Cell Biology

PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

1. Jimena Druker
2. Hao Jiang
3. Dilem Shakir
4. Fraser Child
5. Vanesa Alvarez
6. Melpomeni Platani
7. Andrea Corno
8. Constance Alabert
9. Adrian T Saurin
10. Jason R Swedlow
11. Sonia Rocha
12. Angus I Lamond

• Curated by eLife

  eLife Assessment

  This compelling work describes how the cell cycle-regulating phosphatase subunit, RepoMan, is regulated by the oxygen-dependent, metabolite-sensing hydroxylase PHD1. The characterisation of how proline hydroxylation alters signalling at the molecular and cellular level provides important evidence to enhance our understanding of how 2-oxoglutarate-dependent dioxygenases influence the cell cycle and mitosis.

Reviewed by eLife

Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress

1. Ginto George
2. Heather P. Harding
3. Richard Kay
4. David Ron
5. Adriana Ordóñez

Reviewed by Review Commons

Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage

1. Yuta Yamazaki
2. Keiko Kono

• Curated by eLife

  eLife Assessment

  This work provides an important resource identifying 72 proteins as novel candidates for plasma membrane and/or cell wall damage repair in budding yeast, and describes the temporal coordination of exocytosis and endocytosis during the repair process. The data are convincing; however, additional experimental validation will better support the claim that repair proteins shuttle between the bud tip and the damage site.

Reviewed by eLife

Linking Germline Telomere Removal to Global Programmed DNA Elimination in Tetrahymena Genome Differentiation

1. Kohei Nagao
2. Kazufumi Mochizuki

• Curated by eLife

  eLife Assessment

  This important study reveals intriguing connections between chromosome breakage and DNA elimination during programmed genome rearrangement in the ciliate Tetrahymena thermophila. By developing a novel FISH approach that distinguishes germline and somatic telomeres, the authors provide compelling evidence that chromosome breakage removes germline telomeres along with hundreds of kilobases of germline-limited sequences. By disrupting a single chromosome breakage site, they further showed that DNA elimination was globally affected, which opens up a new direction for mechanistic studies. Thus, this work reveals additional similarity between the programmed DNA elimination in ciliates and nematodes that underlies the transition from germline to somatic telomeres.

Reviewed by eLife

Fission yeast cells use distinct cell size control mechanisms for size adaptation to osmotic, oxidative, or low glucose conditions

1. Elena J. Cabral
2. Pablo Andres
3. Geraldin Argandona
4. Paige Duggan
5. Benjamin M. Kuran
6. Kristi E. Miller

Reviewed by Review Commons

Bone marrow hemogenic endothelial cells contribute multilineage hematopoietic progenitors in adult mice

1. Jing-Xin Feng
2. Mei-Ting Yang
3. Caiyi C. Li
4. Ferenc Livák
5. Abdalla Abdelmaksoud
6. Dunrui Wang
7. Giovanna Tosato

• Curated by eLife

  eLife Assessment

  The study proposed hemogenic endothelium in adult BM using lineage tracing. Though the study is potentially valuable, the data is incomplete due to the lack of control and insufficient analysis. There is potential for the study to be improved by further revision.

Reviewed by eLife

IP3R2 mediated inter-organelle Ca ²⁺ signaling orchestrates melanophagy

1. Suman Saurav
2. Rajender K Motiani

Reviewed by Review Commons

Active flows drive clustering and sorting of membrane components with differential affinity to dynamic actin cytoskeleton

1. Abrar Bhat
2. Amit Das
3. Meenakshi Iyer
4. Sarayu Beri
5. Sankarshan Talluri
6. Darius Koester
7. Madan Rao
8. Satyajit Mayor

Reviewed by preLights

The dynamics of ciliogenesis in prepubertal mouse meiosis reveal new clues about testicular maturation during puberty

1. I Pérez-Moreno
2. P López-Jiménez
3. H Zapata
4. S Pérez-Martín
5. M López-Panadés
6. B Barbeito
7. J Urtasun-Elizari
8. I Roig
9. FR Garcia-Gonzalo
10. J Page
11. R Gómez

Reviewed by Review Commons

Non-synaptic exocytosis along the axon shaft and its regulation by the submembrane periodic skeleton

1. Theresa Wiesner
2. Christopher Parperis
3. Fanny Boroni-Rueda
4. Nicolas Jullien
5. Afonso Mendes
6. Léa Marie
7. Louisa Mezache
8. Marie-Jeanne Papandréou
9. Ricardo Henriques
10. Christophe Leterrier

Reviewed by Review Commons