Cell Biology

Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair

1. James S. White
2. Jasmine J. Su
3. Elizabeth M. Ruark
4. Junmin Hua
5. M. Shane Hutson
6. Andrea Page-McCaw

• Curated by eLife

  eLife assessment

  This work addresses an important biological question: what is the cellular basis of wound healing? Using the Drosophila pupal notum as a model, the paper provides an elegant, thorough, descriptive characterisation of syncytia-driven wound closure using state-of-the-art confocal live imaging of the pupal notum. The authors meticulously characterize the cell-cell fusion events during wound healing, but without any mechanisms to inhibit cell fusion, it is incomplete, since it remains unclear whether cell fusion is required or not for speeding wound healing and/ or increasing the level of actin resources at the leading edge.

Reviewed by eLife

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

1. Reshma Thamkachy
2. Bethan Medina-Pritchard
3. Sang Ho Park
4. Carla G. Chiodi
5. Juan Zou
6. Maria de la Torre-Barranco
7. Kazuma Shimanaka
8. Maria Alba Abad
9. Cristina Gallego Páramo
10. Regina Feederle
11. Emilija Ruksenaite
12. Patrick Heun
13. Owen R. Davies
14. Juri Rappsilber
15. Dina Schneidman-Duhovny
16. Uhn-Soo Cho
17. A. Arockia Jeyaprakash

Reviewed by Review Commons

ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

1. Cristina Cacho-Navas
2. Carmen López-Pujante
3. Natalia Reglero-Real
4. Natalia Colás-Algora
5. Ana Cuervo
6. Jose Javier Conesa
7. Susana Barroso
8. Gema de Rivas
9. Sergio Ciordia
10. Alberto Paradela
11. Gianluca D'Agostino
12. Carlo Manzo
13. Jorge Feito
14. Germán Andrés
15. Francisca Molina-Jiménez
16. Pedro Majano
17. Isabel Correas
18. José-Maria Carazo
19. Sussan Nourshargh
20. Meritxell Huch
21. Jaime Millán

• Curated by eLife

  eLife assessment

  The authors report useful findings on novel function of apical ICAM1 in regulating bile duct homeostasis in the liver. The strength of evidence is solid using appropriate methodolgy with only minor weakness. The findings will be of interest to researchers in hepatology and membrane traffic biology.

Reviewed by eLife

The novel bacterial effector protein Cb EPF1 mediates ER-LD membrane contacts to regulate host lipid droplet metabolism

1. Rajendra Kumar Angara
2. Arif Sadi
3. Stacey D. Gilk

Reviewed by Review Commons

Aurora B controls microtubule stability to regulate abscission dynamics in stem cells

1. Snježana Kodba
2. Amber Öztop
3. Eri van Berkum
4. Eugene A. Katrukha
5. Malina K. Iwanski
6. Wilco Nijenhuis
7. Lukas C. Kapitein
8. Agathe Chaigne

Reviewed by preLights

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

1. Taylor E. Lange
2. Ali Naji
3. Ransome van der Hoeven
4. Hong Liang
5. Yong Zhou
6. Gerald R.V. Hammond
7. John F. Hancock
8. Kwang-jin Cho

Reviewed by Review Commons

Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-B

1. Daniel Ballmer
2. Bungo Akiyoshi

• Curated by eLife

  eLife assessment

  This important study identifies the mitotic localization mechanism for Aurora B and INCENP (parts of the chromosomal passenger complex, CPC) in Trypanosoma brucei. The mechanism differs from that in the more commonly studied opisthokonts and is supported by compelling RNAi and imaging experiments, targeted mutations, immunoprecipitations with crosslinking/mass spec, and AlphaFold interaction predictions. The findings will be of interest to cell biologists working on cell division, parasitologists, and those interested in the evolution of mitotic mechanisms.

Reviewed by eLife

KIF1C, an RNA transporting kinesin-3, undergoes liquid-liquid phase separation through its C-terminal disordered domain

1. Qi Geng
2. Jakia Jannat Keya
3. Takashi Hotta
4. Kristen J Verhey

Reviewed by Review Commons

Reduction of cortical pulling at mitotic entry facilitates aster centration

1. Anne Rosfelter
2. Ghislain de Labbey
3. Janet Chenevert
4. Rémi Dumollard
5. Sebastien Schaub
6. Zoltan Machaty
7. Lydia Besnardeau
8. Daniel Gonzalez Suarez
9. Céline Hebras
10. Hervé Turlier
11. David R. Burgess
12. Alex McDougall

Reviewed by Review Commons

Identification of plants’ functional counterpart of the metazoan mediator of DNA Damage checkpoint 1

1. Zdravko J Lorković
2. Michael Klingenbrunner
3. Chung Hyun Cho
4. Frédéric Berger

Reviewed by Review Commons