1. GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer

    This article has 11 authors:
    1. Yuki Kito
    2. Tania J. González-Robles
    3. Sharon Kaisari
    4. Juhee Pae
    5. Sheena Faye Garcia
    6. Juliana Ortiz-Pacheco
    7. Beatrix Ueberheide
    8. Ruth Lehmann
    9. Antonio Marzio
    10. Gergely Rona
    11. Michele Pagano
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel resistance in cancer. The evidence for these claims is currently inadequate; concerns include the use of cell lines that have been reported to lack the mitotic surveillance pathway, insufficient consideration of paclitaxel mechanisms of action, and an overinterpretation of correlative results.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity

    This article has 12 authors:
    1. Elsa Meneses-Salas
    2. Marianna Arnold
    3. Moises Castellá
    4. Frank Hsieh
    5. Ruben Fernández-Santiago
    6. Mario Ezquerra
    7. Alicia Garrido
    8. María-José Martí
    9. Carlos Enric
    10. Suzanne R. Pfeffer
    11. Kalpana Merchant
    12. Albert Lu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study presents the potentially interesting concept that LRRK2 regulates cellular BMP levels and their release via extracellular vesicles, with GCase activity further modulating this process in mutant LRRK2-expressing cells. However, the evidence supporting the conclusions remains incomplete, and certain statistical analyses are inadequate. This work would be of interest to cell biologists working on Parkinson's disease.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Intestinal stem cell renewal controlled by capillary morphogenesis gene 2 following injury

    This article has 6 authors:
    1. Lucie Bracq
    2. Audrey Chuat
    3. Béatrice Kunz
    4. Olivier Burri
    5. Romain Guiet
    6. F. Gisou van der Goot

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

    This article has 10 authors:
    1. Fan Zhang
    2. Yuan Wang
    3. Luyang Zhang
    4. Chunjie Wang
    5. Deping Chen
    6. Haibo Liu
    7. Ren Xu
    8. Cole M. Haynes
    9. Jae-Hyuck Shim
    10. Xianpeng Ge
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is convincing and the revised manuscript is largely improved. This paper holds potential interest for skeletal biologists who study the pathogenesis of age-associated skeletal disorders.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Aging-associated Increase of GATA4 levels in Articular Cartilage is Linked to Impaired Regenerative Capacity of Chondrocytes and Osteoarthritis

    This article has 9 authors:
    1. Meagan J. Makarczyk
    2. Yiqian Zhang
    3. Alyssa Aguglia
    4. Olivia Bartholomew
    5. Sophie Hines
    6. Suyash Sinkar
    7. Silvia Liu
    8. Craig Duvall
    9. Hang Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo data. The work will be of broad interest to cell biologists and orthopedic clinicians.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Clearance of protein aggregates during cell division

    This article has 7 authors:
    1. Shoukang Du
    2. Yuhan Wang
    3. Bowen Chen
    4. Shuangshuang Xie
    5. Kuan Yoow Chan
    6. David C Hay
    7. Ting Gang Chew
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      How misfolded proteins are segregated and cleared is a significant question in cell biology, since clearance of these aggregates can protect against pathologies that may otherwise arise. The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the anaphase promoting complex (APC). These are valuable and interesting new observations, and the evidence supporting these claims is solid.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  7. Profiling the physiological impact of aberrant folded-state protein filamentation in cells

    This article has 9 authors:
    1. Tal Levin
    2. Hector Garcia-Seisdedos
    3. Arseniy Lobov
    4. Matthias Wojtynek
    5. Alexander Alexandrov
    6. Ghil Jona
    7. Dikla Levi
    8. Ohad Medalia
    9. D. Emmanuel Levy

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation

    This article has 10 authors:
    1. Alaknanda Emery
    2. Orest W. Blaschuk
    3. Thao D. Dinh
    4. Tim McPhee
    5. Rouven Becker
    6. Andrew D. Abell
    7. Krzysztof M. Mrozik
    8. Andrew C.W. Zannettino
    9. Rebecca L Robker
    10. Darryl L Russell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript describes important findings regarding the significance of CHD2 in ovarian folliculogenesis. Overall, the results lead to convincing conclusions, with minimal concerns raised by the reviewers. Both the results and conclusions are well discussed. This work will be of interest to ovarian biologists and physicians working on female fertility.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Kinesin Autoinhibition Requires Elbow Phosphorylation

    This article has 6 authors:
    1. Guanghan Chen
    2. Zhengyang Guo
    3. Zhiwen Zhu
    4. Shanshan Xie
    5. Tianhua Zhou
    6. Guangshuo Ou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In their important manuscript, Chen et al. investigate the phospho-regulation of the C. elegans kinesin-2 motor protein OSM-3, revealing that the kinase, NEKL-3, phosphorylates a serine/threonine patch at the hinge region of the motor to mediate autoinhibition until it reaches the ciliary middle segment. The findings are supported by robust genetic data, in vivo imaging, and motility assays with wild-type and mutant motors. Overall, the study provides a compelling contribution to understanding the regulation of OSM-3 kinesin activity both on the molecular and cellular levels.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. A novel approach to tagging tubulin reveals MT assembly dynamics of the axoneme in Trypanosoma brucei

    This article has 9 authors:
    1. Daniel Abbühl
    2. Martina Pružincová
    3. Luděk Štěpánek
    4. Eleonore Bouscasse
    5. Rita Azevedo
    6. Mariette Matondo
    7. Vladimir Varga
    8. Serge Bonnefoy
    9. Philippe Bastin

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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