1. Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

    This article has 8 authors:
    1. Charlien Vandersmissen
    2. Sofie Demeyer
    3. Kris Jacobs
    4. Lien Boogaerts
    5. Sara Gutiérrez Fernández
    6. Heidi Segers
    7. Lucía Chávez-Gutiérrez
    8. Jan Cools

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

    This article has 16 authors:
    1. Youyou Zhang
    2. Mu Xu
    3. Jiao Yuan
    4. Zhongyi Hu
    5. Junjie Jiang
    6. Jie Huang
    7. Bingwei Wang
    8. Jianfeng Shen
    9. Meixiao Long
    10. Yi Fan
    11. Kathleen T Montone
    12. Janos L Tanyi
    13. Omid Tavana
    14. Ho Man Chan
    15. Xiaowen Hu
    16. Lin Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding that PRMT inhibitors may exert synergistic effects with PARP inhibitors to eliminate ovarian and triple-negative cancer cells in vitro and in vivo using preclinical mouse models. The evidence supporting the claims of the authors is solid, although the inclusion of novelty justification would have strengthened the study. The work will be of interest to scientists working on breast cancer and ovarian cancer.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. The DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    This article has 7 authors:
    1. Ariunaa Bayanjargal
    2. Cenny Taslim
    3. Iftekhar A Showpnil
    4. Julia Selich-Anderson
    5. Jesse C Crow
    6. Stephen L Lessnick
    7. Emily R Theisen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper investigates how the EWS::FLI1 fusion protein organizes chromatin topology and regulates gene expression in an aggressive pediatric bone cancer known as Ewing sarcoma. The authors used the most recent genomics methodologies to provide solid-based evidence for the role of a short alpha helix in the DNA binding domain of FLI1 in modulating binding to GGAA microsatellites and promoting enhancer activity. The study provides valuable insight into the underlying oncogenic mechanisms in Ewing sarcoma, despite the inherent limitations of the some of the techniques used.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  4. Aging represses lung tumorigenesis and alters tumor suppression

    This article has 12 authors:
    1. Emily G. Shuldiner
    2. Saswati Karmakar
    3. Min K. Tsai
    4. Jess D. Hebert
    5. Yuning J. Tang
    6. Laura Andrejka
    7. Minwei Wang
    8. Colin R. Detrick
    9. Hongchen Cai
    10. Rui Tang
    11. Dmitri A. Petrov
    12. Monte M. Winslow

    Reviewed by PREreview

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  5. Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    This article has 11 authors:
    1. Joakim Karlsson
    2. Vasu R Sah
    3. Roger Olofsson Bagge
    4. Irina Kuznetsova
    5. Munir Iqbal
    6. Samuel Alsén
    7. Sofia Stenqvist
    8. Alka Saxena
    9. Lars Ny
    10. Lisa M Nilsson
    11. Jonas A Nilsson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on tumor-reactive T cells in liver metastases of uveal melanoma (UM). The authors conducted single-cell RNA sequencing to identify potential tumor-reactive T cells and used PDX models for functional analysis. The evidence supporting their claims is solid. The work will be of interest to scientists working in the field of uveal melanoma.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

    This article has 8 authors:
    1. Kai Sha
    2. Renyuan Zhang
    3. Aerken Maolake
    4. Shalini Singh
    5. Gurkamal Chatta
    6. Kevin H Eng
    7. Kent L Nastiuk
    8. John J Krolewski
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a potentially valuable finding regarding the role of cytokine signaling in the mechanism of response and resistance to castration therapy in prostate cancer. The evidence, although solid for some aspects of the work, is incomplete and only partially supports the main claims.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

    This article has 15 authors:
    1. Megan E Patton
    2. Sherwin Kelekar
    3. Lauren J Taylor
    4. Angela E Dean
    5. Qianying Zuo
    6. Rhishikesh N Thakare
    7. Sung Hwan Lee
    8. Emily Gentry
    9. Morgan Panitchpakdi
    10. Pieter Dorrestein
    11. Yazen Alnouti
    12. Zeynep Madak-Erdogan
    13. Ju-Seog Lee
    14. Milton J Finegold
    15. Sayeepriyadarshini Anakk
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable insights into the influence of sex on bile acid metabolism and the risk of hepatocellular carcinoma (HCC). The data to support that there are inter-relationships between sex, bile acids, and HCC in mice are solid, but for the most part, they are descriptive. At this point, there is not enough evidence to determine the clinical significance of the findings, given the differences in bile acid composition between mice and men.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

    This article has 9 authors:
    1. Ismail M Meraz
    2. Mourad Majidi
    3. Renduo Song
    4. Meng Feng
    5. Lihui Gao
    6. Qi Wang
    7. Jing Wang
    8. Elizabeth Shpall
    9. Jack A Roth
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides a novel and promising NPRL2 gene therapy for enhanced immunotherapy response in a KRAS/STK11 mutant anti-PD1 resistant metastatic NSCLC humanized mouse model. Overall, the authors presented a large amount of convincing in vivo data to demonstrate that NPRL2 gene therapy induces antitumor activity through DC-mediated antigen presentation and cytotoxic immune cell activation. This work will be of interest and useful to medical biologists and oncologists in the research field of KRAS-mutant NSCLC.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

    This article has 11 authors:
    1. Samarjit Jana
    2. Mainak Mondal
    3. Sagar Mahale
    4. Bhavana Gupta
    5. Kaval Reddy Prasasvi
    6. Lekha Kandasami
    7. Neha Jha
    8. Abhishek Chowdhury
    9. Vani Santosh
    10. Chandrasekhar Kanduri
    11. Kumaravel Somasundaram
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study reports, with convincing evidence, that a long non-coding RNA disrupts the activity of the tumor suppressor p53 to contribute to the growth and therapeutic response of glioblastoma. The work will be relevant to scientists working on non-coding RNAs and brain tumors.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. Dual Targeting of Histone Deacetylases and MYC as Potential Treatment Strategy for H3-K27M Pediatric Gliomas

    This article has 11 authors:
    1. Danielle Algranati
    2. Roni Oren
    3. Bareket Dassa
    4. Liat Fellus-Alyagor
    5. Alexander Plotnikov
    6. Haim Barr
    7. Alon Harmelin
    8. Nir London
    9. Guy Ron
    10. Noa Furth
    11. Efrat Shema
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work contributes to the study of H3-K27M mutated pediatric gliomas. It convincingly demonstrates that the concomitant targeting of histone deacetylases (HDACs) and the transcription factor MYC results in a notable reduction in cell viability and tumor growth. This reduction is linked to the suppression of critical oncogenic pathways, particularly mTOR signaling, emphasizing the role of these pathways in the disease's pathogenesis. The current version of the manuscript is important because it unveils a vulnerability from dual targeting HDACs and MYC in the context of pediatric gliomas. This work will be of interest to cancer epigenetics and therapeutics research, with a focus on the neuro-oncology field.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity