Cancer Biology

FoxN1-dependent thymic epithelial cells promote T-cell leukemia development

1. Marinella N Ghezzo
2. Mónica T Fernandes
3. Ivette Pacheco-Leyva
4. Pedro M Rodrigues
5. Rui S Machado
6. Marta A S Araújo
7. Ravi K Kalathur
8. Matthias E Futschik
9. Nuno L Alves
10. Nuno R dos Santos

Reviewed by PREreview

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

1. Sarah M Chang
2. Muhammad Bin Munim
3. Sonia E Trojan
4. Huel Cox
5. Anna Shevzov-Zebrun
6. Keene L Abbott
7. Renee Chang
8. Matthew G Vander Heiden

• Curated by eLife

  eLife Assessment

  This study presents important findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide convincing evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of broad interest to researchers working in cancer and cell metabolism.

Reviewed by eLife

An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer

1. Jodie R. Malcolm
2. Jack Stenning
3. Jacob Pope
4. Jakub Łukaszonek
5. Susanna F. Rose
6. Taylor E. Smith
7. Lesley Gilbert
8. Sally R. James
9. Katherine S. Bridge
10. William J. Brackenbury
11. Andrew N. Holding

Reviewed by Review Commons

High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study

1. Ming Liu
2. Linping Lu
3. Lingxiang Zhu
4. Xiaoni Zhang
5. Yuanyuan Liu
6. Xiaojing Ren
7. Shimin Liu
8. Shaochen Cheng
9. Mingyan Xu
10. Chao Lu
11. Yan Peng
12. Wenmei Su
13. Yong Guo
14. Shifu Chen

Reviewed by PREreview

Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

1. Wanqiu Wang
2. Mengqi Yang
3. Fanglei Gong
4. Zhenyu Zhang
5. Yanping Ma
6. Haihuang Li
7. Yu Zhao
8. Changzheng Du
9. Ningning Li
10. Guiwei He
11. Kun Sun

• Curated by eLife

  eLife Assessment

  This study examines the role of the fungal pathogen Candida albicans in the progression of colorectal cancer, a relevant and urgent topic given the global incidence of colon cancer. While the findings are useful and provide solid experimental work and insight into how Candida may contribute to tumor progression, the small patient sample size, reliance on in vitro models, and absence of in vivo validation may limit its impact. This work will interest scientists studying cancer progression and the role played by pathogens.

Reviewed by eLife

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman spectroscopy and AI

1. Kai Chang
2. Mamatha Serasanambati
3. Baba Ogunlade
4. Hsiu-Ju Hsu
5. James Agolia
6. Ariel Stiber
7. Jeffrey Gu
8. Jay Chadokiya
9. Grayson E. Rodriguez
10. Prabhjeet Singh
11. Saurabh Sharma
12. Amanda Gonçalves
13. Ojasvi Verma
14. Fareeha Safir
15. Nhat Vu
16. K. Christopher Garcia
17. Daniel Delitto
18. Amanda Kirane
19. Jennifer A. Dionne

Reviewed by Arcadia Science

Integrated Human Transcriptomics Identifies Fallopian Tube Progenitors as Plausible Precursors of High-Grade Serous Ovarian Cancer

1. Qian Li
2. Keren Cheng
3. Lili Sun
4. Wei Yan

• Curated by eLife

  eLife Assessment

  This valuable study reports a substantial single-cell RNAseq and bulk RNAseq dataset from multiple high-grade serous ovarian cancers, including a single-cell atlas of human fallopian tube epithelium. The bioinformatic analysis investigating the lineage and location of epithelial progenitor cells is convincing, although this will require experimental validation. The work also provides a resource to examine additional features of normal fallopian tubes and ovarian cancers, and for developing methods for early detection and tumour stratification.

Reviewed by eLife