Cell Biology

SLC25A46 localizes to sites of mitochondrial fission and fusion and loss of function variants alter the oligomerization states of MFN2 and OPA1

1. Jana Schuettpelz
2. Alexandre Janer
3. Hana Antonicka
4. Eric A. Shoubridge

Reviewed by Review Commons

Testing the ion-current model for flagellar length sensing and IFT regulation

1. Hiroaki Ishikawa
2. Jeremy Moore
3. Dennis R Diener
4. Markus Delling
5. Wallace F Marshall

• Curated by eLife

  eLife assessment

  This paper is valuable and of interest to scientists studying primary cilia/flagellar formation and regulation. It addresses how ciliary/flagellar length is controlled and whether calcium negatively regulates Intraflagellar transport (IFT) injection. The study convincingly demonstrates that calcium influx correlates with flagellar length, but calcium does not appear to work as a negative regulator of IFT injection, which challenges a previous model. The models and methods are generally sound, but some conclusions would be strengthened by additional experimental support.

Reviewed by eLife

Widespread nuclear lamina injuries defeat proteostatic purposes of α-synuclein amyloid inclusions

1. Shemin Mansuri
2. Aanchal Jain
3. Richa Singh
4. Shivali Rawat
5. Debodyuti Mondal
6. Swasti Raychaudhuri

Reviewed by Review Commons

Patch repair protects cells from the small pore-forming toxin aerolysin

1. Roshan Thapa
2. Peter A. Keyel

Reviewed by Review Commons

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes

1. Zihan Zhu
2. Isabelle Becam
3. Corinne A. Tovey
4. Eugenie C. Yen
5. Fred Bernard
6. Antoine Guichet
7. Paul T. Conduit

Reviewed by Review Commons

Redox regulation of KV7 channels through EF3 hand of calmodulin

1. Eider Nuñez
2. Frederick Jones
3. Arantza Muguruza-Montero
4. Janire Urrutia
5. Alejandra Aguado
6. Covadonga Malo
7. Ganeko Bernardo-Seisdedos
8. Carmen Domene
9. Oscar Millet
10. Nikita Gamper
11. Alvaro Villarroel

• Curated by eLife

  eLife assessment

  Oxidation regulation of neuronal Kv7 channels contributes to the regulation of brain excitability. The manuscript concludes that this regulation is due to a disruption of the interaction between the S2S3 linker of Kv7 with the CaM EF3 site. The proposed mechanism is potentially important, but there are several weaknesses with the presentation and interpretation of the data that need to be addressed.

Reviewed by eLife

BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes

1. Samuel JP Taylor
2. Laura Bel Borja
3. Flavie Soubigou
4. Jack Houston
5. Dhanya K Cheerambathur
6. Federico Pelisch

• Curated by eLife

  eLife assessment

  This fundamental work addresses the role of the mitotic kinase PLK-1 in meiosis, using C. elegans as a model system. The valuable findings are convincing and combine beautiful cell biology and biochemical assays. The work will be of broad interest to people working on Plk1 and/or in meiosis in many different systems.

Reviewed by eLife

Centriolar subdistal appendages promote double strand break repair through homologous recombination

1. Guillermo Rodríguez-Real
2. Andrés Domínguez-Calvo
3. Rosario Prados-Carvajal
4. Aleix Bayona-Feliú
5. Sónia Gomes-Pereira
6. Fernando R. Balestra
7. Pablo Huertas

Reviewed by Review Commons

ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous Component

1. Henna Ilmonen
2. Suvi Jauhiainen
3. Pia Vuola
4. Heta Rasinkangas
5. Heidi H Pulkkinen
6. Sara Keränen
7. Miika Kiema
8. Jade J Liikkanen
9. Nihay Laham-Karam
10. Svetlana Laidinen
11. Einari Aavik
12. Kimmo Lappalainen
13. Jouko Lohi
14. Johanna Aronniemi
15. Tiit Örd
16. Minna U Kaikkonen
17. Päivi Salminen
18. Erkki Tukiainen
19. Seppo Ylä-Herttuala
20. Johanna P Laakkonen

• Curated by eLife

  eLife assessment

  The authors address an important clinical entity and an important area of unmet clinical need. The authors use a combination of in vitro and in vivo experiments to learn how stromal cells surrounding vessels in venous malformations (VM) and angiomatosis of soft tissue (AST) contribute to the angiogenic activities driving the vascular lesions. They discovered that secretion of transforming growth factor-alpha (TGFa) from both endothelial cells and stromal cells, shows evidence for EGF-receptor phosphorylation. In addition, they show that afatinib, a pan-ErbB TKI inhibitor may have therapeutic benefits.

Reviewed by eLife

The filipodia-like protrusions of adjacent somatic cells shape the developmental potential of mouse oocytes

1. Flora Crozet
2. Gaëlle Letort
3. Christelle Da Silva
4. Adrien Eichmuller
5. Anna Francesca Tortorelli
6. Morgane Belle
7. Julien Dumont
8. Tristan Piolot
9. Aurélien Dauphin
10. Fanny Coulpier
11. Alain Chédotal
12. Jean-Léon Maître
13. Marie-Hélène Verlhac
14. Hugh.J Clarke
15. Marie-Emilie Terret

Reviewed by Review Commons