Cell Biology

Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy

1. Victoria L. Hewitt
2. Leonor Miller-Fleming
3. Simonetta Andreazza
4. Francesca Mattedi
5. Julien Prudent
6. Franck Polleux
7. Alessio Vagnoni
8. Alexander J. Whitworth

Reviewed by Review Commons

Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast

1. Rachael E. Turner
2. Paul F. Harrison
3. Angavai Swaminathan
4. Calvin A. Kraupner-Taylor
5. Melissa J. Curtis
6. Belinda J. Goldie
7. Michael M. See
8. Amanda L. Peterson
9. Ralf B. Schittenhelm
10. David R. Powell
11. Darren J. Creek
12. Bernhard Dichtl
13. Traude H. Beilharz

• Curated by eLife

  Evaluation Summary:

  This study aims to provide a comprehensive analysis of factors governing polyadenylation site selection in yeast. Overall, the authors reveal that multiple but distinct inputs including polyadenylation machinery integrity, transcription elongation rate, nucleotide availability and chromatin landscape all contribute to controlling cleavage and polyadenylation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

1. Patrick Morley Willoughby
2. Molly Allen
3. Jessica Yu
4. Roman Korytnikov
5. Tianhui Chen
6. Yupeng Liu
7. Isis So
8. Neil Macpherson
9. Jennifer Mitchell
10. Rodrigo Fernandez-Gonzalez
11. Ashley E. E. Bruce

• Curated by eLife

  Evaluation Summary:

  Willoughby et al. examine the role of Rab25 in early embryogenesis in zebrafish. They implicate Rab25 activity in abscission and show various defects including delayed epiboly and altered cell behaviors associated with defective acting dynamics. Overall, this is an interesting and well-written paper. However, there are a number of important controls that are missing and some connections such as the implication of membrane recycling that require stronger experimental validation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Micronuclei arising due to loss of KIF18A form stable micronuclear envelopes and do not promote tumorigenesis

1. Leslie A. Sepaniac
2. Whitney Martin
3. Louise A. Dionne
4. Timothy M. Stearns
5. Laura G. Reinholdt
6. Jason Stumpff

Reviewed by Review Commons

Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes

1. Nicholas Strash
2. Sophia DeLuca
3. Geovanni L Janer Carattini
4. Soon Chul Heo
5. Ryne Gorsuch
6. Nenad Bursac

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to scientists in the field of regenerative medicine. The authors compare effects of persistent lentiviral expression of various mitogens in cardiomyocytes in vitro. Technically experiments are of a very high standard, but the data are somewhat difficult to translate to the in vivo situation. The statistical analyses would have to be robust and sufficient for the conclusions to be supported by the data.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

A low Smc flux avoids collisions and facilitates chromosome organization in Bacillus subtilis

1. Anna Anchimiuk
2. Virginia S Lioy
3. Florian Patrick Bock
4. Anita Minnen
5. Frederic Boccard
6. Stephan Gruber

• Curated by eLife

  Evaluation Summary:

  This manuscript presents some intriguing data to support the notion that B. subtilis cells have tuned a variety of parameters related to SMC loading and translocation to ensure that individual complexes do not collide. This is likely an important but poorly understood aspect of condensins/SMCs, and as such represents a valuable contribution to the field and should be of interest to a broad set of readers.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

1. Laura Le Pelletier
2. Matthieu Mantecon
3. Jennifer Gorwood
4. Martine Auclair
5. Roberta Foresti
6. Roberto Motterlini
7. Mireille Laforge
8. Michael Atlan
9. Bruno Fève
10. Jacqueline Capeau
11. Claire Lagathu
12. Veronique Bereziat

Reviewed by eLife

Adiponectin Preserves Metabolic Fitness During Aging

1. Na Li
2. Zhuzhen Zhang
3. Shangang Zhao
4. Yi Zhu
5. Christy M. Gliniak
6. Lavanya Vishvanath
7. Yu A. An
8. May-yun Wang
9. Yingfeng Deng
10. Qingzhang Zhu
11. Toshiharu Onodera
12. Orhan K Oz
13. Ruth Gordillo
14. Rana K. Gupta
15. Ming Liu
16. Tamas L. Horvath
17. Vishwa Deep Dixit
18. Philipp E. Scherer

Reviewed by eLife

Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery

1. Markus Quante
2. Jasper Iske
3. Timm Heinbokel
4. Bhavna N. Desai
5. Hector Rodriguez Cetina Biefer
6. Yeqi Nian
7. Felix Krenzien
8. Hirofumi Uehara
9. Ryoichi Maenosono
10. Haruhito Azuma
11. Johann Pratschke
12. Christine Falk
13. Tammy Lo
14. Eric Sheu
15. Ali Tavakkoli
16. David Perkins
17. Maria-Luisa Alegre
18. Alexander S. Banks
19. Abdallah Elkhal
20. Stefan G. Tullius

Reviewed by eLife

The role of sigma-1 receptor in organization of endoplasmic reticulum signaling microdomains

1. Vladimir Zhemkov
2. Jonathon A. Ditlev
3. Wan-Ru Lee
4. Jen Liou
5. Michael K. Rosen
6. Ilya Bezprozvanny

Reviewed by eLife