1. Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

    This article has 12 authors:
    1. Justine Bajohr
    2. Erica Y. Scott
    3. Arman Olfat
    4. Mehrshad Sadria
    5. Kevin Lee
    6. Maria Fahim
    7. Hiba T. Taha
    8. Daniela Lozano Casasbuenas
    9. Ann Derham
    10. Scott A. Yuzwa
    11. Gary D. Bader
    12. Maryam Faiz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides a useful advance in generating mouse oligodendrocytes by direct lineage conversion from cortical astrocytes. The authors demonstrate that Sox10 converts astrocytes to MBP+ oligodendrocytes, whereas Olig2 expression converts astrocytes to PDFRalpha+ oligodendrocyte progenitor cells. The data supporting the conclusions are solid, but there are concerns regarding select figures and the experiments being limited to in vitro studies.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects

    This article has 15 authors:
    1. Archana Kamalakar
    2. Brendan Tobin
    3. Sundus Kaimari
    4. M Hope Robinson
    5. Afra I Toma
    6. Timothy Cha
    7. Samir Chihab
    8. Irica Moriarity
    9. Surabhi Gautam
    10. Pallavi Bhattaram
    11. Shelly Abramowicz
    12. Hicham Drissi
    13. Andrés J García
    14. Levi B Wood
    15. Steven L Goudy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Therapeutic treatments for congenital and acquired craniofacial (CF) bone abnormalities are not well developed. This study provides convincing evidence for an innovative regenerative treatment for pediatric craniofacial bone loss using Jagged1-PEG-MAL hydrogel with pediatric human bone cells. The report is a valuable advance in this field.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

    This article has 9 authors:
    1. Emily Delgouffe
    2. Samuel Madureira Silva
    3. Frédéric Chalmel
    4. Wilfried Cools
    5. Camille Raets
    6. Kelly Tilleman
    7. Guy T’Sjoen
    8. Yoni Baert
    9. Ellen Goossens
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents new knowledge of the spermatogonial stem cell (SSC) niche in trans women after gender-affirming hormone therapy (GAHT). The evidence supporting the claims is convincing. The work will be of interest to researchers and clinicians working in the field of reproductive medicine and andrology.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  4. FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

    This article has 8 authors:
    1. Yuki Kaneda
    2. Haruhiko Miyata
    3. Zoulan Xu
    4. Keisuke Shimada
    5. Maki Kamoshita
    6. Tatsuya Nakagawa
    7. Chihiro Emori
    8. Masahito Ikawa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports that FBXO24 is essential for the normal formation and function of the sperm flagellum, motility, and male fertility in mice. The evidence supporting the direct role of this protein in preventing RNP granule formation in the sperm flagellum is compelling. This work will be of interest to biomedical researchers who work on testicular biology and male fertility.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Gestational exposure to high heat-humidity conditions impairs mouse embryonic development

    This article has 3 authors:
    1. Avinchal Manhas
    2. Amritesh Sarkar
    3. SRIMONTA GAYEN

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Dynamic readout of the Hh gradient in the Drosophila wing disc reveals pattern-specific tradeoffs between robustness and precision

    This article has 3 authors:
    1. Rosalío Reyes
    2. Arthur D. Lander
    3. Marcos Nahmad
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the precision conferred by dynamical interpretation of morphogen gradients. The evidence supporting the claims of the authors is convincing, with compelling theoretical analysis and solid yet incomplete experimental data. With the experimental part strengthened, the work could be of interest to the developmental biology and developmental systems biology communities.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. BMP signalling facilitates transit amplification in the developing chick and human cerebellum

    This article has 5 authors:
    1. Victoria Rook
    2. Parthiv Haldipur
    3. Kathleen J Millen
    4. Thomas Butts
    5. Richard J Wingate
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study investigates BMP signaling mechanisms in the developing chick cerebellum to better understand germinal layer formation, cellular amplification and neuronal differentiation. The data from human tissue is compelling and lends support to the possible links of these processes to medulloblastoma, although this study does raise exciting questions regarding the generalized role of BMP signaling during normal development and malignant growth. Overall, this is an important study with beautifully presented findings.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

    This article has 9 authors:
    1. Rei Yagasaki
    2. Ryo Nakamura
    3. Yuuki Shikaya
    4. Ryosuke Tadokoro
    5. Ruolin Hao
    6. Zhe Wang
    7. Mototsugu Eiraku
    8. Masafumi Inaba
    9. Yoshiko Takahashi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study reports the development of a novel organoid system for studying the emergence of autorhythmic gut peristaltic contractions through the interaction between interstitial cells of Cajal and smooth muscle cells. While the utility of the organoids for studying hindgut development is well illustrated by showing, for example, a previously unappreciated potential role for smooth muscle cells in regulating the firing rate of interstitial cells of Cajal, some of the functional analyses are incomplete. There are some concerns about the specificity and penetrance of perturbations and the reproducibility of the phenotypes. With these concerns properly addressed, this paper will be of interest to those studying the development and physiology of the gut.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

    This article has 13 authors:
    1. Jing Wang
    2. Yingying Yin
    3. Lei Yang
    4. Junchao Qin
    5. Zixiang Wang
    6. Chunhong Qiu
    7. Yuan Gao
    8. Gang Lu
    9. Fei Gao
    10. Zi-jiang Chen
    11. Xiyu Zhang
    12. Hongbin Liu
    13. Zhaojian Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reports an important discovery highlighting the essential role of the putative ion channel, TMC7, in acrosome formation during sperm development and thus male fertility. The evidence for the requirement of TMC7 in acrosome biogenesis and sperm function is convincing, although its function as an ion channel remains to be further determined. Overall, this work will be of great interest to developmental biologists and ion channel physiologists alike.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  10. The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

    This article has 7 authors:
    1. Syeda Nayab Fatima Abidi
    2. Sara Chan
    3. Kerstin Seidel
    4. Daniel Lafkas
    5. Louis Vermeulen
    6. Frank Peale
    7. Christian W Siebel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work aimed at deconstructing how sebaceous gland differentiation is controlled in adult skin. Using monoclonal antibodies designed to inhibit specific Notch ligands or receptors, the authors present solid evidence that the Jag2/Notch1 signaling axis is a crucial regulator of sebocyte progenitor proliferation and sebocyte differentiation. The valuable findings presented here contribute to the growing evidence that Notch signaling not only plays a role during the development of the skin and its appendages but also regulates cell fate in adult homeostatic tissues. From a translational perspective, it is intriguing that the effect of Jag2 or Notch1 inhibition, which leads to the accumulation of proliferative stem/progenitor cells in the sebaceous gland and prevents sebocyte differentiation, is reversible.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity