1. Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process

    This article has 8 authors:
    1. Ke Ning
    2. Yuanyuan Xie
    3. Lingke Feng
    4. Wen Sun
    5. Can Fang
    6. Rong Pan
    7. Yan Li
    8. Ling Yu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The ingenious design in this study achieved the observation of 3D cell spheroids from an additional lateral view and gained more comprehensive information than the traditional one angle of imaging. This extended the methods to investigate cell behaviors in the growth or migration of tumor organoids in a time-lapse manner and these extensions should be important to the field. The authors provide compelling evidence that the methods work as described.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Blocking SHP2 benefits FGFR2 inhibitor and overcomes its resistance in FGFR2-amplified gastric cancer

    This article has 11 authors:
    1. Yue Zhang
    2. Hanbing Wang
    3. Yutao Wei
    4. Yunfeng Pan
    5. Xueru Song
    6. Tao Shi
    7. Jie Shao
    8. Lixia Yu
    9. Baorui Liu
    10. Yue Wang
    11. Jia Wei
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Based on the perceived low efficacy of current therapies targeted to FGFR2 in gastric cancer (GC), the authors investigate an approach which combines SHP2 inhibition with existing FGFR2 inhibitors. The data were largely collected and analysed using solid and validated methodology. There is some useful data regarding combination therapy in a new clinical cohort, which supports previous studies that have reported the potential of targeting RTKs together with phosphatases.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

    This article has 12 authors:
    1. Jiadong Zhou
    2. Xiao Albert Zhou
    3. Li Hu
    4. Yujie Ma
    5. Jun Zhan
    6. Zhanzhan Xu
    7. Mei Zhou
    8. Qinjian Shen
    9. Zhaofei Liu
    10. Shaohua Ma
    11. Yuntao Xie
    12. Jiadong Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this fundamental study, the authors describe ELF3 as a candidate driver of luminal progenitor transformation, such that its up-regulation during replicative stress conditions and in BRCA1 deficient cells may permit cell proliferation by suppressing genome instability. While the work is certainly of interest, the supporting data remain incomplete as luminal progenitor cells could not be isolated, which would be needed in order to definitively determine whether ELF3 is a driver of transformation in these cells. Overall this paper may offer insight into mechanisms by which BRCA1 deficiency fuels breast tumorigenesis.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Eliminating Aggressive Cancers via PROTAC-like Inducers of Ferroptosis

    This article has 10 authors:
    1. Avital Oknin-Vaisman
    2. Deepanjan Panda
    3. Rostislav Novak
    4. Eliya Bitman-Lotan
    5. Nikolett Pahor
    6. Yamen Abu Ahmed
    7. Guy Kamnesky
    8. Markus E. Diefenbacher
    9. Ashraf Brik
    10. Amir Orian

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  5. Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells

    This article has 8 authors:
    1. Huanhuan Joyce Chen
    2. Eric E Gardner
    3. Yajas Shah
    4. Kui Zhang
    5. Abhimanyu Thakur
    6. Chen Zhang
    7. Olivier Elemento
    8. Harold Varmus
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Given a great need for novel human model systems to study small cell lung cancer (SCLC), the authors describe an important pre-clinical model with broad potential for the study of how genetic perturbations or drug treatments alter SCLC tumor growth, metastasis, and response to therapy. For the major finding, the authors provide convincing evidence that RB/TP53 suppression coupled with MYC overexpression in an ES cell-derived model system results in aggressive and metastatic SCLC. However, the impact of the work would have been increased with the inclusion of a broader set of genetic perturbations, such as over-expression of MYCL, to better model major SCLC phenotypes. The new model described will be of significant interest to researchers studying lung cancer.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  6. Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

    This article has 10 authors:
    1. Yang Peng
    2. Jing Yang
    3. Jixing Ao
    4. Yilin Li
    5. Jia Shen
    6. Xiang He
    7. Dihong Tang
    8. Chaonan Chu
    9. Congrong Liu
    10. Liang Weng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful manuscript, the authors performed scRNA-seq on a diverse cohort of 15 early-stage cervical cancer patients. Correlative data is provided to support the possible establishment of an immunosuppressive microenvironment near SCL26A3+ cells, and an association of these cells with upstaging at time of surgery. However without more extensive validation, the evidence supporting the conclusions remains incomplete. Overall, this paper will provide a potentially helpful dataset for researchers studying cervical cancer.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Oncogenic and teratogenic effects of p53Y217C, a mouse model of the human hotspot mutant p53Y220C

    This article has 9 authors:
    1. Sara Jaber
    2. Eliana Eldawra
    3. Jeanne Rakotopare
    4. Marc Gabriel
    5. Vincent Lejour
    6. Iva Simeonova
    7. Antonin Morillon
    8. Boris Bardot
    9. Franck Toledo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work is of fundamental significance and has a compelling level of evidence for the role of mutant p53 in regulation of tumorigenesis using an in vivo mouse model. The study is well-conducted and will be of interest to a broad audience including those interested in p53, transcription factors and cancer biology.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

    This article has 20 authors:
    1. Shengsheng Zhao
    2. Ji Lin
    3. Bingzi Zhu
    4. Yin Jin
    5. Qiantong Dong
    6. Xiaojiao Ruan
    7. Dan Jin
    8. Yongdong Yi
    9. Binglong Bai
    10. Hongzheng Li
    11. Danna Liang
    12. Jianhua Lu
    13. Letian Meng
    14. Xiang Wang
    15. Yuekai Cui
    16. Yuyang Gu
    17. Xian Shen
    18. Xufeng Lu
    19. Shangrui Rao
    20. Weijian Sun
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Overall, this fundamental study identified a novel role of NOLC1 in regulating p53 nuclear transcriptional activity and p53-mediated ferroptosis in gastric cancer. The evidence supporting the conclusions is solid, although some new evidence is needed to make it more robust. The work will be of broad interest to cancer biologists and oncologists.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Monitoring of Cell-free Human Papillomavirus DNA in Metastatic or Recurrent Cervical Cancer: Clinical Significance and Treatment Implications

    This article has 7 authors:
    1. Zhuomin Yin
    2. Tao Feng
    3. Qing Xu
    4. Wumin Dai
    5. Maowei Ni
    6. Juan Ni
    7. Hanmei Lou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In the field of early detection of disease and recurrence and monitoring of treatment efficacy by cfDNA analysis, this study presents a useful finding that HPV cfDNA level monitoring provides advantages over serum levels of squamous cell carcinoma antigen (SCC-Ag), specifically for HPV+ cervical cancer. The data were collected and analysed using solid and validated methodology but the sample number was limited.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism

    This article has 4 authors:
    1. Priyojit Das
    2. Rebeca San Martin
    3. Tian Hong
    4. Rachel Patton McCord
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study explores the role of spatial genome organization in oncogenic transformation, addressing an ambitious and significant topic. The authors have assembled comprehensive datasets from various subtypes of localized and lung-metastatic breast cancer cells, as well as from healthy and cancerous lung cells. They identified switching patterns in the 3D genome organization of lung-metastatic breast cancer cells, revealing a reconfiguration of genome architecture that resembles that of lung cells. If validated, this study could be critical for the field; however, at this stage, it is incomplete, as the main claims are only partially substantiated.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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