Cell Biology

Cell size, density, and nutrient dependency of unicellular algal gravitational sinking velocities

1. Teemu P. Miettinen
2. Annika L. Gomez
3. Yanqi Wu
4. Weida Wu
5. Thomas R. Usherwood
6. Yejin Hwang
7. Benjamin R. K. Roller
8. Martin F. Polz
9. Scott R. Manalis

Reviewed by Arcadia Science

The SARS CoV-1 3a protein disrupts Golgi complex morphology and cargo trafficking

1. Rex R. Gonzales
2. Carolyn E. Machamer

Reviewed by ScreenIT

Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: potential implications for SARS-CoV-2 infection of vascular endothelial cells

1. Quezia K Toe
2. Theo Issitt
3. Abdul S Mahomed
4. Ioannis Panselinas
5. Fatma Almaghlouth
6. Anne Burke-Gaffney
7. S John Wort
8. Gregory J Quinlan

Reviewed by ScreenIT

WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2

1. Luiz Guilherme H. S. Aragão
2. Júlia T. Oliveira
3. Jairo R. Temerozo
4. Mayara A. Mendes
5. José Alexandre Salerno
6. Carolina da S. G. Pedrosa
7. Teresa Puig-Pijuan
8. Carla P. Veríssimo
9. Isis M. Ornelas
10. Thayana Torquato
11. Gabriela Vitória
12. Carolina Q. Sacramento
13. Natalia Fintelman-Rodrigues
14. Suelen da Silva Gomes Dias
15. Vinicius Cardoso Soares
16. Leticia R. Q. Souza
17. Karina Karmirian
18. Livia Goto-Silva
19. Diogo Biagi
20. Estela M. Cruvinel
21. Rafael Dariolli
22. Daniel R. Furtado
23. Patrícia T. Bozza
24. Helena L. Borges
25. Thiago Moreno L. Souza
26. Marília Zaluar P. Guimarães
27. Stevens Rehen

Reviewed by ScreenIT

Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

1. Emi Sano
2. Sayaka Deguchi
3. Ayaka Sakamoto
4. Natsumi Mimura
5. Ai Hirabayashi
6. Yukiko Muramoto
7. Takeshi Noda
8. Takuya Yamamoto
9. Kazuo Takayama

Reviewed by ScreenIT

Effect of SARS-CoV-2 proteins on vascular permeability

1. Rossana Rauti
2. Meishar Shahoha
3. Yael Leichtmann-Bardoogo
4. Rami Nasser
5. Eyal Paz
6. Rina Tamir
7. Victoria Miller
8. Tal Babich
9. Kfir Shaked
10. Avner Ehrlich
11. Konstantinos Ioannidis
12. Yaakov Nahmias
13. Roded Sharan
14. Uri Ashery
15. Ben Meir Maoz

Reviewed by ScreenIT

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

1. Francisco S. Mesquita
2. Laurence Abrami
3. Oksana Sergeeva
4. Priscilla Turelli
5. Enya Qing
6. Béatrice Kunz
7. Charlène Raclot
8. Jonathan Paz Montoya
9. Luciano A. Abriata
10. Tom Gallagher
11. Matteo Dal Peraro
12. Didier Trono
13. Giovanni D’Angelo
14. F. Gisou van der Goot

Reviewed by ScreenIT

Integrative vectors for regulated expression of SARS-CoV-2 proteins implicated in RNA metabolism

1. Stefan Bresson
2. Nic Robertson
3. Emanuela Sani
4. Tomasz W Turowski
5. Vadim Shchepachev
6. Michaela Kompauerova
7. Christos Spanos
8. Aleksandra Helwak
9. David Tollervey

Reviewed by ScreenIT

The Type 2 Asthma Mediator IL-13 Inhibits Severe Acute Respiratory Syndrome Coronavirus 2 Infection of Bronchial Epithelium

1. Luke R. Bonser
2. Walter L. Eckalbar
3. Lauren Rodriguez
4. Jiangshan Shen
5. Kyung Duk Koh
6. Khadija Ghias
7. Lorna T. Zlock
8. Stephanie Christenson
9. Prescott G. Woodruff
10. Walter E. Finkbeiner
11. David J. Erle

Reviewed by ScreenIT

A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval

1. Andreas Gerondopoulos
2. Philipp Bräuer
3. Tomoaki Sobajima
4. Zhiyi Wu
5. Joanne L Parker
6. Philip C Biggin
7. Francis A Barr
8. Simon Newstead

• Curated by eLife

  Evaluation Summary:

  Binding of cargo to sorting receptors in membrane trafficking is essential to cellular organization. This work is significant because it generates a detailed model of the key residues accounting for specificity and affinity of binding by the KDEL receptor. Interestingly, it is not the affinity per se that accounts for the specificity of cargo binding but rather charge-based exclusion of potentially competing signals.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife