTORC1 activity affects blood cell homeostasis. The work will be of interest to researchers studying developmental haematopoiesis, metabolic regulation and autophagy.

Reviewed by eLife

Matrix Rigidity Governs Switch-Like Oscillatory State Transitions of the Segmentation Clock in Isolated Presomitic Mesoderm Cells

1. Chun-Yen Sung
2. Yuqian Yang
3. Usha Kadiyala
4. Owen Blanchard
5. Liam Yourston
6. Derek Walker
7. Linyuan Li
8. Shiyu Sun
9. Zhaoyi Xu
10. Mariela Lopez Gonzalez
11. Jianping Fu
12. Qiong Yang

Reviewed by preLights