Cancer Biology

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

1. Youyou Zhang
2. Mu Xu
3. Jiao Yuan
4. Zhongyi Hu
5. Junjie Jiang
6. Yanrong Sun
7. Jie Huang
8. Yuxin Wang
9. Bingwei Wang
10. Jianfeng Shen
11. Meixiao Long
12. Yi Fan
13. Kathleen T Montone
14. Janos L Tanyi
15. Sarah H Kim
16. Omid Tavana
17. Robert H Vonderheide
18. Ho Man Chan
19. Susan M Domchek
20. Xiaowen Hu
21. Lin Zhang

• Curated by eLife

  eLife Assessment

  This study presents a rather valuable finding that a combination of arginine methyltransferase inhibitors synergize with PARP inhibitors to kill ovarian and triple negative cancer cells. The evidence supporting the claims of the authors is solid, although some comments and elaborations in the main text would have enhanced the comprehension and clarity of the data. The work will be of interest to scientists working in the field of breast cancer.

Reviewed by eLife

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

1. Erika Tsingos
2. Advaita M. Dick
3. Baubak Bajoghli

• Curated by eLife

  eLife Assessment

  This important study combines agent-based modelling and in vivo experiments in medaka embryos to provide new insights into the role of the thymic niche in T cell development. The modelling yields some interesting and solid findings regarding the importance of thymic epithelial cells. This study would be of interest to oncologists, immunologists, and mathematical modelers.

Reviewed by eLife

Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing

1. Einav Someach
2. Debdatta Halder
3. Avishay Spitzer
4. Chaya Barbolin
5. Michael Tyler
6. Reut Halperin
7. Moshe Biton
8. Amit Tirosh
9. Itay Tirosh

• Curated by eLife

  eLife Assessment

  This is a valuable study that uses single-cell RNA sequencing to define tumor-intrinsic transcriptional programs that characterize distinct types of small intestine neuroendocrine tumors. The evidence supporting the claims of the authors is solid, but would benefit from a larger sample size. The work will be of interest to cancer biologists studying neuroendocrine tumors, as well as those studying tumor heterogeneity more broadly.

Reviewed by eLife

The lnc-FANCI-2 intrinsically restricts RAS signaling in HPV16-infected cervical cancer

1. Haibin Liu
2. Lulu Yu
3. Vladimir Majerciak
4. Thomas Meyer
5. Ming Yi
6. Peter F Johnson
7. Maggie Cam
8. Douglas R Lowy
9. Zhi-Ming Zheng

• Curated by eLife

  eLife Assessment

  This study reports important new insights into the roles of a long noncoding RNA, lnc-FANCI-2, in the progression of cervical cancer induced by a type of human papillomavirus. Through a blend of cell biological, biochemical, and genetic analyses of RNA and protein expression, protein-protein interaction, cell signaling, and cell morphology, the authors provide convincing evidence that lnc-FANCI-2 affects cervical cancer outcome by regulating the RAS signaling pathway. These findings will be of interest to scientists in the fields of cervical cancer, long noncoding RNA, and cell signaling.

Reviewed by eLife

Recurrent cancer-associated ERBB4 mutations are transforming and confer resistance to targeted therapies

1. Veera K. Ojala
2. Sini Ahonen
3. Aura Tuohisto-Kokko
4. Olaya Esparta
5. Peppi Suominen
6. Anne Jokilammi
7. Iman Farahani
8. Deepankar Chakroborty
9. Nikol Dibus
10. Steffen Boettcher
11. Tomi T. Airenne
12. Mark S. Johnson
13. Lisa D. Eli
14. Klaus Elenius
15. Kari J. Kurppa

Reviewed by Review Commons

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

1. Sarah M Chang
2. Muhammad Bin Munim
3. Sonia E Trojan
4. Anna Shevzov-Zebrun
5. Keene L Abbott
6. Matthew G Vander Heiden

• Curated by eLife

  eLife Assessment

  This study presents valuable findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide solid evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of interest to researchers working in cancer and cell metabolism.

Reviewed by eLife

p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

1. Ravi Kumar
2. Simon Couly
3. Bruna R Muys
4. Xiao Ling Li
5. Ioannis Grammatikakis
6. Ragini Singh
7. Mary Guest
8. Xinyu Wen
9. Wei Tang
10. Stefan Ambs
11. Lisa M Jenkins
12. Erica C Pehrsson
13. Raj Chari
14. Tsung-Ping Su
15. Ashish Lal

• Curated by eLife

  eLife Assessment

  In this study, the authors investigate the role of ZMAT3, a p53 target gene, in tumor suppression and RNA splicing regulation. Using quantitative proteomics, the authors uncover that ZMAT3 knockout leads to upregulation of HKDC1, a gene linked to mitochondrial respiration, and that ZMAT3 suppresses HKDC1 expression by inhibiting c-JUN-mediated transcription. This set of convincing evidence reveals a fundamental mechanism by which ZMAT3 contributes to p53-driven tumor suppression by regulating mitochondrial respiration.

Reviewed by eLife

Design of combination therapeutics from protein response to drugs in ovarian cancer cells

1. Alexandra Franz
2. Ciyue Shen
3. Fabian Coscia
4. Kenneth Munroe
5. Lea Charaoui
6. Anil Korkut
7. Matthias Mann
8. Augustin Luna
9. Chris Sander

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors provide a simple yet elegant approach to identifying therapeutic targets that synergize to prevent therapeutic resistance in ovarian cancer using cell lines, data-independent acquisition proteomics, and bioinformatic analysis. The authors convincingly identify several combinations of pharmaceuticals that were able to overcome or prevent therapeutic resistance in culture models of ovarian cancer, a disease with an unmet diagnostic and therapeutic need. However, the extent to which these findings may extend to more complex models of ovarian cancer remains unclear.

Reviewed by eLife

Tumoral CD24 tunes platelets binding and pro-metastatic functions

1. Vincent Mittelheisser
2. Cristina Liboni
3. Clarisse Mouriaux
4. Silvia Maria Grazia Trivigno
5. Louis Bochler
6. Maria Garcia-Leon
7. Annabel Larnicol
8. Laetitia Paulen
9. Tristan Stemmelen
10. Pierre Henri Mangin
11. Olivier Lefebvre
12. Jacky G. GOETZ

Reviewed by preLights

PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

1. Jiongke Wang
2. Yujie Shi
3. Ying Wang
4. Yingqiang Shen
5. Huan Liu
6. Silu Sun
7. Yimei Wang
8. Xikun Zhou
9. Yu Zhou
10. Xin Zeng
11. Jing Li
12. Qianming Chen

• Curated by eLife

  eLife Assessment

  This manuscript determines how PA28g, a proteasome regulator that is overexpressed in tumors, and C1QBP, a mitochondrial protein for maintaining oxidative phosphorylation that plays a role in tumor progression, interact in tumor cells to promote their growth, migration and invasion. Additional experiments and analyses that supported the theoretical models for the interaction have been performed in response to the reviews. The overall findings and conceptual framework are important and the evidence is solid. A logical extrapolation of this work is to test the C1QBP mutants using functional assays to determine whether the mutations can decrease the protein stability mediated by the interaction with PA28g.

Reviewed by eLife