1. Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

    This article has 11 authors:
    1. Haruna Gekko
    2. Ruri Nomura
    3. Daiki Kuzuhara
    4. Masato Kaneyasu
    5. Genpei Koseki
    6. Deepak Adhikari
    7. Yasuyuki Mio
    8. John Carroll
    9. Tomohiro Kono
    10. Hiroaki Funahashi
    11. Takuya Wakai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates the role of Drp1 in early embryo development. The authors have addressed most of the original comments and the work now presents convincing evidence on how this protein influences mitochondrial localization and partitioning during the first embryonic divisions. The research employs the Trim-Away technique to eliminate Drp1 in zygotes, revealing critical insights into mitochondrial clustering, spindle formation, and embryonic development.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  2. Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction

    This article has 6 authors:
    1. Aurélien Villedieu
    2. Olinda Alegria-Prévot
    3. Carole Phan
    4. Yu Ieda
    5. Francis Corson
    6. Jérôme Gros

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

    This article has 8 authors:
    1. Alwyn Dady
    2. Lindsay Davidson
    3. Nicolas Loyer
    4. Sophie Rappich
    5. Greg Findlay
    6. Timothy Sanders
    7. Jens Januschke
    8. Kate G. Storey

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Mechanical cues organize planar cell polarity during vertebrate morphogenesis and embryonic wound repair

    This article has 9 authors:
    1. Chih-Wen Chu
    2. Satheeja Velayudhan
    3. Jakob H. Schauser
    4. Sapna Krishnakumar
    5. Stephanie Yang
    6. Keiji Itoh
    7. Dominique Alfandari
    8. Ala Trusina
    9. Sergei Y. Sokol

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish

    This article has 6 authors:
    1. Yi Wang
    2. Thomas Nguyen
    3. Qingan He
    4. Oliver Has
    5. Kiarash Forouzesh
    6. Dae Seok Eom
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a valuable study showing that differentiated cells of the zebrafish skin form membrane protrusions called cytonemes that contact and likely transmit Notch signals to cells of the undifferentiated layer below. The data are convincing that cytoneme like protrusions from the periderm are required for proper periderm structure, proliferation, gene expression, and Notch signaling. Evidence that inflammatory signaling through IL-17 affects epidermal differentiation, Notch and cytoneme formation is solid, but whether these are through a single common or two parallel pathways requires further investigation.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Genetic compensation in podocalyxin-like mutants during zebrafish liver development

    This article has 8 authors:
    1. Alexis N Ross
    2. Natalie M Miscik
    3. Sharanya Maanasi Kalasekar
    4. James D Harris
    5. Mimi Tran
    6. Aavrati Saxena
    7. Steven Andrew Baker
    8. Kimberley Jane Evason
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript by Ross, Miscik, and others describes an intriguing series of observations made when investigating the requirement for podxl during hepatic development in zebrafish. Understanding how genetic compensation pathways are involved in gene function is an important question. However, there is incomplete evidence provided in the manuscript at this point to conclude that discrepancies between observed phenotypes are due to genetic compensation.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Glial betaPix is essential for blood vessel integrity in the zebrafish brain

    This article has 7 authors:
    1. ShihChing Chiu
    2. Qinchao Zhou
    3. Chenglu Xiao
    4. Linlu Bai
    5. Xiaojun Zhu
    6. Wanqiu Ding
    7. Jing-Wei Xiong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable manuscript presents findings supported by solid data to identify a surprising glia-exclusive function for betapix in vascular integrity and angiogenesis. The manuscript also describes the optimisation of a modified CRISPR-based Zwitch approach to generate conditional knockouts in zebrafish.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Organization of the apical extracellular matrix during tubular organ formation

    This article has 6 authors:
    1. J. Luke Woodward
    2. Jeffrey Matthew
    3. Rutuparna Joshi
    4. Vishakha Vishwakarma
    5. Ying Xiao
    6. SeYeon Chung

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. The essential role of connective-tissue cells during axolotl limb regeneration

    This article has 12 authors:
    1. Damián García-García
    2. Dunja Knapp
    3. Minjoo Kim
    4. Katelyn Jamwal
    5. Heath Fuqua
    6. Ryan P. Seaman
    7. Riley E. Grindle
    8. Sergej Nowoshilow
    9. Maria Novatchkova
    10. Fred W. Kolling
    11. Joel H. Graber
    12. Prayag Murawala

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

    This article has 9 authors:
    1. Katsuyuki Nishi
    2. Taro Sakamaki
    3. Akiomi Nagasaka
    4. Kevin S Kao
    5. Kay Sadaoka
    6. Masahide Asano
    7. Nobuyuki Yamamoto
    8. Akifumi Takaori-Kondo
    9. Masanori Miyanishi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable insights into the heterogeneity of hematopoietic stem cells and age-associated myeloid-biased hematopoiesis. While several aspects of the study are intriguing and merit further investigation, the current results remain incomplete and additional data are necessary to substantiate the conclusions. Some of the methods and data analyses partially support the claims.

    Reviewed by eLife, preLights

    This article has 15 evaluationsAppears in 2 listsLatest version Latest activity
Page 1 of 89 Next