1. Organization of the apical extracellular matrix during tubular organ formation

    This article has 5 authors:
    1. J. Luke Woodward
    2. Jeffrey Matthew
    3. Vishakha Vishwakarma
    4. Ying Xiao
    5. SeYeon Chung

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. The essential role of connective-tissue cells during axolotl limb regeneration

    This article has 12 authors:
    1. Damián García-García
    2. Dunja Knapp
    3. Minjoo Kim
    4. Katelyn Jamwal
    5. Heath Fuqua
    6. Ryan P. Seaman
    7. Riley E. Grindle
    8. Sergej Nowoshilow
    9. Maria Novatchkova
    10. Fred W. Kolling
    11. Joel H. Graber
    12. Prayag Murawala

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

    This article has 9 authors:
    1. Katsuyuki Nishi
    2. Taro Sakamaki
    3. Akiomi Nagasaka
    4. Kevin S Kao
    5. Kay Sadaoka
    6. Masahide Asano
    7. Nobuyuki Yamamoto
    8. Akifumi Takaori-Kondo
    9. Masanori Miyanishi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable insights into the heterogeneity of hematopoietic stem cells and age-associated myeloid-biased hematopoiesis. While several aspects of the study are intriguing and merit further investigation, the current results remain incomplete and additional data are necessary to substantiate the conclusions. Some of the methods and data analyses partially support the claims.

    Reviewed by eLife, preLights

    This article has 15 evaluationsAppears in 2 listsLatest version Latest activity
  4. FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

    This article has 6 authors:
    1. Rosanna CG Smith
    2. Maryam Clark
    3. Mireya Vazquez-Prada
    4. Marc Astick
    5. Kristina C Tubby
    6. Stephen R Price
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors conducted a valuable study that investigates a molecular pathway mediating the transformation of a cell aggregate into a sheet known as the nucleus laminaris, a crucial site for auditory processing. While the study offers a comprehensive view of the sequence of developmental events and suggests possible roles for FGF signaling, the transcription factor Mafb, and the cell surface adhesive molecule Cadherin-23 in this process, the current data were considered incomplete.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

    This article has 3 authors:
    1. Estefania Sanchez-Vasquez
    2. Marianne E Bronner
    3. Magdalena Zernicka-Goetz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Sanchez-Vasquez et al establish an innovative approach to induce aneuploidy in preimplantation embryos. This important study extends the author's previous publications evaluating the consequences of aneuploidy in the mammalian embryo. In this work, the authors investigate the developmental potential of aneuploid embryos and characterize changes in gene expression profiles under normoxic and hypoxic culture conditions. Using a solid methodology they identify sensitivity to Hif1alpha loss in aneuploid embryos, and in further convincing experiments they assess how levels of DNA damage and DNA repair are altered under hypoxic and normoxic conditions.

    Reviewed by eLife, preLights

    This article has 8 evaluationsAppears in 2 listsLatest version Latest activity
  6. Cardiac Fibroblasts regulate myocardium and coronary vasculature development via the collagen signaling pathway

    This article has 6 authors:
    1. Yiting Deng
    2. Yuanhang He
    3. Juan Xu
    4. Haoting He
    5. Manling Zhang
    6. Guang Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides a comprehensive analysis of gene expression and bioinformatics data, offering important insights into the roles of fibroblasts in cardiac development. The large and well-analyzed single-cell RNA sequencing (scRNA-seq) dataset is compelling and a significant contribution to the field, and will be of broad interest to the scientific community.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  7. The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

    This article has 9 authors:
    1. Rei Yagasaki
    2. Ryo Nakamura
    3. Yuuki Shikaya
    4. Ryosuke Tadokoro
    5. Ruolin Hao
    6. Zhe Wang
    7. Mototsugu Eiraku
    8. Masafumi Inaba
    9. Yoshiko Takahashi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports the development of a novel organoid system for studying the emergence of autorhythmic gut peristaltic contractions through the interaction between interstitial cells of Cajal and smooth muscle cells. The authors further utilized the system to provide convincing evidence for a previously unappreciated potential role for smooth muscle cells in regulating the firing rate of interstitial cells of Cajal. The work will be of interest to those studying development and physiology of the gut.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  8. Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    This article has 8 authors:
    1. Leonid Peshkin
    2. Enrico Maria Daldello
    3. Elizabeth Van Itallie
    4. Matthew Sonnett
    5. Johannes Kreuzer
    6. Wilhelm Haas
    7. Marc W Kirschner
    8. Catherine Jessus
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important paper describes a comprehensive quantitative phospho-proteomic analysis of the meiotic progression of Xenopus oocytes. Using time-resolved proteomic analyses, the authors provide insights into changes in protein levels and phosphorylation states to an unprecedented depth, quality, and quantitative detail. The key findings are compelling and offer a helpful resource for the scientific community.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

    This article has 3 authors:
    1. Li He
    2. Jiayu Wen
    3. Qi Dai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory mechanisms both in vivo and in vitro. The work will be of broad interest to researchers working on growth factor signaling mechanisms and vertebrate development.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  10. Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

    This article has 12 authors:
    1. David W Wolfson
    2. Joshua A Hull
    3. Yongwu Li
    4. Trevor J Gonzalez
    5. Mourya D Jayaram
    6. Garth W Devlin
    7. Valentina Cigliola
    8. Kelsey A Oonk
    9. Alan Rosales
    10. Nenad Bursac
    11. Aravind Asokan
    12. Kenneth D Poss
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study identifies novel approaches to improving transgene expression in the injured mammalian myocardium through a combination of a tissue regeneration enhancer element and engineered AAVs - specifically, a liver-detargeting capsid, AAV.cc84, and an in vivo library screen-selected AAV-IR41. The evidence is convincing, and the AAV vectors are of fundamental value to the field of cardiac gene therapy. Future research exploring how to combine the features of AAV.cc84 and AAV-IR41 could yield an even more promising vector for therapeutic use.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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