Cell Biology

Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

1. Natasja Barki
2. Laura Jenkins
3. Sara Marsango
4. Domonkos Dedeo
5. Daniele Bolognini
6. Louis Dwomoh
7. Aisha M Abdelmalik
8. Margaret Nilsen
9. Manon Stoffels
10. Falko Nagel
11. Stefan Schulz
12. Andrew B Tobin
13. Graeme Milligan

• Curated by eLife

  eLife assessment

  In this study, the authors present important tools for monitoring distinct tissue-specific patterns of agonist-induced Free Fatty Acid receptor 2 phosphorylation. The work includes several validation experiments, which provide convincing evidence that will be beneficial for the scientific community.

Reviewed by eLife

Mechanical coupling coordinates microtubule growth

1. Bonnibelle K Leeds
2. Katelyn F Kostello
3. Yuna Y Liu
4. Christian R Nelson
5. Sue Biggins
6. Charles L Asbury

• Curated by eLife

  eLife assessment

  In this technically advanced and important piece of work, the authors study the coordination of microtubule growth in kinetochore fibers using force spectroscopy and numerical simulations. With compelling evidence the authors address the question of how microtubules, which naturally exhibit variable growth rates, can coordinate their behavior by mechanical coupling so as to function as a single unit in generating forces during chromosome segregation.

Reviewed by eLife

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

1. Hasan Mamar
2. Roberta Fajka-Boja
3. Mónika Mórocz
4. Eva Pinto Jurado
5. Siham Zentout
6. Alexandra Mihuț
7. Anna Georgina Kopasz
8. Mihály Mérey
9. Rebecca Smith
10. Lajos Haracska
11. Sébastien Huet
12. Gyula Timinszky

Reviewed by preLights

Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

1. Nadja Kern
2. Rui Dong
3. Shawn M Douglas
4. Ronald D Vale
5. Meghan A Morrissey

Reviewed by Review Commons, preLights

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS-1 and p38 signaling

1. Juliane C Campos
2. Ziyun Wu
3. Paige D Rudich
4. Sonja K Soo
5. Meeta Mistry
6. Julio CB Ferreira
7. T Keith Blackwell
8. Jeremy M Van Raamsdonk

Reviewed by Review Commons

Apoptosis recognition receptors regulate skin tissue repair in mice

1. Olivia Justynski
2. Kate Bridges
3. Will Krause
4. Maria Fernanda Forni
5. Quan M Phan
6. Teresa Sandoval-Schaefer
7. Kristyn Carter
8. Diane E King
9. Henry C Hsia
10. Michael I Gazes
11. Steven D Vyce
12. Ryan R Driskell
13. Kathryn Miller-Jensen
14. Valerie Horsley

• Curated by eLife

  eLife assessment

  The authors studied the mechanisms by which dead cells are removed from the wounded skin in a process called efferocytosis. By analyzing different cell populations in the skin, the authors find that proteins involved in mediating the cell death and marking the cells as undergoing this process are elevated during distinct times in the wound healing program. Interestingly, these same proteins are elevated even higher in diabetic wounds. Finally the authors demonstrate that blocking the process of efferocytosis alters the wound healing program, thus illustrating its importance in effective wound repair.

Reviewed by eLife

N-WASP-dependent branched actin polymerization attenuates B-cell receptor signaling by increasing the molecular density of receptor clusters

1. Anshuman Bhanja
2. Margaret K Seeley-Fallen
3. Michelle Lazzaro
4. Arpita Upadhyaya
5. Wenxia Song

• Curated by eLife

  eLife assessment

  This is an important study highlighting a distinct role of WASP dependent actin foci in B cell antigen receptor signalling. The evidence supporting the conclusions is compelling. The proposal of higher molecular density in B cell receptor clustering leading to kinase exclusion and attenuated signalling is provocative as it contrasts with models for other antigen receptors.

Reviewed by eLife