1. High-density sampling reveals volume growth in human tumours

    This article has 6 authors:
    1. Arman Angaji
    2. Michel Owusu
    3. Christoph Velling
    4. Nicola Dick
    5. Donate Weghorn
    6. Johannes Berg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The article uses a cell-based model to investigate how mutations and cells spread throughout a tumour. The paper uses published data and the proposed model to understand how growth and death mechanisms lead to the observed data. This work provides an important insight into the early stages of tumour development. From the work provided here, the results are convincing, using a thorough analysis.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Restraint of melanoma progression by cells in the local skin environment

    This article has 7 authors:
    1. Yilun Ma
    2. Mohita Tagore
    3. Miranda V Hunter
    4. Ting-Hsiang Huang
    5. Emily Montal
    6. Joshua M Weiss
    7. Richard M White
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important study, the authors used a zebrafish model and scRNAseq analysis to show that a subset of keratinocytes within melanoma microenvironment highly up-regulate Twist and undergo Epithelial-Mesenchymal Transition (EMT). Surprisingly, when overexpressing Twist in keratinocytes, the resulting alteration in keratinocytes is inhibitory for melanoma invasion in both zebrafish and human cell culture models. The results are supported by overall convincing experimental data that provide new insights into the interactions between melanoma cells and their environment.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1

    This article has 17 authors:
    1. Jordina Rincon-Torroella
    2. Marco Dal Molin
    3. Brian Mog
    4. Gyuri Han
    5. Evangeline Watson
    6. Nicolas Wyhs
    7. Shun Ishiyama
    8. Taha Ahmedna
    9. Il Minn
    10. Nilofer Azad
    11. Chetan Bettegowda
    12. Nickolas Papadopoulos
    13. Kenneth W Kinzler
    14. Shibin Zhou
    15. Bert Vogelstein
    16. Kathleen Gabrielson
    17. Surojit Sur
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding and developed ME3BP-7 as a novel microencapsulated formulation of 3BP, which specifically targets MCT1-overexpressing PDAC cells. It demonstrates its specificity and efficacy in vitro and in PDAC mouse models, with significant anti-tumor effects and improved serum stability. Overall, the evidence supporting the authors' claims is solid.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer

    This article has 10 authors:
    1. Xujin Wei
    2. Jie Liu
    3. Jia Cheng
    4. Wangyu Cai
    5. Wen Xie
    6. Kang Wang
    7. Lingyun Lin
    8. Jingjing Hou
    9. Jianchun Cai
    10. Huiqin Zhuo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors provide useful data to support the existence of a regulatory pathway starting with SPI1-driven ZFP36L1 expression, that goes on to downregulate HDAC3 expression at the transcript level, leading to PD-L1 upregulation due to implied enhanced acetylation of its promoter region. This is therefore an interesting pathway that adds to our understanding of how PD-L1 expression is controlled in gastric cancer. However, this is likely one of many possible pathways that impact PD-L1 expression, and the data are currently incomplete to support the claims made.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. The T cell receptor β chain repertoire of tumor infiltrating lymphocytes improves neoantigen prediction and prioritization

    This article has 18 authors:
    1. Thi Mong Quynh Pham
    2. Thanh Nhan Nguyen
    3. Bui Que Tran Nguyen
    4. Thi Phuong Diem Tran
    5. Nguyen My Diem Pham
    6. Hoang Thien Phuc Nguyen
    7. Thi Kim Cuong Ho
    8. Dinh Viet Linh Nguyen
    9. Huu Thinh Nguyen
    10. Duc Huy Tran
    11. Thanh Sang Tran
    12. Truong Vinh Ngoc Pham
    13. Minh Triet Le
    14. Thi Tuong Vy Nguyen
    15. Minh-Duy Phan
    16. Hoa Giang
    17. Hoai-Nghia Nguyen
    18. Le Son Tran
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents a potentially valuable approach by combining two measurements (pHLA binding and pHLA-TCR binding) to improve predictions of which mutations in colorectal cancer are likely to be presented to and recognised by the immune system. While this approach is promising, the evidence supporting the primary claim remains somewhat incomplete. The experimental validation of the computational predictions with actual immune responses is still limited, despite the increase in sample size from 4 to 8 in this revision.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

    This article has 9 authors:
    1. Qianqian Ju
    2. Wenjing Sheng
    3. Meichen Zhang
    4. Jing Chen
    5. Liucheng Wu
    6. Xiaoyu Liu
    7. Wentao Fang
    8. Hui Shi
    9. Cheng Sun
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work provides solid evidence that Transforming Growth Factor β Activated Kinase 1 (TAK1) regulates esophageal squamous cell carcinoma (ESCC) tumor proliferation and metastasis. The findings are valuable to the field of molecular tumor biology in general and to the understanding of ESCC tumor invasiveness and metastatic potential.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Mitochondrial stress-induced protein carboxyl-terminal alanine threonine tailing (msiCAT-tailing) facilitates glioblastoma tumorigenesis through the modulation of mitochondrial functions

    This article has 13 authors:
    1. Bei Zhang
    2. Ting Cai
    3. Esha Reddy
    4. Yuanna Wu
    5. Adaeze Scholastical Gbufor
    6. Yinglu Tang
    7. Isha Mondal
    8. Jerry Wang
    9. Yawei Shen
    10. Qing Liu
    11. Winson S Ho
    12. Rongze Olivia Lu
    13. Zhihao Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Glioblastoma is one of the most aggressive cancers without a cure. Glioblastoma cells are known to have high mitochondrial potential. This useful study demonstrates the critical role of the ribosome-associated quality control (RQC) pathway in regulating mitochondrial membrane potential and glioblastoma growth. Some assays are incomplete; further revision will improve the significance of this study.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice

    This article has 1 author:
    1. Zheng Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides a valuable strategy for treating mouse cutaneous squamous cell carcinoma (mCSCC) with serum derived from mCSCC-exposed mice. The exploration of serum-derived antibodies as a potential therapy for curing cancer is particularly promising but the study provides incomplete evidence for specific effects of mCSCC-binding serum antibodies. This study will be of interest to scientists seeking a novel immunotherapeutic strategy in cancer therapy.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

    This article has 14 authors:
    1. Jianwen Chen
    2. Bao Zhao
    3. Hong Dong
    4. Tianliang Li
    5. Xiang Cheng
    6. Wang Gong
    7. Jing Wang
    8. Junran Zhang
    9. Gang Xin
    10. Yanbao Yu
    11. Yu L Lei
    12. Jennifer D Black
    13. Zihai Li
    14. Haitao Wen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The author demonstrates that deficiency or pharmacological inhibition of O-glcNac transferase (OGT) enhances tumor immunity in colorectal cancer models. This useful study unveils that OGT deficiency triggers a DNA damage response that can affect immune status in colorectal cancers. It provides convincing evidence showing that OGT-mediated processing of HSF1 is crucial in maintaining genomic integrity.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Engineering PEG10-assembled endogenous virus-like particles with genetically encoded neoantigen peptides for cancer vaccination

    This article has 11 authors:
    1. Ruijing Tang
    2. Luobin Guo
    3. Tingyu Wei
    4. Tingting Chen
    5. Huan Yang
    6. Honghao Ye
    7. Fangzhou Lin
    8. Yongyi Zeng
    9. Haijun Yu
    10. Zhixiong Cai
    11. Xiaolong Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable strategy to co-deliver peptides and adjuvants to antigen-presenting cells by engineering the Virus-like particle (VLP). The evidence supporting the claims of the authors is convincing, but the antitumour efficacy is unimpressive and would benefit from more antitumor experiments. The work will be of broad interest to bioengineers and medical biologists focusing on cancer vaccines.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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