1. RAB18 Orchestrates Signaling Protein Ciliary Homeostasis by Facilitating BBSome Diffusion through the Transition Zone for Ciliary Entry

    This article has 5 authors:
    1. Wei-Yue Sun
    2. Jingchao Zhang
    3. Yan Wei
    4. Linda S. Zhao
    5. Zhen-Chuan Fan

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration

    This article has 8 authors:
    1. Hyunggu Hahn
    2. Carole Daly
    3. John Little
    4. Nicole A. Perry-Hauser
    5. Emmanuel Flores-Espinoza
    6. Asuka Inoue
    7. Bianca Plouffe
    8. Alex Rojas Bie Thomsen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study that provides CCR7-APEX2 proximity labelling mass spectrometry data that is expected to provide new insights into CCR7 signaling partners and pathways. The study is technically easy to follow and the data is convincing. It will be interesting in the future to have complementary studies in lymphocytes/dendritic cells that endogenously express CCR7. This is of value to the community, and there are likely multiple opportunities to use the APEX2 data set to extend these findings, strengthen some claims, and even explore a new pathway identified in the APEX2 data set.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in C. elegans

    This article has 6 authors:
    1. Bhumil Patel
    2. Maryke Grobler
    3. Alberto Herrera
    4. Elias Logari
    5. Valery Ortiz
    6. Needhi Bhalla
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study examining the role of conserved PCH-2 protein at different stages of C. elegans meiosis. The authors use elegant molecular genetic approaches to provide convincing evidence to support their claims. The work will be of interest to scientists studying meiosis, DNA recombination, and chromosome segregation.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  4. Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion

    This article has 4 authors:
    1. Jean De Seze
    2. Maud Bongaerts
    3. Benoit Boulevard
    4. Mathieu Coppey
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study combines compelling experiments with optogenetic actuation and convincing theory to understand how signalling proteins control the switch between cell protrusion and retraction, two essential processes in single cell migration. The authors examine the importance of the basal concentration and recruitment dynamics of a guanine exchange factor (GEF) on the activity of the downstream effectors RhoA and Cdc42, which control retraction and protrusion. The experimental and theoretical evidence provides a model of RhoA's involvement in both protrusion and retraction and shows that these complex processes are highly dependent on the concentration and activity dynamics of the components.

    Reviewed by eLife

    This article has 16 evaluationsAppears in 1 listLatest version Latest activity
  5. Spatial confinement induces reciprocating migration of epidermal keratinocytes and forms triphasic epithelia

    This article has 13 authors:
    1. Takuma Nohara
    2. Junichi Kumamoto
    3. Yosuke Mai
    4. Mayuna Shimano
    5. Sora Kato
    6. Hiroyuki Kitahata
    7. Hideki Nakamura
    8. Shota Takashima
    9. Mika Watanabe
    10. Masaharu Nagayama
    11. Tsukasa Oikawa
    12. Hideyuki Ujiie
    13. Ken Natsuga
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and subsequent mesenchymal-to-epithelial transition (MET) while migrating through a membrane with 3.0-µm micropores, and, thus, provides a valuable tool to study EMT and possibly wound regeneration or metastasis. Furthermore, a set of experiments provides solid data suggesting that TGF beta signaling and actin polymerization promote movement of epithelial cells into the pores, while Piezo1 and Keratin 6 prevent keratinocyte migration and EMT.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    This article has 9 authors:
    1. Dan Wu
    2. Venkateswararao Eeda
    3. Zahra Maria
    4. Komal Rawal
    5. Audrey Wang
    6. Oana Herlea-Pana
    7. Ram Babu Undi
    8. Hui-Ying Lim
    9. Weidong Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study presents important findings on inositol-requiring enzyme (IRE1α) inhibition on diet-induced obesity (overnutrition) and insulin resistance where IRE1α inhibition enhances thermogenesis and reduces the metabolically active and M1-like macrophages in adipose tissue. The evidence supporting the conclusions is convincing and the work will be of interest to cell biologists and biochemists working in metabolism, insulin resistance, and inflammation.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

    This article has 8 authors:
    1. Rachel Pudlowski
    2. Lingyi Xu
    3. Ljiljana Milenkovic
    4. Chandan Kumar
    5. Katherine Hemsworth
    6. Zayd Aqrabawi
    7. Tim Stearns
    8. Jennifer T Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study by Pudlowski et al. shows that a previously-identified protein complex, composed of delta- and epsilon-tubulin together with TEDC1 and TEDC2, functions in generating centriolar triplet microtubules, and that this is crucial for the proper formation of centriolar subdomains and the stability of centrioles throughout the cell cycle. This is an important study that advances our understanding of centriole biogenesis and structure and is supported by convincing evidence based on knockout cell lines, immunoprecipitation, and ultrastructure expansion microscopy. The work is of interest to cell biologists, in particular researchers with interest in centrosome biology.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. SRS microscopy identifies inhibition of vitellogenesis as a mediator of lifespan extension by caloric restriction in C. elegans

    This article has 7 authors:
    1. Bowen Yang
    2. Bryce Manifold
    3. Wuji Han
    4. Catherin DeSousa
    5. Wanyi Zhu
    6. Aaron Streets
    7. Denis V. Titov

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. Srs2/PARI DNA helicase mediates abscission inhibition in response to chromatin bridges in yeast and human cells

    This article has 5 authors:
    1. Monica Dam
    2. Nicola Brownlow
    3. Audrey Furst
    4. Coralie Spiegelhalter
    5. Manuel Mendoza

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. An unconventional interaction interface between the peroxisomal targeting factor Pex5 and Eci1 enables PTS1 independent import

    This article has 9 authors:
    1. Lior Peer
    2. Nadav Elad
    3. Orly Dym
    4. Asa Tirosh
    5. Jossef Jacobovitch
    6. Shira Albeck
    7. Maya Schuldiner
    8. Yoav Peleg
    9. Einat Zalckvar

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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