Developmental Biology

Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration

1. Victor M Lewis
2. Rafael A Fernandez
3. Samuel G Horst
4. Carlos A Gonzalez
5. Kryn Stankunas

• Curated by eLife

  eLife Assessment

  The results in this study are useful because they begin to establish a causal link between physical activity and the cellular mechanisms of regeneration. The evidence presented is largely solid, supporting the conclusion that exercise-induced changes in the extracellular matrix disrupt regeneration; however, some claims are incomplete, requiring additional controls and a clearer distinction between the effects of mechanical loading and mechanical injury to the blastema. The work will be of interest to researchers in regenerative medicine.

Reviewed by eLife

Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development

1. Alexandre Carayon
2. Helen Strutt
3. David Strutt

• Curated by eLife

  eLife Assessment

  This useful paper examined the mechanism of planar cell polarity (PCP) using Drosophila pupal wing, investigating how 'cellular level', 'molecular level' and 'tissue level' mechanisms intersect to establish PCP. This represents progress for the field and the conclusions are mostly backed up by solid data. Whereas the manuscript is sound overall, remaining concerns could be addressed by textual clarification of the concepts used in the manuscript.

  [Editors' note: this paper was reviewed by Review Commons and revised by the authors.]

Reviewed by eLife

Dachsous-Fat Signaling Shapes the Drosophila Wing through Mechanical Forces

1. Bipin Kumar Tripathi
2. Zhenru Zhou
3. Kenneth D. Irvine

Reviewed by Review Commons

ADAM interact with large protein complexes to regulate Histone modification, gene expression and splicing

1. Ankit Pandey
2. Helene Cousin
3. Shiv Kumar
4. Louis Taylor
5. Ashmita Chander
6. Kelsey Coppenrath
7. Nikko-Ideen Shaidani
8. Marko Horb
9. Dominique Alfandari

Reviewed by Review Commons

Corneal lens curvature depends on localized chitin secretion

1. Neha Ghosh
2. Jessica E. Treisman

Reviewed by Review Commons

HoxB-derived hoxba and hoxbb clusters are essential for the anterior–posterior positioning of zebrafish pectoral fins

1. Morimichi Kikuchi
2. Renka Fujii
3. Daiki Kobayashi
4. Yuki Kawabe
5. Haruna Kanno
6. Sohju Toyama
7. Farah Tawakkal
8. Kazuya Yamada
9. Akinori Kawamura

• Curated by eLife

  eLife Assessment

  This important study advances our understanding of vertebrate forelimb development, specifically the contribution of Hox genes to zebrafish pectoral fin formation. The authors have employed a robust and extensive genetic approach to tackle a key and unresolved question. The findings are overall convincing and will be of broad interest to developmental and evolutionary biologists.

Reviewed by eLife

Spectraplakin cooperates with noncentrosomal microtubule regulators to orient dendritic microtubules in Drosophila

1. Matthew Davies
2. Neeraja Sanal
3. Neele Wolterhoff
4. Ulrike Gigengack
5. Yitao Shen
6. Ines Hahn
7. Sebastian Rumpf

• Curated by eLife

  eLife Assessment

  Davies et al. present a valuable study proposing that Shot can act as a molecular linker between microtubules and actin during dendrite pruning, suggesting an intriguing role in non-centrosomal microtubule organization. However, the experimental evidence is incomplete and does not robustly support these claims, and the lack of a cohesive model connecting the findings weakens the overall impact. While the data suggest that Shot, actin, and microtubule nucleation contribute to dendritic pruning, their precise interplay remains unresolved.

Reviewed by eLife

ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility

1. Shuntai Yu
2. Guoliang Yin
3. Peng Jin
4. Weilin Zhang
5. Yingchao Tian
6. Xiaotong Xu
7. Tianyu Shao
8. Yushan Li
9. Fei Sun
10. Yun Zhu
11. Fengchao Wang

• Curated by eLife

  eLife Assessment

  This valuable study reports a critical role of the axonemal protein ANKRD5 in sperm motility and male fertility. Convincing data were presented to support the main conclusion. This work will be of interest to biomedical researchers who study ciliogenesis, sperm biology, and male fertility.

Reviewed by eLife

Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids

1. Kyoung Jo
2. Zong-Yuan Liu
3. Gauri Patel
4. Zhiyuan Yu
5. LiAng Yao
6. Seth Teague
7. Craig Johnson
8. Jason Spence
9. Idse Heemskerk

• Curated by eLife

  eLife Assessment

  This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence showing that endogenous FGF ligands, acting through FGF receptors localized basolaterally, are determinant in the acquisition of specific cell fates. These observations will be of broad relevance to the FGF field.

Reviewed by eLife

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo

1. Michelle Lohbihler
2. Amos A. Lim
3. Stéphane Massé
4. Maggie Kwan
5. Omar Mourad
6. Olya Mastikhina
7. Brandon M. Murareanu
8. Malak Elbatarny
9. Renu Sarao
10. Beiping Qiang
11. Wahiba Dhahri
12. Matthew L. Chang
13. Alice L.Y. Xu
14. Amine Mazine
15. Shahryar Khattak
16. Sara S. Nunes
17. Kumaraswamy Nanthakumar
18. Michael A. Laflamme
19. Stephanie Protze

Reviewed by preLights