Cell Biology

Lipid homeostasis is essential for a maximal ER stress response

1. Gilberto Garcia
2. Hanlin Zhang
3. Sophia Moreno
4. C Kimberly Tsui
5. Brant Michael Webster
6. Ryo Higuchi-Sanabria
7. Andrew Dillin

• Curated by eLife

  eLife assessment

  This valuable study addresses the anticipated but poorly understood interconnections between ER proteostasis and lipid metabolism. The authors discovered key metabolic enzymes required for integration of ER stress and lipid synthesis and followed up with several direct experiments that provide solid evidence for a broad conservation of the described interactions.

Reviewed by eLife

Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

1. Ines Hernandez-Perez
2. Javier Rubio
3. Adrian Baumann
4. Henrique Girao
5. Miriam Ferrando
6. Elena Rebollo
7. Anna M Aragay
8. María Isabel Geli

• Curated by eLife

  eLife assessment

  Hernandez-Perez et al. perform a detailed analysis of Kazrin, a widely expressed protein that appears to be involved in many diverse cellular processes, but whose exact function is unknown. The authors employ mouse embryonic fibroblasts and biochemistry to investigate the function of Kazrin and determine that Kazrin promotes the dynein/dynactin-dependent transport of early endosomes. These findings are valuable to those in the field of intracellular transport, but the story will benefit from additional experiments to prove the main claims, or from textual modifications.

Reviewed by eLife

The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts

1. Han Nim Lee
2. Jenu Varghese Chacko
3. Ariadna Gonzalez Solís
4. Kuo-En Chen
5. Jessica AS Barros
6. Santiago Signorelli
7. A Harvey Millar
8. Richard David Vierstra
9. Kevin W Eliceiri
10. Marisa S Otegui

• Curated by eLife

  eLife assessment

  In this important study, the role of NBR1 in the degradation of photodamaged chloroplasts is analyzed, advancing our knowledge of chloroplast homeostasis in response to environmental stress. The evidence presented is convincing, in some parts even compelling, and the results are valuable for the plant and the autophagy research community.

Reviewed by eLife

The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction

1. Khairunnisa M. Semesta
2. Angelica Garces
3. Nikoleta G. Tsvetanova

Reviewed by Life Science Editors Foundation, Review Commons

Mechanisms and physiological function of daily haemoglobin oxidation rhythms in red blood cells

1. Andrew D Beale
2. Edward A Hayter
3. Priya Crosby
4. Utham K Valekunja
5. Rachel S Edgar
6. Johanna E Chesham
7. Elizabeth S Maywood
8. Fatima H Labeed
9. Akhilesh B Reddy
10. Kenneth P Wright
11. Kathryn S Lilley
12. David A Bechtold
13. Michael H Hastings
14. John S O'Neill

Reviewed by Review Commons

Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

1. Rafael Soares Godoy
2. Nicholas D Cober
3. David P Cook
4. Emma McCourt
5. Yupu Deng
6. Liyuan Wang
7. Kenny Schlosser
8. Katelynn Rowe
9. Duncan J Stewart

• Curated by eLife

  eLife Assessment:

  The manuscript by Godoy and colleagues is an important contribution to the understanding of how lung endothelial regeneration progresses following endothelial ablation. The novelty and elegance of this study are rooted in the regional and specific ablation of lung endothelial cells using diphtheria toxin without the massive inflammatory activation that is seen with lung injury induced by bacterial infections, viral infections, or lipopolysaccharide. The data convincingly demonstrate that there is an emergence of a highly proliferative lung endothelial subpopulation that drives endothelial regeneration. The translational implications of the study include the identification of potential therapeutic targets to augment endothelial regeneration as a treatment for ALI/ARDS. This study will be of interest to vascular biologists, lung biologists, and researchers studying adult tissue regeneration.

Reviewed by eLife

Adenoviral chromatin organization primes for early gene activation

1. Uwe Schwartz
2. Tetsuro Komatsu
3. Claudia Huber
4. Floriane Lagadec
5. Conradin Baumgartl
6. Elisabeth Silberhorn
7. Margit Nuetzel
8. Fabienne Rayne
9. Eugenia Basyuk
10. Edouard Bertrand
11. Michael Rehli
12. Harald Wodrich
13. Gernot Laengst

Reviewed by Review Commons

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

1. Jonas R Knudsen
2. Kaspar W Persson
3. Carlos Henriquez-Olguin
4. Zhencheng Li
5. Nicolas Di Leo
6. Sofie A Hesselager
7. Steffen H Raun
8. Janne R Hingst
9. Raphaël Trouillon
10. Martin Wohlwend
11. Jørgen FP Wojtaszewski
12. Martin AM Gijs
13. Thomas Elbenhardt Jensen

• Curated by eLife

  eLife assessment

  This paper provides strong evidence for the important point that microtubule function is required for the proper localization of Glut4 glucose transporters in an insulin responsive compartment. This membrane localization is required in turn for effective translocation of Glut4 to the muscle cell surface in response to the hormone.

Reviewed by eLife

De novo serine biosynthesis is protective in mitochondrial disease

1. Christopher B Jackson
2. Anastasiia Marmyleva
3. Ryan Awadhpersad
4. Geoffray Monteuuis
5. Takayuki Mito
6. Nicola Zamboni
7. Takashi Tatsuta
8. Amy E. Vincent
9. Liya Wang
10. Thomas Langer
11. Christopher J Carroll
12. Anu Suomalainen

Reviewed by Review Commons

An in silico FSHD muscle fiber for modeling DUX4 dynamics and predicting the impact of therapy

1. Matthew V Cowley
2. Johanna Pruller
3. Massimo Ganassi
4. Peter S Zammit
5. Christopher RS Banerji

Reviewed by Review Commons