Cell Biology

  1. MAP7-driven cytoskeletal remodeling establishes epithelial polarity for male germ cell progression

    1. Koji Kikuchi
    2. Toshihiko Fujimori
    3. Mami Nakagawa
    4. Keisuke Ohta
    5. Ryuki Shimada
    6. Sayoko Fujimura
    7. Kei-ichiro Yasunaga
    8. Shingo Usuki
    9. Naoki Tani
    10. Akira Nakamura
    11. Kimi Araki
    12. Kei-ichiro Ishiguro

    Reviewed by Review Commons

    2 evaluationsAppears in 1 listLatest version Latest activity

  2. Intraflagellar transport-20 coiled-coil domain mediates the channelrhodopsins trafficking to the cilia in Chlamydomonas reinhardtii

    1. Alka Kumari
    2. Suneel Kateriya

    Reviewed by Arcadia Science

    3 evaluationsAppears in 1 listLatest version Latest activity

  3. Stress granules and protein aggregates reveal intracellular resource competition

    1. Hannah E. Buchholz
    2. Sean A. Martin
    3. Jane E. Dorweiler
    4. Derek C. Prosser
    5. Emily M. Sontag
    6. Anita L. Manogaran

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity

  4. Division Asymmetry Drives Cell Size Variability in Budding Yeast

    1. Félix Proulx-Giraldeau
    2. Xin Gao
    3. Yagya Chadha
    4. Jordan Xiao
    5. Kurt M. Schmoller
    6. Jan M. Skotheim
    7. Paul Francois

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

    1. Atsushi Matsumoto
    2. Akihito Inoko
    3. Takuya Tanaka
    4. Gen-Ichi Konishi
    5. Waki Hosoda
    6. Takahiro Kojima
    7. Koji Ohnishi
    8. Junichi Ikenouchi

    • Curated by eLife

      eLife Assessment

      This paper presents the fundamental discovery that lipid metabolic imbalance induced by Snail, an EMT-related transcription factor, contributes to the acquisition of chemoresistance in cancer cells. The evidence, supported by a wide range of methods and adequate quantification, provides a convincing mechanistic explanation of how Snail drives ectopic expression of the cholesterol- and drug-efflux transporter ABCA1. This work, which introduces a novel therapeutic concept targeting invasive cancer, will be of broad interest to researchers in cancer biology, lipid metabolism, and cell biology.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  6. Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

    1. Gabriel M Kline
    2. Lisa Boinon
    3. Adrian Guerrero
    4. Sergei Kutseikin
    5. Gabrielle Cruz
    6. Marnie P Williams
    7. Ryan J Paxman
    8. William E Balch
    9. Jeffery W Kelly
    10. Tingwei Mu
    11. R Luke Wiseman

    • Curated by eLife

      eLife Assessment

      This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis remodeling. The evidence supporting the conclusions is convincing, with rigorous assays used to benchmark the changes in potency and efficacy of the AA263 analogs as well as AA263 targets. The ability of AA263 analogs to restore the loss of function associated with disease-associated proteins prone to misfolding will be of interest to pharmacologists, chemical biologists, and cell biologists, as well as those working on protein misfolding disorders.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  7. ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

    1. Daniel A. Reed
    2. Anna E. Howell
    3. Nadia Kuepper
    4. Alice M. H. Tran
    5. Astrid Magenau
    6. Deborah S. Barkauskas
    7. Max Nobis
    8. Cecilia R. Chambers
    9. Victoria Lee
    10. Lily M. Channon
    11. Jessie Zhu
    12. Shona Ritchie
    13. Janett Stoehr
    14. Kaitlin Wylie
    15. Julia Chen
    16. Denise Attwater
    17. Kate Harvey
    18. Sunny Z. Wu
    19. Kate Saw
    20. Ruth J. Lyons
    21. Anaiis Zaratzian
    22. Michael Tayao
    23. Andrew Da Silva
    24. David Gallego-Ortega
    25. Anthony J. Gill
    26. Thomas R. Cox
    27. Brooke A. Pereira
    28. Kendelle J. Murphy
    29. Jennifer P. Morton
    30. Elgene Lim
    31. Alexander Swarbrick
    32. Sandra O’Toole
    33. Michael S. Samuel
    34. C. Elizabeth Caldon
    35. Alexandra Zanin-Zhorov
    36. Paul Timpson
    37. David Herrmann

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Specialisation of meiotic kinetochores revealed through a synthetic SAC strategy

    1. Lori B Koch
    2. Christos Spanos
    3. Adele L Marston

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Ceramide transfer protein regulates G-protein coupled phospholipase signalling in Drosophila photoreceptors

    1. Shirish Mishra
    2. Ali Khan
    3. Vaisaly R Nath
    4. Tejaswini Manoj
    5. BG Thejaswini
    6. Amruta Naik
    7. Ujjaini Dasgupta
    8. Padinjat Raghu

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Sterols regulate ciliary membrane dynamics and hedgehog signaling in health and disease

    1. Antonin Lamazière
    2. Lucie Kozlowski
    3. Jesus Ayala-Sanmartin
    4. Manal Farhat
    5. Nabil Belaid
    6. Alexandre Certain
    7. Bertrand Isidor
    8. Thomas Besnard
    9. Germain Trugnan
    10. Gregory J Pazour
    11. Gaëtan Després
    12. Céline Deseille
    13. Sarah Moreno
    14. Thibaut Eguether

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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