1. Oviductin sets the species-specificity of the mammalian zona pellucida

    This article has 12 authors:
    1. Daniel de la Fuente
    2. Maria Maroto
    3. Yulia N Cajas
    4. Karina Cañón-Beltrán
    5. Raul Fernandez-Gonzalez
    6. Ana Munoz-Maceda
    7. Juana M Sanchez-Puig
    8. Rafael Blasco
    9. Paula Cots
    10. Manuel Aviles
    11. Dimitrios Rizos
    12. Alfonso Gutiérrez-Adán
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study unravels the mechanisms underlying mammalian sperm-oocyte recognition and penetration, shedding light on cross-species interactions. It provides solid evidence that exposure of sperm to oviductal fluid or OVGP1 proteins from bovine, murine, or human sources imparts species-specific zona pellucida (ZP) recognition, ensuring that only sperm from the corresponding species can penetrate the ZP, regardless of its origin. These findings hold significant potential for reproductive biology, offering insights to enhance porcine in vitro fertilization (IVF), which frequently suffers from polyspermy, as well as advancing human IVF through improved intrinsic sperm selection.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    This article has 11 authors:
    1. Pengzhen Dong
    2. Yue Li
    3. Yuying Wang
    4. Qiang Zhao
    5. Tianfeng Lu
    6. Jian Chen
    7. Tianyu Guo
    8. Jun Ma
    9. Bing Yang
    10. Honggang Wu
    11. Hai Huang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates how inter-organ communication between the tracheal stem cells and the fat body plays a key role in the directed migration of tracheal stem cells in Drosophila. The evidence supporting the claims of the authors is solid. The work would be of interest to researchers in the fields of developmental biology and cancer biology.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Modularity of the segmentation clock and morphogenesis

    This article has 3 authors:
    1. James E. Hammond
    2. Ruth E. Baker
    3. Berta Verd

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

    This article has 12 authors:
    1. Joseph A Bisson
    2. Miriam Gordillo
    3. Ritu Kumar
    4. Neranjan de Silva
    5. Ellen Yang
    6. Kelly M Banks
    7. Zhong-Dong Shi
    8. Kihyun Lee
    9. Dapeng Yang
    10. Wendy K Chung
    11. Danwei Huangfu
    12. Todd Evans
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates the function of a critical regulator of human early cardiac development. The convincing examination of GATA6 function is thorough and well-executed. The study will be of interest to scientists working on how the human heart acquires its identity.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

    This article has 19 authors:
    1. Denise Ragusa
    2. Chun-Wai Suen
    3. Gabriel Torregrosa-Cortés
    4. Fabio Pastorino
    5. Ayona Johns
    6. Ylenia Cicirò
    7. Liza Dijkhuis
    8. Susanne van den Brink
    9. Michele Cilli
    10. Connor Byrne
    11. Giulia-Andreea Ionescu
    12. Joana Cerveira
    13. Kamil R Kranc
    14. Victor Hernandez-Hernandez
    15. Mirco Ponzoni
    16. Anna Bigas
    17. Jordi Garcia-Ojalvo
    18. Alfonso Martinez Arias
    19. Cristina Pina
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate because the primary claims are not supported. Overall, the hematopoietic progenitor cells generated in this system need to be better defined.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    This article has 17 authors:
    1. Ruben Sebastian-Perez
    2. Shoma Nakagawa
    3. Xiaochuan Tu
    4. Sergi Aranda
    5. Martina Pesaresi
    6. Pablo Aurelio Gomez-Garcia
    7. Marc Alcoverro-Bertran
    8. Jose Luis Gomez-Vazquez
    9. Davide Carnevali
    10. Eva Borràs
    11. Eduard Sabidó
    12. Laura Martin
    13. Malka Nissim-Rafinia
    14. Eran Meshorer
    15. Maria Victoria Neguembor
    16. Luciano Di Croce
    17. Maria Pia Cosma
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study examines heterochromatin domain dynamics using a model system that allows reversible transition from an embryonic stem cell to a 2-cell-like state. The authors present a solid resource to the research community that will further the understanding of changes in the chromatin-bound proteome during the 2C-to-ESC transition. However, conclusions related to the functional roles of the interaction between the SWI/SNF complex component SMARCAD1 and the DNA Topoisomerase II Binding protein (TOPBP1) remain incomplete.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition

    This article has 6 authors:
    1. Yuhkoh Satouh
    2. Takaki Tatebe
    3. Isei Tanida
    4. Junji Yamaguchi
    5. Yasuo Uchiyama
    6. Ken Sato
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper reports important findings on giant organelle complexes containing endosomes and lysosomes (termed endosomal-lysosomal organelles form assembly structures [ELYSAs]) present in mouse oocytes and 1- to 2-cell embryos. The data showing the localization and dynamics of ELYSAs during oocyte/embryo maturation are convincing. This work will be of interest to general cell biologists and developmental biologists.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

    This article has 5 authors:
    1. Igor Kondrychyn
    2. Liqun He
    3. Haymar Wint
    4. Christer Betsholtz
    5. Li-Kun Phng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study convincingly shows that aquaporin-mediated cell migration plays a key role in blood vessel formation during zebrafish development. In particular, the paper implicates hydrostatic pressure and water flow as mechanisms controlling endothelial cell migration during angiogenic sprouting. This fundamental study is highly novel and significantly advances our understanding of cell migration during morphogenesis. As such, this work will be of great interest to developmental and cell biologists working on organogenesis, angiogenesis, and cell migration.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

    This article has 8 authors:
    1. Kayleigh Bozon
    2. Hartmut Cuny
    3. Delicia Z Sheng
    4. Ella MMA Martin
    5. Alena Sipka
    6. Paul Young
    7. David T Humphreys
    8. Sally L Dunwoodie
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      NAD deficiency perturbs embryonic development resulting in multiple congenital malformations, collectively termed Congenital NAD Deficiency Disorder (CNDD). The authors report fundamental findings demonstrating that extra-embryonic visceral yolk sac endoderm is critical for NAD de novo synthesis during early organogenesis and perturbations of this pathway may underlie CNDD. The authors combine gene expression with metabolic assays to provide solid evidence of an essential role of the extra-embryonic visceral yolk sac in both mouse and human embryos.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    This article has 8 authors:
    1. Adriana K Alexander
    2. Karina F Rodriguez
    3. Yu-Ying Chen
    4. Ciro M Amato
    5. Martin A Estermann
    6. Barbara Nicol
    7. Xin Xu
    8. Humphrey Hung-Chang Yao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, which will be of interest to developmental and reproductive biologists, as well as andrologists, are supported by convincing data.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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