Biophysics

  1. The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

    1. Hai Li
    2. Chia-Ying Huang
    3. Elena G Govorunova
    4. Oleg A Sineshchekov
    5. Adrian Yi
    6. Kenneth J Rothschild
    7. Meitian Wang
    8. Lei Zheng
    9. John L Spudich

    • Curated by eLife

      Evaluation Summary:

      This manuscript reports a significant contribution towards an improved mechanistic understanding of light gated anion channels. The studies, which use the recently established method of in meso in situ serial data collection (IMISX), provide a basis for optimizing the anion channelrhodopsin GtACR1 from the alga Guillardia theta as a neuron-inhibiting optogenetics tool. The work will be of interest to anyone using optogenetics for functional studies. The reviewers had a few comments regarding technical aspects of the work.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Energy landscape of the SARS-CoV-2 reveals extensive conformational heterogeneity

    1. Ghoncheh Mashayekhi
    2. John Vant
    3. Abhigna Polavarapu
    4. Abbas Ourmazd
    5. Abhishek Singharoy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

    1. Shreyas Bhat
    2. Marco Niello
    3. Klaus Schicker
    4. Christian Pifl
    5. Harald H Sitte
    6. Michael Freissmuth
    7. Walter Sandtner

    • Curated by eLife

      Evaluation Summary:

      This paper will be of interest to scientists interested in mechanistic studies of ion-coupled transporters. The authors demonstrate that dopamine, catecholamine and serotonin transporters - albeit structurally very similar - differ in the number of transport substrates and they define the underlying functional basis of this difference using a range of sophisticated techniques. This is an extremely nice and interesting study. providing new tools and new insights into an important class of transporter. Since many drugs that block one of the transporters also modify the two others, the paper may help to define pharmaceutical approaches that specifically block only one of them and that might allow for a better treatment of psychiatric diseases. The data analysis is rigorous and the conclusions are justified by the data, but the paper should be made more "user friendly" so that a wider audience could appreciate it better.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  4. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes

    1. Meghna Gupta
    2. Caleigh M. Azumaya
    3. Michelle Moritz
    4. Sergei Pourmal
    5. Amy Diallo
    6. Gregory E. Merz
    7. Gwendolyn Jang
    8. Mehdi Bouhaddou
    9. Andrea Fossati
    10. Axel F. Brilot
    11. Devan Diwanji
    12. Evelyn Hernandez
    13. Nadia Herrera
    14. Huong T. Kratochvil
    15. Victor L. Lam
    16. Fei Li
    17. Yang Li
    18. Henry C. Nguyen
    19. Carlos Nowotny
    20. Tristan W. Owens
    21. Jessica K. Peters
    22. Alexandrea N. Rizo
    23. Ursula Schulze-Gahmen
    24. Amber M. Smith
    25. Iris D. Young
    26. Zanlin Yu
    27. Daniel Asarnow
    28. Christian Billesbølle
    29. Melody G. Campbell
    30. Jen Chen
    31. Kuei-Ho Chen
    32. Un Seng Chio
    33. Miles Sasha Dickinson
    34. Loan Doan
    35. Mingliang Jin
    36. Kate Kim
    37. Junrui Li
    38. Yen-Li Li
    39. Edmond Linossi
    40. Yanxin Liu
    41. Megan Lo
    42. Jocelyne Lopez
    43. Kyle E. Lopez
    44. Adamo Mancino
    45. Frank R. Moss
    46. Michael D. Paul
    47. Komal Ishwar Pawar
    48. Adrian Pelin
    49. Thomas H. Pospiech
    50. Cristina Puchades
    51. Soumya Govinda Remesh
    52. Maliheh Safari
    53. Kaitlin Schaefer
    54. Ming Sun
    55. Mariano C Tabios
    56. Aye C. Thwin
    57. Erron W. Titus
    58. Raphael Trenker
    59. Eric Tse
    60. Tsz Kin Martin Tsui
    61. Feng Wang
    62. Kaihua Zhang
    63. Yang Zhang
    64. Jianhua Zhao
    65. Fengbo Zhou
    66. Yuan Zhou
    67. Lorena Zuliani-Alvarez
    68. QCRG Structural Biology Consortium
    69. David A Agard
    70. Yifan Cheng
    71. James S Fraser
    72. Natalia Jura
    73. Tanja Kortemme
    74. Aashish Manglik
    75. Daniel R. Southworth
    76. Robert M Stroud
    77. Danielle L Swaney
    78. Nevan J Krogan
    79. Adam Frost
    80. Oren S Rosenberg
    81. Kliment A Verba

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Dynamic Interactions of Fully Glycosylated SARS-CoV-2 Spike Protein with Various Antibodies

    1. Yiwei Cao
    2. Yeol Kyo Choi
    3. Martin Frank
    4. Hyeonuk Woo
    5. Sang-Jun Park
    6. Min Sun Yeom
    7. Chaok Seok
    8. Wonpil Im

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. The role of host cell glycans on virus infectivity: The SARS-CoV-2 case

    1. Silvia Acosta-Gutiérrez
    2. Joseph Buckley
    3. Giuseppe Battaglia

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Vitamin C Binds to SARS Coronavirus-2 Main Protease Essential for Viral Replication

    1. Tek Narsingh Malla
    2. Suraj Pandey
    3. Luis Aldama
    4. Dennisse Feliz
    5. Moraima Noda
    6. Ishwor Poudyal
    7. George N. Phillips
    8. Emina A. Stojković
    9. Marius Schmidt

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

    1. Lorena Zuzic
    2. Firdaus Samsudin
    3. Aishwary T. Shivgan
    4. Palur V. Raghuvamsi
    5. Jan K Marzinek
    6. Alister Boags
    7. Conrado Pedebos
    8. Nikhil Kumar Tulsian
    9. Jim Warwicker
    10. Paul MacAry
    11. Max Crispin
    12. Syma Khalid
    13. Ganesh S. Anand
    14. Peter J Bond

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (M pro )

    1. Ali Ebrahim
    2. Blake T. Riley
    3. Desigan Kumaran
    4. Babak Andi
    5. Martin R. Fuchs
    6. Sean McSweeney
    7. Daniel A. Keedy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Binding of SARS-CoV-2 fusion peptide to host membranes

    1. Stefan L. Schaefer
    2. Hendrik Jung
    3. Gerhard Hummer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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