Cell Biology

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

1. Valerie Perea
2. Christian Cole
3. Justine Lebeau
4. Vivian Dolina
5. Kelsey R Baron
6. Aparajita Madhavan
7. Jeffery W Kelly
8. Danielle A Grotjahn
9. R Luke Wiseman

Reviewed by Review Commons

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

1. Danielle B Buglak
2. Pauline Bougaran
3. Molly R Kulikauskas
4. Ziqing Liu
5. Elizabeth Monaghan-Benson
6. Ariel L Gold
7. Allison P Marvin
8. Andrew Burciu
9. Natalie T Tanke
10. Morgan Oatley
11. Shea N Ricketts
12. Karina Kinghorn
13. Bryan N Johnson
14. Celia E Shiau
15. Stephen Rogers
16. Christophe Guilluy
17. Victoria L Bautch

• Curated by eLife

  eLife assessment

  Endothelial cells mediate the growth of the vascular system, but they also need to prevent vascular leakage, which involves interactions with neighboring endothelial cells through junctional protein complexes. This important study provides a full mechanistic insight into how Sun1 is achieving its function, which supports the concept that nuclear anchoring is critical for proper mechanosensing and junctional organization. Although the evidence supporting the claims of the authors is solid and there are several merits and strengths in this study, a weakness is that some important controls are missing. The work will be of broad interest to cell biologists and vascular biologists.

Reviewed by eLife

Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles

1. Yunsheng Zhang
2. Nana Ding
3. Yizhen Li
4. Xiaoyun Zhao
5. Shiping Yang
6. Ping Fu
7. Yousong Peng
8. Haojie Cheng
9. Min Ouyang
10. Ruiping Wang
11. Yu Wang
12. Hanyun Liu
13. Yan Chen
14. Xiaoqin Huang
15. Li Yu
16. Yongjun Tan

Reviewed by Life Science Editors

Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles

1. Xia Li
2. Dongmei Liu
3. Eric Griffis
4. Peter Novick

Reviewed by Review Commons

Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans

1. Chen Lesnik
2. Rachel Kaletsky
3. Jasmine M. Ashraf
4. Salman Sohrabi
5. Vanessa Cota
6. Titas Sengupta
7. William Keyes
8. Shijing Luo
9. Coleen T. Murphy

Reviewed by Life Science Editors

Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

1. Erika Cecon
2. Atsuro Oishi
3. Marine Luka
4. Delphine Ndiaye-Lobry
5. Arnaud François
6. Mathias Lescuyer
7. Fany Panayi
8. Julie Dam
9. Patricia Machado
10. Ralf Jockers

• Curated by eLife

  eLife assessment

  Understanding specific tau-tau interactions that play key roles in Alzheimer's disease and tauopathies will enable the elucidation of the toxic tau species involved in the pathogenesis of these diseases and therapeutic development in this area. In this paper, the authors developed a series of NanoBiT complementation-based tau biosensors to monitor tau intramolecular and intermolecular interactions. This paper will be of high interest to a broad target audience including researchers in the field of biophysics, biochemistry, cell biology, neuroscience, neuropathology, and drug discovery as well as physicians.

Reviewed by eLife

The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

1. Vikrant K Bhosle
2. Chunxiang Sun
3. Sajedabanu Patel
4. Tse Wing Winnie Ho
5. Johannes Westman
6. Dustin A Ammendolia
7. Fatemeh Mirshafiei Langari
8. Noah Fine
9. Nicole Toepfner
10. Zhubing Li
11. Manraj Sharma
12. Judah Glogauer
13. Mariana I Capurro
14. Nicola L Jones
15. Jason T Maynes
16. Warren L Lee
17. Michael Glogauer
18. Sergio Grinstein
19. Lisa A Robinson

Reviewed by Review Commons

Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner

1. Udo N. Onwubiko
2. Dhanya Kalathil
3. Emma Koory
4. Sahara Pokharel
5. Hayden Roberts
6. Ahmad Mitoubsi
7. Maitreyi Das

Reviewed by Review Commons

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

1. Kunli Zhao
2. Kohichi Matsunaga
3. Kouichi Mizuno
4. Hao Wang
5. Katsuhide Okunishi
6. Tetsuro Izumi

• Curated by eLife

  eLife assessment

  This is a well-done study to understand how Rab27 and its effectors regulate insulin secretion. The present work examines the relative hierarchy of exophilin-8 and melanophilin using single vs double knockouts and rescue experiments to show that melanophilin functions downstream of and potentially redundantly from Exo8. Imaging and protein co-localization studies were done in a rigorous way. The data are solid, and some additional data will make the work fully compelling. Overall this is an important study that sheds new light on the regulation of insulin granule exocytosis.

Reviewed by eLife

Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

1. Yufei Jiang
2. Yan He
3. Songting Liu
4. Gaizhen Li
5. Dunjin Chen
6. Wenbo Deng
7. Ping Li
8. Ying Zhang
9. Jinxiang Wu
10. Jianing Li
11. Longmei Wang
12. Jiajing Lin
13. Haibin Wang
14. Shuangbo Kong
15. Guixiu Shi

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the role and function of the Gaq axis on the inflammatory response during decidualization essential for early pregnancy. The evidence supporting the claims of the authors is solid, although some of the methodology and data interpretation require further clarification and justification. The work will be of interest to reproductive biologists and clinicians.

Reviewed by eLife