Developmental Biology

Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

1. Ayanthi Bhattacharya
2. Hemalatha Rao
3. Sonia Q Sen

• Curated by eLife

  eLife Assessment

  The study provides an important advance towards understanding how spatial and temporal transcriptional programs are integrated to regulate lineage-specific chromatin and enhancer activation. The functional evidence is currently based on limited evidence, but the current data provide a solid correlative and conceptual foundation. Functional experiments directly linking Gsb occupancy to chromatin state and regulation of some lineage-specific targets would further strengthen the causal interpretation of the model. Clarifying the scope of conclusions and explicitly acknowledging the technical limitations of current chromatin assays would provide a more balanced interpretation of the manuscript.

Reviewed by eLife

Matrix Rigidity Governs Switch-Like Oscillatory State Transitions of the Segmentation Clock in Isolated Presomitic Mesoderm Cells

1. Chun-Yen Sung
2. Yuqian Yang
3. Usha Kadiyala
4. Owen Blanchard
5. Liam Yourston
6. Derek Walker
7. Linyuan Li
8. Shiyu Sun
9. Zhaoyi Xu
10. Mariela Lopez Gonzalez
11. Jianping Fu
12. Qiong Yang

Reviewed by preLights