Cell Biology

Transcription inhibition suppresses nuclear blebbing and rupture independently of nuclear rigidity

1. Isabel K. Berg
2. Marilena L. Currey
3. Sarthak Gupta
4. Yasmin Berrada
5. Bao V. Nguyen
6. Mai Pho
7. Alison E. Patteson
8. J. M. Schwarz
9. Edward J. Banigan
10. Andrew D. Stephens

Reviewed by Review Commons

Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

1. Kai M. Bracey
2. Pi’illani Noguchi
3. Courtney Edwards
4. Alisa Cario
5. Guoqiang Gu
6. Irina Kaverina

• Curated by eLife

  eLife assessment

  This is a valuable study of the mechanisms of microtubule organization in pancreatic islet beta cells that enable optimal insulin secretion. Using a combination of live imaging and photo-kinetic assays in an in vitro culture system, the authors solidly demonstrate that kinesin-1-mediated microtubule sliding, which has previously been known from neurons and embryos, is important for establishing the sub-membranous microtubule band in response to glucose levels in beta cells. The inclusion of an animal model or primary cells, as well as data on the physiological relevance of the finding, would have strengthened the study. The work will be of interest to cell biologists studying cytoskeletal dynamics and organelle trafficking and to translational biologists working on diabetes.

Reviewed by eLife

Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium

1. Jennifer Sheridan
2. Aline Grata
3. Eve E. Suva
4. Enzo Bresteau
5. Linus R. Mitchell
6. Osama Hassan
7. Brian Mitchell

Reviewed by Arcadia Science

Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

1. Ukrae H Cho
2. Martin W Hetzer

• Curated by eLife

  eLife assessment

  This important study outlines a new role for caspases during cellular differentiation. The methodology used is convincing and state-of-the-art. The newly discovered cellular cascade described here uncovers that caspases can achieve high substrate specificity during differentiation. As such, the work will be of broad interest to cell biologists.

Reviewed by eLife

The maintenance of centriole appendages and motile cilia basal body anchoring relies on TBCCD1

1. Bruno Carmona
2. Carolina Camelo
3. Manon Mehraz
4. Michel Lemullois
5. Mariana Lince Faria
6. Étienne Coyaud
7. H. Susana Marinho
8. João Gonçalves
9. Sofia Nolasco
10. Francisco Pinto
11. Brian Raught
12. Anne-Marie Tassin
13. France Koll
14. Helena Soares

Reviewed by Arcadia Science

CryoET shows cofilactin filaments inside the microtubule lumen

1. Camilla Ventura Santos
2. Stephen L. Rogers
3. Andrew P. Carter

Reviewed by Arcadia Science

Cooperative Motility, Force Generation and Mechanosensing in a Foraging Non-Photosynthetic Diatom

1. Peng Zheng
2. Kayo Kumadaki
3. Christopher Quek
4. Zeng Hao Lim
5. Yonatan Ashenafi
6. Zhi Ting Yip
7. Jay Newby
8. Andrew J. Alverson
9. Yan Jie
10. Gregory Jedd

Reviewed by Arcadia Science

Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition

1. Julia S. Spear
2. Katharine A. White

Reviewed by Arcadia Science, ASAPbio crowd review

Tunnelling nanotube formation is driven by Eps8/IRSp53‐dependent linear actin polymerization

1. J Michael Henderson
2. Nina Ljubojevic
3. Sevan Belian
4. Thibault Chaze
5. Daryl Castaneda
6. Aude Battistella
7. Quentin Giai Gianetto
8. Mariette Matondo
9. Stéphanie Descroix
10. Patricia Bassereau
11. Chiara Zurzolo

Reviewed by Arcadia Science, Review Commons

Targeted volume correlative light and electron microscopy of an environmental marine microorganism

1. Karel Mocaer
2. Giulia Mizzon
3. Manuel Gunkel
4. Aliaksandr Halavatyi
5. Anna Steyer
6. Viola Oorschot
7. Martin Schorb
8. Charlotte Le Kieffre
9. Daniel P. Yee
10. Fabien Chevalier
11. Benoit Gallet
12. Johan Decelle
13. Yannick Schwab
14. Paolo Ronchi

Reviewed by Review Commons, Arcadia Science