Cancer Biology

Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6

1. Kirsty M Ferguson
2. Carla Blin
3. Claudia Garcia-Diaz
4. Harry Bulstrode
5. Raul Bardini Bressan
6. Katrina McCarten
7. Steven M. Pollard

Reviewed by Review Commons

Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

1. Simei Go
2. Constantinos Demetriou
3. Giampiero Valenzano
4. Sophie Hughes
5. Simone Lanfredini
6. Helen Ferry
7. Edward Arbe-Barnes
8. Shivan Sivakumar
9. Rachel Bashford-Rogers
10. Mark R Middleton
11. Somnath Mukherjee
12. Jennifer Morton
13. Keaton Jones
14. Eric O Neill

• Curated by eLife

  eLife assessment

  This valuable manuscript provides an interesting account documenting the role of resident CD56(br) NK cells in driving interaction with dendritic cells that attract CD8+ T cells to the pancreas cancer tumor microenvironment (TME). The work convincingly illustrates how irradiation combined with CCR5i and PD1 blockade leads to a reduction in pancreatic cancer growth that correlates with a reduction in Treg cells and enhancement of NK and CD8 T cells in the TME. The correlation of NKC1 signature with survival in pancreatic cancer patients is indeed of broader interest regarding potential relevance to other types of cancer.

Reviewed by eLife

A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRvIII, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo

1. Alex Weiss
2. Cassandra D'Amata
3. Bret J Pearson
4. Madeline N Hayes

• Curated by eLife

  eLife assessment

  This study presents a valuable syngeneic zebrafish model for studying glioblastoma and will be of interest to neuro-oncologists and cancer biologists. Using a feasible in vivo model to study the tumour microenvironment, cell/cell interaction, and immunity, the data are compelling, and opens up new lines of inquiries for future investigation on the impact of efferocytosis on tumor progression and cell of origin in this model as well as assessments of drug resistance mechanisms, using inhibitors to MAPK , Akt and/or mTOR pathway.

Reviewed by eLife

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

1. Fang Huang
2. Zhenwei Dai
3. Jinmiao Yu
4. Kainan Wang
5. Chaoqun Chen
6. Dan Chen
7. Jinrui Zhang
8. Jinyao Zhao
9. Mei Li
10. Wenjing Zhang
11. Xiaojie Li
12. Yangfan Qi
13. Yang Wang

• Curated by eLife

  eLife assessment

  This study presents a rather valuable finding on the RBM7 function in spicing regulation and uncharacterized role of MFGE8 splicing alteration in breast cancer metastasis. The evidence supporting the claims of the authors is solid. The work will be of broad interest to clinicians, medical researchers and scientists working on breast cancer.

Reviewed by eLife

Prognostic Significance of preoperative serum CA125, CA19-9, CA72-4, CEA, and AFP in Patients with Endometrial cancer

1. Zi-hao Wang
2. Yun-zheng Zhang
3. Shu-wen Ge
4. Luhe-Shan
5. Bo Wang
6. Zi-yu Zhang
7. Qi-jun Wu
8. Xiao-xin Ma

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on prognostic values of serum CA125, CEA, and AFP for predicting patient outcomes of endometrial cancer. The evidence supporting the claims of the authors is solid, although inclusion of detailed discussion of present results with prior documented findings would have strengthened the study. The work will be of interest to scientists working on endometrial cancer.

Reviewed by eLife

Emerging role of oncogenic ß-catenin in exosome biogenesis as a driver of immune escape in hepatocellular carcinoma

1. Camille Dantzer
2. Justine Vaché
3. Aude Brunel
4. Isabelle Mahouche
5. Anne-Aurélie Raymond
6. Jean-William Dupuy
7. Melina Petrel
8. Paulette Bioulac-Sage
9. David Perrais
10. Nathalie Dugot-Senant
11. Mireille Verdier
12. Barbara Bessette
13. Clotilde Billottet
14. Violaine Moreau

• Curated by eLife

  eLife assessment

  Hepatocellular carcinoma (HCC) is a particularly aggressive form of cancer, with an increasing number of treatment options approved for use in patients over the past decade. However, the biology of HCC and identifiable therapeutic targets have not been as clear, even in the era of molecular oncology. Likewise, the cellular biology of HCC, including the role of intercellular communication, has not been well elucidated. In this compelling study, Dantzer et al. provide fundamental insight into the role of beta-catenin on intercellular communication occurring via extracellular vesicles, with implications for immune evasion in a cancer increasingly being treated using immuno-oncologic agents.

Reviewed by eLife

Post-transcriptional control drives Aurora kinase A expression in human cancers

1. Roberta Cacioppo
2. Deniz Rad
3. Giulia Pagani
4. Paolo Gandellini
5. Catherine Lindon

Reviewed by Review Commons

RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

1. Yang Liu
2. Yi Jiang
3. Peng Qiu
4. Tie Ma
5. Yang Bai
6. Jiawen Bu
7. Yueting Hu
8. Ming Jin
9. Tong Zhu
10. Xi Gu

• Curated by eLife

  eLife assessment

  This valuable paper first demonstrated that RGS10 was identified as a biomarker to evaluate the prognosis of breast cancer. To prevent the loss of RGS10 theoretically provide a new strategy for the treatment of breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples and an animal model would have strengthened the study. The work will be of interest to clinicians working on breast cancer.

Reviewed by eLife

Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

1. Khanh N. Dinh
2. Monika K. Kurpas
3. Marek Kimmel

• Curated by eLife

  eLife assessment

  This study uses numerical simulations to characterize and compare variants of two widely used mathematical models and then applies those models to inferring evolutionary parameters from breast cancer data. The copious numerical results will be of some interest to mathematical biologists working with similar models. The finding that many breast cancer mutations are mildly deleterious is valuable but the evidence supporting this claim is incomplete because the mathematical modelling and statistical methods are insufficiently justified and inadequately validated.

Reviewed by eLife

STIL overexpression shortens lifespan and reduces tumor formation in mice

1. Amira-Talaat Moussa
2. Marco R. Cosenza
3. Timothy Wohlfromm
4. Katharina Brobeil
5. Anthony Hill
6. Annarita Patrizi
7. Karin Müller-Decker
8. Tim Holland-Letz
9. Anna Jauch
10. Bianca Kraft
11. Alwin Krämer

Reviewed by Review Commons