Cell Biology

Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation

1. Rafael Soares Godoy
2. Nicholas D Cober
3. David P Cook
4. Emma McCourt
5. Yupu Deng
6. Liyuan Wang
7. Kenny Schlosser
8. Katelynn Rowe
9. Duncan J Stewart

• Curated by eLife

  eLife Assessment:

  The manuscript by Godoy and colleagues is an important contribution to the understanding of how lung endothelial regeneration progresses following endothelial ablation. The novelty and elegance of this study are rooted in the regional and specific ablation of lung endothelial cells using diphtheria toxin without the massive inflammatory activation that is seen with lung injury induced by bacterial infections, viral infections, or lipopolysaccharide. The data convincingly demonstrate that there is an emergence of a highly proliferative lung endothelial subpopulation that drives endothelial regeneration. The translational implications of the study include the identification of potential therapeutic targets to augment endothelial regeneration as a treatment for ALI/ARDS. This study will be of interest to vascular biologists, lung biologists, and researchers studying adult tissue regeneration.

Reviewed by eLife

Adenoviral chromatin organization primes for early gene activation

1. Uwe Schwartz
2. Tetsuro Komatsu
3. Claudia Huber
4. Floriane Lagadec
5. Conradin Baumgartl
6. Elisabeth Silberhorn
7. Margit Nuetzel
8. Fabienne Rayne
9. Eugenia Basyuk
10. Edouard Bertrand
11. Michael Rehli
12. Harald Wodrich
13. Gernot Laengst

Reviewed by Review Commons

Microtubule-mediated GLUT4 trafficking is disrupted in insulin-resistant skeletal muscle

1. Jonas R Knudsen
2. Kaspar W Persson
3. Carlos Henriquez-Olguin
4. Zhencheng Li
5. Nicolas Di Leo
6. Sofie A Hesselager
7. Steffen H Raun
8. Janne R Hingst
9. Raphaël Trouillon
10. Martin Wohlwend
11. Jørgen FP Wojtaszewski
12. Martin AM Gijs
13. Thomas Elbenhardt Jensen

• Curated by eLife

  eLife assessment

  This paper provides strong evidence for the important point that microtubule function is required for the proper localization of Glut4 glucose transporters in an insulin responsive compartment. This membrane localization is required in turn for effective translocation of Glut4 to the muscle cell surface in response to the hormone.

Reviewed by eLife

De novo serine biosynthesis is protective in mitochondrial disease

1. Christopher B Jackson
2. Anastasiia Marmyleva
3. Ryan Awadhpersad
4. Geoffray Monteuuis
5. Takayuki Mito
6. Nicola Zamboni
7. Takashi Tatsuta
8. Amy E. Vincent
9. Liya Wang
10. Thomas Langer
11. Christopher J Carroll
12. Anu Suomalainen

Reviewed by Review Commons

An in silico FSHD muscle fiber for modeling DUX4 dynamics and predicting the impact of therapy

1. Matthew V Cowley
2. Johanna Pruller
3. Massimo Ganassi
4. Peter S Zammit
5. Christopher RS Banerji

Reviewed by Review Commons

Multiomics study of CHCHD10 ^S59L -related disease reveals energy metabolism downregulation: OXPHOS and β-oxidation deficiencies associated with lipids alterations

1. Blandine Madji Hounoum
2. Rachel Bellon
3. Emmanuelle C Genin
4. Sylvie Bannwarth
5. Antoine Lefevre
6. Lucile Fleuriol
7. Delphine Debayle
8. Anne-Sophie Gay
9. Agnès Petit-Paitel
10. Sandra Lacas-Gervais
11. Hélène Blasco
12. Patrick Emond
13. Veronique Paquis-Flucklinger
14. Jean-Ehrland Ricci

Reviewed by Review Commons

Conformational change of the Plasmodium TRAP I domain is essential for sporozoite migration and transmission of malaria

1. Friedrich Braumann
2. Dennis Klug
3. Jessica Kehrer
4. Chafen Lu
5. Timothy A. Springer
6. Friedrich Frischknecht

Reviewed by Review Commons

Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

1. Long Shuang Huang
2. Mohammad Anas
3. Jingsong Xu
4. Bisheng Zhou
5. Peter T Toth
6. Yamuna Krishnan
7. Anke Di
8. Asrar B Malik

• Curated by eLife

  eLife assessment

  In this important study, Di et al., examine the mechanism by which potassium channels are activated prior to NLRP3 inflammasome activation. The main strength of the study is that it uses a combination of cell culture work and a mouse model to address the cell biology of inflammasome activation. However, certain aspects of the study including the characterization of inflammasome activation and the evidence to support the role of Rab11a in the translocation of TWIK2 are incomplete.

Reviewed by eLife

IRE1 RNase controls CD95-mediated cell death

1. Diana Pelizzari-Raymundo
2. Victoria Maltret
3. Manon Nivet
4. Raphael Pineau
5. Alexandra Papaioannou
6. Xingchen Zhou
7. Flavie Caradec
8. Sophie Martin
9. Matthieu Le Gallo
10. Tony Avril
11. Eric Chevet
12. Elodie Lafont

Reviewed by Review Commons

Reticular Adhesion Formation is Mediated by Flat Clathrin Lattices and Opposed by Fibrillar Adhesions

1. Laura Hakanpää
2. Amr Abouelezz
3. An-Sofie Lenaerts
4. Seyda Culfa
5. Michael Algie
6. Jenny Bärlund
7. Pekka Katajisto
8. Harvey T. McMahon
9. Leonardo Almeida-Souza

Reviewed by Review Commons