Developmental Biology

The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice

1. Atsuko Kageyama
2. Narumi Ogonuki
3. Takuya Wakai
4. Takafumi Namiki
5. Yui Kawata
6. Manabu Ozawa
7. Yasuhiro Yamada
8. Toshiyuki Fukada
9. Atsuo Ogura
10. Rafael Fissore
11. Naomi Kashiwazaki
12. Junya Ito

• Curated by eLife

  eLife Assessment

  This study presents significant and novel insights into the roles of zinc in mammalian meiosis/fertilization events. These findings are useful to our understanding of these processes. The evidence presented is solid, with experiments being well-designed, carefully described, and interpreted with appropriate rigor. The authors acknowledge the lack of mechanistic insight which represents the main limitation of the study.

Reviewed by eLife

Extracellular adenosine deamination primes tip organizer development in Dictyostelium

1. Pavani Hathi
2. Baskar Ramamurthy

• Curated by eLife

  eLife Assessment

  During the development of the unicellular eukaryote Dictyostelium discoideum, cells aggregate into mounds, forming protrusions or tips, which then become the front of migrating slugs and the top of fruiting bodies. This valuable study identifies adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation and convincingly shows that ADGF catalyses the conversion of adenosine to ammonia, allowing ammonia to initiate tip formation, and then elucidates pathways upstream and downstream of ADGF. The authors discuss the intriguing possibility that mammalian ADGF may also similarly regulate development.

Reviewed by eLife, Arcadia Science

Dissecting gene regulatory networks governing human cortical cell fate

1. Jingwen W. Ding
2. Chang N. Kim
3. Megan S. Ostrowski
4. Yashodara Abeykoon
5. Bryan J. Pavlovic
6. Jenelle L. Wallace
7. Nathan K. Schaefer
8. Tomasz J. Nowakowski
9. Alex A. Pollen

Reviewed by preLights

Complementary Volume Electron Microscopy-based approaches reveal ultrastructural changes in germline intercellular bridges of D. melanogaster

1. Irina Kolotuev
2. Abigayle Williams
3. Caroline Kizilyaprak
4. Stephanie Pellegrino
5. Lindsay Lewellyn

Reviewed by Review Commons

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

1. Tim Casey-Clyde
2. S John Liu
3. Angelo Pelonero
4. Juan Antonio Camara Serrano
5. Camilla Teng
6. Yoon-Gu Jang
7. Harish N Vasudevan
8. Arun Padmanabhan
9. Jeffrey Ohmann Bush
10. David R Raleigh

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable to determine changes in the cell type-specific gene expression during development. Results backed by solid evidence demonstrate that Eed is required for craniofacial osteoblast differentiation and mesenchymal proliferation after the induction of the neural crest.

Reviewed by eLife

Getting a head start: Craniofacial heterochrony in marsupials involves dynamic changes to molecular and cellular mechanisms underlying neural crest development

1. Axel H Newton
2. Ella R Farley
3. Andrew T Major
4. Jennifer C Hutchison
5. Ben M Lawrence
6. Karen E Sears
7. Marilyn B Renfree
8. Aiden M C Couzens
9. Geoff Shaw
10. Sara Ord
11. Richard A Schneider
12. Andrew J Pask

Reviewed by preLights

Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration

1. Victor M Lewis
2. Rafael A Fernandez
3. Samuel G Horst
4. Carlos A Gonzalez
5. Kryn Stankunas

• Curated by eLife

  eLife Assessment

  The results in this study are useful because they begin to establish a causal link between physical activity and the cellular mechanisms of regeneration. The evidence presented is largely solid, supporting the conclusion that exercise-induced changes in the extracellular matrix disrupt regeneration; however, some claims are incomplete, requiring additional controls and a clearer distinction between the effects of mechanical loading and mechanical injury to the blastema. The work will be of interest to researchers in regenerative medicine.

Reviewed by eLife

Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development

1. Alexandre Carayon
2. Helen Strutt
3. David Strutt

• Curated by eLife

  eLife Assessment

  This useful paper examined the mechanism of planar cell polarity (PCP) using Drosophila pupal wing, investigating how 'cellular level', 'molecular level' and 'tissue level' mechanisms intersect to establish PCP. This represents progress for the field and the conclusions are mostly backed up by solid data. Whereas the manuscript is sound overall, remaining concerns could be addressed by textual clarification of the concepts used in the manuscript.

  [Editors' note: this paper was reviewed by Review Commons and revised by the authors.]

Reviewed by eLife

Dachsous-Fat Signaling Shapes the Drosophila Wing through Mechanical Forces

1. Bipin Kumar Tripathi
2. Zhenru Zhou
3. Kenneth D. Irvine

Reviewed by Review Commons

ADAM interact with large protein complexes to regulate Histone modification, gene expression and splicing

1. Ankit Pandey
2. Helene Cousin
3. Shiv Kumar
4. Louis Taylor
5. Ashmita Chander
6. Kelsey Coppenrath
7. Nikko-Ideen Shaidani
8. Marko Horb
9. Dominique Alfandari

Reviewed by Review Commons