Cancer Biology

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

1. Jae Hun Shin
2. Jooyoung Park
3. Jaechul Lim
4. Jaekwang Jeong
5. Ravi K Dinesh
6. Stephen E Maher
7. Jeonghyun Kim
8. Soyeon Park
9. Jun Young Hong
10. John Wysolmerski
11. Jungmin Choi
12. Alfred LM Bothwell

• Curated by eLife

  eLife Assessment

  This valuable study proposes that protein secreted by colon cancer cells induces cells with Paneth-like properties that favor colon cancer metastasis. The evidence supporting the conclusions is solid but the study would benefit from more direct experiments to test the functional role of Paneth-like cells and to monitor metastasis from colon tumors. The work will be of interest to researchers studying colon cancer metastasis.

Reviewed by eLife

Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing

1. Einav Someach
2. Debdatta Halder
3. Avishay Spitzer
4. Chaya Barbolin
5. Michael Tyler
6. Reut Halperin
7. Moshe Biton
8. Amit Tirosh
9. Itay Tirosh

• Curated by eLife

  eLife Assessment

  This study analyzes a cohort of small intestine neuroendocrine tumors, and the description of tumor-intrinsic programs that govern such rare cancers is felt to be valuable. The methods are for the most part felt to be solid, however, some broad concerns were raised that the possible separation of samples by a program may be impacted by fresh versus frozen sequencing. Similarly, the heterogeneity of the SiNET tumor microenvironment is unclear given a mixing of subtypes and the proliferation of NE and immune cells in SiNET could be influenced by technical factors. Recommendations were made to extend these data with other published datasets of SiNET tumors, expanding technical clarity and details, and validating findings using cell lines/PDX if available.

Reviewed by eLife

An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

1. Chiara Capitani
2. Jessica Iorio
3. Elena Lastraioli
4. Claudia Duranti
5. Giacomo Bagni
6. Ginevra Chioccioli Altadonna
7. Rossella Colasurdo
8. Giorgia Scarpellino
9. Scott P. Fraser
10. Andrea Becchetti
11. Mustafa B. A. Djamgoz
12. Annarosa Arcangeli

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

Reviewed by eLife

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

1. Chong Zhang
2. Zuoyan Zhang
3. Yuchen Wu
4. Jing Cheng
5. Kaizhi Luo
6. Zhidi Li
7. Manman Zhang
8. Jian Wang
9. Yangling Li

• Curated by eLife

  eLife Assessment

  This manuscript provides valuable mechanistic insight into NSCLC progression, both in terms of tumour metastasis and the development of chemoresistance. The authors draw upon a range of techniques and assays and although the evidence shown is solid, suggestions by the two reviewers will strengthen the message. The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies.

Reviewed by eLife

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

1. Zuzana Outla
2. Gizem Oyman-Eyrilmez
3. Katerina Korelova
4. Magdalena Prechova
5. Lukas Frick
6. Lenka Sarnova
7. Piyush Bisht
8. Petra Novotna
9. Jan Kosla
10. Patricia Bortel
11. Yasmin Borutzki
12. Andrea Bileck
13. Christopher Gerner
14. Mohammad Rahbari
15. Nuh Rahbari
16. Emrullah Birgin
17. Bibiana Kvasnicova
18. Andrea Galisova
19. Katerina Sulkova
20. Andreas Bauer
21. Njainday Jobe
22. Ondrej Tolde
23. Eva Sticova
24. Daniel Rosel
25. Tracy O’Connor
26. Martin Otahal
27. Daniel Jirak
28. Mathias Heikenwälder
29. Gerhard Wiche
30. Samuel M Meier-Menches
31. Martin Gregor

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding in understanding the role of plectin in the development and progression of hepatocellular carcinoma (HCC). The evidence supporting the conclusions is convincing because multiple orthogonal ways were used to demonstrate the requirement of this target in liver cancer models. However, the study is incomplete as the downstream molecular activities of plectin that mediate the cancer phenotypes were not fully evaluated.

Reviewed by eLife

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

1. Weijie Wu
2. Miao Yu
3. Qianchen Li
4. Yiqian Zhao
5. Lei Zhang
6. Yi Sun
7. Zhenbin Wang
8. Yuqing Gong
9. Wenjing Wang
10. Chenying Liu
11. Jing Zhang
12. Yan Tang
13. Xiaojie Xu
14. Xiaojing Guo
15. Jun Zhan
16. Hongquan Zhang

• Curated by eLife

  eLife Assessment

  This manuscript presents a valuable finding on the impact of FRMD8 loss on tumor progression and the resistance to tamoxifen therapy. The author conducted systematic experiments to explore the role of FRMD8 in breast cancer and its potential regulatory mechanisms, confirming that FRMD8 affects tamoxifen resistance and convincingly validating this hypothesis through a series of experiments.

Reviewed by eLife

Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

1. Erika Tsingos
2. Advaita M Dick
3. Baubak Bajoghli

• Curated by eLife

  eLife Assessment

  This valuable study combines agent-based modelling and in vivo experiments in medaka embryos to provide new insights into the role of the thymic niche in T cell development. The modelling yields some interesting findings regarding the importance of thymic epithelial cells, for some of which the evidence is incomplete. This study would be of interest to oncologists, immunologists, and mathematical modelers.

Reviewed by eLife

Mapping the niche of breast cancer metastases in lung and liver

1. Magdalena K. Sznurkowska
2. Francesc Castro-Giner
3. Yongzhan Zhang
4. Alexander Ring
5. Fabienne Dominique Schwab
6. Francesca Albrecht
7. Kirsten D. Mertz
8. Karin Strittmatter
9. Lauren L. Ozimski
10. Selina Budinjas
11. Gaël Auray
12. Claudio Giachino
13. Verdon Taylor
14. Ana Gvozdenovic
15. Ilaria Malanchi
16. Heike Frauchiger-Heuer
17. Andreas Wicki
18. Marcus Vetter
19. Nicola Aceto

Reviewed by Life Science Editors Foundation

A novel HER2 protein identification methodology in breast cancer cells using Raman spectroscopy and Raman imaging: an analytical validation study

1. H. Abramczyk
2. J. Surmacki
3. M. Kopeć

Reviewed by Arcadia Science

Bestrophin-4 relays Hes4 and interacts with Twist1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

1. Zijing Wang
2. Bihan Xia
3. Shaochong Qi
4. Xian Zhang
5. Xiaoshuang Zhang
6. Yan Li
7. Huimin Wang
8. Miao Zhang
9. Ziyi Zhao
10. David Kerr
11. Li Yang
12. Shijie Cai
13. Jinlin Yang

• Curated by eLife

  eLife Assessment

  The findings of this valuable manuscript advance our understanding of the significance of Bestrophin isoform 4 (BEST4) in suppressing colorectal cancer (CRC) progression. The authors used appropriate and validated methodology, such as the knockout of BEST4 using CRISPR/Cas9 in CRC cells, to provide a solid foundation for elucidating the potential link between BEST4 and CRC progression.

Reviewed by eLife