Cell Biology

  2. MED26-enriched condensates drive erythropoiesis through modulating transcription pausing

    1. Shicong Zhu
    2. Xiaoting Zhang
    3. Na Li
    4. Xinying Zhao
    5. Man Li
    6. Si Xie
    7. Qiuyu Yue
    8. Yunfeng Li
    9. Dong Li
    10. Fan Wu
    11. Zile Zhang
    12. Ziqi Feng
    13. Yiyang Zhang
    14. Wonhyung Choi
    15. Xinyi Jia
    16. Yuelin Deng
    17. Qi Hu
    18. Xingyun Yao
    19. Xiaofei Gao
    20. Hsiang-Ying Lee

    • Curated by eLife

      eLife Assessment

      The study is important to show the role of MED26 in red cell formation. Linking transcription pausing with erythropoiesis is a key discovery. The data are solid although there are still spaces to improve. The in vivo data are limited by specificity concerns on their Cre model. Having RNA-seq, using more erythroid markers such as band3 and a4-integrin, and orthogonal validation with iPSC-erythropoiesis model will improve the study.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. MuSK-BMP signaling in adult muscle stem cells maintains quiescence and regulates myofiber size

    1. Laura A Madigan
    2. Diego Jaime
    3. Isabella Chen
    4. Justin R Fallon

    • Curated by eLife

      eLife Assessment

      This valuable study provides solid support for the participation of the BMP-binding domain of MuSK, a tyrosine kinase mostly known for its role at the neuromuscular junction, in the maintenance and activation of muscle stem cells (SCs). These mononucleated cells, located between the muscle fiber basal lamina and its plasma membrane, are normally quiescent, but following muscle damage, become activated, proliferate, and mediate muscle regeneration. These cells are known to respond to a variety of signaling pathways, but this study makes the case for BMP acting via binding to MuSK in maintaining the quiescent state.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  7. Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity

    1. Takao Yogo
    2. Yuichiro Iwamoto
    3. Hans Jiro Becker
    4. Takaharu Kimura
    5. Reiko Ishida
    6. Ayano Sugiyama-Finnis
    7. Tomomasa Yokomizo
    8. Toshio Suda
    9. Sadao Ota
    10. Satoshi Yamazaki

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Multi-color fluorescence live-cell imaging in Dictyostelium discoideum

    1. Hidenori Hashimura
    2. Satoshi Kuwana
    3. Hibiki Nakagwa
    4. Kenichi Abe
    5. Tomoko Adachi
    6. Toyoko Sugita
    7. Shoko Fujishiro
    8. Gen Honda
    9. Satoshi Sawai

    Reviewed by Arcadia Science

    7 evaluationsAppears in 1 listLatest version Latest activity
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