Developmental Biology

Multiple pathways prevent bi-parental mitochondria transmission in C. elegans

1. Valentine Melin
2. Justine Cailloce
3. Fanny Husson
4. Jorge Merlet
5. Vincent Galy

• Curated by eLife

  eLife Assessment

  This valuable work used molecular biology, cell biology, and genetic approaches to unravel individual genes and potential pathways that contribute to paternal mitochondrial inheritance using C. elegans as the model organism. Their microscopy method is cutting edge, with sufficient biological replicates, proper control, and appropriate statistics. These findings are convincing and are of general interest for understanding mitochondrial inheritance in C. elegans, which could have implications for understanding similar biological processes in other organisms.

Reviewed by eLife

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction

1. Aurélien Villedieu
2. Olinda Alegria-Prévot
3. Carole Phan
4. Yu Ieda
5. Francis Corson
6. Jérôme Gros

Reviewed by preLights

Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

1. Alwyn Dady
2. Lindsay Davidson
3. Nicolas Loyer
4. Sophie Rappich
5. Greg Findlay
6. Timothy Sanders
7. Jens Januschke
8. Kate G. Storey

Reviewed by Review Commons

Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair

1. Chih-Wen Chu
2. Satheeja Velayudhan
3. Jakob H. Schauser
4. Sapna Krishnakumar
5. Stephanie Yang
6. Keiji Itoh
7. Dominique Alfandari
8. Ala Trusina
9. Sergei Y. Sokol

Reviewed by preLights

Genetic compensation in podocalyxin-like mutants during zebrafish liver development

1. Alexis N Ross
2. Natalie M Miscik
3. Sharanya Maanasi Kalasekar
4. James D Harris
5. Mimi Tran
6. Aavrati Saxena
7. Steven Andrew Baker
8. Kimberley Jane Evason

• Curated by eLife

  eLife Assessment

  The manuscript by Ross, Miscik, and others describes an intriguing series of observations made when investigating the requirement for podxl during hepatic development in zebrafish. Understanding how genetic compensation pathways are involved in gene function is an important question. However, there is incomplete evidence provided in the manuscript at this point to conclude that discrepancies between observed phenotypes are due to genetic compensation.

Reviewed by eLife

The essential role of connective-tissue cells during axolotl limb regeneration

1. Damián García-García
2. Dunja Knapp
3. Minjoo Kim
4. Katelyn Jamwal
5. Heath Fuqua
6. Ryan P. Seaman
7. Riley E. Grindle
8. Sergej Nowoshilow
9. Maria Novatchkova
10. Fred W. Kolling
11. Joel H. Graber
12. Prayag Murawala

Reviewed by preLights