Cancer Biology

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

1. Yiwei Huang
2. Gujie Wu
3. Guoshu Bi
4. Lin Cheng
5. Jiaqi Liang
6. Ming Li
7. Huan Zhang
8. Guangyao Shan
9. Zhengyang Hu
10. Zhencong Chen
11. Zongwu Lin
12. Wei Jiang
13. Qun Wang
14. Junjie Xi
15. Shanye Yin
16. Cheng Zhan

• Curated by eLife

  eLife Assessment

  This study reports single-cell RNA sequencing results of lung adenocarcinoma, comparing 4 treatment-naive and 5 post-neoadjuvant chemotherapy tumor samples. Of interest is the delineation of two macrophage subtypes: Anti-mac cells (CD45+CD11b+CD86+) and Pro-mac cells (CD45+CD11b+ARG+), with the proportion of Pro-mac/pro-tumorigenic cells significantly increasing in LUAD tissues after neoadjuvant chemotherapy. In terms of significance, the findings might be useful. However issues remain after the revision with lengthy descriptive clustering type analysis, insufficient statistical support, and inefficient figure presentation. As it stands, the level of supportive evidence is inadequate.

Reviewed by eLife

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

1. Maojin Tian
2. Le Yang
3. Ziqian Zhao
4. Jigang Li
5. Lianqing Wang
6. Qingqing Yin
7. Wei Hu
8. Yunwei Lou
9. Jianxin Du
10. Peiqing Zhao

• Curated by eLife

  eLife Assessment

  This important study investigates the molecular mechanisms underpinning how the tumor necrosis factor alpha-induced protein (TIPE) regulates aerobic glycolysis to promote tumor growth in melanoma. Convincing data using multiple independent approaches provides new insights into the molecular mechanisms underpinning aerobic glycolysis in melanoma cells. The work will be of interest to biomedical researchers working in cancer and metabolism.

Reviewed by eLife

Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

1. Yaroslav Kainov
2. Fursham Hamid
3. Eugene V Makeyev

• Curated by eLife

  eLife Assessment

  This important study substantially advances our understanding of noncoding somatic mutations by identifying a novel class of mutations that affect 3'UTR polyadenylation signals enriched in tumor suppressor genes in cancer. The evidence supporting the conclusions is convincing, with rigorous statistical analyses. The work will be of broad interest to cancer researchers.

Reviewed by eLife

CPT1A mediates radiation sensitivity in colorectal cancer

1. Zhenhui Chen
2. Lu Yu
3. Zhihao Zheng
4. Xusheng Wang
5. Qiqing Guo
6. Yuchuan Chen
7. Yaowei Zhang
8. Yuqin Zhang
9. Jianbiao Xiao
10. Keli Chen
11. Hongying Fan
12. Yi Ding

• Curated by eLife

  eLife Assessment

  This study reports a valuable finding for the treatment of colorectal cancer (CRC), as the authors demonstrated that the enzyme CPT1A plays an significant role in the response to radiotherapy in CRC patients. However, the reviewers found that the results presented are still incomplete.

Reviewed by eLife

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

1. Anna Shemorry
2. Willem den Besten
3. Melinda M. Mulvihill
4. Curt J. Essenburg
5. Nicole Blaquiere
6. Tracy Kleinheinz
7. Elisia Villemure
8. Frank Peale
9. Gauri Deshmukh
10. Danilo Maddalo
11. Elizabeth Levy
12. Kebing Yu
13. Matthew R. Steensma
14. Elizabeth A. Tovar
15. Emily Wolfrum
16. Karthik Nagapudi
17. Robert A. Blake
18. William F. Forrest
19. Steven T. Staben
20. Carrie R. Graveel
21. Wayne J. Fairbrother
22. Ingrid E. Wertz

Reviewed by PREreview

Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

1. Ananda Kishore Mukherjee
2. Subhajit Dutta
3. Ankita Singh
4. Shalu Sharma
5. Shuvra Shekhar Roy
6. Antara Sengupta
7. Megha Chatterjee
8. Soujanya Vinayagamurthy
9. Sulochana Bagri
10. Divya Khanna
11. Meenakshi Verma
12. Dristhi Soni
13. Anshul Budharaja
14. Sagar Kailasrao Bhisade
15. Vivek Anand
16. Ahmad Perwez
17. Nija George
18. Mohammed Faruq
19. Ishaan Gupta
20. Radhakrishnan Sabarinathan
21. Shantanu Chowdhury

• Curated by eLife

  eLife Assessment

  This study presents an important finding on the role of telomeres in modulating interleukin-1 signaling and tumor immunity in TNBC. The evidence supporting these findings is solid, presented through comprehensive analyses including TNBC clinical samples, tumor-derived organoids, cancer cells, and xenografts. The work will be of broad interest to cell and medical biologists focusing on TNBC.

Reviewed by eLife

Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

1. Xinlei Cai
2. Yi Ye
3. Xiaoping Liu
4. Zhaoyuan Fang
5. Luonan Chen
6. Fei Li
7. Hongbin Ji

• Curated by eLife

  eLife Assessment

  This paper contains valuable ideas for methodology concerned with the identification of genes associated with disease prognosis in a broad range of cancers. However, there are concerns that the statistical properties of MEMORY are incompletely investigated and described. Further, more precise details about the implementation of the method would increase the replicability of the findings by other researchers.

Reviewed by eLife

SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

1. Amol Tandon
2. Josh Stern

Reviewed by PREreview

Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

1. Jae Hun Shin
2. Jooyoung Park
3. Jaechul Lim
4. Jaekwang Jeong
5. Ravi K Dinesh
6. Stephen E Maher
7. Jeonghyun Kim
8. Soyeon Park
9. Jun Young Hong
10. John Wysolmerski
11. Jungmin Choi
12. Alfred LM Bothwell

• Curated by eLife

  eLife Assessment

  This valuable study proposes that protein secreted by colon cancer cells induces cells with Paneth-like properties that favor colon cancer metastasis. The evidence supporting the conclusions is strong but would benefit from more direct experiments to test the functional role of Paneth-like cells and to monitor metastasis from colon tumors. The work will be of interest to researchers studying colon cancer metastasis.

Reviewed by eLife

An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

1. Chiara Capitani
2. Jessica Iorio
3. Elena Lastraioli
4. Claudia Duranti
5. Giacomo Bagni
6. Ginevra Chioccioli Altadonna
7. Rossella Colasurdo
8. Giorgia Scarpellino
9. Scott P. Fraser
10. Andrea Becchetti
11. Mustafa B. A. Djamgoz
12. Annarosa Arcangeli

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

Reviewed by eLife