Cell Biology

Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis

1. Benjamin Pillet
2. Alfonso Méndez-Godoy
3. Guillaume Murat
4. Sébastien Favre
5. Michael Stumpe
6. Laurent Falquet
7. Dieter Kressler

• Curated by eLife

  Evaluation Summary:

  Ribosomal proteins are prone to aggregation. This work provides strong experimental support for a novel mechanism by which the level of the mRNA encoding two different ribosomal proteins is fine-tuned by variation in the abundance or availability of their chaperones. This regulation is proposed to operate through mRNA degradation at the translating ribosome. The data are extensive - from genetic observations that hint at the existence of a feedback loop, through interaction mechanisms, to biological significance. The logical links between the different steps in the analysis are clear, sound and well set out. The conclusions are unanticipated, but convincingly supported and very likely relevant and important for other systems beyond yeast.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast

1. Mercè Gomar‐Alba
2. Vasilisa Pozharskaia
3. Bogdan Cichocki
4. Celia Schaal
5. Arun Kumar
6. Basile Jacquel
7. Gilles Charvin
8. J Carlos Igual
9. Manuel Mendoza

Reviewed by Review Commons

Nanoviricides Platform Technology based NV-387 polymer Protects Remdesivir from Plasma-Mediated Catabolism in vitro: Importance of its increased lifetime for in vivo action

1. Ashok Chakraborty
2. Anil Diwan
3. Vinod Arora
4. Yogesh Thakur
5. Preetam Holkar
6. Vijetha Chinige

Reviewed by ScreenIT

Tunneling nanotubes provide a route for SARS-CoV-2 spreading

1. Anna Pepe
2. Stefano Pietropaoli
3. Matthijn Vos
4. Giovanna Barba-Spaeth
5. Chiara Zurzolo

Reviewed by ScreenIT

An iTSC-derived placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility in syncytiotrophoblasts

1. J Chen
2. JA Neil
3. JP Tan
4. R Rudraraju
5. M Mohenska
6. YBY Sun
7. G Sun
8. Y Zhou
9. Y Li
10. D Drew
11. P Pymm
12. WH Tham
13. FJ Rossello
14. G Nie
15. X Liu
16. K Subbarao
17. JM Polo

Reviewed by ScreenIT

Expression and novel alternative purification of the recombinant nucleocapsid (N) protein of SARS-CoV-2 in Escherichia coli for the serodiagnosis of COVID-19

1. Jose David Rosales
2. William Quintero
3. Jhon Cruz
4. Balbino Perdomo
5. Militza Quintero
6. Marcos Bastidas
7. Jose Domingo Lugo
8. Keila Rivas Rodriguez
9. Juan Carlos Freites-Perez
10. Annie Castillo

Reviewed by ScreenIT

Protein Arginylation Is Regulated during SARS-CoV-2 Infection

1. Janaina Macedo-da-Silva
2. Livia Rosa-Fernandes
3. Vinicius de Morais Gomes
4. Veronica Feijoli Santiago
5. Deivid Martins Santos
6. Catarina Maria Stanischesk Molnar
7. Bruno Rafael Barboza
8. Edmarcia Elisa de Souza
9. Rodolfo Ferreira Marques
10. Silvia Beatriz Boscardin
11. Edison Luiz Durigon
12. Claudio Romero Farias Marinho
13. Carsten Wrenger
14. Suely Kazue Nagahashi Marie
15. Giuseppe Palmisano

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Fibroblast-expressed LRRC15 suppresses SARS-CoV-2 infection and controls antiviral and antifibrotic transcriptional programs

1. Lipin Loo
2. Matthew A. Waller
3. Cesar L. Moreno
4. Alexander J. Cole
5. Alberto Ospina Stella
6. Oltin-Tiberiu Pop
7. Ann-Kristin Jochum
8. Omar Hasan Ali
9. Christopher E. Denes
10. Zina Hamoudi
11. Felicity Chung
12. Anupriya Aggarwal
13. Jason K. K. Low
14. Karishma Patel
15. Rezwan Siddiquee
16. Taeyoung Kang
17. Suresh Mathivanan
18. Joel P. Mackay
19. Lukas Flatz
20. Daniel Hesselson
21. Stuart Turville
22. G. Gregory Neely

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation

1. Margarida Dantas
2. Andreia Oliveira
3. Paulo Aguiar
4. Helder Maiato
5. Jorge G. Ferreira

Reviewed by Review Commons, ASAPbio crowd review

DAAM mediates the assembly of long-lived, treadmilling stress fibers in collectively migrating epithelial cells in Drosophila

1. Kristin M Sherrard
2. Maureen Cetera
3. Sally Horne-Badovinac

• Curated by eLife

  Evaluation Summary:

  This paper is of broad interest to readers who are interested in understanding cell migration and the cytoskeleton. It characterizes new behaviors of actin-based stress fibers in vivo during collective cell migration, and provides important observations that contribute to our fundamental understanding of these structures. The use of high-resolution live imaging in combination with Drosophila genetics and pharmacological inhibitors provides compelling data that supports the major claims of the paper.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife