Developmental Biology

Transcriptional Repression of reaper by Stand Still Safeguards Female Germline Development in Drosophila

1. Masaya Matsui
2. Shinichi Kawaguchi
3. Toshie Kai

Reviewed by Review Commons

Cataloguing the postnatal small intestinal transcriptome during the first postnatal month

1. Luiz Fernando Silva Oliveira
2. Radhika S Khetani
3. Yu-Syuan Wu
4. Venkata Siva Dasuri
5. Amanda W Harrington
6. Oluwabunmi Olaloye
7. Jeffrey Goldsmith
8. David T Breault
9. Liza Konnikova
10. Shannan J Ho Sui
11. Amy E O’Connell

• Curated by eLife

  eLife Assessment

  This study presents a useful inventory of genes that are up- and down-regulated in the mouse small intestine (duodenum and ileum) during the first postnatal month; the data were collected and analyzed using solid and validated methodology and can be used as a starting point for additional validation of specific markers and for follow-up functional studies. Some aspects of the study were incomplete, with claims being only partially supported by the data, and it is suggested that additional validation be performed. The authors attempted to correlate gene expression changes with periods of high and low NEC susceptibility, but these correlations are speculative and not supported by functional follow-up studies. Discussion of gene expression changes with NEC susceptibility would be more appropriate to include in the Discussion section and to be tempered in the results section.

Reviewed by eLife

Spatiotemporal WNT and BMP gradients orchestrate regional enteroendocrine cell diversity along the Drosophila midgut

1. Jiaying Lv
2. Xingting Guo
3. Rongwen Xi

• Curated by eLife

  eLife Assessment

  This valuable study is a comprehensive investigation into the regulatory mechanisms and regional distribution of enteroendocrine cell subtypes in the Drosophila midgut, significantly advancing the understanding of how WNT and BMP gradients contribute to EE diversity. The methodological foundation and robust genetic evidence are solid in supporting the key roles of compartment boundary signals, particularly WNT and BMP, in specifying EE subtypes and division modes. However, there is a lack of full mechanistic insight regarding Notch pathway involvement, incomplete quantification of phenotype data, and insufficient global pattern analysis, which detracts from fully supporting some proposed models. Overall, the study provides a platform for future work but would benefit from stronger data integration and expanded mechanistic exploration.

Reviewed by eLife

Deep learning predicts tissue outcomes in retinal organoids

1. Cassian Afting
2. Norin Bhatti
3. Christina Schlagheck
4. Encarnación Sánchez Salvador
5. Laura Herrera-Astorga
6. Rashi Agarwal
7. Risa Suzuki
8. Nicolaj Hackert
9. Hanns-Martin Lorenz
10. Lucie Zilova
11. Joachim Wittbrodt
12. Tarik Exner

Reviewed by Review Commons

Lineage domains and cytoskeletal cables organize a cellular square grid in a crustacean

1. Beatrice L. Steinert
2. Leo Blondel
3. Chandrashekar Kuyyamudi
4. Evangelia Stamataki
5. Anastasios Pavlopoulos
6. Cassandra G. Extavour

Reviewed by preLights

Chronic replication stress-mediated genomic instability disrupts placenta development in mice

1. Mumingjiang Munisha
2. Rui Huang
3. Jordan Khan
4. John C. Schimenti

Reviewed by Review Commons