Cell Biology

Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

1. Melissa Lubeck
2. Ritam Naha
3. Yulia Schaumkessel
4. Philipp Westhoff
5. Anja Stefanski
6. Patrick Petzsch
7. Kai Stühler
8. Karl Köhrer
9. Andreas P. M. Weber
10. Ruchika Anand
11. Andreas S. Reichert
12. Arun Kumar Kondadi

Reviewed by Review Commons

Atlas of Fshr expression from novel reporter mice

1. Hongqian Chen
2. Hui-Qing Fang
3. Jin-Tao Liu
4. Shi-Yu Chang
5. Li-Ben Cheng
6. Ming-Xin Sun
7. Jian-Rui Feng
8. Ze-Min Liu
9. Yong-Hong Zhang
10. Clifford J Rosen
11. Peng Liu

• Curated by eLife

  eLife assessment

  These valuable findings develop a mouse model with trackable fusion Fshr protein, which will be of use to the field. The animal model helps to elucidate the expression and function of the FSH receptor in extra-gonadal tissues. The strength of the evidence is solid in most parts, although additional validation of the localization data would strengthen the study considerably.

Reviewed by eLife

Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol

1. Salam Dabsan
2. Gali Zur
3. Naim Abu-Freha
4. Shahar Sofer
5. Iris Grossman-Haham
6. Ayelet Gilad
7. Aeid Igbaria

Reviewed by Review Commons

Mechanisms of cilia regeneration in Xenopus multiciliated epithelium in vivo

1. Venkatramanan G. Rao
2. Vignesharavind Subramanianbalachandar
3. Magdalena M. Magaj
4. Stefanie Redemann
5. Saurabh S. Kulkarni

Reviewed by Review Commons, Arcadia Science

Actin dynamics sustains spatial gradients of membrane tension in adherent cells

1. Juan Manuel García-Arcos
2. Amine Mehidi
3. Julissa Sánchez Velázquez
4. Pau Guillamat
5. Caterina Tomba
6. Laura Houzet
7. Laura Capolupo
8. Giovanni D’Angelo
9. Adai Colom
10. Elizabeth Hinde
11. Charlotte Aumeier
12. Aurélien Roux

Reviewed by preLights

Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators

1. Roberto Notario Manzano
2. Thibault Chaze
3. Eric Rubinstein
4. Esthel Penard
5. Mariette Matondo
6. Chiara Zurzolo
7. Christel Brou

• Curated by eLife

  eLife assessment

  Notario Manzano et al. offer a valuable first analysis of proteins within tunneling nanotubes (TNTs), membranous bridges connecting cells. This work distinguishes TNTs from extracellular vesicles, but further experimental and analytical tools are needed to refine the TNT proteome. Solid data supports a role for tetraspanins CD9 and CD81 in TNT function. The proposed model for CD9 and CD81 is over-interpreted and requires additional evidence for stronger support.

Reviewed by eLife

Ca ²⁺ binding to Esyt is required to modulate membrane contact site density in Drosophila photoreceptors

1. Vaisaly R Nath
2. Harini Krishnan
3. Shirish Mishra
4. Padinjat Raghu

Reviewed by Review Commons

Identification of Glucosidase II that regulates STIM1 activation dynamics

1. Yangchun Du
2. Sisi Zheng
3. Feifan Wang
4. Jia Li
5. Xiaoman Yuan
6. Chao Xi
7. Yandong Zhou
8. Youjun Wang

Reviewed by PREreview

The ORP9-ORP11 dimer promotes sphingomyelin synthesis

1. Birol Cabukusta
2. Shalom Borst Pauwels
3. Jimmy JLL Akkermans
4. Niek Blomberg
5. Aat A Mulder
6. Roman I Koning
7. Martin Giera
8. Jacques Neefjes

• Curated by eLife

  eLife assessment

  This valuable manuscript systematically addresses the role of intracellular lipid transfer proteins on cellular lipid levels. It provides convincing evidence on the role of ORP9 and ORP11 in sphingolipid metabolism at the Golgi complex. This article will be of broad interest to cell biologists interested in lipid metabolism and membrane biology.

Reviewed by eLife

Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

1. Holly Merta
2. Kaitlynn Gov
3. Tadamoto Isogai
4. Blessy Paul
5. Achinta Sannigrahi
6. Arun Radhakrishnan
7. Gaudenz Danuser
8. W. Mike Henne

Reviewed by PREreview