Cell Biology

Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

1. Kazuki Inoue
2. Yongli Qin
3. Yuhan Xia
4. Jie Han
5. Ruoxi Yuan
6. Jun Sun
7. Ren Xu
8. Jean X Jiang
9. Matthew B Greenblatt
10. Baohong Zhao

• Curated by eLife

  eLife assessment

  This paper is of interest for skeletal biologists studying bone marrow stem/progenitor cells and bone remodeling. Using Adipoq-Cre-driven conditional deletion of Csf1 that encodes M-CSF and reanalyzing publicly available scRNAseq data, the authors recognize a subpopulation of bone marrow cells (i.e. AdipoQ-lineage progenitors) as an important source of M-CSF. The authors found that M-CSF production from these bone marrow cells influences the development of macrophages and osteoclasts as well as bone mass, including the bone loss associated with estrogen deficiency. This is a clearly written and nicely presented study that has potential to offer important new information regarding the source of M-CSF in the bone marrow.

Reviewed by eLife

Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeast

1. Nikolay Kornakov
2. Stefan Westermann

Reviewed by Review Commons