Developmental Biology

Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells

1. Toshihiro Kawasaki
2. Toshiya Nishimura
3. Naoki Tani
4. Carina Ramos
5. Emil Karaulanov
6. Minori Shinya
7. Kenji Saito
8. Emily Taylor
9. René F Ketting
10. Kei-ichiro Ishiguro
11. Minoru Tanaka
12. Kellee R Siegfried
13. Noriyoshi Sakai

• Curated by eLife

  eLife Assessment

  This important paper describes the regulatory pathway of rRNA synthesis by Meioc-Piwil1 in germ cell differentiation in zebrafish. Using the molecular genetic and cytological approaches, the authors provide convincing evidence that Meioc antagonizes Piwil1, which downregulates the 45S pre-rRNA synthesis by heterochromatin formation for spermatocyte differentiation. The results will be of use to researchers in the field of germ cell/meiosis as well as RNA biosynthesis and chromatin.

Reviewed by eLife

Spectral decomposition unlocks ascidian morphogenesis

1. Joel Dokmegang
2. Emmanuel Faure
3. Patrick Lemaire
4. Edwin Munro
5. Madhav Mani

• Curated by eLife

  eLife Assessment

  In this important work, a quantitative analysis method for three-dimensional morphogenetic processes during embryonic development is introduced. The proposed method is a pipeline combining several methods, allowing quantitative analysis of developmental processes without cell segmentation and tracking. Upon application of their method, the authors obtain convincing evidence that ascidian gastrulation is a two-step process. This work should be of interest to a broad range of developmental biologists who aim to obtain a quantitative understanding of morphogenesis.

Reviewed by eLife

A low-level Cdkn1c/p57 ^kip2 expression in spinal progenitors drives the transition from proliferative to neurogenic modes of division

1. Baptiste Mida
2. Nathalie Lehman
3. Fanny Coulpier
4. Kamal Bouhali
5. Rosette Goiame
6. Morgane Thomas-Chollier
7. Evelyne Fischer
8. Xavier Morin

Reviewed by Review Commons

The retinoic acid receptor regulates development of a key evolutionary novelty - the molluscan shell

1. Keisuke Shimizu
2. Paul A. O’Neill
3. Kazuyoshi Endo
4. Tetsuhiro Kudoh

Reviewed by Arcadia Science

Prenatal exposure to environmental stressors alters gut macrophage development and gastrointestinal function of male offspring

1. Dang M. Nguyen
2. Sarah K. Monroe
3. Danielle N. Rendina
4. Kevin S. Boyd
5. Erika D. Rispoli
6. Olivia M. Wirfel
7. A. Brayan Campos-Salazar
8. Anna R. Araujo
9. Trisha V. Vaidyanathan
10. Virginia L. Keziah
11. Benjamin A. Devlin
12. Caroline J. Smith
13. Staci D. Bilbo

Reviewed by preLights

Site-specific DNA demethylation during spermatogenesis presets the sites of nucleosome retention in mouse sperm

1. So Maezawa
2. Masashi Yukawa
3. Akihiko Sakashita
4. Artem Barski
5. Satoshi H Namekawa

• Curated by eLife

  eLife Assessment

  This study provides valuable findings on the role of site-specific DNA methylation changes during spermatogenesis and their contribution to paternal epigenetic inheritance. The study proposes that selective loss of DNA methylation at a subset of promoters is required for nucleosome retention and the establishment of epigenetic states that may influence embryonic gene regulation. The present study's conclusion is mostly supported by solid data.

Reviewed by eLife

SRSF3 is a key regulator of epicardial formation

1. Irina-Elena Lupu
2. Susann Bruche
3. Anob M. Chakrabarti
4. Ian R. McCracken
5. Tamara Carsana
6. Andia N. Redpath
7. Nicola Smart

Reviewed by Review Commons

Pleiotropic function of Dlx5/6 in coordinating the development of mammalian vocal and auditory organs

1. Frida Sánchez-Garrido
2. Victoria Bouzerand
3. Markéta Kaiser
4. Chloé Chaumeton
5. Anastasia Fontaine
6. Tomáš Zikmund
7. Jozef Kaiser
8. Églantine Heude

Reviewed by Review Commons

Single-cell transcriptomes of zebrafish germline reveal progenitor types and feminization by Foxl2l

1. Chen-wei Hsu
2. Hao Ho
3. Ching-Hsin Yang
4. Yan-wei Wang
5. Ker-Chau Li
6. Bon-chu Chung

• Curated by eLife

  eLife Assessment

  This manuscript provides important findings for understanding the mechanisms of a major gene causing the gonad of fish and other vertebrates, including mammals, to become an ovary rather than a testis. Evidence is solid, but alternative explanations for a number of the claims must be considered and discussed. The impact of the work would benefit by placing it in a richer historical context.

Reviewed by eLife

Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development

1. Qian Wang
2. Hongge Li
3. Yingyu Mao
4. Ankur Garg
5. Eun Sil Park
6. Yihua Wu
7. Alyssa Chow
8. John Peregrin
9. Xin Zhang

• Curated by eLife

  eLife Assessment

  This fundamental article significantly advances our understanding of FGF signalling, and in particular highlights the complex modifications affecting this pathway. The evidence for the authors' claims is convincing, combining state of the art conditional gene deletion in the mouse lens with histological and molecular approaches. This work should be of great interest to molecular and developmental biologists beyond the lens community.

Reviewed by eLife