Cancer Biology

  1. High-content microscopy reveals a morphological signature of bortezomib resistance

    1. Megan E Kelley
    2. Adi Y Berman
    3. David R Stirling
    4. Beth A Cimini
    5. Yu Han
    6. Shantanu Singh
    7. Anne E Carpenter
    8. Tarun M Kapoor
    9. Gregory P Way

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  2. MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

    1. Juliana Cazarin
    2. Rachel E. DeRollo
    3. Siti Noor Ain Binti Ahmad Shahidan
    4. Jamison B. Burchett
    5. Daniel Mwangi
    6. Saikumari Krishnaiah
    7. Annie L. Hsieh
    8. Zandra E. Walton
    9. Rebekah Brooks
    10. Stephano S. Mello
    11. Aalim M. Weljie
    12. Chi V. Dang
    13. Brian J. Altman

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  3. Lipid Droplets Fuel Small Extracellular Vesicle Biogenesis

    1. Géraldine C. Genard
    2. Luca Tirinato
    3. Francesca Pagliari
    4. Jessica Da Silva
    5. Alessandro Giammona
    6. Fatema Alquraish
    7. Marie Bordas
    8. Maria Grazia Marafioti
    9. Simone Di Franco
    10. Jeannette Janssen
    11. Daniel Garcia-Calderón
    12. Rachel Hanley
    13. Clelia Nistico
    14. Yoshinori Fukasawa
    15. Torsten Müller
    16. Jeroen Krijgsveld
    17. Matilde Todaro
    18. Francesco Saverio Costanzo
    19. Giorgio Stassi
    20. Michelle Nessling
    21. Karsten Richter
    22. Kendra K. Maass
    23. Carlo Liberale
    24. Joao Seco

    Reviewed by Review Commons

    6 evaluationsAppears in 1 listLatest version Latest activity

  4. Paralog dispensability shapes homozygous deletion patterns in tumor genomes

    1. Barbara De Kegel
    2. Colm J Ryan

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Oncogenic functions of the m6A demethylase FTO in breast cancer cells involving translational upregulation of C/EBPβ-LIP

    1. Hidde R. Zuidhof
    2. Christine Müller
    3. Gertrud Kortman
    4. René Wardenaar
    5. Ekaterina Stepanova
    6. Fabricio Loayza-Puch
    7. Cornelis F. Calkhoven

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. The Drosophila cancer-germline, head-to-head gene pair TrxT and dhd is dispensable for normal brain development but plays a major role in l(3)malignant brain tumour growth

    1. Cristina Molnar
    2. Jan Peter Heinen
    3. Jose Reina
    4. Salud Llamazares
    5. Emilio Palumbo
    6. Giulia Pollarolo
    7. Cayetano Gonzalez

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile

    1. Audrey Burban
    2. Cloe Tessier
    3. Mathieu Larroquette
    4. Joris Guyon
    5. Cloe Lubiato
    6. Mathis Pinglaut
    7. Maxime Toujas
    8. Johanna Galvis
    9. Benjamin Dartigues
    10. Emmanuelle Georget
    11. H Artee Luchman
    12. Samuel Weiss
    13. David Cappellen
    14. Nathalie Nicot
    15. Barbara Klink
    16. Macha Nikolski
    17. Lucie Brisson
    18. Thomas Mathivet
    19. Andreas Bikfalvi
    20. Thomas Daubon
    21. Ahmad Sharanek

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Convergent epigenetic evolution drives relapse in acute myeloid leukemia

    1. Kevin Nuno
    2. Armon Azizi
    3. Thomas Koehnke
    4. Caleb Lareau
    5. Asiri Ediriwickrema
    6. M Ryan Corces
    7. Ansuman T Satpathy
    8. Ravindra Majeti

    • Curated by eLife

      eLife assessment

      This important work substantially advances our understanding of how resistant leukemia can arise without changes in mutational patterns by displaying epigenetic changes. The evidence supporting the conclusions is compelling, with rigorous genomic assays done on primary samples. and state-of-the-art microscopy. The work will be of broad interest to hematologists and cancer biologists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Role of HAO2 in rats with chronic kidney disease by regulating fatty acid metabolic processes in renal tissue

    1. Xunjia Li
    2. Chengxuan Liu
    3. Aimin Yang
    4. Youfeng Shen
    5. Jian Xu
    6. Deyu Zuo

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

    1. Brandon H Hayes
    2. Mai Wang
    3. Hui Zhu
    4. Steven H Phan
    5. Lawrence J Dooling
    6. Jason C Andrechak
    7. Alexander H Chang
    8. Michael P Tobin
    9. Nicholas M Ontko
    10. Tristan Marchena
    11. Dennis E Discher

    • Curated by eLife

      eLife assessment

      The authors provide compelling evidence that MSP1 inhibition (leading to chromosomal instability or CIN in the cancer cells) increases phagocytosis and that tumors with CIN respond better to macrophage therapeutics. In this important study, they demonstrate particularly impressive survival rates for mouse models of CIN B16 tumors treated with adoptively transferred macrophages, CD47-SIRPα blockade, and anti-Tyrp1 IgG.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity
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