Cell Biology

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

1. Ruina Luan
2. Ge Sun
3. Baosheng Zhou
4. Manlin Wang
5. Yu Bai
6. Chunyu Wang
7. Shengli Wang
8. Kai Zeng
9. Jianwei Feng
10. Mingcong He
11. Lin Lin
12. Yuntao Wei
13. Qiang Zhang
14. Yue Zhao

Reviewed by Review Commons

Continuous muscle, glial, epithelial, neuronal, and hemocyte cell lines for Drosophila research

1. Nikki Coleman-Gosser
2. Yanhui Hu
3. Shiva Raghuvanshi
4. Shane Stitzinger
5. Weihang Chen
6. Arthur Luhur
7. Daniel Mariyappa
8. Molly Josifov
9. Andrew Zelhof
10. Stephanie E Mohr
11. Norbert Perrimon
12. Amanda Simcox

• Curated by eLife

  eLife assessment

  This useful work describes the establishment and characterization of new cell lines derived from specific tissues of the fruit fly Drosophila. The evidence supporting the claims of the authors is solid, although the characterization of the cell lines is incomplete and the genomic findings are not presented in a user-friendly manner. These lines could be a useful resource that complements in vivo Drosophila genetics, improving biochemistry and facilitating high-throughput screening.

Reviewed by eLife

PERK signaling promotes mitochondrial elongation by remodeling membrane phosphatidic acid

1. Valerie Perea
2. Christian Cole
3. Justine Lebeau
4. Vivian Dolina
5. Kelsey R Baron
6. Aparajita Madhavan
7. Jeffery W Kelly
8. Danielle A Grotjahn
9. R Luke Wiseman

Reviewed by Review Commons

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

1. Danielle B Buglak
2. Pauline Bougaran
3. Molly R Kulikauskas
4. Ziqing Liu
5. Elizabeth Monaghan-Benson
6. Ariel L Gold
7. Allison P Marvin
8. Andrew Burciu
9. Natalie T Tanke
10. Morgan Oatley
11. Shea N Ricketts
12. Karina Kinghorn
13. Bryan N Johnson
14. Celia E Shiau
15. Stephen Rogers
16. Christophe Guilluy
17. Victoria L Bautch

• Curated by eLife

  eLife assessment

  Endothelial cells mediate the growth of the vascular system, but they also need to prevent vascular leakage, which involves interactions with neighboring endothelial cells through junctional protein complexes. This important study provides a full mechanistic insight into how Sun1 is achieving its function, which supports the concept that nuclear anchoring is critical for proper mechanosensing and junctional organization. Although the evidence supporting the claims of the authors is solid and there are several merits and strengths in this study, a weakness is that some important controls are missing. The work will be of broad interest to cell biologists and vascular biologists.

Reviewed by eLife

Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles

1. Yunsheng Zhang
2. Nana Ding
3. Yizhen Li
4. Xiaoyun Zhao
5. Shiping Yang
6. Ping Fu
7. Yousong Peng
8. Haojie Cheng
9. Min Ouyang
10. Ruiping Wang
11. Yu Wang
12. Hanyun Liu
13. Yan Chen
14. Xiaoqin Huang
15. Li Yu
16. Yongjun Tan

Reviewed by Life Science Editors

Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles

1. Xia Li
2. Dongmei Liu
3. Eric Griffis
4. Peter Novick

Reviewed by Review Commons

Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans

1. Chen Lesnik
2. Rachel Kaletsky
3. Jasmine M. Ashraf
4. Salman Sohrabi
5. Vanessa Cota
6. Titas Sengupta
7. William Keyes
8. Shijing Luo
9. Coleen T. Murphy

Reviewed by Life Science Editors

Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

1. Erika Cecon
2. Atsuro Oishi
3. Marine Luka
4. Delphine Ndiaye-Lobry
5. Arnaud François
6. Mathias Lescuyer
7. Fany Panayi
8. Julie Dam
9. Patricia Machado
10. Ralf Jockers

• Curated by eLife

  eLife assessment

  Understanding specific tau-tau interactions that play key roles in Alzheimer's disease and tauopathies will enable the elucidation of the toxic tau species involved in the pathogenesis of these diseases and therapeutic development in this area. In this paper, the authors developed a series of NanoBiT complementation-based tau biosensors to monitor tau intramolecular and intermolecular interactions. This paper will be of high interest to a broad target audience including researchers in the field of biophysics, biochemistry, cell biology, neuroscience, neuropathology, and drug discovery as well as physicians.

Reviewed by eLife

The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

1. Vikrant K Bhosle
2. Chunxiang Sun
3. Sajedabanu Patel
4. Tse Wing Winnie Ho
5. Johannes Westman
6. Dustin A Ammendolia
7. Fatemeh Mirshafiei Langari
8. Noah Fine
9. Nicole Toepfner
10. Zhubing Li
11. Manraj Sharma
12. Judah Glogauer
13. Mariana I Capurro
14. Nicola L Jones
15. Jason T Maynes
16. Warren L Lee
17. Michael Glogauer
18. Sergio Grinstein
19. Lisa A Robinson

Reviewed by Review Commons

Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner

1. Udo N. Onwubiko
2. Dhanya Kalathil
3. Emma Koory
4. Sahara Pokharel
5. Hayden Roberts
6. Ahmad Mitoubsi
7. Maitreyi Das

Reviewed by Review Commons