Cancer Biology

Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenya Women diagnosed with Breast Cancer

1. Michael Kitoi
2. John Gitau
3. Godfrey Wagutu
4. Kennedy Mwangi
5. Florence Ngonga
6. Francis Makokha

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on mutations in ZNF217, ZNF703, and ZNF750 through 23 breast cancer samples alongside matched normal tissues in Kenyan breast cancer patients. The evidence supporting the claims of the authors is solid, yet the analysis of the manuscript lacks methodological transparency, statistical detail, and sufficient comparison with existing large-scale datasets. The work will be of interest to medical biologists and scientists working in the field of breast cancer.

Reviewed by eLife

Blocking Osteoprotegerin Reprograms Cancer Associated Fibroblast to Promotes Immune Infiltration into the Tumor Microenvironment

1. Yao Wang
2. Hara Apostolopoulou
3. Im Hong Sun
4. Arjan Bains
5. David Gibbs
6. Sui Huang
7. Tamara Alliston
8. Ajay Maker
9. Thea Tlsty
10. Vasilis Ntranos
11. James M Gardner
12. Anil Bhushan

• Curated by eLife

  eLife Assessment

  This study presents an important finding by identifying OPG as a novel stromal checkpoint influencing T-cell anti-tumor responses, thereby shedding new light on the complex interplay between the tumor microenvironment and immune regulation. The data are robust and the experimental approaches are sound, providing solid support for the study's conclusions; however, there are a number of additional questions raised by the data. Of particular note are the questions raised on the mechanistic effects of TRAIL versus RANKL. In addition, it would broaden the interest in this study to include more translational human data to complement the work presented.

Reviewed by eLife

Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

1. Naphannop Sereesongsaeng
2. Carole JR Bataille
3. Angela J Russell
4. Nicolas Bery
5. Fernando Sialana
6. Jyoti Choudhary
7. Ami Miller
8. Terry H Rabbitts

• Curated by eLife

  eLife Assessment

  This important paper reports the development of proteins and small molecules that induce degradation of a clinically-relevant oncogenic transcription factor, LMO2. The findings provide a proof of concept that PROTAC-type chemicals can be developed against intrinsically disordered proteins. The methods provide a blueprint for rational design of PROTACs starting from intracellular antibody paratopes. Overall, the paper is supported by solid evidence and will be of interest to chemical biologists and cancer pharmacologists.

Reviewed by eLife

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

1. Megan E Patton
2. Sherwin Kelekar
3. Lauren J Taylor
4. Angela E Dean
5. Qianying Zuo
6. Rhishikesh N Thakare
7. Sung Hwan Lee
8. Emily Gentry
9. Morgan Panitchpakdi
10. Pieter Dorrestein
11. Yazen Alnouti
12. Zeynep Madak-Erdogan
13. Ju-Seog Lee
14. Milton J Finegold
15. Sayeepriyadarshini Anakk

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into the influence of sex on bile acid metabolism and the risk of hepatocellular carcinoma (HCC). The data to support that there are inter-relationships between sex, bile acids, and HCC in mice are convincing, although this is a largely descriptive study. Future studies are needed to understand the interaction of sex hormones, bile acids, and chronic liver diseases and cancer at a mechanistic level. Also, there is not enough evidence to determine the clinical significance of the findings given the differences in bile acid composition between mice and men.

Reviewed by eLife

In depth profiling of the cancer proteome from the flowthrough of standard RNA- preparation kits for precision oncology

1. Filip Mundt Madsen
2. Annelaura Bach Nielsen
3. Juanjuan Wang
4. Josephine Kerzel Duel
5. Christina Westmose Yde
6. Martina Amnitzbøll Eriksen
7. Ulrik Lassen
8. Finn Cilius Nielsen
9. Kristoffer Rohrberg
10. Matthias Mann

Reviewed by preLights

Targeting a novel chloroquine derivative to lysosomes induces massive and irreversible damage to lysosomes and suppresses autophagosomes and lysosomes assembly in cancer

1. Nitish Chauhan
2. Ananda Guha Majumdar
3. Sujit Kumar Bhutia
4. Papiya Dey
5. Mahesh Subramanian
6. Birija Sankar Patro

Reviewed by Arcadia Science

Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

1. Christopher Graser
2. Wenbo Wu
3. Cole Christini
4. Mia Petljak
5. Franziska Michor

• Curated by eLife

  eLife Assessment

  This valuable study presents a theoretical model of how punctuated mutations influence multistep adaptation, supported by empirical evidence from some TCGA cancer cohorts. This solid model is noteworthy for cancer researchers as it points to the case for possible punctuated evolution rather than gradual genomic change. However, the parametrization and systematic evaluation of the theoretical framework in the context of tumor evolution remain incomplete, and alternative explanations for the empirical observations are still plausible.

Reviewed by eLife

Mitochondrial stress-induced protein carboxyl-terminal alanine threonine tailing (msiCAT-tailing) facilitates glioblastoma tumorigenesis through the modulation of mitochondrial functions

1. Bei Zhang
2. Ting Cai
3. Esha Reddy
4. Yuanna Wu
5. Adaeze Scholastical Gbufor
6. Yinglu Tang
7. Isha Mondal
8. Jerry Wang
9. Yawei Shen
10. Qing Liu
11. Winson S Ho
12. Rongze Olivia Lu
13. Zhihao Wu

• Curated by eLife

  eLife Assessment

  Glioblastoma is among the most aggressive cancers without a cure, and its cells are characterized by high mitochondrial membrane potential. This manuscript provides solid evidence that glioblastoma tumorigenesis is closely linked to mitochondrial stress. The study makes a valuable contribution to the field by advancing our understanding of the metabolic mechanisms driving glioblastoma and highlighting potential therapeutic targets.

Reviewed by eLife

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

1. Youyou Zhang
2. Mu Xu
3. Jiao Yuan
4. Zhongyi Hu
5. Junjie Jiang
6. Yanrong Sun
7. Jie Huang
8. Yuxin Wang
9. Bingwei Wang
10. Jianfeng Shen
11. Meixiao Long
12. Yi Fan
13. Kathleen T Montone
14. Janos L Tanyi
15. Sarah H Kim
16. Omid Tavana
17. Robert H Vonderheide
18. Ho Man Chan
19. Susan M Domchek
20. Lin Zhang
21. Xiaowen Hu

• Curated by eLife

  eLife Assessment

  This study presents a valuable and interesting finding that a combination of arginine methyltransferase inhibitors synergize with PARP inhibitors to eliminate ovarian and triple negative cancer cell lines in vitro and in vivo using preclinical mouse models. The data were collected and analyzed using solid and validated methodology and can be used as a starting point for the development of novel therapeutics. The work will be of broad interest to scientists working in the field of breast cancer and ovarian cancer.

Reviewed by eLife

Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

1. Inbal Avraham-Davidi
2. Simon Mages
3. Johanna Klughammer
4. Noa Moriel
5. Shinya Imada
6. Matan Hofree
7. Evan Murray
8. Jonathan Chen
9. Karin Pelka
10. Arnav Mehta
11. Genevieve M Boland
12. Toni Delorey
13. Leah Caplan
14. Danielle Dionne
15. Robert Strasser
16. Jana Lalakova
17. Anezka Niesnerova
18. Hao Xu
19. Morgane Rouault
20. Itay Tirosh
21. Nir Hacohen
22. Fei Chen
23. Omer Yilmaz
24. Jatin Roper
25. Orit Rozenblatt-Rosen
26. Mor Nitzan
27. Aviv Regev

• Curated by eLife

  eLife Assessment

  This work presents a valuable resource combining scRNA-seq and spatial transcriptomics studies to map mouse pre-clinical models of colorectal cancer, identifying distinct cellular programs and microenvironments that could enhance patient stratification and therapeutic approaches in colorectal cancer. While the evidence provided in the manuscript are not fully validated, these solid data were collected and analyzed using a validated methodology that will be of interest to the community in future studies.

Reviewed by eLife