Cancer Biology

Prognostic Significance of preoperative serum CA125, CA19-9, CA72-4, CEA, and AFP in Patients with Endometrial cancer

1. Zi-hao Wang
2. Yun-zheng Zhang
3. Shu-wen Ge
4. Luhe-Shan
5. Bo Wang
6. Zi-yu Zhang
7. Qi-jun Wu
8. Xiao-xin Ma

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on prognostic values of serum CA125, CEA, and AFP for predicting patient outcomes of endometrial cancer. The evidence supporting the claims of the authors is solid, although inclusion of detailed discussion of present results with prior documented findings would have strengthened the study. The work will be of interest to scientists working on endometrial cancer.

Reviewed by eLife

Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

1. Camille Dantzer
2. Justine Vaché
3. Aude Brunel
4. Isabelle Mahouche
5. Anne-Aurélie Raymond
6. Jean-William Dupuy
7. Melina Petrel
8. Paulette Bioulac-Sage
9. David Perrais
10. Nathalie Dugot-Senant
11. Mireille Verdier
12. Barbara Bessette
13. Clotilde Billottet
14. Violaine Moreau

• Curated by eLife

  eLife assessment

  Hepatocellular carcinoma (HCC) is a particularly aggressive form of cancer, with an increasing number of treatment options approved for use in patients over the past decade. However, the biology of HCC and identifiable therapeutic targets have not been as clear, even in the era of molecular oncology. Likewise, the cellular biology of HCC, including the role of intercellular communication, has not been well elucidated. In this compelling study, Dantzer et al. provide fundamental insight into the role of beta-catenin on intercellular communication occurring via extracellular vesicles, with implications for immune evasion in a cancer increasingly being treated using immuno-oncologic agents.

Reviewed by eLife

Post-transcriptional control drives Aurora kinase A expression in human cancers

1. Roberta Cacioppo
2. Deniz Rad
3. Giulia Pagani
4. Paolo Gandellini
5. Catherine Lindon

Reviewed by Review Commons

RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

1. Yang Liu
2. Yi Jiang
3. Peng Qiu
4. Tie Ma
5. Yang Bai
6. Jiawen Bu
7. Yueting Hu
8. Ming Jin
9. Tong Zhu
10. Xi Gu

• Curated by eLife

  eLife assessment

  This valuable paper first demonstrated that RGS10 was identified as a biomarker to evaluate the prognosis of breast cancer. To prevent the loss of RGS10 theoretically provide a new strategy for the treatment of breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples and an animal model would have strengthened the study. The work will be of interest to clinicians working on breast cancer.

Reviewed by eLife

Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

1. Khanh N. Dinh
2. Monika K. Kurpas
3. Marek Kimmel

• Curated by eLife

  eLife assessment

  This study uses numerical simulations to characterize and compare variants of two widely used mathematical models and then applies those models to inferring evolutionary parameters from breast cancer data. The copious numerical results will be of some interest to mathematical biologists working with similar models. The finding that many breast cancer mutations are mildly deleterious is valuable but the evidence supporting this claim is incomplete because the mathematical modelling and statistical methods are insufficiently justified and inadequately validated.

Reviewed by eLife

STIL overexpression shortens lifespan and reduces tumor formation in mice

1. Amira-Talaat Moussa
2. Marco R. Cosenza
3. Timothy Wohlfromm
4. Katharina Brobeil
5. Anthony Hill
6. Annarita Patrizi
7. Karin Müller-Decker
8. Tim Holland-Letz
9. Anna Jauch
10. Bianca Kraft
11. Alwin Krämer

Reviewed by Review Commons

Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

1. Kyle Spinler
2. Michael Hamilton
3. Jeevisha Bajaj
4. Yutaka Shima
5. Emily Diaz
6. Marcie Kritzik
7. Tannishtha Reya

• Curated by eLife

  eLife assessment

  The study presents important findings on the role of MSI2-HOXA9 translocation in chronic myeloid leukemia. The authors provide convincing evidence supporting the role of this translocation in leukemogenesis by using elegant mouse modeling and in vitro mechanistic studies. Consistent with the reviews, the studies can be strengthened with further murine and cell line experiments.

Reviewed by eLife

RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia

1. Mengya Zhao
2. Beiying Dai
3. Xiaodong Li
4. Yixin Zhang
5. Chun Qiao
6. Yaru Qin
7. Zhao Li
8. Qingmei Li
9. Shuzhen Wang
10. Yong Yang
11. Yijun Chen

• Curated by eLife

  eLife assessment

  In this important study, the authors describe a novel function for RAPSYN in bcr-abl fusion associated leukemia, presenting convincing evidence that RAPSYN stabilizes the oncogenic BCR-ABL fusion protein. Compared to an earlier version of the manuscript, the authors have added data using primary samples that strengthen the conclusions.

Reviewed by eLife

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

1. Keene L Abbott
2. Ahmed Ali
3. Bradley I Reinfeld
4. Amy Deik
5. Sonu Subudhi
6. Madelyn D Landis
7. Rachel A Hongo
8. Kirsten L Young
9. Tenzin Kunchok
10. Christopher S Nabel
11. Kayla D Crowder
12. Johnathan R Kent
13. Maria Lucia L Madariaga
14. Rakesh K Jain
15. Kathryn E Beckermann
16. Caroline A Lewis
17. Clary B Clish
18. Alexander Muir
19. W Kimryn Rathmell
20. Jeffrey Rathmell
21. Matthew G Vander Heiden

• Curated by eLife

  eLife assessment

  This study provides an important finding that the local abundance of metabolites impacts the biology of the tumor microenvironment by utilizing kidney tumors from patients and adjacent normal tissues. The evidence supporting the claims of the authors is convincing. The work will of interest to the research community working on metabolism and kidney cancer especially.

Reviewed by eLife

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

1. Dongyue Jiao
2. Huiru Sun
3. Xiaying Zhao
4. Yingji Chen
5. Zeheng Lv
6. Qing Shi
7. Yao Li
8. Chenji Wang
9. Kun Gao

• Curated by eLife

  eLife assessment

  This study reports a novel substrate and a mediator of oncogenesis downstream of mTORC1, a fundamental advance in our understanding of the mechanistic basis of mTORC1-regulated cap-dependent translation and protein synthesis. Using an array of biochemical, proteomic and functional assays, the authors provide compelling evidence for a novel mTORC1/S6K1-IBTK-eIF4A1 signaling axis that promotes cancer pathogenic translation. This work is of broad interest and significance, given the importance of aberrant protein synthesis in cancer.

Reviewed by eLife