Cell Biology

PILS-Nir1 is a novel phosphatidic acid biosensor that reveals mechanisms of lipid production

1. Claire C. Weckerly
2. Taylor A. Rahn
3. Max Ehrlich
4. Rachel C. Wills
5. Joshua G. Pemberton
6. Michael V. Airola
7. Gerald R. V. Hammond

Reviewed by Review Commons

Vacuolar H+-ATPase determines daughter cell fates through asymmetric segregation of the nucleosome remodeling and deacetylase complex

1. Zhongyun Xie
2. Yongping Chai
3. Zhiwen Zhu
4. Zijie Shen
5. Zhengyang Guo
6. Zhiguang Zhao
7. Long Xiao
8. Zhuo Du
9. Guangshuo Ou
10. Wei Li

• Curated by eLife

  eLife assessment

  The authors make the intriguing proposal that the NuRD complex in C. elegans, which has been linked to regulation of the cell death protein EGL-1 before, becomes asymmetrically distributed after cell division and that this asymmetry relies on V-ATPase activity. Whereas some disagreement remained between the reviewers' and the authors' interpretation, the final version incorporated alternative possibilities in the text, and with careful interpretation, the current manuscript's model is supported by solid data, and represents a valuable contribution to the field.

Reviewed by eLife

Growth-dependent concentration gradient of the oscillating Min system in Escherichia coli

1. Claudia Parada
2. Ching-Cher Sanders Yan
3. Cheng-Yu Hung
4. I-Ping Tu
5. Chao-Ping Hsu
6. Yu-Ling Shih

Reviewed by Review Commons

Time-resolved interactome profiling deconvolutes secretory protein quality control dynamics

1. Madison T Wright
2. Bibek Timalsina
3. Valeria Garcia Lopez
4. Jake N Hermanson
5. Sarah Garcia
6. Lars Plate

Reviewed by Review Commons

Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen

1. Rajdeep Banerjee
2. Thomas J Meyer
3. Margaret C Cam
4. Sukhbir Kaur
5. David D Roberts

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the cell composition in mouse spleen depleted for the CD47 receptor and its signaling ligand Thrombospondin in hematopoietic differentiation. The supporting evidence is convincing with analytical improvements on the individual contributions of the signaling components and with functional studies. This work has implications for the role of CD47/Thsp in extramedullary erythropoiesis in mouse spleen and will be of interest to medical biologists working on cell signaling, transfusion medicine, and cell therapy.

Reviewed by eLife

Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor internalization

1. Silvia Sposini
2. Rim Baccouch
3. Mathias Lescuyer
4. Aditi A Mali
5. Véronique De Smedt-Peyrusse
6. Joyce Heuninck
7. Ana Gorse
8. Thierry Durroux
9. Pierre Trifilieff
10. David Perrais
11. Isabel Alves

Reviewed by Review Commons

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

1. Ritobrata Ghose
2. Fabio Pezzano
3. Rémi Badia
4. Savvas Kourtis
5. Ilir Sheraj
6. Shubhamay Das
7. Antoni Gañez Zapater
8. Upamanyu Ghose
9. Sara Musa-Afaneh
10. Lorena Espinar
11. Albert Coll-Manzano
12. Katja Parapatics
13. Saška Ivanova
14. Paula Sànchez-Fernàndez-de-Landa
15. Dragana Radivojevikj
16. Valeria Venturini
17. Stefan Wieser
18. Antonio Zorzano
19. André C. Müller
20. Verena Ruprecht
21. Sara Sdelci

Reviewed by preLights

Neutrophils actively swell to potentiate rapid migration

1. Tamas L Nagy
2. Evelyn Strickland
3. Orion D Weiner

• Curated by eLife

  eLife assessment

  This fundamental study significantly advances our understanding of the role of water influx and swelling on neutrophil migration in response to chemoattractant. The evidence supporting the conclusions, based on a genome-wide CRISPR screen and high quality cellular observations, is compelling. This paper will be of interest to cell biologists and biophysicists working on cell migration.

Reviewed by eLife

Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

1. Hsiao-Fen Han
2. Shao-Fu Nien
3. Hang-Shiang Jiang
4. Jui-Ching Wu
5. Chia-Yi Chiang
6. Man-Tzu Li
7. Leng-Jie Huang
8. Sufeng Chiang
9. Lien-Chieh Lin
10. Yi-Ting Chuang
11. Yu-Ho Lin
12. Chao-Wen Wang
13. Yi-Chun Wu

• Curated by eLife

  eLife assessment

  This a useful study that reports a genetic regulatory network that accounts for altered lipid metabolism in response to two different bacterial diets of C. elegans. The proposed mechanism, linking vitamin B12, S-adenosyl methionine (SAM), phosphatidylcholine (PC), and neutral lipid levels, is solid but has been previously demonstrated by other studies using similar assays. The evidence to support a new layer of regulation, via the production of phospho-choline by ASM-3/acid sphingomyelinase, requires further substantiation.

Reviewed by eLife

Coordination between cytoskeletal organization, cell contraction and extracellular matrix development, is depended on LOX for aneurysm prevention

1. Rohtem Aviram
2. Shelly Zaffryar-Eilot
3. Anna Kaganovsky
4. Anas Odeh
5. Shay Melamed
6. Ruslana Militsin
7. Cameron B. Pinnock
8. Ariel Shemesh
9. Raz Palty
10. Santhi K. Ganesh
11. Peleg Hasson

Reviewed by Review Commons