Cancer Biology

Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in cancer

1. Qian Wang
2. Liping Li
3. Lin You
4. Shuai Wang
5. Lei Han
6. Bingnan Wang
7. Liping Yao
8. Yesu Addepalli
9. Yong Lu
10. Ilgen Mender
11. Ann M Flusche
12. Chiho Kim
13. Nageswari Yarravarapu
14. Andrew Lemoff
15. Lawrence Lum
16. Jerry W Shay
17. Yonghao Yu
18. Chuo Chen

• Curated by eLife

  eLife Assessment

  This important study reports the development of the first tankyrase degrader and demonstrates its enhanced ability to inhibit β-catenin signaling compared to conventional tankyrase inhibitors. The evidence supporting the conclusions is comprehensive and convincing, based on rigorous biochemical and cellular analyses. The findings will be of broad interest to researchers studying Wnt signaling, protein degradation, and cancer biology.

Reviewed by eLife

RAB14-dependent tubulovesicular recycling directs MET to invadopodia, promoting TNBC cell invasion

1. Amrita Khamari
2. Atreyee Guria
3. Kiran Tak
4. Rajiv Sharma
5. Yannis Kalaidzidis
6. Sunando Datta

• Curated by eLife

  eLife Assessment

  This revised paper provides solid evidence for HGF-induced trafficking of the HGF receptor, MET, together with metalloprotease MT1-MMP into invadopodia and the role of this trafficking in triple-negative breast cancer (TNBC) cell invasion in vitro. The evidence could be improved with additional experimental controls and analysis, but the findings will be valuable for cancer cell biologists investigating TNBC.

Reviewed by eLife

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

1. Beatrice Gini
2. Philippe Gui
3. Wei Wu
4. D Lucas Kerr
5. Lisa Tan
6. Dora Barbosa
7. Victor Olivas
8. Paul Allegakoen
9. Carlos Gomez
10. Patrick R Halliday
11. Sarah Elmes
12. Veronica Steri
13. Turja Chakrabarti
14. Trever G Bivona
15. Collin M Blakely

• Curated by eLife

  eLife Assessment

  In this important study, the authors describe the mechanisms by which CDK4/6 overexpression mediates resistance to Osimertinib in EGFR mutant lung cancer models. Their data show that CD4/6 overexpressing cells had increased replicative stress and genomic instability. The evidence is solid, but inclusion of some additional experiments would make this stronger.

Reviewed by eLife

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications

1. Marta Lopes
2. Tiago L. Duarte
3. Maria J. Teles
4. Laura Mosteo
5. Sérgio Chacim
6. Eliana Aguiar
7. Joana Pereira-Reis
8. Mónica Oliveira
9. André M. N. Silva
10. Nuno Gonçalves
11. Gabriela Martins
12. Isabella Y. Kong
13. Magnus Zethoven
14. Stephin Vervoort
15. Sandra Martins
16. Miguel Quintela
17. Edwin D Hawkins
18. Fernanda Trigo
19. João T. Guimarães
20. José M. Mariz
21. Graça Porto
22. Delfim Duarte

Reviewed by PREreview

Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer

1. Michael Kitoi
2. John Gitau
3. Godfrey Wagutu
4. Kennedy Mwangi
5. Florence Ngonga
6. Francis Makokha

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the mutational and expression profile of ZNF217, ZNF750, ZNF703 Zinc finger genes in Kenya women with BCs. The evidence supporting the claims of the authors is solid. The work will be of interest to scientists or clinicians working in the field of diagnosis and detection for breast cancer.

Reviewed by eLife

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma

1. Alina Ritter
2. Malenka Zimmermann
3. Florian H. Geyer
4. Pablo Táboas
5. David Obermeier
6. Martha J. Carreño Gonzalez
7. Kimberley M. Hanssen
8. Tobias Faehling
9. Jana Siebenlist
10. Annika Jeschke
11. Laura Romero-Pérez
12. Roland Imle
13. Ana Banito
14. Enrique de Álava
15. Wolfgang Hartmann
16. Uta Dirksen
17. Thomas G. P. Grünewald
18. Florencia Cidre-Aranaz

Reviewed by preLights

FoxN1-dependent thymic epithelial cells promote T-cell leukemia development

1. Marinella N Ghezzo
2. Mónica T Fernandes
3. Ivette Pacheco-Leyva
4. Pedro M Rodrigues
5. Rui S Machado
6. Marta A S Araújo
7. Ravi K Kalathur
8. Matthias E Futschik
9. Nuno L Alves
10. Nuno R dos Santos

Reviewed by PREreview

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

1. Sarah M Chang
2. Muhammad Bin Munim
3. Sonia E Trojan
4. Huel Cox
5. Anna Shevzov-Zebrun
6. Keene L Abbott
7. Renee Chang
8. Matthew G Vander Heiden

• Curated by eLife

  eLife Assessment

  This study presents important findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide convincing evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of broad interest to researchers working in cancer and cell metabolism.

Reviewed by eLife