Developmental Biology

Alteration of long- and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

1. Katsuyuki Nishi
2. Taro Sakamaki
3. Akiomi Nagasaka
4. Kevin Shuolong Kao
5. Kay Sadaoka
6. Masahide Asano
7. Nobuyuki Yamamoto
8. Akifumi Takaori-Kondo
9. Masanori Miyanishi

• Curated by eLife

  eLife Assessment

  This manuscript provides valuable insights into the heterogeneity of hematopoietic stem cells and age-associated myeloid-biased hematopoiesis. While several aspects of the study are intriguing and merit further investigation, the current results remain incomplete and additional data are necessary to substantiate the conclusions. Some of the methods and data analyses partially support the claims.

Reviewed by eLife, preLights

FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

1. Rosanna CG Smith
2. Maryam Clark
3. Mireya Vazquez-Prada
4. Marc Astick
5. Kristina C Tubby
6. Stephen R Price

• Curated by eLife

  eLife Assessment

  The authors conducted a valuable study that investigates a molecular pathway mediating the transformation of a cell aggregate into a sheet known as the nucleus laminaris, a crucial site for auditory processing. While the study offers a comprehensive view of the sequence of developmental events and suggests possible roles for FGF signaling, the transcription factor Mafb, and the cell surface adhesive molecule Cadherin-23 in this process, the current data were considered incomplete.

Reviewed by eLife

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

1. Yiting Deng
2. Yuanhang He
3. Juan Xu
4. Haoting He
5. Manling Zhang
6. Guang Li

• Curated by eLife

  eLife Assessment

  This study provides a comprehensive analysis of gene expression and bioinformatics data, offering important insights into the roles of fibroblasts in cardiac development. The large and well-analyzed single-cell RNA sequencing (scRNA-seq) dataset is compelling and a significant contribution to the field, and will be of broad interest to the scientific community.

Reviewed by eLife

The gut contractile organoid for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

1. Rei Yagasaki
2. Ryo Nakamura
3. Yuuki Shikaya
4. Ryosuke Tadokoro
5. Ruolin Hao
6. Zhe Wang
7. Mototsugu Eiraku
8. Masafumi Inaba
9. Yoshiko Takahashi

• Curated by eLife

  eLife Assessment

  This valuable study reports the development of a novel organoid system for studying the emergence of autorhythmic gut peristaltic contractions through the interaction between interstitial cells of Cajal and smooth muscle cells. The authors further utilized the system to provide convincing evidence for a previously unappreciated potential role for smooth muscle cells in regulating the firing rate of interstitial cells of Cajal. The work will be of interest to those studying development and physiology of the gut.

Reviewed by eLife

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

1. Leonid Peshkin
2. Enrico maria Daldello
3. Elizabeth S Van Itallie
4. Matthew Sonnett
5. Johannes Kreuzer
6. Wilhelm Haas
7. Marc W Kirschner
8. Catherine Jessus

• Curated by eLife

  eLife Assessment

  This important paper describes a comprehensive quantitative phospho-proteomic analysis of the meiotic progression of Xenopus oocytes. Using time-resolved proteomic analyses, the authors provide insights into changes in protein levels and phosphorylation states to an unprecedented depth, quality, and quantitative detail. The key findings are compelling and offer a helpful resource for the scientific community.

Reviewed by eLife

PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

1. Li He
2. Jiayu Wen
3. Qi Dai

• Curated by eLife

  eLife Assessment

  This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory mechanisms both in vivo and in vitro. The work will be of broad interest to researchers working on growth factor signaling mechanisms and vertebrate development.

Reviewed by eLife

NR2F2 is required in the embryonic testis for fetal Leydig cell development

1. Aitana Perea-Gomez
2. Natividad Bellido Carreras
3. Magali Dhellemmes
4. Furong Tang
5. Coralie Le Gallo
6. Marie-Christine Chaboissier

Reviewed by eLife

Meteorins regulate the formation of the left-right organizer and the establishment of vertebrate body asymmetry

1. Fanny Eggeler
2. Jonathan Boulanger-Weill
3. Flavia De Santis
4. Laura Belleri
5. Karine Duroure
6. Thomas O Auer
7. Shahad Albadri
8. Filippo Del Bene

• Curated by eLife

  eLife Assessment

  This study presents important insights into the regulation of left-right organ formation. By combining genetic perturbation of all three Meteorin genes in zebrafish and timelapse imaging, the authors identify an essential role for this protein family in the establishment of left-right patterning. They provide convincing evidence that Meteorins are required for the morphogenesis of dorsal forerunner cells, the precursors of the left-right organizer (also named Kupffer's vesicle) in zebrafish. In line with this, Meteorins were shown to genetically interact with integrins ItgaV and Itgb1b to regulate dorsal forerunner cell clustering.

Reviewed by eLife

Argonaute proteins regulate the timing of the spermatogenic transcriptional program

1. Maria de las Mercedes Carro
2. Alexis Dziubek
3. Amanda Touey
4. Elizabeth A. Popkowski
5. Mark Abdelmassih
6. Leah Simon
7. Stephanie Tanis
8. Faraz Ahmed
9. Jen K. Grenier
10. Andrew Grimson
11. Paula E. Cohen

Reviewed by Review Commons

Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila

1. LE Sánchez-Cisneros
2. M Barrera-Velázquez
3. Dimitri Kromm
4. P Bun
5. H Merchant-Larios
6. LD Ríos-Barrera

Reviewed by Review Commons