Cell Biology

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

1. Lenno Krenning
2. Stijn Sonneveld
3. Marvin E Tanenbaum

Reviewed by Review Commons

Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by Antidepressants

1. Oleg O. Glebov

Reviewed by ScreenIT

Monitoring single-cell dynamics of entry into quiescence during an unperturbed life cycle

1. Basile Jacquel
2. Théo Aspert
3. Damien Laporte
4. Isabelle Sagot
5. Gilles Charvin

Reviewed by Review Commons

Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockouts

1. Mirjam Pennauer
2. Katarzyna Buczak
3. Cristina Prescianotto-Baschong
4. Martin Spiess

Reviewed by Review Commons

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging

1. Sara Sepe
2. Francesca Rossiello
3. Valeria Cancila
4. Fabio Iannelli
5. Valentina Matti
6. Giada Cicio
7. Matteo Cabrini
8. Eugenia Marinelli
9. Busola R Alabi
10. Alessia di Lillo
11. Arianna Di Napoli
12. Jerry W Shay
13. Claudio Tripodo
14. Fabrizio d’Adda di Fagagna

Reviewed by ScreenIT

Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection

1. Jiarui Wang
2. Mengting Han
3. Anish R. Roy
4. Haifeng Wang
5. Leonhard Möckl
6. Leiping Zeng
7. W.E. Moerner
8. Lei S. Qi

Reviewed by ScreenIT

Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

1. Maureen C Lamb
2. Chathuri P Kaluarachchi
3. Thiranjeewa I Lansakara
4. Samuel Q Mellentine
5. Yiling Lan
6. Alexei V Tivanski
7. Tina L Tootle

• Curated by eLife

  Evaluation Summary:

  This manuscript explores the relationship between stiffness of migrating cells and the stiffness of the substrate of which they are migrating. Specifically, the authors show that the actin-bundling protein Fascin limits the levels of activated myosin to alter stiffness of the migratory substrate. This is a well-controlled study, and with some additional clarifications of methods and extensions to some analyses that would strengthen the paper, it will be of broad interest to cell biologists, particularly those studying cell migration.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control – a Complex Early Trait (‘CoV-MAC-TED’) for Combating SARS-CoV-2-Induced Cell Reprogramming

1. José Hélio Costa
2. Gunasekaran Mohanapriya
3. Revuru Bharadwaj
4. Carlos Noceda
5. Karine Leitão Lima Thiers
6. Shahid Aziz
7. Shivani Srivastava
8. Manuela Oliveira
9. Kapuganti Jagadis Gupta
10. Aprajita Kumari
11. Debabrata Sircar
12. Sarma Rajeev Kumar
13. Arvind Achra
14. Ramalingam Sathishkumar
15. Alok Adholeya
16. Birgit Arnholdt-Schmitt

Reviewed by ScreenIT

A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

1. Sho W Suzuki
2. Akihiko Oishi
3. Nadia Nikulin
4. Jeff R Jorgensen
5. Matthew G Baile
6. Scott D Emr

• Curated by eLife

  Evaluation Summary:

  This paper will be of broad interest to the vesicle trafficking field, as it defines how an evolutionarily conserved SNX-BAR protein (Mvp1) sorts cargo proteins into membrane tubules emanating from the endosome and recruits a dynamin-like "pinchase" to release the tubule so cargo can move to the Golgi complex.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

1. Katalin Skrapits
2. Miklós Sárvári
3. Imre Farkas
4. Balázs Göcz
5. Szabolcs Takács
6. Éva Rumpler
7. Viktória Váczi
8. Csaba Vastagh
9. Gergely Rácz
10. András Matolcsy
11. Norbert Solymosi
12. Szilárd Póliska
13. Blanka Tóth
14. Ferenc Erdélyi
15. Gábor Szabó
16. Michael D Culler
17. Cecile Allet
18. Ludovica Cotellessa
19. Vincent Prévot
20. Paolo Giacobini
21. Erik Hrabovszky

• Curated by eLife

  Evaluation Summary:

  This multifaceted study focuses on neurons in the brain that produce a small peptide molecule known as GnRH, which is central to reproduction in its role as the releasing hormone for gonadotropins from the anterior pituitary. The findings will be of interest to scientists interested in the role of neuropeptides in determining normal brain function and the onset of neurodegenerative disorders. The authors provide a detailed anatomical and molecular characterization of a large, previously unnoticed population of GnRH neurons, located in basal ganglia (mainly putamen) in humans, which diverge from the population of GnRH neurons regulating the pituitary, in number (much larger), morphology and, possibly, origin (not from olfactory placode). Moreover, the study rekindles the idea that GnRH producing neurons in other regions of the brain outside the hypothalamus may be involved in neural processes unrelated to reproduction such as locomotion and decision making.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife