Cancer Biology

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

1. Kamila J Bienkowska
2. Stephany Gallardo Y
3. Nur S Zainal
4. Matthew Ellis
5. Maria-Antoinette Lopez
6. Judith Austine
7. Sai Pittla
8. Serena J Chee
9. Aiman Alzetani
10. Emily C Shaw
11. Christian H Ottensmeier
12. Gareth J Thomas
13. Christopher J Hanley

Reviewed by Review Commons

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation

1. Roza H. A. Masalmeh
2. John C. Dawson
3. Virginia Alvarez Garcia
4. Morwenna T. Muir
5. Roderick N. Carter
6. Giles Hardingham
7. Cameron Davies
8. Rosina Graham
9. Alex von Kriegsheim
10. Jair Marques Junior
11. Chinmayi Pednekar
12. Steven M. Pollard
13. Neil O. Carragher
14. Valerie G. Brunton
15. Margaret C. Frame

Reviewed by Review Commons

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

1. Wei Qi Guinevere Sew
2. Maria Molano-Fernández
3. Zhiquan Li
4. Artim Lange
5. Nahia Pérez de Ciriza
6. Lene Juel Rasmussen
7. Héctor Herranz

Reviewed by Review Commons

Acquired resistance to sotorasib in KRASG12C mutant NSCLC is vulnerable to PI3K-mTOR pathway inhibition mediated by 4E-BP1 regulator of cap-dependent translation

1. Ismail M Meraz
2. Shuhong Wu
3. Yi Xu
4. Lihui Gao
5. Meng Feng
6. Chenghui Ren
7. Renduo Song
8. Ran Zhang
9. Qi Wang
10. Yuanxin Xi
11. Sung Yun Jung
12. Jing Wang
13. Bingliang Fang
14. Mourad Majidi
15. Jack A Roth

• Curated by eLife

  eLife Assessment

  The authors investigate mechanisms of acquired resistance (AR) to KRAS-G12C inhibitors (sotorasib) in non-small cell lung cancer, proposing that resistance arises from signaling rewiring rather than additional mutations. While the study addresses a valuable clinical question, it is limited by several weaknesses in experimental rigor, data interpretation, and presentation, meaning the strength of evidence is incomplete

Reviewed by eLife

Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system

1. Christopher B. Nelson
2. Jadon K. Wells
3. Ekaagra Kesarwani
4. Alexander P. Sobinoff
5. Jixuan Gao
6. Karen L. MacKenzie
7. Rebecca C. Poulos
8. Urwah Nawaz
9. Xiang Wang
10. Heide L. Ford
11. Hilda A. Pickett

Reviewed by Review Commons

Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

1. Naphannop Sereesongsaeng
2. Carole JR Bataille
3. Angela J Russell
4. Nicolas Bery
5. Fernando Sialana
6. Jyoti Choudhary
7. Ami Miller
8. Terry H Rabbitts

• Curated by eLife

  eLife Assessment

  This paper reports the development of proteins and small molecules that drive bridge LMO2, an oncogenic transcription factor in T-ALL, to E3 ligases (Cereblon and VHL), and demonstrates their effectiveness in degrading FMO2, causing growth arrest and inducing apoptosis in T cell lines in vitro. The findings are valuable because they provide evidence that intrinsically disordered proteins can be targeted for degradation by PROTAC-type chemicals. The paper also provides a route for rational PROTAC design based on intracellular antibody paratopes. Overall, the paper is supported by solid evidence and will be of interest to chemical biologists and cancer pharmacologists.

Reviewed by eLife

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

1. Antara Sengupta
2. Soujanya Vinayagamurthy
3. Drishti Soni
4. Rajlekha Deb
5. Ananda Kishore Mukherjee
6. Subhajit Dutta
7. Jushta Jaiswal
8. Mukta Yadav
9. Shalu Sharma
10. Sulochana Bagri
11. Shuvra Shekhar Roy
12. Priya Poonia
13. Ankita Singh
14. Divya Khanna
15. Amit Kumar Bhatt
16. Akshay Sharma
17. Suman Saurav
18. Rajender K Motiani
19. Shantanu Chowdhury

• Curated by eLife

  eLife Assessment

  The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

Reviewed by eLife

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1

1. G. Silvani
2. C. Kopecky
3. S. Romanazzo
4. V. Rodriguez
5. A. Das
6. E. Pandzic
7. J. G. Lock
8. C Chaffer
9. K. Poole
10. K. A. Kilian

Reviewed by preLights

Reconfiguration of tumor cells with LCOR transcription factor mRNA nanotherapy to enhance immunotherapy efficacy

1. Gabriel Serra-Mir
2. Elena Haro-Martínez
3. Chiara Cannatà
4. José Ángel Palomeque
5. Sandra Blasco-Benito
6. Anna López-Plana
7. María Sanz-Flores
8. Marc Sabartés
9. Cristina Fornaguera
10. Toni Celià-Terrassa

Reviewed by Review Commons

Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

1. Megan E Patton
2. Sherwin Kelekar
3. Lauren J Taylor
4. Angela E Dean
5. Qianying Zuo
6. Rhishikesh N Thakare
7. Sung Hwan Lee
8. Emily Gentry
9. Morgan Panitchpakdi
10. Pieter Dorrestein
11. Yazen Alnouti
12. Zeynep Madak-Erdogan
13. Ju-Seog Lee
14. Milton J Finegold
15. Sayeepriyadarshini Anakk

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into the influence of sex on bile acid metabolism and the risk of hepatocellular carcinoma (HCC). The data to support that there are inter-relationships between sex, bile acids, and HCC in mice are convincing, although this is a largely descriptive study. Future studies are needed to understand the interaction of sex hormones, bile acids, and chronic liver diseases and cancer at a mechanistic level. Also, there is not enough evidence to determine the clinical significance of the findings given the differences in bile acid composition between mice and men.

Reviewed by eLife