Cell Biology

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

1. Janani Gopalan
2. Mitchell H Omar
3. Ankita Roy
4. Nelly M Cruz
5. Jerome Falcone
6. Kiana N Jones
7. Katherine A Forbush
8. Jonathan Himmelfarb
9. Benjamin S Freedman
10. John D Scott

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to cell biologists interested in understanding processes that regulate the biogenesis of the primary cilium, and to others interested in ciliopathies (ie disorders of the primary cilium). The authors have identified a novel pathway that controls the generation and length of primary cilia and show that its effects are mediated at least in part through its effects on regulating the cytoskeleton. They suggest that this pathway may also have clinical relevance for autosomal dominant polycystic disease, but the data and rationale underlying this part of the study wold need to be strengthened.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

An endosome-associated actin network involved in directed apical plasma membrane growth

1. Luis Daniel Ríos-Barrera
2. Maria Leptin

Reviewed by Review Commons

Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions

1. Anant Narayan Bhatt
2. Abhishek Kumar
3. Yogesh Rai
4. Neeraj Kumari
5. Dhiviya Vedagiri
6. Krishnan H. Harshan
7. Vijayakumar Chinnadurai
8. Sudhir Chandna

Reviewed by ScreenIT

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

1. Lenno Krenning
2. Stijn Sonneveld
3. Marvin E Tanenbaum

Reviewed by Review Commons

Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by Antidepressants

1. Oleg O. Glebov

Reviewed by ScreenIT

Monitoring single-cell dynamics of entry into quiescence during an unperturbed life cycle

1. Basile Jacquel
2. Théo Aspert
3. Damien Laporte
4. Isabelle Sagot
5. Gilles Charvin

Reviewed by Review Commons

Shared and specific functions of Arfs 1–5 at the Golgi revealed by systematic knockouts

1. Mirjam Pennauer
2. Katarzyna Buczak
3. Cristina Prescianotto-Baschong
4. Martin Spiess

Reviewed by Review Commons

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging

1. Sara Sepe
2. Francesca Rossiello
3. Valeria Cancila
4. Fabio Iannelli
5. Valentina Matti
6. Giada Cicio
7. Matteo Cabrini
8. Eugenia Marinelli
9. Busola R Alabi
10. Alessia di Lillo
11. Arianna Di Napoli
12. Jerry W Shay
13. Claudio Tripodo
14. Fabrizio d’Adda di Fagagna

Reviewed by ScreenIT

Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection

1. Jiarui Wang
2. Mengting Han
3. Anish R. Roy
4. Haifeng Wang
5. Leonhard Möckl
6. Leiping Zeng
7. W.E. Moerner
8. Lei S. Qi

Reviewed by ScreenIT

Fascin limits Myosin activity within Drosophila border cells to control substrate stiffness and promote migration

1. Maureen C Lamb
2. Chathuri P Kaluarachchi
3. Thiranjeewa I Lansakara
4. Samuel Q Mellentine
5. Yiling Lan
6. Alexei V Tivanski
7. Tina L Tootle

• Curated by eLife

  Evaluation Summary:

  This manuscript explores the relationship between stiffness of migrating cells and the stiffness of the substrate of which they are migrating. Specifically, the authors show that the actin-bundling protein Fascin limits the levels of activated myosin to alter stiffness of the migratory substrate. This is a well-controlled study, and with some additional clarifications of methods and extensions to some analyses that would strengthen the paper, it will be of broad interest to cell biologists, particularly those studying cell migration.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife