Cell Biology

MuSK-BMP signaling in adult muscle stem cells maintains quiescence and regulates myofiber size

1. Laura A Madigan
2. Diego Jaime
3. Isabella Chen
4. Justin R Fallon

• Curated by eLife

  eLife Assessment

  This valuable study provides solid support for the participation of the BMP-binding domain of MuSK, a tyrosine kinase mostly known for its role at the neuromuscular junction, in the maintenance and activation of muscle stem cells (SCs). These mononucleated cells, located between the muscle fiber basal lamina and its plasma membrane, are normally quiescent, but following muscle damage, become activated, proliferate, and mediate muscle regeneration. These cells are known to respond to a variety of signaling pathways, but this study makes the case for BMP acting via binding to MuSK in maintaining the quiescent state.

Reviewed by eLife

Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity

1. Takao Yogo
2. Yuichiro Iwamoto
3. Hans Jiro Becker
4. Takaharu Kimura
5. Reiko Ishida
6. Ayano Sugiyama-Finnis
7. Tomomasa Yokomizo
8. Toshio Suda
9. Sadao Ota
10. Satoshi Yamazaki

Reviewed by Arcadia Science

Multi-color fluorescence live-cell imaging in Dictyostelium discoideum

1. Hidenori Hashimura
2. Satoshi Kuwana
3. Hibiki Nakagwa
4. Kenichi Abe
5. Tomoko Adachi
6. Toyoko Sugita
7. Shoko Fujishiro
8. Gen Honda
9. Satoshi Sawai

Reviewed by Arcadia Science

Long range mutual activation establishes Rho and Rac polarity during cell migration

1. Henry De Belly
2. Andreu Fernandez Gallen
3. Evelyn Strickland
4. Dorothy C. Estrada
5. Patrick J. Zager
6. Tamas L. Nagy
7. Janis K Burkhardt
8. Hervé Turlier
9. Orion D. Weiner

Reviewed by preLights

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast

1. Catherine Tan
2. Michael C. Lanz
3. Matthew Swaffer
4. Jan Skotheim
5. Fred Chang

Reviewed by preLights