1. Telomeres control human telomerase ( hTERT ) expression through non-telomeric TRF2

    This article has 19 authors:
    1. Antara Sengupta
    2. Soujanya Vinayagamurthy
    3. Drishti Soni
    4. Rajlekha Deb
    5. Ananda Kishore Mukherjee
    6. Subhajit Dutta
    7. Jushta Jaiswal
    8. Mukta Yadav
    9. Shalu Sharma
    10. Sulochana Bagri
    11. Shuvra Shekhar Roy
    12. Priya Poonia
    13. Ankita Singh
    14. Divya Khanna
    15. Amit Kumar Bhatt
    16. Akshay Sharma
    17. Suman Saurav
    18. Rajender K Motiani
    19. Shantanu Chowdhury
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors of this important study investigate how telomere length regulates hTERT expression via non-telomeric binding of the telomere-associated protein TRF2. They conclusively show that TRF2 binding to long telomeres results in a reduction in its binding to the hTERT promoter, while short telomeres restore TRF2 binding in the hTERT promoter, recruiting repressor complexes like PRC2, and suppressing hTERT expression. There is convincing support for the claims and the findings should be of broad interest for cell biologists and those working in fields where telomeres alter function, such as cancer and aging.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

    This article has 27 authors:
    1. Inbal Avraham-Davidi
    2. Simon Mages
    3. Johanna Klughammer
    4. Noa Moriel
    5. Shinya Imada
    6. Matan Hofree
    7. Evan Murray
    8. Jonathan Chen
    9. Karin Pelka
    10. Arnav Mehta
    11. Genevieve M Boland
    12. Toni Delorey
    13. Leah Caplan
    14. Danielle Dionne
    15. Robert Strasser
    16. Jana Lalakova
    17. Anezka Niesnerova
    18. Hao Xu
    19. Morgane Rouault
    20. Itay Tirosh
    21. Nir Hacohen
    22. Fei Chen
    23. Omer Yilmaz
    24. Jatin Roper
    25. Orit Rozenblatt-Rosen
    26. Mor Nitzan
    27. Aviv Regev
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work presents a useful resource combining scRNA-seq and spatial transcriptomics studies to map mouse pre-clinical models of colorectal cancer, identifying distinct cellular programs and microenvironments that could enhance patient stratification and therapeutic approaches in colorectal cancer. While the novelty of the biological findings remains limited and incompletely supported by the evidence provided in the manuscript, the data were collected and analyzed using a validated methodology that will be of interest to the community in future studies.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. In vivo targeted and deterministic single cell malignant transformation

    This article has 6 authors:
    1. Pierluigi Scerbo
    2. Benjamin Tisserand
    3. Marine Delagrange
    4. Héloïse Debare
    5. David Bensimon
    6. Bertrand Ducos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study employs an optogenetics approach aimed at activating oncogene (KRASG12V) expression in a single somatic cell, with a focus on following the progression of activated cell to examine tumourigenesis probabilities under altered tissue environments. Although the description of the methodologies applied is incomplete, the authors propose a mechanism whereby reactivation of re-programming factors correlates with the increased likelihood of a mutant cell undergoing malignant transformation. This work will be of interest to developmental and cancer biologists, especially in relation to the genetic tools described.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    This article has 12 authors:
    1. Jiongke Wang
    2. Yujie Shi
    3. Ying Wang
    4. Yingqiang Shen
    5. Huan Liu
    6. Silu Sun
    7. Yimei Wang
    8. Xikun Zhou
    9. Yu Zhou
    10. Xin Zeng
    11. Jing Li
    12. Qianming Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work attempts to demonstrate an ATP-independent non-canonical role of proteasomal component PA28y in the promotion of oral squamous cell carcinoma growth, migration, and invasion. Although the authors have addressed some concerns, uncertainties regarding the PA28g-C1QBP direct interaction still exist. The overall findings of the manuscript are useful, but the validation evidence is incomplete.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  5. Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma

    This article has 20 authors:
    1. Kerstin Seidel
    2. Robert Piskol
    3. Thi Thu Thao Nguyen
    4. Amy Shelton
    5. Charisa Cottonham
    6. Cecile C de la Cruz
    7. Joseph Castillo
    8. Jesse Garcia
    9. Udi Segal
    10. Mark Merchant
    11. Yeqing Angela Yang
    12. Jasmine Chen
    13. Musa Ahmed
    14. Alexis Scherl
    15. Rajesh Vij
    16. Lluc Mosteiro
    17. Yan Wu
    18. Zora Modrusan
    19. Ciara Metcalfe
    20. Chris Siebel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, Seidel et al. identify and characterize a novel subset of hepatocellular carcinoma patient-derived xenograft models defined by active Jagged 1-Notch2 signaling and a distinctive progenitor-like gene expression profile. Within the limitations of the PDX system they used, their methods are state-of-the-art, their data are strong and believable, and their conclusions are convincing. However, the ability to identify HCC patients that might respond is limited, and the mechanistic assessment downstream of JAG1/NOTCH2 is relatively descriptive. Some additional clarifications and experiments would strengthen the paper.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    This article has 10 authors:
    1. Chong Zhang
    2. Zuoyan Zhang
    3. Yueyi Wu
    4. Yuchen Wu
    5. Jing Cheng
    6. Kaizhi Luo
    7. Zhidi Li
    8. Manman Zhang
    9. Jian Wang
    10. Yangling Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides valuable mechanistic insight into NSCLC progression, both in terms of tumour metastasis and the development of chemoresistance. The authors draw upon a range of techniques and assays and the evidence shown is solid and has been strengthened by incorporation of suggestions by the two reviewers. The work presented will be of interest to cancer biologists and more broadly to those interested in NSCLC translational studies.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  7. STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

    This article has 8 authors:
    1. Huan Fang
    2. Huichun Liang
    3. Chuanyu Yang
    4. Dewei Jiang
    5. Qianmei Luo
    6. Wenming Cao
    7. Huifeng Zhang
    8. Ceshi Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental approaches, others lack sufficient validation. Additionally, there are instances where critical experimental controls appear to be absent.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

    This article has 10 authors:
    1. Han V Han
    2. Richard Efem
    3. Barbara Rosati
    4. Kevin Lu
    5. Sara Maimouni
    6. Ya-Ping Jiang
    7. Valeria Montoya
    8. Ando Van Der Velden
    9. Wei-Xing Zong
    10. Richard Z Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The significance of the findings is valuable, with implications for immunotherapy design in pancreatic ductal adenocarcinoma. The evidence was considered incomplete and partially supportive of the major claims.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Spatial multi-omics defines a shared glioblastoma infiltrative signature at the resection margin

    This article has 13 authors:
    1. Balagopal Pai
    2. Susana Isabel Ramos
    3. Wan Sze Cheng
    4. Tanvi Joshi
    5. Gabrielle Price
    6. Jessica Tome-Garcia
    7. German Nudelman
    8. Sanjana Shroff
    9. Kristin Beaumont
    10. Yong Raymund
    11. Robert Sebra
    12. Elena Zaslavsky
    13. Nadejda Mincheva Tsankova

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Tks5 interactome reveals ER-associated machinery translation in invadosomes

    This article has 12 authors:
    1. Léa Normand
    2. Benjamin Bonnard
    3. Margaux Sala
    4. Sylvaine Di-Tommaso
    5. Cyril Dourthe
    6. Anne-Aurélie Raymond
    7. Jean-William Dupuy
    8. Luc Mercier
    9. Jacky G. Goetz
    10. Violaine Moreau
    11. Elodie Henriet
    12. Frédéric Saltel

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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