Cancer Biology

Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications

1. Marta Lopes
2. Tiago L. Duarte
3. Maria J. Teles
4. Laura Mosteo
5. Sérgio Chacim
6. Eliana Aguiar
7. Joana Pereira-Reis
8. Mónica Oliveira
9. André M. N. Silva
10. Nuno Gonçalves
11. Gabriela Martins
12. Isabella Y. Kong
13. Magnus Zethoven
14. Stephin Vervoort
15. Sandra Martins
16. Miguel Quintela
17. Edwin D Hawkins
18. Fernanda Trigo
19. João T. Guimarães
20. José M. Mariz
21. Graça Porto
22. Delfim Duarte

Reviewed by PREreview

DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

1. Simar Pal Singh
2. Kumar Mangalam
3. Michelle D van den Beukel
4. Sjoerd van Deventer
5. Marije B Overdijk
6. M Guy Roukens
7. Kim CM Santegoets
8. Esther CW Breij
9. Martin ter Beest
10. Willem PJ Cox
11. Annemiek B van Spriel

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma through antibody clustering, independent of complement. The central findings are supported by solid evidence, although some mechanistic details, including the specific Fc receptor requirements for crosslinking-mediated cytotoxicity, remain unresolved. As the findings are based primarily on in vitro models, further validation would be required to support broader translational conclusions. The previous review comments were addressed by the authors and have improved the work.

Reviewed by eLife

Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer

1. Michael Kitoi
2. John Gitau
3. Godfrey Wagutu
4. Kennedy Mwangi
5. Florence Ngonga
6. Francis Makokha

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the mutational and expression profile of ZNF217, ZNF750, ZNF703 Zinc finger genes in Kenya women with BCs. The evidence supporting the claims of the authors is solid. The work will be of interest to scientists or clinicians working in the field of diagnosis and detection for breast cancer.

Reviewed by eLife

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma

1. Alina Ritter
2. Malenka Zimmermann
3. Florian H. Geyer
4. Pablo Táboas
5. David Obermeier
6. Martha J. Carreño Gonzalez
7. Kimberley M. Hanssen
8. Tobias Faehling
9. Jana Siebenlist
10. Annika Jeschke
11. Laura Romero-Pérez
12. Roland Imle
13. Ana Banito
14. Enrique de Álava
15. Wolfgang Hartmann
16. Uta Dirksen
17. Thomas G. P. Grünewald
18. Florencia Cidre-Aranaz

Reviewed by preLights

FoxN1-dependent thymic epithelial cells promote T-cell leukemia development

1. Marinella N Ghezzo
2. Mónica T Fernandes
3. Ivette Pacheco-Leyva
4. Pedro M Rodrigues
5. Rui S Machado
6. Marta A S Araújo
7. Ravi K Kalathur
8. Matthias E Futschik
9. Nuno L Alves
10. Nuno R dos Santos

Reviewed by PREreview

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

1. Patrick B Jonker
2. Mumina Sadullozoda
3. Guillaume Cognet
4. Juan J Apiz Saab
5. Kelly H Sokol
6. Violet X Wu
7. Deepa Kumari
8. Colin Sheehan
9. Mete E Ozgurses
10. Darby Agovino
11. Grace Croley
12. Lindsey N Dzierozynski
13. Chufan Cai
14. Leah M Ziolkowski
15. Smit A Patel
16. Althea Bock-Hughes
17. Kay F Macleod
18. Hardik Shah
19. Jonathan L Coloff
20. Evan C Lien
21. Alexander Muir

• Curated by eLife

  eLife Assessment

  This important study demonstrates that nutrient stress engenders metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). By combining cell line and mouse models, the authors provide compelling evidence showing that arginine depletion from the microenvironment disrupts lipid homeostasis in PDAC resulting in ferroptosis upon exposure of tumors to polyunsaturated fatty acids. This report is likely to be of broad interest to researchers interested in studying cancer biology, metabolic adaptations and stress responses.

Reviewed by eLife

Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

1. Sarah M Chang
2. Muhammad Bin Munim
3. Sonia E Trojan
4. Huel Cox
5. Anna Shevzov-Zebrun
6. Keene L Abbott
7. Renee Chang
8. Matthew G Vander Heiden

• Curated by eLife

  eLife Assessment

  This study presents important findings on the relationship between nutrient availability and NAD/NADH levels, which in turn regulate biomass production in cancer cells. The authors provide convincing evidence to support their claims, offering insight into why it is difficult to predict which nutrients limit cancer cell growth: both cell type and nutrient availability together determine the oxidative capacity that constrains the synthesis of various metabolic intermediates. The manuscript will be of broad interest to researchers working in cancer and cell metabolism.

Reviewed by eLife

Restraint of melanoma progression by cells in the local skin environment

1. Yilun Ma
2. Mohita Tagore
3. Miranda V Hunter
4. Ting-Hsiang Huang
5. Emily Montal
6. Joshua M Weiss
7. Yingxiao Shi
8. Tuulia Vallius
9. Peter K Sorger
10. Richard M White

• Curated by eLife

  eLife Assessment

  In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo Epithelial-Mesenchymal Transition (EMT). Surprisingly, when overexpressing Twist in keratinocytes, the resulting alteration in keratinocytes is inhibitory for melanoma invasion in both zebrafish and human cell culture models. The results are supported by convincing experimental data that provide new insights into the interactions between melanoma cells and their environment.

Reviewed by eLife

An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer

1. Jodie R. Malcolm
2. Jack Stenning
3. Jacob Pope
4. Jakub Łukaszonek
5. Susanna F. Rose
6. Taylor E. Smith
7. Lesley Gilbert
8. Sally R. James
9. Katherine S. Bridge
10. William J. Brackenbury
11. Andrew N. Holding

Reviewed by Review Commons

High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study

1. Ming Liu
2. Linping Lu
3. Lingxiang Zhu
4. Xiaoni Zhang
5. Yuanyuan Liu
6. Xiaojing Ren
7. Shimin Liu
8. Shaochen Cheng
9. Mingyan Xu
10. Chao Lu
11. Yan Peng
12. Wenmei Su
13. Yong Guo
14. Shifu Chen

Reviewed by PREreview