Cell Biology

  1. Dietary bacteria control C. elegans fat content through pathways converging at phosphatidylcholine

    1. Hsiao-Fen Han
    2. Shao-Fu Nien
    3. Hang-Shiang Jiang
    4. Jui-Ching Wu
    5. Chia-Yi Chiang
    6. Man-Tzu Li
    7. Leng-Jie Huang
    8. Sufeng Chiang
    9. Lien-Chieh Lin
    10. Yi-Ting Chuang
    11. Yu-Ho Lin
    12. Chao-Wen Wang
    13. Yi-Chun Wu

    • Curated by eLife

      eLife assessment

      This a useful study that reports a genetic regulatory network that accounts for altered lipid metabolism in response to two different bacterial diets of C. elegans. The proposed mechanism, linking vitamin B12, S-adenosyl methionine (SAM), phosphatidylcholine (PC), and neutral lipid levels, is solid but has been previously demonstrated by other studies using similar assays. The evidence to support a new layer of regulation, via the production of phospho-choline by ASM-3/acid sphingomyelinase, requires further substantiation.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Coordination between cytoskeletal organization, cell contraction and extracellular matrix development, is depended on LOX for aneurysm prevention

    1. Rohtem Aviram
    2. Shelly Zaffryar-Eilot
    3. Anna Kaganovsky
    4. Anas Odeh
    5. Shay Melamed
    6. Ruslana Militsin
    7. Cameron B. Pinnock
    8. Ariel Shemesh
    9. Raz Palty
    10. Santhi K. Ganesh
    11. Peleg Hasson

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Identification of a third myosin-5a-melanophilin interaction that mediates the association of myosin-5a with melanosomes

    1. Jiabin Pan
    2. Rui Zhou
    3. Lin-Lin Yao
    4. Jie Zhang
    5. Ning Zhang
    6. Qing-Juan Cao
    7. Shaopeng Sun
    8. Xiang-dong Li

    • Curated by eLife

      eLife assessment

      This study represents a useful description of a third interaction site between melanophilin and myosin-5a which has a role in regulating the distribution of pigment granules in melanocytes. While much of the data forms a solid case for this interaction, the inclusion of controls for the cellular studies and measurement of interaction affinities would have been helpful.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. Re-assessment of the subcellular localization of Bazooka/Par-3 in Drosophila : No evidence for localization to the nucleus and the neuromuscular junction

    1. Soya Kim
    2. Jaffer Shahab
    3. Andreas Wodarz

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons

    1. Yi-Ju Chen
    2. Shun-Cheng Tseng
    3. Peng-Tzu Chen
    4. Eric Hwang

    • Curated by eLife

      eLife assessment

      In their valuable study, Chen et al. investigate the neuronal role of HMMR, a microtubule-associated protein typically associated with cell division. Their findings indicate that HMMR is necessary for proper neuronal morphology and the generation of polymerizing microtubules within neurites, potentially by promoting the function of TPX2. This solid body of work is the first step in deciphering the influence of a mitotic microtubule-associated protein in organizing microtubules in neurons and will be of interest to the neurobiology and cytoskeleton fields.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  6. A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

    1. David Trombley McSwiggen
    2. Helen Liu
    3. Ruensern Tan
    4. Sebastia Agramunt Puig
    5. Lakshmi B Akella
    6. Russell Berman
    7. Mason Bretan
    8. Hanzhe Chen
    9. Xavier Darzacq
    10. Kelsey Ford
    11. Ruth Godbey
    12. Eric Gonzalez
    13. Adi Hanuka
    14. Alec Heckert
    15. Jaclyn J Ho
    16. Stephanie L Johnson
    17. Reed Kelso
    18. Aaron Klammer
    19. Ruchira Krishnamurthy
    20. Jifu Li
    21. Kevin Lin
    22. Brian Margolin
    23. Patrick McNamara
    24. Laurence Meyer
    25. Sarah E Pierce
    26. Akshay Sule
    27. Connor Stashko
    28. Yangzhong Tang
    29. Daniel J Anderson
    30. Hilary P Beck

    • Curated by eLife

      eLife assessment

      This work presents an important technological advance, in the form of a high throughput platform for Single Particle Tracking allowing us to measure millions of cells and thousands of compounds per day. Analysis of the diffusional behaviour of fluorescently-tagged targets permits the identification of, and differentiation between, small molecules that bind directly or affect the target indirectly. The methodology and metrics employed are compelling, leading to the identification of multiple compounds that effectively change the diffusive state of the estrogen receptor, the POC target of the study.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  7. Microtubule-dependent orchestration of centriole amplification in brain multiciliated cells

    1. Amélie-Rose Boudjema
    2. Rémi Balagué
    3. Cayla E Jewett
    4. Gina M LoMastro
    5. Olivier Mercey
    6. Adel Al Jord
    7. Marion Faucourt
    8. Alexandre Schaeffer
    9. Camille Noûs
    10. Nathalie Delgehyr
    11. Andrew J Holland
    12. Nathalie Spassky
    13. Alice Meunier

    • Curated by eLife

      eLife assessment

      In this important study, Boudjema et al. use cell culture models and advanced microscopic imaging to provide detailed analyses of the cellular events underlying centriole amplification, apical migration, and assembly of hundreds of motile cilia in multi-ciliated cells. This largely descriptive work provides a better understanding of this process that is of interest to cell biologists studying centrioles and cilia. Most of the claims are supported by the data, but the study would benefit from additional analyses regarding the roles of microtubules, which are currently incomplete, and from text editing to improve accessibility and readability, especially for a wider audience.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. ESCRT disruption provides evidence against signaling functions for synaptic exosomes

    1. Erica C Dresselhaus
    2. Kathryn P Harris
    3. Cassandra R R Blanchette
    4. Kate Koles
    5. Steven J Del Signore
    6. Matthew F Pescosolido
    7. Biljana Ermanoska
    8. Mark Rozencwaig
    9. Rebecca C Soslowsky
    10. Michael J Parisi
    11. Bryan A Stewart
    12. Timothy J Mosca
    13. Avital Adah Rodal

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

    1. Mohammad Zeeshan
    2. Ravish Rashpa
    3. David J. Ferguson
    4. George Mckeown
    5. Raushan Nugmanova
    6. Amit K. Subudhi
    7. Raphael Beyeler
    8. Sarah L. Pashley
    9. Robert Markus
    10. Declan Brady
    11. Magali Roques
    12. Andrew R. Bottrill
    13. Andrew M. Fry
    14. Arnab Pain
    15. Sue Vaughan
    16. Anthony A. Holder
    17. Eelco C. Tromer
    18. Mathieu Brochet
    19. Rita Tewari

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Gαi2 Interaction with EB1 Controls Microtubule Dynamics and Rac1 Activity in Xenopus Neural Crest Cell Migration

    1. Soraya Villaseca
    2. Juan Ignacio Leal
    3. Lina Mariana Tovar
    4. María José Ruiz
    5. Jossef Guajardo
    6. Hernan Morales-Navarrete
    7. Roberto Mayor
    8. Marcela Torrejón

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity
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